EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173141 (Gene tree)
Gene ID: 78988
Gene Symbol: MRPL57
Alias: MRP63
Full Name: mitochondrial ribosomal protein L57
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 2,852 bases
Position: chr13:21,176,233-21,179,084
Accession: 14514
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000310726	MRP-63	PF14978.6	5.9e-37	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000309594	MRPL57-201	2246	XM_017020740	ENSP00000310726	102 (aa)	XP_016876229	Q9BQC6

Gene Model

Click here to download ENSG00000173141's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000173141	C-Peptide	4E-6	23251661

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173141's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173141	MRPL57	70	57.746	ENSAPOG00000020722	mrpl57	66	57.746	Acanthochromis_polyacanthus
ENSG00000173141	MRPL57	100	82.353	ENSAMEG00000018855	MRPL57	100	82.353	Ailuropoda_melanoleuca
ENSG00000173141	MRPL57	100	51.961	ENSACIG00000010952	mrpl57	99	51.961	Amphilophus_citrinellus
ENSG00000173141	MRPL57	100	57.843	ENSAOCG00000007480	mrpl57	99	57.843	Amphiprion_ocellaris
ENSG00000173141	MRPL57	100	57.843	ENSAPEG00000001827	mrpl57	99	57.843	Amphiprion_percula
ENSG00000173141	MRPL57	100	56.863	ENSATEG00000011752	mrpl57	99	56.863	Anabas_testudineus
ENSG00000173141	MRPL57	100	62.745	ENSAPLG00000011494	-	99	62.745	Anas_platyrhynchos
ENSG00000173141	MRPL57	100	65.686	ENSACAG00000002758	MRPL57	100	65.686	Anolis_carolinensis
ENSG00000173141	MRPL57	100	54.902	ENSACLG00000025308	mrpl57	99	54.902	Astatotilapia_calliptera
ENSG00000173141	MRPL57	100	56.863	ENSAMXG00000025429	mrpl57	95	56.863	Astyanax_mexicanus
ENSG00000173141	MRPL57	100	80.392	ENSBTAG00000003315	MRPL57	100	80.392	Bos_taurus
ENSG00000173141	MRPL57	100	92.157	ENSCJAG00000046501	-	100	92.157	Callithrix_jacchus
ENSG00000173141	MRPL57	100	91.176	ENSCJAG00000046444	-	100	91.176	Callithrix_jacchus
ENSG00000173141	MRPL57	99	82.178	ENSCAFG00000029758	-	100	82.178	Canis_familiaris
ENSG00000173141	MRPL57	99	60.194	ENSCAFG00000004240	-	99	60.194	Canis_familiaris
ENSG00000173141	MRPL57	99	82.178	ENSCAFG00020025438	MRPL57	99	82.178	Canis_lupus_dingo
ENSG00000173141	MRPL57	100	79.412	ENSCHIG00000013087	-	100	79.412	Capra_hircus
ENSG00000173141	MRPL57	100	56.863	ENSCHIG00000025160	-	98	56.863	Capra_hircus
ENSG00000173141	MRPL57	100	81.373	ENSCPOG00000035269	MRPL57	100	81.373	Cavia_porcellus
ENSG00000173141	MRPL57	100	97.059	ENSCATG00000017899	MRPL57	100	97.059	Cercocebus_atys
ENSG00000173141	MRPL57	100	97.059	ENSCSAG00000018138	MRPL57	100	97.059	Chlorocebus_sabaeus
ENSG00000173141	MRPL57	100	80.392	ENSCHOG00000003526	MRPL57	100	80.392	Choloepus_hoffmanni
ENSG00000173141	MRPL57	100	65.686	ENSCPBG00000020740	MRPL57	98	65.686	Chrysemys_picta_bellii
ENSG00000173141	MRPL57	100	96.078	ENSCANG00000015404	MRPL57	100	96.078	Colobus_angolensis_palliatus
ENSG00000173141	MRPL57	100	81.373	ENSCGRG00001003685	Mrpl57	100	81.373	Cricetulus_griseus_chok1gshd
ENSG00000173141	MRPL57	100	81.373	ENSCGRG00000015788	Mrpl57	100	81.373	Cricetulus_griseus_crigri
ENSG00000173141	MRPL57	100	56.863	ENSCSEG00000002654	mrpl57	99	56.863	Cynoglossus_semilaevis
ENSG00000173141	MRPL57	100	53.922	ENSCVAG00000010878	mrpl57	99	53.922	Cyprinodon_variegatus
ENSG00000173141	MRPL57	99	62.376	ENSDARG00000007285	mrpl57	98	62.376	Danio_rerio
ENSG00000173141	MRPL57	100	82.353	ENSDNOG00000017817	MRPL57	100	82.353	Dasypus_novemcinctus
ENSG00000173141	MRPL57	100	85.294	ENSDORG00000028118	Mrpl57	100	85.294	Dipodomys_ordii
ENSG00000173141	MRPL57	100	81.373	ENSETEG00000010036	MRPL57	100	81.373	Echinops_telfairi
ENSG00000173141	MRPL57	100	80.392	ENSEASG00005022791	MRPL57	100	80.392	Equus_asinus_asinus
ENSG00000173141	MRPL57	100	79.412	ENSECAG00000034997	MRPL57	100	79.412	Equus_caballus
ENSG00000173141	MRPL57	100	68.627	ENSEEUG00000008608	MRPL57	100	68.627	Erinaceus_europaeus
ENSG00000173141	MRPL57	100	56.863	ENSELUG00000023731	mrpl57	99	56.863	Esox_lucius
ENSG00000173141	MRPL57	100	83.333	ENSFCAG00000024896	MRPL57	100	83.333	Felis_catus
ENSG00000173141	MRPL57	100	61.765	ENSFALG00000014840	MRPL57	100	61.765	Ficedula_albicollis
ENSG00000173141	MRPL57	100	78.431	ENSFDAG00000012746	MRPL57	100	78.431	Fukomys_damarensis
ENSG00000173141	MRPL57	100	52.941	ENSFHEG00000019735	mrpl57	99	52.941	Fundulus_heteroclitus
ENSG00000173141	MRPL57	100	58.824	ENSGMOG00000020491	mrpl57	100	58.824	Gadus_morhua
ENSG00000173141	MRPL57	100	61.765	ENSGALG00000039783	MRPL57	99	61.765	Gallus_gallus
ENSG00000173141	MRPL57	100	54.902	ENSGAFG00000011242	mrpl57	99	54.902	Gambusia_affinis
ENSG00000173141	MRPL57	100	56.863	ENSGACG00000010947	mrpl57	100	56.863	Gasterosteus_aculeatus
ENSG00000173141	MRPL57	100	65.686	ENSGAGG00000018101	MRPL57	98	65.686	Gopherus_agassizii
ENSG00000173141	MRPL57	100	99.020	ENSGGOG00000014501	MRPL57	100	99.020	Gorilla_gorilla
ENSG00000173141	MRPL57	100	55.882	ENSHBUG00000020484	mrpl57	99	55.882	Haplochromis_burtoni
ENSG00000173141	MRPL57	100	81.373	ENSHGLG00000005720	MRP63	100	81.373	Heterocephalus_glaber_female
ENSG00000173141	MRPL57	100	65.686	ENSHGLG00100001658	MRPL57	100	65.686	Heterocephalus_glaber_male
ENSG00000173141	MRPL57	100	53.922	ENSHCOG00000003154	mrpl57	99	53.922	Hippocampus_comes
ENSG00000173141	MRPL57	100	55.882	ENSIPUG00000016074	mrp63	100	55.882	Ictalurus_punctatus
ENSG00000173141	MRPL57	100	85.294	ENSSTOG00000005771	MRPL57	100	85.294	Ictidomys_tridecemlineatus
ENSG00000173141	MRPL57	100	55.882	ENSKMAG00000017113	mrpl57	99	55.882	Kryptolebias_marmoratus
ENSG00000173141	MRPL57	100	53.922	ENSLBEG00000020535	mrpl57	99	53.922	Labrus_bergylta
ENSG00000173141	MRPL57	100	60.784	ENSLACG00000015182	MRPL57	94	60.784	Latimeria_chalumnae
ENSG00000173141	MRPL57	75	61.039	ENSLOCG00000017356	mrpl57	99	61.039	Lepisosteus_oculatus
ENSG00000173141	MRPL57	99	83.168	ENSLAFG00000016751	MRPL57	100	83.168	Loxodonta_africana
ENSG00000173141	MRPL57	100	97.059	ENSMFAG00000034030	MRPL57	100	97.059	Macaca_fascicularis
ENSG00000173141	MRPL57	100	97.059	ENSMMUG00000016562	MRPL57	100	97.059	Macaca_mulatta
ENSG00000173141	MRPL57	100	97.059	ENSMNEG00000024205	MRPL57	100	97.059	Macaca_nemestrina
ENSG00000173141	MRPL57	100	97.059	ENSMLEG00000007593	MRPL57	100	97.059	Mandrillus_leucophaeus
ENSG00000173141	MRPL57	100	53.922	ENSMAMG00000021998	mrpl57	99	53.922	Mastacembelus_armatus
ENSG00000173141	MRPL57	100	54.902	ENSMZEG00005019837	mrpl57	99	54.902	Maylandia_zebra
ENSG00000173141	MRPL57	100	60.784	ENSMGAG00000015610	MRPL57	100	60.784	Meleagris_gallopavo
ENSG00000173141	MRPL57	100	78.431	ENSMAUG00000012206	Mrpl57	100	78.431	Mesocricetus_auratus
ENSG00000173141	MRPL57	100	81.373	ENSMOCG00000014838	Mrpl57	100	81.373	Microtus_ochrogaster
ENSG00000173141	MRPL57	100	55.882	ENSMMOG00000016157	-	99	55.882	Mola_mola
ENSG00000173141	MRPL57	100	55.882	ENSMMOG00000007464	mrpl57	99	55.882	Mola_mola
ENSG00000173141	MRPL57	100	73.529	ENSMODG00000024156	MRPL57	100	73.529	Monodelphis_domestica
ENSG00000173141	MRPL57	100	54.902	ENSMALG00000020059	mrpl57	99	54.902	Monopterus_albus
ENSG00000173141	MRPL57	100	83.333	ENSMUSG00000021967	Mrpl57	100	83.333	Mus_musculus
ENSG00000173141	MRPL57	100	84.314	MGP_PahariEiJ_G0030374	Mrpl57	100	84.314	Mus_pahari
ENSG00000173141	MRPL57	100	83.333	MGP_SPRETEiJ_G0020250	Mrpl57	100	83.333	Mus_spretus
ENSG00000173141	MRPL57	98	81.000	ENSMPUG00000000617	MRPL57	68	81.000	Mustela_putorius_furo
ENSG00000173141	MRPL57	100	73.529	ENSMLUG00000029331	MRPL57	100	73.529	Myotis_lucifugus
ENSG00000173141	MRPL57	100	83.333	ENSNGAG00000016942	Mrpl57	100	83.333	Nannospalax_galili
ENSG00000173141	MRPL57	100	53.922	ENSNBRG00000012130	mrpl57	99	53.922	Neolamprologus_brichardi
ENSG00000173141	MRPL57	100	97.059	ENSNLEG00000027945	MRPL57	100	97.059	Nomascus_leucogenys
ENSG00000173141	MRPL57	100	72.549	ENSMEUG00000011995	MRPL57	100	72.549	Notamacropus_eugenii
ENSG00000173141	MRPL57	100	80.769	ENSODEG00000020136	-	100	80.769	Octodon_degus
ENSG00000173141	MRPL57	100	82.353	ENSODEG00000019044	-	100	82.353	Octodon_degus
ENSG00000173141	MRPL57	100	55.882	ENSONIG00000020728	mrpl57	99	55.882	Oreochromis_niloticus
ENSG00000173141	MRPL57	100	72.115	ENSOANG00000009036	MRPL57	100	72.115	Ornithorhynchus_anatinus
ENSG00000173141	MRPL57	100	55.882	ENSORLG00000029659	mrpl57	89	55.882	Oryzias_latipes
ENSG00000173141	MRPL57	100	55.882	ENSORLG00020000382	mrpl57	89	55.882	Oryzias_latipes_hni
ENSG00000173141	MRPL57	100	55.882	ENSORLG00015019416	mrpl57	89	55.882	Oryzias_latipes_hsok
ENSG00000173141	MRPL57	100	53.922	ENSOMEG00000012875	mrpl57	99	53.922	Oryzias_melastigma
ENSG00000173141	MRPL57	100	87.255	ENSOGAG00000003209	MRPL57	100	87.255	Otolemur_garnettii
ENSG00000173141	MRPL57	87	66.292	ENSOARG00000013641	MRPL57	100	66.292	Ovis_aries
ENSG00000173141	MRPL57	100	99.020	ENSPPAG00000031962	MRPL57	100	99.020	Pan_paniscus
ENSG00000173141	MRPL57	100	84.314	ENSPPRG00000016959	MRPL57	100	84.314	Panthera_pardus
ENSG00000173141	MRPL57	100	84.314	ENSPTIG00000005446	MRPL57	100	84.314	Panthera_tigris_altaica
ENSG00000173141	MRPL57	100	99.020	ENSPTRG00000049719	MRPL57	100	99.020	Pan_troglodytes
ENSG00000173141	MRPL57	100	97.059	ENSPANG00000011852	MRPL57	100	97.059	Papio_anubis
ENSG00000173141	MRPL57	100	60.784	ENSPSIG00000001788	MRPL57	100	60.784	Pelodiscus_sinensis
ENSG00000173141	MRPL57	100	50.980	ENSPMGG00000003040	mrpl57	99	50.980	Periophthalmus_magnuspinnatus
ENSG00000173141	MRPL57	100	83.333	ENSPEMG00000003727	Mrpl57	100	83.333	Peromyscus_maniculatus_bairdii
ENSG00000173141	MRPL57	99	51.961	ENSPMAG00000009966	mrpl57	100	51.961	Petromyzon_marinus
ENSG00000173141	MRPL57	100	76.471	ENSPCIG00000027384	MRPL57	100	76.471	Phascolarctos_cinereus
ENSG00000173141	MRPL57	100	57.843	ENSPLAG00000017087	mrpl57	99	57.843	Poecilia_latipinna
ENSG00000173141	MRPL57	100	57.843	ENSPLAG00000017093	-	99	57.843	Poecilia_latipinna
ENSG00000173141	MRPL57	100	57.843	ENSPLAG00000004522	MRPL57	99	57.843	Poecilia_latipinna
ENSG00000173141	MRPL57	100	57.843	ENSPMEG00000019360	-	99	57.843	Poecilia_mexicana
ENSG00000173141	MRPL57	100	57.843	ENSPMEG00000022617	mrpl57	99	57.843	Poecilia_mexicana
ENSG00000173141	MRPL57	100	55.882	ENSPREG00000002528	mrpl57	99	55.882	Poecilia_reticulata
ENSG00000173141	MRPL57	100	98.039	ENSPPYG00000005200	MRPL57	100	98.039	Pongo_abelii
ENSG00000173141	MRPL57	100	82.353	ENSPCAG00000007256	MRPL57	100	82.353	Procavia_capensis
ENSG00000173141	MRPL57	100	75.490	ENSPVAG00000016311	MRPL57	100	75.490	Pteropus_vampyrus
ENSG00000173141	MRPL57	100	55.882	ENSPNYG00000022163	mrpl57	99	55.882	Pundamilia_nyererei
ENSG00000173141	MRPL57	100	53.922	ENSPNAG00000018898	mrpl57	98	53.922	Pygocentrus_nattereri
ENSG00000173141	MRPL57	100	96.078	ENSRBIG00000030940	-	100	96.078	Rhinopithecus_bieti
ENSG00000173141	MRPL57	100	96.078	ENSRBIG00000011478	-	100	96.078	Rhinopithecus_bieti
ENSG00000173141	MRPL57	96	76.531	ENSRROG00000032305	-	100	76.531	Rhinopithecus_roxellana
ENSG00000173141	MRPL57	100	96.078	ENSRROG00000003371	-	100	96.078	Rhinopithecus_roxellana
ENSG00000173141	MRPL57	70	77.465	ENSSHAG00000007692	MRPL57	99	77.465	Sarcophilus_harrisii
ENSG00000173141	MRPL57	100	59.804	ENSSFOG00015005870	mrpl57	98	59.804	Scleropages_formosus
ENSG00000173141	MRPL57	99	55.446	ENSSMAG00000019955	mrpl57	100	55.446	Scophthalmus_maximus
ENSG00000173141	MRPL57	100	50.980	ENSSDUG00000019348	mrpl57	99	50.980	Seriola_dumerili
ENSG00000173141	MRPL57	100	50.980	ENSSLDG00000023968	-	99	50.980	Seriola_lalandi_dorsalis
ENSG00000173141	MRPL57	100	50.980	ENSSLDG00000008894	mrpl57	99	50.980	Seriola_lalandi_dorsalis
ENSG00000173141	MRPL57	100	62.745	ENSSPUG00000014485	MRPL57	98	62.745	Sphenodon_punctatus
ENSG00000173141	MRPL57	99	53.465	ENSSPAG00000019370	-	100	53.465	Stegastes_partitus
ENSG00000173141	MRPL57	99	53.465	ENSSPAG00000017014	mrpl57	100	53.465	Stegastes_partitus
ENSG00000173141	MRPL57	100	73.529	ENSSSCG00000031280	MRPL57	100	73.529	Sus_scrofa
ENSG00000173141	MRPL57	100	63.725	ENSTGUG00000011395	MRPL57	100	63.725	Taeniopygia_guttata
ENSG00000173141	MRPL57	100	57.843	ENSTRUG00000001715	mrpl57	99	57.843	Takifugu_rubripes
ENSG00000173141	MRPL57	100	75.490	ENSTTRG00000016918	MRPL57	100	75.490	Tursiops_truncatus
ENSG00000173141	MRPL57	100	84.314	ENSUAMG00000001484	MRPL57	100	84.314	Ursus_americanus
ENSG00000173141	MRPL57	100	84.314	ENSUMAG00000015080	MRPL57	100	84.314	Ursus_maritimus
ENSG00000173141	MRPL57	61	82.258	ENSVVUG00000013124	-	75	77.778	Vulpes_vulpes
ENSG00000173141	MRPL57	83	64.516	ENSVVUG00000002384	-	72	64.516	Vulpes_vulpes
ENSG00000173141	MRPL57	100	53.922	ENSXCOG00000013394	mrpl57	99	53.922	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	11402041.	ISS	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	21873635.	IBA	Component
GO:0005761	mitochondrial ribosome	11402041.	ISS	Component
GO:0005762	mitochondrial large ribosomal subunit	28892042.	IDA	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0032543	mitochondrial translation	11402041.	ISS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process