EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000172922 (Gene tree)
Gene ID: 84153
Gene Symbol: RNASEH2C
Alias: AYP1|AGS3
Full Name: ribonuclease H2 subunit C
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 6,943 bases
Position: chr11:65,714,005-65,720,947
Accession: 24116
RBP type: canonical RBP
Summary: This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000308193	RNase_H2_suC	PF08615.11	1.2e-27	1	1
ENSP00000432897	RNase_H2_suC	PF08615.11	5.6e-27	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000527610	RNASEH2C-202	835	-	ENSP00000432897	247 (aa)	-	E9PN81
ENST00000644198	RNASEH2C-211	1807	-	-	- (aa)	-	-
ENST00000531596	RNASEH2C-205	2085	-	ENSP00000435717	164 (aa)	-	Q8TDP1
ENST00000643214	RNASEH2C-209	2643	-	-	- (aa)	-	-
ENST00000646597	RNASEH2C-213	1082	-	-	- (aa)	-	-
ENST00000534482	RNASEH2C-207	3311	-	ENSP00000432081	164 (aa)	-	Q8TDP1
ENST00000644142	RNASEH2C-210	1750	-	ENSP00000493695	164 (aa)	-	Q8TDP1
ENST00000308418	RNASEH2C-201	2794	-	ENSP00000308193	164 (aa)	-	Q8TDP1
ENST00000530192	RNASEH2C-204	576	-	-	- (aa)	-	-
ENST00000642430	RNASEH2C-208	1909	-	-	- (aa)	-	-
ENST00000645835	RNASEH2C-212	1596	-	-	- (aa)	-	-
ENST00000533698	RNASEH2C-206	710	-	-	- (aa)	-	-
ENST00000528220	RNASEH2C-203	2798	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000172922's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000172922	Acne Vulgaris	3E-11	24927181

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000172922	rs4645915	11	65714051	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000172922's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000172922	RNASEH2C	100	75.439	ENSAMEG00000017348	RNASEH2C	100	75.439	Ailuropoda_melanoleuca
ENSG00000172922	RNASEH2C	100	91.463	ENSANAG00000032535	RNASEH2C	100	91.463	Aotus_nancymaae
ENSG00000172922	RNASEH2C	100	67.857	ENSBTAG00000005577	RNASEH2C	100	67.857	Bos_taurus
ENSG00000172922	RNASEH2C	100	90.244	ENSCJAG00000001965	RNASEH2C	100	90.244	Callithrix_jacchus
ENSG00000172922	RNASEH2C	100	75.595	ENSCAFG00000013292	RNASEH2C	100	75.595	Canis_familiaris
ENSG00000172922	RNASEH2C	100	75.595	ENSCAFG00020015077	RNASEH2C	100	75.595	Canis_lupus_dingo
ENSG00000172922	RNASEH2C	100	67.879	ENSCHIG00000013681	RNASEH2C	100	69.048	Capra_hircus
ENSG00000172922	RNASEH2C	65	76.852	ENSTSYG00000028658	-	65	76.852	Carlito_syrichta
ENSG00000172922	RNASEH2C	100	66.265	ENSCPOG00000013696	RNASEH2C	100	66.265	Cavia_porcellus
ENSG00000172922	RNASEH2C	100	90.854	ENSCCAG00000025461	RNASEH2C	100	90.854	Cebus_capucinus
ENSG00000172922	RNASEH2C	99	65.854	ENSCLAG00000016534	RNASEH2C	99	65.854	Chinchilla_lanigera
ENSG00000172922	RNASEH2C	100	96.341	ENSCSAG00000007985	RNASEH2C	100	96.341	Chlorocebus_sabaeus
ENSG00000172922	RNASEH2C	100	94.512	ENSCANG00000039373	RNASEH2C	100	94.512	Colobus_angolensis_palliatus
ENSG00000172922	RNASEH2C	100	69.880	ENSCGRG00001015383	Rnaseh2c	100	69.880	Cricetulus_griseus_chok1gshd
ENSG00000172922	RNASEH2C	100	69.880	ENSCGRG00000012179	Rnaseh2c	100	69.880	Cricetulus_griseus_crigri
ENSG00000172922	RNASEH2C	100	75.595	ENSDNOG00000035155	RNASEH2C	99	75.595	Dasypus_novemcinctus
ENSG00000172922	RNASEH2C	100	73.054	ENSDORG00000023624	Rnaseh2c	100	73.054	Dipodomys_ordii
ENSG00000172922	RNASEH2C	53	70.115	ENSETEG00000015293	-	81	71.264	Echinops_telfairi
ENSG00000172922	RNASEH2C	75	69.531	ENSETEG00000020048	-	100	69.531	Echinops_telfairi
ENSG00000172922	RNASEH2C	100	75.904	ENSEASG00005004302	RNASEH2C	100	75.301	Equus_asinus_asinus
ENSG00000172922	RNASEH2C	100	76.506	ENSECAG00000017289	RNASEH2C	100	75.904	Equus_caballus
ENSG00000172922	RNASEH2C	100	78.049	ENSFCAG00000044095	RNASEH2C	100	78.049	Felis_catus
ENSG00000172922	RNASEH2C	100	60.795	ENSFDAG00000011974	RNASEH2C	100	60.795	Fukomys_damarensis
ENSG00000172922	RNASEH2C	100	70.122	ENSHGLG00000013478	RNASEH2C	100	70.122	Heterocephalus_glaber_female
ENSG00000172922	RNASEH2C	100	70.122	ENSHGLG00100019352	RNASEH2C	100	70.122	Heterocephalus_glaber_male
ENSG00000172922	RNASEH2C	100	68.786	ENSSTOG00000019410	RNASEH2C	100	68.786	Ictidomys_tridecemlineatus
ENSG00000172922	RNASEH2C	100	74.390	ENSJJAG00000019320	Rnaseh2c	100	74.390	Jaculus_jaculus
ENSG00000172922	RNASEH2C	100	71.006	ENSLAFG00000015641	RNASEH2C	100	71.006	Loxodonta_africana
ENSG00000172922	RNASEH2C	100	93.902	ENSMFAG00000042754	-	100	93.902	Macaca_fascicularis
ENSG00000172922	RNASEH2C	100	94.512	ENSMFAG00000038096	-	100	94.512	Macaca_fascicularis
ENSG00000172922	RNASEH2C	100	94.512	ENSMMUG00000016234	-	100	94.512	Macaca_mulatta
ENSG00000172922	RNASEH2C	98	92.547	ENSMMUG00000019837	RNASEH2C	100	78.138	Macaca_mulatta
ENSG00000172922	RNASEH2C	100	95.122	ENSMNEG00000040939	RNASEH2C	100	95.122	Macaca_nemestrina
ENSG00000172922	RNASEH2C	100	69.880	ENSMAUG00000016346	Rnaseh2c	100	69.880	Mesocricetus_auratus
ENSG00000172922	RNASEH2C	100	79.518	ENSMICG00000008882	RNASEH2C	100	79.518	Microcebus_murinus
ENSG00000172922	RNASEH2C	100	68.235	ENSMOCG00000013231	Rnaseh2c	100	68.235	Microtus_ochrogaster
ENSG00000172922	RNASEH2C	90	51.351	ENSMODG00000009547	-	90	51.351	Monodelphis_domestica
ENSG00000172922	RNASEH2C	100	65.060	MGP_CAROLIEiJ_G0022560	Rnaseh2c	99	66.279	Mus_caroli
ENSG00000172922	RNASEH2C	100	65.663	ENSMUSG00000024925	Rnaseh2c	100	65.663	Mus_musculus
ENSG00000172922	RNASEH2C	100	66.867	MGP_PahariEiJ_G0014057	Rnaseh2c	100	66.867	Mus_pahari
ENSG00000172922	RNASEH2C	100	73.837	ENSMPUG00000011629	RNASEH2C	100	75.000	Mustela_putorius_furo
ENSG00000172922	RNASEH2C	100	73.214	ENSMLUG00000008777	RNASEH2C	100	73.214	Myotis_lucifugus
ENSG00000172922	RNASEH2C	100	58.537	ENSNGAG00000020391	Rnaseh2c	100	58.537	Nannospalax_galili
ENSG00000172922	RNASEH2C	100	96.341	ENSNLEG00000005833	-	100	96.341	Nomascus_leucogenys
ENSG00000172922	RNASEH2C	98	46.250	ENSMEUG00000006205	-	99	46.250	Notamacropus_eugenii
ENSG00000172922	RNASEH2C	100	66.265	ENSODEG00000017806	RNASEH2C	100	66.265	Octodon_degus
ENSG00000172922	RNASEH2C	100	79.651	ENSOGAG00000014128	RNASEH2C	100	79.651	Otolemur_garnettii
ENSG00000172922	RNASEH2C	100	67.273	ENSOARG00000017675	RNASEH2C	100	68.452	Ovis_aries
ENSG00000172922	RNASEH2C	100	99.190	ENSPPAG00000042592	-	100	99.190	Pan_paniscus
ENSG00000172922	RNASEH2C	100	79.268	ENSPPRG00000000774	RNASEH2C	100	79.268	Panthera_pardus
ENSG00000172922	RNASEH2C	100	78.049	ENSPTIG00000011677	RNASEH2C	100	78.049	Panthera_tigris_altaica
ENSG00000172922	RNASEH2C	100	99.595	ENSPTRG00000038742	RNASEH2C	100	99.595	Pan_troglodytes
ENSG00000172922	RNASEH2C	100	93.117	ENSPANG00000015965	RNASEH2C	100	93.117	Papio_anubis
ENSG00000172922	RNASEH2C	100	69.643	ENSPEMG00000018577	Rnaseh2c	100	69.643	Peromyscus_maniculatus_bairdii
ENSG00000172922	RNASEH2C	100	95.732	ENSPPYG00000003051	RNASEH2C	100	95.732	Pongo_abelii
ENSG00000172922	RNASEH2C	100	69.767	ENSPCAG00000007887	RNASEH2C	100	70.349	Procavia_capensis
ENSG00000172922	RNASEH2C	100	78.313	ENSPCOG00000021092	RNASEH2C	100	78.313	Propithecus_coquereli
ENSG00000172922	RNASEH2C	100	74.545	ENSPVAG00000016950	RNASEH2C	100	74.545	Pteropus_vampyrus
ENSG00000172922	RNASEH2C	100	65.663	ENSRNOG00000020700	Rnaseh2c	100	65.663	Rattus_norvegicus
ENSG00000172922	RNASEH2C	100	92.713	ENSRBIG00000040124	RNASEH2C	100	92.713	Rhinopithecus_bieti
ENSG00000172922	RNASEH2C	100	92.713	ENSRROG00000044910	RNASEH2C	99	95.513	Rhinopithecus_roxellana
ENSG00000172922	RNASEH2C	100	90.854	ENSSBOG00000034781	RNASEH2C	100	90.854	Saimiri_boliviensis_boliviensis
ENSG00000172922	RNASEH2C	100	74.405	ENSSSCG00000012979	RNASEH2C	100	74.405	Sus_scrofa
ENSG00000172922	RNASEH2C	100	53.049	ENSTTRG00000016928	RNASEH2C	100	53.049	Tursiops_truncatus
ENSG00000172922	RNASEH2C	100	74.854	ENSUAMG00000020793	RNASEH2C	100	74.854	Ursus_americanus
ENSG00000172922	RNASEH2C	100	73.099	ENSUMAG00000010791	RNASEH2C	100	73.099	Ursus_maritimus
ENSG00000172922	RNASEH2C	95	70.886	ENSVPAG00000006579	RNASEH2C	100	70.886	Vicugna_pacos
ENSG00000172922	RNASEH2C	96	73.292	ENSVVUG00000027076	RNASEH2C	78	74.233	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005634	nucleus	-	IEA	Component
GO:0006401	RNA catabolic process	21177858.	IDA	Process
GO:0032299	ribonuclease H2 complex	21177858.	IDA	Component