EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172795 (Gene tree)
Gene ID: 167227
Gene Symbol: DCP2
Alias: NUDT20
Full Name: decapping mRNA 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 45,494 bases
Position: chr5:112,976,702-113,022,195
Accession: 24452
RBP type: canonical RBP
Summary: The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000425770	DCP2	PF05026.13	1e-28	1	1
ENSP00000373715	DCP2	PF05026.13	1.2e-28	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12923261	Functional characterization of the mammalian mRNA decapping enzyme hDcp2.	RNA	2003 Sep	Piccirillo C	-
19233875	Mutational analysis of a Dcp2-binding element reveals general enhancement of decapping by 5'-end stem-loop structures.	Nucleic Acids Res	2009 Apr	Li Y	doi: 10.1093/nar/gkp087
18039849	Transcript-specific decapping and regulated stability by the human Dcp2 decapping protein.	Mol Cell Biol	2008 Feb	Li Y	-
16177138	A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.	RNA	2005 Nov	Rehwinkel J	-
18643965	Plant stress granules and mRNA processing bodies are distinct from heat stress granules.	Plant J	2008 Nov	Weber C	doi: 10.1111/j.1365-313X.2008.03623.x
27694842	Structural basis of mRNA-cap recognition by Dcp1-Dcp2.	Nat Struct Mol Biol	2016 Nov	Mugridge JS	doi: 10.1038/nsmb.3301
27183195	Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.	Nat Struct Mol Biol	2016 Jun	Valkov E	doi: 10.1038/nsmb.3232
26134871	Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation.	Biol Reprod	2015 Aug	Ma J	doi: 10.1095/biolreprod.115.130344
31231973	Pat1 RNA-binding proteins: Multitasking shuttling proteins.	Wiley Interdiscip Rev RNA	2019 Jun 24:e1557	Vindry C	doi: 10.1002/wrna.1557
18439994	Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway.	Dev Biol	2008 Jun 1	Jud MC	doi: 10.1016/j.ydbio.2008.02.059
20543818	The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.	EMBO J	2010 Jul 21	Braun JE	doi: 10.1038/emboj.2010.124
23535175	Role of Rck-Pat1b binding in assembly of processing-bodies.	RNA Biol	2013 Apr	Ozgur S	doi: 10.4161/rna.24086

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000515408	DCP2-208	8029	-	ENSP00000425770	385 (aa)	-	Q8IU60
ENST00000389063	DCP2-201	8947	XM_017009163	ENSP00000373715	420 (aa)	XP_016864652	Q8IU60
ENST00000510046	DCP2-205	369	-	-	- (aa)	-	-
ENST00000502635	DCP2-202	514	-	-	- (aa)	-	-
ENST00000512751	DCP2-206	570	-	ENSP00000427198	74 (aa)	-	D6RCL0
ENST00000513585	DCP2-207	1572	-	ENSP00000424982	402 (aa)	-	H0Y9T5
ENST00000508359	DCP2-204	838	-	-	- (aa)	-	-
ENST00000504961	DCP2-203	852	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000172795's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000172795	Cryptorchidism	4.2500000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172795's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172795	DCP2	61	86.695	ENSAPOG00000011309	dcp2	98	86.695	Acanthochromis_polyacanthus
ENSG00000172795	DCP2	96	95.631	ENSAMEG00000012589	DCP2	96	95.631	Ailuropoda_melanoleuca
ENSG00000172795	DCP2	98	62.857	ENSAOCG00000008222	dcp2	99	62.857	Amphiprion_ocellaris
ENSG00000172795	DCP2	99	61.098	ENSAPEG00000015029	dcp2	98	61.098	Amphiprion_percula
ENSG00000172795	DCP2	99	63.981	ENSATEG00000010972	dcp2	98	63.981	Anabas_testudineus
ENSG00000172795	DCP2	99	78.657	ENSAPLG00000013540	DCP2	99	78.657	Anas_platyrhynchos
ENSG00000172795	DCP2	100	82.270	ENSACAG00000007587	DCP2	100	82.270	Anolis_carolinensis
ENSG00000172795	DCP2	100	99.221	ENSANAG00000028729	DCP2	100	99.221	Aotus_nancymaae
ENSG00000172795	DCP2	99	65.854	ENSACLG00000019153	dcp2	98	65.854	Astatotilapia_calliptera
ENSG00000172795	DCP2	99	68.990	ENSAMXG00000030817	dcp2	99	68.990	Astyanax_mexicanus
ENSG00000172795	DCP2	100	93.853	ENSBTAG00000000767	DCP2	100	93.853	Bos_taurus
ENSG00000172795	DCP2	100	98.961	ENSCJAG00000016536	DCP2	100	98.961	Callithrix_jacchus
ENSG00000172795	DCP2	100	96.919	ENSCAFG00000016236	DCP2	100	96.919	Canis_familiaris
ENSG00000172795	DCP2	100	94.090	ENSCHIG00000011569	DCP2	100	94.090	Capra_hircus
ENSG00000172795	DCP2	100	96.883	ENSTSYG00000008219	DCP2	100	96.883	Carlito_syrichta
ENSG00000172795	DCP2	96	84.483	ENSCAPG00000007221	DCP2	98	84.483	Cavia_aperea
ENSG00000172795	DCP2	100	94.076	ENSCPOG00000001648	DCP2	100	94.076	Cavia_porcellus
ENSG00000172795	DCP2	100	98.701	ENSCCAG00000034353	DCP2	100	98.701	Cebus_capucinus
ENSG00000172795	DCP2	100	99.481	ENSCATG00000000044	DCP2	100	99.481	Cercocebus_atys
ENSG00000172795	DCP2	100	95.498	ENSCLAG00000014751	DCP2	100	95.498	Chinchilla_lanigera
ENSG00000172795	DCP2	100	99.048	ENSCSAG00000014920	DCP2	100	99.048	Chlorocebus_sabaeus
ENSG00000172795	DCP2	96	95.050	ENSCHOG00000004156	DCP2	100	95.050	Choloepus_hoffmanni
ENSG00000172795	DCP2	100	88.860	ENSCPBG00000013899	DCP2	100	88.860	Chrysemys_picta_bellii
ENSG00000172795	DCP2	60	58.798	ENSCING00000023586	-	99	58.798	Ciona_intestinalis
ENSG00000172795	DCP2	62	56.723	ENSCSAVG00000008510	-	75	56.723	Ciona_savignyi
ENSG00000172795	DCP2	100	99.481	ENSCANG00000030239	DCP2	100	99.481	Colobus_angolensis_palliatus
ENSG00000172795	DCP2	100	83.023	ENSCGRG00001017084	Dcp2	100	83.023	Cricetulus_griseus_chok1gshd
ENSG00000172795	DCP2	96	91.667	ENSCGRG00000016060	Dcp2	97	91.667	Cricetulus_griseus_crigri
ENSG00000172795	DCP2	99	62.963	ENSCSEG00000016855	dcp2	99	62.963	Cynoglossus_semilaevis
ENSG00000172795	DCP2	99	67.943	ENSDARG00000104242	dcp2	99	67.943	Danio_rerio
ENSG00000172795	DCP2	97	93.720	ENSDNOG00000005616	DCP2	97	93.720	Dasypus_novemcinctus
ENSG00000172795	DCP2	95	88.725	ENSDORG00000010088	Dcp2	100	88.725	Dipodomys_ordii
ENSG00000172795	DCP2	100	96.445	ENSEASG00005015174	DCP2	100	96.445	Equus_asinus_asinus
ENSG00000172795	DCP2	100	97.922	ENSECAG00000005486	DCP2	100	97.922	Equus_caballus
ENSG00000172795	DCP2	80	100.000	ENSEEUG00000005752	DCP2	80	100.000	Erinaceus_europaeus
ENSG00000172795	DCP2	99	68.720	ENSELUG00000016839	dcp2	98	68.720	Esox_lucius
ENSG00000172795	DCP2	100	97.922	ENSFCAG00000001895	DCP2	100	97.922	Felis_catus
ENSG00000172795	DCP2	96	95.556	ENSFDAG00000021292	DCP2	99	95.556	Fukomys_damarensis
ENSG00000172795	DCP2	99	68.052	ENSFHEG00000009849	dcp2	98	68.052	Fundulus_heteroclitus
ENSG00000172795	DCP2	65	84.800	ENSGMOG00000020483	dcp2	96	84.800	Gadus_morhua
ENSG00000172795	DCP2	100	84.456	ENSGALG00000000215	DCP2	100	85.492	Gallus_gallus
ENSG00000172795	DCP2	99	66.408	ENSGAFG00000008150	dcp2	98	66.925	Gambusia_affinis
ENSG00000172795	DCP2	99	63.659	ENSGACG00000018562	dcp2	100	63.659	Gasterosteus_aculeatus
ENSG00000172795	DCP2	98	82.892	ENSGAGG00000023812	DCP2	96	82.892	Gopherus_agassizii
ENSG00000172795	DCP2	100	99.481	ENSGGOG00000014412	DCP2	100	99.481	Gorilla_gorilla
ENSG00000172795	DCP2	99	65.854	ENSHBUG00000007508	dcp2	98	65.854	Haplochromis_burtoni
ENSG00000172795	DCP2	100	95.261	ENSHGLG00000007853	DCP2	100	95.261	Heterocephalus_glaber_female
ENSG00000172795	DCP2	96	93.643	ENSHGLG00100009051	DCP2	96	93.643	Heterocephalus_glaber_male
ENSG00000172795	DCP2	100	61.848	ENSHCOG00000014236	dcp2	99	61.848	Hippocampus_comes
ENSG00000172795	DCP2	99	67.857	ENSIPUG00000001485	dcp2	99	67.857	Ictalurus_punctatus
ENSG00000172795	DCP2	100	88.631	ENSSTOG00000013213	DCP2	95	96.296	Ictidomys_tridecemlineatus
ENSG00000172795	DCP2	100	90.758	ENSJJAG00000010518	Dcp2	100	90.758	Jaculus_jaculus
ENSG00000172795	DCP2	86	68.182	ENSKMAG00000016066	dcp2	95	68.182	Kryptolebias_marmoratus
ENSG00000172795	DCP2	96	75.980	ENSLACG00000000580	DCP2	100	75.980	Latimeria_chalumnae
ENSG00000172795	DCP2	100	73.460	ENSLOCG00000009013	dcp2	100	73.460	Lepisosteus_oculatus
ENSG00000172795	DCP2	100	96.209	ENSLAFG00000013735	DCP2	100	96.209	Loxodonta_africana
ENSG00000172795	DCP2	100	99.481	ENSMFAG00000039717	DCP2	100	99.481	Macaca_fascicularis
ENSG00000172795	DCP2	100	97.201	ENSMMUG00000013553	DCP2	100	97.201	Macaca_mulatta
ENSG00000172795	DCP2	100	99.221	ENSMNEG00000035476	DCP2	100	99.221	Macaca_nemestrina
ENSG00000172795	DCP2	100	99.481	ENSMLEG00000039382	DCP2	100	99.481	Mandrillus_leucophaeus
ENSG00000172795	DCP2	99	61.637	ENSMAMG00000019169	dcp2	98	61.637	Mastacembelus_armatus
ENSG00000172795	DCP2	99	65.854	ENSMZEG00005009123	dcp2	98	65.854	Maylandia_zebra
ENSG00000172795	DCP2	100	91.726	ENSMAUG00000013325	Dcp2	100	91.726	Mesocricetus_auratus
ENSG00000172795	DCP2	100	98.187	ENSMICG00000013792	DCP2	100	98.187	Microcebus_murinus
ENSG00000172795	DCP2	100	90.780	ENSMOCG00000014965	Dcp2	100	90.780	Microtus_ochrogaster
ENSG00000172795	DCP2	100	88.626	ENSMODG00000015636	DCP2	100	88.626	Monodelphis_domestica
ENSG00000172795	DCP2	61	82.906	ENSMALG00000002751	dcp2	98	82.906	Monopterus_albus
ENSG00000172795	DCP2	100	91.232	MGP_CAROLIEiJ_G0022246	Dcp2	100	91.232	Mus_caroli
ENSG00000172795	DCP2	100	92.417	ENSMUSG00000024472	Dcp2	100	92.417	Mus_musculus
ENSG00000172795	DCP2	100	92.654	MGP_PahariEiJ_G0018979	Dcp2	100	92.654	Mus_pahari
ENSG00000172795	DCP2	100	92.417	MGP_SPRETEiJ_G0023158	Dcp2	100	92.417	Mus_spretus
ENSG00000172795	DCP2	100	96.682	ENSMPUG00000012723	DCP2	100	96.682	Mustela_putorius_furo
ENSG00000172795	DCP2	100	95.519	ENSMLUG00000012772	DCP2	100	95.519	Myotis_lucifugus
ENSG00000172795	DCP2	99	65.854	ENSNBRG00000000726	dcp2	98	65.854	Neolamprologus_brichardi
ENSG00000172795	DCP2	100	99.286	ENSNLEG00000011594	DCP2	100	99.286	Nomascus_leucogenys
ENSG00000172795	DCP2	93	90.886	ENSODEG00000010689	DCP2	95	90.886	Octodon_degus
ENSG00000172795	DCP2	96	83.498	ENSOANG00000011141	DCP2	91	83.498	Ornithorhynchus_anatinus
ENSG00000172795	DCP2	100	90.995	ENSOCUG00000010437	DCP2	100	90.995	Oryctolagus_cuniculus
ENSG00000172795	DCP2	100	67.273	ENSORLG00000019046	dcp2	100	67.273	Oryzias_latipes
ENSG00000172795	DCP2	61	70.940	ENSORLG00020022081	dcp2	93	70.940	Oryzias_latipes_hni
ENSG00000172795	DCP2	100	67.532	ENSORLG00015013219	dcp2	100	67.532	Oryzias_latipes_hsok
ENSG00000172795	DCP2	61	83.884	ENSOMEG00000014254	dcp2	69	83.884	Oryzias_melastigma
ENSG00000172795	DCP2	100	95.735	ENSOGAG00000008583	DCP2	100	95.735	Otolemur_garnettii
ENSG00000172795	DCP2	100	93.224	ENSOARG00000016039	DCP2	100	93.224	Ovis_aries
ENSG00000172795	DCP2	96	97.567	ENSPPAG00000042108	DCP2	99	97.567	Pan_paniscus
ENSG00000172795	DCP2	100	97.662	ENSPPRG00000022029	DCP2	100	97.662	Panthera_pardus
ENSG00000172795	DCP2	100	97.922	ENSPTIG00000021303	DCP2	100	97.922	Panthera_tigris_altaica
ENSG00000172795	DCP2	100	99.762	ENSPTRG00000050185	DCP2	100	99.762	Pan_troglodytes
ENSG00000172795	DCP2	100	99.481	ENSPANG00000007042	DCP2	100	99.481	Papio_anubis
ENSG00000172795	DCP2	99	73.316	ENSPKIG00000024658	dcp2	99	73.316	Paramormyrops_kingsleyae
ENSG00000172795	DCP2	100	85.579	ENSPSIG00000014210	DCP2	99	85.579	Pelodiscus_sinensis
ENSG00000172795	DCP2	99	61.500	ENSPMGG00000005790	dcp2	99	61.500	Periophthalmus_magnuspinnatus
ENSG00000172795	DCP2	100	92.254	ENSPEMG00000009060	Dcp2	100	92.254	Peromyscus_maniculatus_bairdii
ENSG00000172795	DCP2	100	91.169	ENSPCIG00000010189	DCP2	100	91.169	Phascolarctos_cinereus
ENSG00000172795	DCP2	99	64.455	ENSPFOG00000003762	dcp2	99	64.455	Poecilia_formosa
ENSG00000172795	DCP2	99	65.722	ENSPLAG00000004843	dcp2	99	65.722	Poecilia_latipinna
ENSG00000172795	DCP2	99	64.218	ENSPMEG00000006739	dcp2	99	64.218	Poecilia_mexicana
ENSG00000172795	DCP2	99	65.296	ENSPREG00000012185	dcp2	99	65.296	Poecilia_reticulata
ENSG00000172795	DCP2	81	99.306	ENSPPYG00000015688	-	100	99.306	Pongo_abelii
ENSG00000172795	DCP2	100	98.187	ENSPCOG00000021762	DCP2	100	98.187	Propithecus_coquereli
ENSG00000172795	DCP2	100	96.209	ENSPVAG00000007891	DCP2	100	96.209	Pteropus_vampyrus
ENSG00000172795	DCP2	61	85.000	ENSPNYG00000007021	dcp2	94	85.000	Pundamilia_nyererei
ENSG00000172795	DCP2	99	69.139	ENSPNAG00000021008	dcp2	99	69.139	Pygocentrus_nattereri
ENSG00000172795	DCP2	100	92.654	ENSRNOG00000045895	LOC100912393	100	92.654	Rattus_norvegicus
ENSG00000172795	DCP2	100	99.481	ENSRBIG00000038595	DCP2	100	99.481	Rhinopithecus_bieti
ENSG00000172795	DCP2	100	99.481	ENSRROG00000028314	DCP2	100	99.481	Rhinopithecus_roxellana
ENSG00000172795	DCP2	100	99.221	ENSSBOG00000005894	DCP2	100	99.221	Saimiri_boliviensis_boliviensis
ENSG00000172795	DCP2	99	85.142	ENSSHAG00000001019	DCP2	99	85.142	Sarcophilus_harrisii
ENSG00000172795	DCP2	99	68.095	ENSSFOG00015007113	dcp2	99	68.095	Scleropages_formosus
ENSG00000172795	DCP2	99	64.066	ENSSMAG00000011284	dcp2	98	64.066	Scophthalmus_maximus
ENSG00000172795	DCP2	99	64.359	ENSSDUG00000021505	dcp2	99	64.359	Seriola_dumerili
ENSG00000172795	DCP2	85	98.319	ENSSARG00000014082	DCP2	82	98.319	Sorex_araneus
ENSG00000172795	DCP2	99	78.517	ENSSPUG00000015802	DCP2	98	78.517	Sphenodon_punctatus
ENSG00000172795	DCP2	61	77.311	ENSSPAG00000014862	dcp2	90	77.311	Stegastes_partitus
ENSG00000172795	DCP2	100	96.632	ENSSSCG00000014204	DCP2	100	96.632	Sus_scrofa
ENSG00000172795	DCP2	100	62.532	ENSTNIG00000004284	dcp2	100	62.532	Tetraodon_nigroviridis
ENSG00000172795	DCP2	65	99.200	ENSTBEG00000003640	DCP2	100	99.200	Tupaia_belangeri
ENSG00000172795	DCP2	100	87.648	ENSTTRG00000001693	DCP2	100	87.648	Tursiops_truncatus
ENSG00000172795	DCP2	100	96.682	ENSUMAG00000017002	DCP2	100	96.682	Ursus_maritimus
ENSG00000172795	DCP2	100	94.787	ENSVPAG00000006003	DCP2	100	94.787	Vicugna_pacos
ENSG00000172795	DCP2	100	96.919	ENSVVUG00000025978	DCP2	100	96.919	Vulpes_vulpes
ENSG00000172795	DCP2	100	70.901	ENSXETG00000021514	dcp2	100	70.901	Xenopus_tropicalis
ENSG00000172795	DCP2	61	85.408	ENSXCOG00000016409	dcp2	100	85.408	Xiphophorus_couchianus
ENSG00000172795	DCP2	99	67.183	ENSXMAG00000007623	dcp2	98	67.700	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	IEA	Process
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	21873635.	IBA	Process
GO:0000932	P-body	21873635.	IBA	Component
GO:0000932	P-body	20616046.	IDA	Component
GO:0004534	5'-3' exoribonuclease activity	26950371.	IMP	Function
GO:0005515	protein binding	12417715.15231747.15687258.16364915.16699599.18326031.19966221.20543818.20584987.20616046.21876179.23085078.25036637.26496610.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006402	mRNA catabolic process	21070968.28002401.	IDA	Process
GO:0016442	RISC complex	20616046.	IDA	Component
GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	-	TAS	Function
GO:0030054	cell junction	-	IDA	Component
GO:0030145	manganese ion binding	-	IEA	Function
GO:0032211	negative regulation of telomere maintenance via telomerase	26950371.	IMP	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0043488	regulation of mRNA stability	28002401.	IDA	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0050072	m7G(5')pppN diphosphatase activity	21873635.	IBA	Function
GO:0050072	m7G(5')pppN diphosphatase activity	21070968.28002401.	IDA	Function
GO:0070034	telomerase RNA binding	26950371.	IC	Function
GO:0071044	histone mRNA catabolic process	18172165.	IMP	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process
GO:1904872	regulation of telomerase RNA localization to Cajal body	26950371.	IMP	Process