EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172794 (Gene tree)
Gene ID: 326624
Gene Symbol: RAB37
Alias: -
Full Name: RAB37, member RAS oncogene family
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 76,758 bases
Position: chr17:74,670,578-74,747,335
Accession: 30268
RBP type: canonical RBP
Summary: Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000341354	MMR_HSR1	PF01926.23	0.00049	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000481224	RAB37-209	1654	-	ENSP00000436563	223 (aa)	-	Q96AX2
ENST00000613645	RAB37-216	1653	-	ENSP00000483155	223 (aa)	-	Q96AX2
ENST00000531420	RAB37-213	561	-	-	- (aa)	-	-
ENST00000488977	RAB37-210	2195	-	-	- (aa)	-	-
ENST00000533530	RAB37-214	578	-	-	- (aa)	-	-
ENST00000577548	RAB37-215	950	-	-	- (aa)	-	-
ENST00000402449	RAB37-208	1560	-	ENSP00000383934	216 (aa)	-	Q96AX2
ENST00000392610	RAB37-202	2858	-	ENSP00000376387	189 (aa)	-	A8MTC6
ENST00000528438	RAB37-212	1494	-	ENSP00000432086	196 (aa)	-	B7Z3L0
ENST00000527040	RAB37-211	559	-	-	- (aa)	-	-
ENST00000340415	RAB37-201	3804	-	ENSP00000341354	182 (aa)	-	A8MSP2
ENST00000392612	RAB37-203	2528	-	ENSP00000376388	186 (aa)	-	Q96AX2
ENST00000392613	RAB37-204	2617	-	ENSP00000376389	223 (aa)	-	Q96AX2
ENST00000392614	RAB37-205	2704	-	ENSP00000376390	228 (aa)	-	Q96AX2
ENST00000392615	RAB37-206	2655	-	ENSP00000376391	191 (aa)	-	A8MZI4
ENST00000392617	RAB37-207	3780	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000172794's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000172794	Cardiovascular Diseases	1.1600000E-005	-
ENSG00000172794	Fibrinogen	2E-8	28107422
ENSG00000172794	Fibrinogen	2E-8	28107422
ENSG00000172794	Fibrinogen	1E-8	23969696
ENSG00000172794	Fibrinogen	8E-11	20031577

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172794	rs1037171	17	74706839	A	Monocyte count	27863252	[0.033-0.049] unit increase	0.04078738	EFO_0005091
ENSG00000172794	rs10512597	17	74703694	T	Fibrinogen	23969696	[0.006-0.01] unit decrease	0.008	EFO_0004623
ENSG00000172794	rs10512597	17	74703694	A	Fibrinogen	20031577	[NR] mg/dl decrease	6.45	EFO_0004623
ENSG00000172794	rs35489971	17	74704804	A	Coronary artery disease	29212778	[0.028-0.06] unit increase	0.0438	EFO_0000378
ENSG00000172794	rs2034310	17	74695789	C	Lymphocyte counts	27863252	[0.018-0.036] unit increase	0.02706763	EFO_0004587
ENSG00000172794	rs749780	17	74703245	A	Myeloid white cell count	27863252	[0.019-0.035] unit increase	0.02737397	EFO_0007988
ENSG00000172794	rs749780	17	74703245	A	White blood cell count	27863252	[0.022-0.038] unit increase	0.03030224	EFO_0004308
ENSG00000172794	rs12942311	17	74714657	C	Liver fibrosis in pediatric non-alcoholic fatty acid liver disease	28918882			EFO_0003095\|HP_0001395
ENSG00000172794	rs749780	17	74703245	A	Neutrophil count	27863252	[0.016-0.032] unit increase	0.02374859	EFO_0004833
ENSG00000172794	rs9906320	17	74694690	A	Plateletcrit	27863252	[0.017-0.035] unit increase	0.02613192	EFO_0007985
ENSG00000172794	rs77936863	17	74700954	T	Granulocyte count	27863252	[0.016-0.032] unit increase	0.02419283	EFO_0007987
ENSG00000172794	rs749780	17	74703245	A	Sum neutrophil eosinophil counts	27863252	[0.016-0.032] unit increase	0.02407953	EFO_0004833\|EFO_0004842
ENSG00000172794	rs10512597	17	74703694	?	Fibrinogen levels	28107422	unit increase	0.0078	EFO_0004623
ENSG00000172794	rs35489971	17	74704804	?	Fibrinogen levels	28107422	unit increase	0.0077	EFO_0004623
ENSG00000172794	rs749780	17	74703245	A	Sum basophil neutrophil counts	27863252	[0.016-0.032] unit increase	0.02390133	EFO_0004833\|EFO_0005090
ENSG00000172794	rs2084312	17	74699072	?	White blood cell count	30595370			EFO_0004308
ENSG00000172794	rs10512597	17	74703694	T	C-reactive protein levels	30388399	[0.027-0.047] unit decrease	0.037	EFO_0004458
ENSG00000172794	rs2384955	17	74699028	T	C-reactive protein levels	30388399	[0.029-0.053] unit decrease	0.041	EFO_0004458
ENSG00000172794	rs2384955	17	74699028	T	C-reactive protein levels	30388399	[0.026-0.05] unit decrease	0.038	EFO_0004458

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172794's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172794	RAB37	89	82.099	ENSACIG00000023222	-	86	77.041	Amphilophus_citrinellus
ENSG00000172794	RAB37	100	93.956	ENSCPOG00000025645	RAB37	100	91.667	Cavia_porcellus
ENSG00000172794	RAB37	100	96.154	ENSCLAG00000008913	RAB37	100	94.444	Chinchilla_lanigera
ENSG00000172794	RAB37	87	89.937	ENSCVAG00000014416	-	92	83.420	Cyprinodon_variegatus
ENSG00000172794	RAB37	94	79.532	ENSELUG00000023120	-	95	75.122	Esox_lucius
ENSG00000172794	RAB37	100	95.055	ENSFDAG00000015285	RAB37	100	93.056	Fukomys_damarensis
ENSG00000172794	RAB37	87	88.679	ENSGAFG00000014730	-	96	82.383	Gambusia_affinis
ENSG00000172794	RAB37	100	96.703	ENSHGLG00000004384	RAB37	100	94.907	Heterocephalus_glaber_female
ENSG00000172794	RAB37	100	96.703	ENSHGLG00100012557	-	100	94.907	Heterocephalus_glaber_male
ENSG00000172794	RAB37	98	81.461	ENSLBEG00000027539	-	94	76.887	Labrus_bergylta
ENSG00000172794	RAB37	87	89.873	ENSMAMG00000020286	-	76	89.873	Mastacembelus_armatus
ENSG00000172794	RAB37	100	96.154	MGP_CAROLIEiJ_G0017386	Rab37	100	95.370	Mus_caroli
ENSG00000172794	RAB37	100	96.154	ENSMUSG00000020732	Rab37	100	95.370	Mus_musculus
ENSG00000172794	RAB37	100	96.154	MGP_PahariEiJ_G0018517	Rab37	100	95.370	Mus_pahari
ENSG00000172794	RAB37	100	96.154	MGP_SPRETEiJ_G0018231	Rab37	100	95.370	Mus_spretus
ENSG00000172794	RAB37	91	67.857	ENSNBRG00000011872	-	93	67.857	Neolamprologus_brichardi
ENSG00000172794	RAB37	93	85.799	ENSORLG00000024558	-	83	80.198	Oryzias_latipes
ENSG00000172794	RAB37	93	85.799	ENSORLG00020015717	-	83	80.198	Oryzias_latipes_hni
ENSG00000172794	RAB37	93	85.799	ENSORLG00015013564	-	97	81.865	Oryzias_latipes_hsok
ENSG00000172794	RAB37	93	85.207	ENSOMEG00000018494	-	83	79.703	Oryzias_melastigma
ENSG00000172794	RAB37	100	88.525	ENSPCIG00000004450	-	100	86.239	Phascolarctos_cinereus
ENSG00000172794	RAB37	93	86.391	ENSPFOG00000019144	-	83	81.281	Poecilia_formosa
ENSG00000172794	RAB37	93	86.391	ENSPFOG00000006314	-	83	81.281	Poecilia_formosa
ENSG00000172794	RAB37	93	85.799	ENSPMEG00000017161	-	83	80.788	Poecilia_mexicana
ENSG00000172794	RAB37	93	85.799	ENSPMEG00000002564	-	83	80.788	Poecilia_mexicana
ENSG00000172794	RAB37	100	85.648	ENSPPYG00000008601	-	100	85.648	Pongo_abelii
ENSG00000172794	RAB37	91	85.542	ENSPNAG00000021675	-	93	77.889	Pygocentrus_nattereri
ENSG00000172794	RAB37	93	85.207	ENSXMAG00000021303	-	84	80.296	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	15308636.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0032482	Rab protein signal transduction	21873635.	IBA	Process
GO:0035577	azurophil granule membrane	-	TAS	Component
GO:0035579	specific granule membrane	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28151721	Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.	Clin Cancer Res	2017 May 1	Tzeng HT	doi: 10.1158/1078-0432.CCR-16-1520
25183545	Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.	Nat Commun	2014 Sep 3	Tsai CH	doi: 10.1038/ncomms5804.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr17	74744355	Silent	novel	I138I	0.08
ACC	chr17	74729344	Missense_Mutation	NA	A54V	0.2	MMR_HSR1
BLCA	chr17	74744873	Missense_Mutation	NA	A145S	0.34
BLCA	chr17	74745187	Intron	novel		0.17
BLCA	chr17	74745443	3'UTR	novel		0.4
BLCA	chr17	74743184	Missense_Mutation	rs527644258	R101K	0.37	MMR_HSR1
BLCA	chr17	74744352	Silent	rs765627620	V137V	0.13
BLCA	chr17	74742253	Splice_Site	novel	X69_splice	0.33
BLCA	chr17	74745187	Intron	novel		0.49
BRCA	chr17	74743141	Missense_Mutation	rs772882123	A87T	0.27	MMR_HSR1
BRCA	chr17	74740767	Splice_Site	NA	X32_splice	0.44
BRCA	chr17	74743324	Missense_Mutation	NA	S117C	0.34	MMR_HSR1
BRCA	chr17	74729366	Splice_Region	rs759047469	T61T	0.14
BRCA	chr17	74744386	Intron	novel		0.14
BRCA	chr17	74744767	Intron	novel		0.18
BRCA	chr17	74729309	Silent	rs115636998	F42F	0.32
CESC	chr17	74729331	Missense_Mutation	rs753157903	G50S	0.37	MMR_HSR1
CESC	chr17	74744892	Missense_Mutation	novel	R151T	0.68
COAD	chr17	74744788	Intron	novel		0.22
COAD	chr17	74744929	Missense_Mutation	novel	R163S	0.09
COAD	chr17	74740791	Silent	NA	G39G	0.17
COAD	chr17	74745239	Intron	novel		0.4
COAD	chr17	74744444	Intron	novel		0.27
COAD	chr17	74744952	Intron	novel		0.29
COAD	chr17	74745226	Intron	novel		0.17
COAD	chr17	74743165	Missense_Mutation	rs143690968	V95I	0.23	MMR_HSR1
ESCA	chr17	74748623	3'Flank	novel		0.21
GBM	chr17	74744957	Intron	novel		0.24
GBM	chr17	74744739	Intron	novel		0.42
GBM	chr17	74743294	Missense_Mutation	novel	L107H	0.14	MMR_HSR1
GBM	chr17	74744744	Intron	novel		0.65
HNSC	chr17	74743168	Missense_Mutation	novel	T96A	0.27	MMR_HSR1
HNSC	chr17	74745151	Intron	novel		0.46
HNSC	chr17	74745024	Missense_Mutation	novel	F169S	0.08
HNSC	chr17	74745075	Frame_Shift_Del	novel	*I187Pfs4**	0.27
HNSC	chr17	74744868	Splice_Region	novel		0.05
KIRC	chr17	74729338	Missense_Mutation	novel	F52C	0.37	MMR_HSR1
KIRC	chr17	74743340	Missense_Mutation	NA	R122S	0.25	MMR_HSR1
KIRC	chr17	74729363	Frame_Shift_Ins	novel	*T61Ffs7**	0.05	MMR_HSR1
KIRC	chr17	74737059	5'Flank	novel		0.28
KIRP	chr17	74740792	Missense_Mutation	rs750256354	V40I	0.06	MMR_HSR1
KIRP	chr17	74736861	5'Flank	novel		0.27
LGG	chr17	74729293	Missense_Mutation	novel	S37Y	0.39	MMR_HSR1
LGG	chr17	74744796	Intron	novel		0.36
LIHC	chr17	74745590	3'UTR	novel		0.75
LUAD	chr17	74740861	Missense_Mutation	NA	V63F	0.32	MMR_HSR1
LUAD	chr17	74744809	Intron	novel		0.14
LUAD	chr17	74744799	Intron	novel		0.11
LUAD	chr17	74745040	Silent	novel	A174A	0.09
LUAD	chr17	74743170	Silent	novel	T96T	0.54
LUAD	chr17	74745268	Intron	novel		0.23
LUAD	chr17	74744851	Intron	novel		0.09
LUAD	chr17	74745042	Missense_Mutation	NA	K175R	0.12
LUAD	chr17	74745253	Intron	novel		0.2
LUAD	chr17	74745013	Frame_Shift_Del	novel	*G166Wfs9**	0.06
LUSC	chr17	74743165	Missense_Mutation	rs143690968	V95I	0.11	MMR_HSR1
LUSC	chr17	74744790	Intron	novel		0.23
LUSC	chr17	74744754	Intron	novel		0.43
LUSC	chr17	74742274	Missense_Mutation	novel	D75E	0.11	MMR_HSR1
LUSC	chr17	74744344	Frame_Shift_Ins	novel	*V136Tfs3**	0.14
OV	chr17	74744941	Intron	novel		0.05
OV	chr17	74745354	Missense_Mutation	NA	Q205H	0.38
OV	chr17	74729346	Missense_Mutation	NA	T55S	0.15	MMR_HSR1
OV	chr17	74744384	Intron	novel		0.33
PAAD	chr17	74737035	5'Flank	novel		0.2
PRAD	chr17	74740827	Silent	rs530556816	D51D	0.08
PRAD	chr17	74745017	Missense_Mutation	NA	V167I	0.12
PRAD	chr17	74745144	Intron	novel		0.35
PRAD	chr17	74740835	Missense_Mutation	NA	F54S	0.12	MMR_HSR1
PRAD	chr17	74740827	Silent	rs530556816	D51D	0.44
READ	chr17	74729309	Silent	rs115636998	F42F	0.32
READ	chr17	74745449	3'UTR	novel		0.75
SARC	chr17	74737004	5'Flank	novel		0.35
SKCM	chr17	74744344	Missense_Mutation	rs762982946	D135N	0.17
SKCM	chr17	74745242	Intron	novel		0.35
SKCM	chr17	74744786	Intron	novel		0.29
SKCM	chr17	74743158	Silent	NA	F92F	0.08
SKCM	chr17	74745021	Missense_Mutation	NA	P168L	0.12
SKCM	chr17	74740815	Silent	NA	I47I	0.19
SKCM	chr17	74743149	Silent	NA	Q89Q	0.22
SKCM	chr17	74743149	Silent	NA	Q89Q	0.35
SKCM	chr17	74745201	Intron	novel		0.41
SKCM	chr17	74740809	Silent	NA	F45F	0.41
SKCM	chr17	74742280	Silent	NA	V77V	0.13
SKCM	chr17	74744307	Splice_Site	NA	X123_splice	0.23
SKCM	chr17	74745097	Intron	novel		0.25
SKCM	chr17	74745196	Intron	novel		0.59
SKCM	chr17	74744948	Intron	novel		0.33
SKCM	chr17	74743314	Missense_Mutation	novel	N114D	0.63	MMR_HSR1
SKCM	chr17	74729284	Missense_Mutation	novel	G34E	0.21	MMR_HSR1
SKCM	chr17	74743289	Splice_Region	novel	A105A	0.83
SKCM	chr17	74743155	Silent	NA	R91R	0.4
STAD	chr17	74743153	Missense_Mutation	rs770507152	R91W	0.29	MMR_HSR1
STAD	chr17	74740870	Missense_Mutation	NA	D66Y	0.32	MMR_HSR1
STAD	chr17	74745294	Intron	novel		0.22
STAD	chr17	74740795	Missense_Mutation	rs149746610	G41S	0.4	MMR_HSR1
STAD	chr17	74745240	Intron	novel		0.22
STAD	chr17	74743305	Missense_Mutation	novel	D111Y	0.37	MMR_HSR1
THCA	chr17	74729355	Frame_Shift_Del	novel	*I58Sfs8**	0.39	MMR_HSR1
UCEC	chr17	74743296	Missense_Mutation	NA	L108M	0.35	MMR_HSR1
UCEC	chr17	74744310	Splice_Region	novel	A123A	0.26
UCEC	chr17	74743193	Missense_Mutation	novel	Q104R	0.38	MMR_HSR1
UCEC	chr17	74729309	Silent	rs115636998	F42F	0.5
UCEC	chr17	74745287	Intron	novel		0.35
UCEC	chr17	74743159	Nonsense_Mutation	rs150761775	R93*	0.13	MMR_HSR1
UCEC	chr17	74745417	3'UTR	novel		0.39
UCEC	chr17	74729309	Silent	rs115636998	F42F	0.32
UCEC	chr17	74743299	Silent	novel	L109L	0.25
UCEC	chr17	74737052	5'Flank	novel		0.56
UCEC	chr17	74745245	Intron	rs374719761		0.43
UCEC	chr17	74743164	Silent	rs763968925	S94S	0.22
UCEC	chr17	74745564	3'UTR	novel		0.45
UCEC	chr17	74745248	Intron	novel		0.46
UCEC	chr17	74736987	5'Flank	rs774848906		0.18
UCEC	chr17	74729310	Missense_Mutation	NA	D43N	0.11	MMR_HSR1
UCEC	chr17	74742287	Missense_Mutation	novel	K80E	0.35	MMR_HSR1
UCEC	chr17	74729357	Silent	rs749871961	I58I	0.83
UCEC	chr17	74744742	Intron	novel		0.33
UCEC	chr17	74729293	Missense_Mutation	novel	S37Y	0.34	MMR_HSR1
UCEC	chr17	74740810	Silent	novel	L46L	0.23
UCEC	chr17	74745119	Intron	novel		0.41
UCEC	chr17	74742267	Missense_Mutation	novel	T73N	0.28	MMR_HSR1
UCEC	chr17	74744718	Intron	novel		0.28
UCEC	chr17	74745194	Intron	novel		0.35
UCS	chr17	74744794	Intron	novel		0.25
UCS	chr17	74729309	Silent	rs115636998	F42F	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3922	0.00012456
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0663	1.52e-05
LUSC	AMP	0.3573	0.001059
SARC	AMP	0.2374	0.032181
SKCM	AMP	0.2943	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0091	Kaplan-Meier Survival Analysis
KIRC	0.0033	Kaplan-Meier Survival Analysis
SARC	0.0055	Kaplan-Meier Survival Analysis
MESO	0.0013	Kaplan-Meier Survival Analysis
ACC	0.0011	Kaplan-Meier Survival Analysis
UCS	0.0055	Kaplan-Meier Survival Analysis
HNSC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.028	Kaplan-Meier Survival Analysis
BRCA	0.041	Kaplan-Meier Survival Analysis
PAAD	0.038	Kaplan-Meier Survival Analysis
CESC	0.0015	Kaplan-Meier Survival Analysis
KICH	0.039	Kaplan-Meier Survival Analysis
UCEC	0.0018	Kaplan-Meier Survival Analysis
LUAD	0.024	Kaplan-Meier Survival Analysis
UVM	0.049	Kaplan-Meier Survival Analysis
OV	0.028	Kaplan-Meier Survival Analysis