EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173273 (Gene tree)
Gene ID: 8658
Gene Symbol: TNKS
Alias: TIN1|TINF1|TNKS1|PARP-5a|PARP5A|pART5
Full Name: tankyrase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 227,133 bases
Position: chr8:9,555,214-9,782,346
Accession: 11941
RBP type: canonical RBP
Summary: TNKS (Tankyrase) is a Protein Coding gene. Diseases associated with TNKS include Lung Acinar Adenocarcinoma and Cherubism. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and T41 mutants of beta-catenin arent phosphorylated. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is TNKS2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000429890	PARP	PF00644.20	3.9e-26	1	1
ENSP00000311579	PARP	PF00644.20	6.7e-26	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15949576	Telomere stability genes are not mutated in osteosarcoma cell lines.	Cancer Genet Cytogenet	2005 Jul 1	Savage SA	-
12007281	Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.	Pathobiology	2001	Matsutani N	-
26345860	Telomere-associated factor expression in replicative senescence of human embryonic lung fibroblasts.	Genet Mol Res	2015 Aug 10	Du H	doi: 10.4238/2015.August.10.7.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000520408	TNKS-211	1964	-	ENSP00000428299	617 (aa)	-	E7EWY6
ENST00000517652	TNKS-202	267	-	-	- (aa)	-	-
ENST00000521039	TNKS-212	745	-	-	- (aa)	-	-
ENST00000310430	TNKS-201	9620	XM_006716263	ENSP00000311579	1327 (aa)	XP_006716326	O95271
ENST00000522110	TNKS-213	2900	-	ENSP00000430920	243 (aa)	-	E5RHD2
ENST00000518027	TNKS-205	766	-	-	- (aa)	-	-
ENST00000518281	TNKS-206	3897	-	ENSP00000429890	1090 (aa)	-	E7EQ52
ENST00000518635	TNKS-207	503	-	ENSP00000431098	68 (aa)	-	A0A0C4DGE3
ENST00000519930	TNKS-210	357	-	-	- (aa)	-	-
ENST00000519392	TNKS-209	556	-	-	- (aa)	-	-
ENST00000519191	TNKS-208	496	-	-	- (aa)	-	-
ENST00000517989	TNKS-204	603	-	-	- (aa)	-	-
ENST00000517770	TNKS-203	574	-	ENSP00000428185	61 (aa)	-	H0YAW5

Gene Model

Click here to download ENSG00000173273's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000173273	Asthma	3.438001E-05	11022011
ENSG00000173273	Platelet Function Tests	1.8462000E-005	-
ENSG00000173273	Bone Density	2E-6	27397699
ENSG00000173273	Multiple Myeloma	7E-6	23502783

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000173273	rs6422354	8	9581210	G	Bone mineral density (Ward's triangle area)	27397699	[NR] unit increase	0.16	EFO_0007785
ENSG00000173273	rs12545912	8	9744189	C	Multiple myeloma (hyperdiploidy)	23502783	[1.16-1.45]	1.3	EFO_0001378
ENSG00000173273	rs13275502	8	9638608	A	Neuroticism	29255261	z score increase	6.497	EFO_0007660
ENSG00000173273	rs4427176	8	9675889	T	Mosquito bite size	28199695	[0.022-0.049] unit increase	0.0356511	EFO_0008378
ENSG00000173273	rs4383974	8	9761838	C	Systolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006335\|EFO_0004329
ENSG00000173273	rs35231275	8	9762399	A	Pulse pressure x alcohol consumption interaction (2df test)	29912962			EFO_0005763\|EFO_0004329
ENSG00000173273	rs4383974	8	9761838	?	Heel bone mineral density	30048462	[0.014-0.023] unit decrease	0.0182957	EFO_0009270
ENSG00000173273	rs11249939	8	9698990	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000173273	rs7013834	8	9557132	A	General risk tolerance (MTAG)	30643258	[0.009-0.016] unit increase	0.0125	EFO_0008579
ENSG00000173273	rs79488099	8	9776965	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173273's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173273	TNKS	100	98.529	ENSAPOG00000020148	tnksb	92	92.188	Acanthochromis_polyacanthus
ENSG00000173273	TNKS	100	83.500	ENSAPOG00000020020	tnksa	90	85.863	Acanthochromis_polyacanthus
ENSG00000173273	TNKS	100	100.000	ENSAMEG00000005992	TNKS	100	98.569	Ailuropoda_melanoleuca
ENSG00000173273	TNKS	100	82.143	ENSACIG00000018757	tnksb	91	82.812	Amphilophus_citrinellus
ENSG00000173273	TNKS	100	98.529	ENSAOCG00000010070	tnksb	99	90.381	Amphiprion_ocellaris
ENSG00000173273	TNKS	100	98.529	ENSAPEG00000006372	tnksb	99	90.476	Amphiprion_percula
ENSG00000173273	TNKS	100	97.059	ENSAPEG00000002584	tnksa	100	91.163	Amphiprion_percula
ENSG00000173273	TNKS	100	98.529	ENSATEG00000016200	TNKS	100	92.208	Anabas_testudineus
ENSG00000173273	TNKS	100	97.059	ENSATEG00000021596	tnksa	99	90.602	Anabas_testudineus
ENSG00000173273	TNKS	100	98.529	ENSAPLG00000002335	TNKS	90	96.881	Anas_platyrhynchos
ENSG00000173273	TNKS	100	97.892	ENSACAG00000002619	TNKS	90	97.892	Anolis_carolinensis
ENSG00000173273	TNKS	100	100.000	ENSANAG00000022197	TNKS	100	99.171	Aotus_nancymaae
ENSG00000173273	TNKS	100	98.529	ENSACLG00000020662	tnksb	96	92.033	Astatotilapia_calliptera
ENSG00000173273	TNKS	100	97.059	ENSACLG00000024068	tnksa	90	90.628	Astatotilapia_calliptera
ENSG00000173273	TNKS	100	97.059	ENSAMXG00000036982	tnksb	95	89.955	Astyanax_mexicanus
ENSG00000173273	TNKS	100	100.000	ENSBTAG00000001463	TNKS	100	98.870	Bos_taurus
ENSG00000173273	TNKS	100	100.000	ENSCJAG00000012143	TNKS	100	99.171	Callithrix_jacchus
ENSG00000173273	TNKS	100	100.000	ENSCAFG00000006632	TNKS	100	98.945	Canis_familiaris
ENSG00000173273	TNKS	100	100.000	ENSCHIG00000007929	TNKS	100	99.020	Capra_hircus
ENSG00000173273	TNKS	100	100.000	ENSTSYG00000004540	TNKS	100	99.819	Carlito_syrichta
ENSG00000173273	TNKS	100	100.000	ENSCAPG00000010886	TNKS	100	85.060	Cavia_aperea
ENSG00000173273	TNKS	100	100.000	ENSCPOG00000010040	TNKS	100	98.116	Cavia_porcellus
ENSG00000173273	TNKS	100	100.000	ENSCCAG00000020538	TNKS	100	99.020	Cebus_capucinus
ENSG00000173273	TNKS	100	100.000	ENSCATG00000037530	TNKS	100	99.548	Cercocebus_atys
ENSG00000173273	TNKS	100	100.000	ENSCLAG00000001619	TNKS	100	98.493	Chinchilla_lanigera
ENSG00000173273	TNKS	100	100.000	ENSCSAG00000016874	TNKS	100	99.699	Chlorocebus_sabaeus
ENSG00000173273	TNKS	95	93.836	ENSCHOG00000002500	TNKS	100	84.853	Choloepus_hoffmanni
ENSG00000173273	TNKS	100	98.529	ENSCPBG00000027190	-	99	99.096	Chrysemys_picta_bellii
ENSG00000173273	TNKS	72	90.909	ENSCING00000025066	-	99	63.500	Ciona_intestinalis
ENSG00000173273	TNKS	100	91.176	ENSCSAVG00000011230	-	99	73.670	Ciona_savignyi
ENSG00000173273	TNKS	100	100.000	ENSCANG00000041684	TNKS	100	99.699	Colobus_angolensis_palliatus
ENSG00000173273	TNKS	100	100.000	ENSCGRG00001020318	Tnks	100	97.212	Cricetulus_griseus_chok1gshd
ENSG00000173273	TNKS	100	100.000	ENSCGRG00000015982	Tnks	98	99.541	Cricetulus_griseus_crigri
ENSG00000173273	TNKS	100	97.059	ENSCSEG00000005154	-	90	90.017	Cynoglossus_semilaevis
ENSG00000173273	TNKS	100	98.529	ENSCSEG00000011218	tnksb	100	91.736	Cynoglossus_semilaevis
ENSG00000173273	TNKS	100	97.059	ENSCVAG00000014693	tnksa	98	76.083	Cyprinodon_variegatus
ENSG00000173273	TNKS	100	97.059	ENSCVAG00000017903	tnksb	92	92.361	Cyprinodon_variegatus
ENSG00000173273	TNKS	100	98.529	ENSDARG00000062897	tnksb	90	91.460	Danio_rerio
ENSG00000173273	TNKS	100	97.059	ENSDARG00000077650	tnksa	92	93.480	Danio_rerio
ENSG00000173273	TNKS	100	100.000	ENSDORG00000011584	Tnks	98	98.062	Dipodomys_ordii
ENSG00000173273	TNKS	100	100.000	ENSETEG00000011217	TNKS	100	90.664	Echinops_telfairi
ENSG00000173273	TNKS	100	94.118	ENSEBUG00000014360	-	98	80.909	Eptatretus_burgeri
ENSG00000173273	TNKS	100	100.000	ENSEASG00005016972	TNKS	100	99.096	Equus_asinus_asinus
ENSG00000173273	TNKS	100	100.000	ENSECAG00000007431	TNKS	100	99.096	Equus_caballus
ENSG00000173273	TNKS	100	100.000	ENSEEUG00000004699	TNKS	100	91.648	Erinaceus_europaeus
ENSG00000173273	TNKS	100	98.529	ENSELUG00000008089	tnksb	92	91.130	Esox_lucius
ENSG00000173273	TNKS	100	98.529	ENSELUG00000002184	tnksa	92	92.844	Esox_lucius
ENSG00000173273	TNKS	100	100.000	ENSFCAG00000008484	TNKS	100	98.794	Felis_catus
ENSG00000173273	TNKS	100	98.714	ENSFALG00000006742	TNKS	100	98.714	Ficedula_albicollis
ENSG00000173273	TNKS	100	100.000	ENSFDAG00000008742	TNKS	100	98.568	Fukomys_damarensis
ENSG00000173273	TNKS	100	97.059	ENSFHEG00000022069	tnksb	92	89.332	Fundulus_heteroclitus
ENSG00000173273	TNKS	100	97.059	ENSFHEG00000012036	tnksa	90	90.264	Fundulus_heteroclitus
ENSG00000173273	TNKS	100	98.529	ENSGMOG00000007567	tnksb	92	90.951	Gadus_morhua
ENSG00000173273	TNKS	100	98.623	ENSGALG00000043164	TNKS	90	98.623	Gallus_gallus
ENSG00000173273	TNKS	100	97.059	ENSGAFG00000006184	tnksb	92	92.448	Gambusia_affinis
ENSG00000173273	TNKS	100	97.059	ENSGAFG00000005600	tnksa	100	86.410	Gambusia_affinis
ENSG00000173273	TNKS	100	97.059	ENSGACG00000017729	tnksa	98	87.953	Gasterosteus_aculeatus
ENSG00000173273	TNKS	100	98.529	ENSGACG00000012837	tnksb	92	91.583	Gasterosteus_aculeatus
ENSG00000173273	TNKS	100	98.529	ENSGAGG00000020677	TNKS	99	98.255	Gopherus_agassizii
ENSG00000173273	TNKS	100	100.000	ENSGGOG00000011691	TNKS	100	99.699	Gorilla_gorilla
ENSG00000173273	TNKS	100	97.059	ENSHBUG00000023389	tnksa	90	90.719	Haplochromis_burtoni
ENSG00000173273	TNKS	100	98.529	ENSHBUG00000011486	tnksb	92	92.361	Haplochromis_burtoni
ENSG00000173273	TNKS	100	100.000	ENSHGLG00000003279	TNKS	100	98.417	Heterocephalus_glaber_female
ENSG00000173273	TNKS	100	100.000	ENSHGLG00100018150	TNKS	100	98.493	Heterocephalus_glaber_male
ENSG00000173273	TNKS	100	98.529	ENSHCOG00000000804	tnksb	92	91.720	Hippocampus_comes
ENSG00000173273	TNKS	100	97.059	ENSHCOG00000004945	-	91	86.789	Hippocampus_comes
ENSG00000173273	TNKS	100	95.588	ENSIPUG00000023527	tnksb	93	88.317	Ictalurus_punctatus
ENSG00000173273	TNKS	100	98.529	ENSIPUG00000004366	tnksa	93	93.205	Ictalurus_punctatus
ENSG00000173273	TNKS	100	100.000	ENSSTOG00000014515	TNKS	100	98.719	Ictidomys_tridecemlineatus
ENSG00000173273	TNKS	100	100.000	ENSJJAG00000010315	Tnks	100	96.915	Jaculus_jaculus
ENSG00000173273	TNKS	100	97.059	ENSKMAG00000010617	tnksb	95	92.322	Kryptolebias_marmoratus
ENSG00000173273	TNKS	100	97.059	ENSKMAG00000014133	tnksa	100	90.693	Kryptolebias_marmoratus
ENSG00000173273	TNKS	100	98.529	ENSLBEG00000008123	tnksb	92	91.927	Labrus_bergylta
ENSG00000173273	TNKS	100	98.529	ENSLACG00000005186	TNKS	94	95.317	Latimeria_chalumnae
ENSG00000173273	TNKS	100	98.529	ENSLOCG00000012168	tnksb	89	94.671	Lepisosteus_oculatus
ENSG00000173273	TNKS	100	99.083	ENSLAFG00000004786	TNKS	100	98.753	Loxodonta_africana
ENSG00000173273	TNKS	100	100.000	ENSMFAG00000029976	TNKS	100	99.623	Macaca_fascicularis
ENSG00000173273	TNKS	100	100.000	ENSMMUG00000000965	TNKS	100	99.623	Macaca_mulatta
ENSG00000173273	TNKS	100	100.000	ENSMNEG00000041191	TNKS	100	99.623	Macaca_nemestrina
ENSG00000173273	TNKS	100	100.000	ENSMLEG00000029520	TNKS	100	99.623	Mandrillus_leucophaeus
ENSG00000173273	TNKS	100	98.529	ENSMAMG00000001610	tnksb	92	92.361	Mastacembelus_armatus
ENSG00000173273	TNKS	100	97.059	ENSMAMG00000006069	tnksa	98	90.693	Mastacembelus_armatus
ENSG00000173273	TNKS	100	97.059	ENSMZEG00005016736	tnksa	90	90.628	Maylandia_zebra
ENSG00000173273	TNKS	100	98.529	ENSMZEG00005018767	tnksb	92	92.361	Maylandia_zebra
ENSG00000173273	TNKS	100	98.623	ENSMGAG00000008814	TNKS	100	97.747	Meleagris_gallopavo
ENSG00000173273	TNKS	100	100.000	ENSMAUG00000007100	Tnks	100	91.032	Mesocricetus_auratus
ENSG00000173273	TNKS	100	100.000	ENSMICG00000012998	TNKS	100	98.945	Microcebus_murinus
ENSG00000173273	TNKS	100	100.000	ENSMOCG00000022402	Tnks	100	97.287	Microtus_ochrogaster
ENSG00000173273	TNKS	100	97.059	ENSMMOG00000021234	tnksa	99	84.114	Mola_mola
ENSG00000173273	TNKS	100	98.529	ENSMMOG00000010431	tnksb	98	83.786	Mola_mola
ENSG00000173273	TNKS	100	98.529	ENSMODG00000019017	TNKS	88	98.349	Monodelphis_domestica
ENSG00000173273	TNKS	100	95.588	ENSMALG00000011965	tnksa	90	90.759	Monopterus_albus
ENSG00000173273	TNKS	98	84.143	ENSMALG00000017373	tnksb	96	86.673	Monopterus_albus
ENSG00000173273	TNKS	100	100.000	MGP_CAROLIEiJ_G0030977	Tnks	100	96.842	Mus_caroli
ENSG00000173273	TNKS	100	100.000	ENSMUSG00000031529	Tnks	98	100.000	Mus_musculus
ENSG00000173273	TNKS	100	100.000	MGP_PahariEiJ_G0021445	Tnks	100	97.214	Mus_pahari
ENSG00000173273	TNKS	100	100.000	MGP_SPRETEiJ_G0032093	Tnks	100	97.139	Mus_spretus
ENSG00000173273	TNKS	100	100.000	ENSMPUG00000011383	TNKS	100	98.719	Mustela_putorius_furo
ENSG00000173273	TNKS	100	100.000	ENSMLUG00000007233	TNKS	100	98.342	Myotis_lucifugus
ENSG00000173273	TNKS	100	100.000	ENSNGAG00000000489	Tnks	100	97.212	Nannospalax_galili
ENSG00000173273	TNKS	100	97.059	ENSNBRG00000009869	tnksa	99	84.775	Neolamprologus_brichardi
ENSG00000173273	TNKS	100	98.529	ENSNBRG00000001274	tnksb	91	88.999	Neolamprologus_brichardi
ENSG00000173273	TNKS	100	100.000	ENSNLEG00000014966	TNKS	100	95.403	Nomascus_leucogenys
ENSG00000173273	TNKS	93	99.351	ENSMEUG00000012690	-	74	99.351	Notamacropus_eugenii
ENSG00000173273	TNKS	100	100.000	ENSOPRG00000008706	TNKS	88	95.112	Ochotona_princeps
ENSG00000173273	TNKS	100	100.000	ENSODEG00000004893	TNKS	100	98.794	Octodon_degus
ENSG00000173273	TNKS	100	98.529	ENSONIG00000011131	tnksb	92	92.361	Oreochromis_niloticus
ENSG00000173273	TNKS	100	97.059	ENSONIG00000004019	tnksa	92	90.501	Oreochromis_niloticus
ENSG00000173273	TNKS	100	100.000	ENSOANG00000008567	-	98	98.165	Ornithorhynchus_anatinus
ENSG00000173273	TNKS	100	99.633	ENSOCUG00000017773	TNKS	100	98.719	Oryctolagus_cuniculus
ENSG00000173273	TNKS	100	97.059	ENSORLG00000011341	tnksa	93	90.636	Oryzias_latipes
ENSG00000173273	TNKS	100	95.588	ENSORLG00000029690	tnksb	94	91.075	Oryzias_latipes
ENSG00000173273	TNKS	100	97.059	ENSORLG00020010345	tnksa	93	90.545	Oryzias_latipes_hni
ENSG00000173273	TNKS	100	97.059	ENSORLG00015023233	tnksa	99	88.145	Oryzias_latipes_hsok
ENSG00000173273	TNKS	100	97.059	ENSOMEG00000021619	tnksa	93	90.628	Oryzias_melastigma
ENSG00000173273	TNKS	100	95.588	ENSOMEG00000018326	tnksb	91	92.274	Oryzias_melastigma
ENSG00000173273	TNKS	100	100.000	ENSOGAG00000007325	TNKS	100	98.568	Otolemur_garnettii
ENSG00000173273	TNKS	100	100.000	ENSOARG00000010142	TNKS	99	97.964	Ovis_aries
ENSG00000173273	TNKS	100	100.000	ENSPPAG00000029358	TNKS	100	99.699	Pan_paniscus
ENSG00000173273	TNKS	100	100.000	ENSPPRG00000009656	TNKS	100	98.794	Panthera_pardus
ENSG00000173273	TNKS	100	100.000	ENSPTIG00000021233	TNKS	100	99.358	Panthera_tigris_altaica
ENSG00000173273	TNKS	100	100.000	ENSPTRG00000019972	TNKS	100	99.699	Pan_troglodytes
ENSG00000173273	TNKS	100	100.000	ENSPANG00000023565	TNKS	100	99.699	Papio_anubis
ENSG00000173273	TNKS	100	98.529	ENSPKIG00000021889	tnksb	92	93.205	Paramormyrops_kingsleyae
ENSG00000173273	TNKS	100	98.529	ENSPSIG00000003346	TNKS	99	97.706	Pelodiscus_sinensis
ENSG00000173273	TNKS	100	97.368	ENSPMGG00000005157	tnksa	99	96.067	Periophthalmus_magnuspinnatus
ENSG00000173273	TNKS	100	97.059	ENSPMGG00000001350	tnksb	92	90.182	Periophthalmus_magnuspinnatus
ENSG00000173273	TNKS	100	100.000	ENSPEMG00000015511	Tnks	100	99.541	Peromyscus_maniculatus_bairdii
ENSG00000173273	TNKS	100	94.118	ENSPMAG00000008655	-	89	84.734	Petromyzon_marinus
ENSG00000173273	TNKS	100	98.529	ENSPCIG00000011378	-	92	97.085	Phascolarctos_cinereus
ENSG00000173273	TNKS	100	97.059	ENSPFOG00000004982	tnksa	92	90.017	Poecilia_formosa
ENSG00000173273	TNKS	100	97.059	ENSPFOG00000012237	tnksb	92	92.062	Poecilia_formosa
ENSG00000173273	TNKS	100	97.059	ENSPLAG00000004341	-	91	88.918	Poecilia_latipinna
ENSG00000173273	TNKS	100	97.059	ENSPLAG00000014512	tnksb	96	92.766	Poecilia_latipinna
ENSG00000173273	TNKS	100	97.059	ENSPMEG00000019006	tnksa	90	90.719	Poecilia_mexicana
ENSG00000173273	TNKS	100	97.059	ENSPMEG00000018884	tnksb	92	92.541	Poecilia_mexicana
ENSG00000173273	TNKS	100	97.059	ENSPREG00000019745	tnksb	92	92.454	Poecilia_reticulata
ENSG00000173273	TNKS	100	97.059	ENSPREG00000005920	tnksa	91	90.568	Poecilia_reticulata
ENSG00000173273	TNKS	100	100.000	ENSPPYG00000018367	TNKS	100	99.699	Pongo_abelii
ENSG00000173273	TNKS	100	98.529	ENSPCAG00000008732	TNKS	89	96.170	Procavia_capensis
ENSG00000173273	TNKS	100	100.000	ENSPVAG00000011017	TNKS	100	98.342	Pteropus_vampyrus
ENSG00000173273	TNKS	100	97.059	ENSPNYG00000011308	tnksa	98	82.277	Pundamilia_nyererei
ENSG00000173273	TNKS	100	98.529	ENSPNYG00000003131	tnksb	99	92.033	Pundamilia_nyererei
ENSG00000173273	TNKS	100	98.529	ENSPNAG00000010036	tnksa	92	93.664	Pygocentrus_nattereri
ENSG00000173273	TNKS	100	97.059	ENSPNAG00000011906	tnksb	98	79.531	Pygocentrus_nattereri
ENSG00000173273	TNKS	100	99.450	ENSRNOG00000011625	Tnks	100	97.212	Rattus_norvegicus
ENSG00000173273	TNKS	100	100.000	ENSRBIG00000039501	TNKS	100	95.177	Rhinopithecus_bieti
ENSG00000173273	TNKS	100	100.000	ENSRROG00000019710	TNKS	100	99.548	Rhinopithecus_roxellana
ENSG00000173273	TNKS	100	100.000	ENSSBOG00000018538	TNKS	100	99.246	Saimiri_boliviensis_boliviensis
ENSG00000173273	TNKS	100	100.000	ENSSHAG00000012922	-	100	98.624	Sarcophilus_harrisii
ENSG00000173273	TNKS	100	98.529	ENSSFOG00015019144	tnksb	90	93.756	Scleropages_formosus
ENSG00000173273	TNKS	100	98.529	ENSSMAG00000019175	tnksb	100	83.638	Scophthalmus_maximus
ENSG00000173273	TNKS	100	97.059	ENSSMAG00000018031	tnksa	89	90.628	Scophthalmus_maximus
ENSG00000173273	TNKS	100	97.059	ENSSDUG00000020636	-	87	91.289	Seriola_dumerili
ENSG00000173273	TNKS	100	98.529	ENSSDUG00000001625	tnksb	99	85.125	Seriola_dumerili
ENSG00000173273	TNKS	100	98.529	ENSSLDG00000017391	tnksb	92	92.014	Seriola_lalandi_dorsalis
ENSG00000173273	TNKS	100	97.059	ENSSLDG00000018496	-	86	91.552	Seriola_lalandi_dorsalis
ENSG00000173273	TNKS	100	99.358	ENSSARG00000013977	TNKS	100	97.666	Sorex_araneus
ENSG00000173273	TNKS	100	100.000	ENSSPUG00000004444	TNKS	92	97.153	Sphenodon_punctatus
ENSG00000173273	TNKS	100	98.529	ENSSPAG00000014845	tnksb	92	92.188	Stegastes_partitus
ENSG00000173273	TNKS	100	97.059	ENSSPAG00000001035	-	99	83.394	Stegastes_partitus
ENSG00000173273	TNKS	100	100.000	ENSSSCG00000015851	TNKS	100	98.794	Sus_scrofa
ENSG00000173273	TNKS	100	98.806	ENSTGUG00000004835	TNKS	95	98.806	Taeniopygia_guttata
ENSG00000173273	TNKS	100	98.529	ENSTRUG00000010518	tnksb	90	91.491	Takifugu_rubripes
ENSG00000173273	TNKS	100	90.278	ENSTRUG00000010911	tnksa	90	88.028	Takifugu_rubripes
ENSG00000173273	TNKS	100	98.529	ENSTNIG00000018875	tnksb	92	91.594	Tetraodon_nigroviridis
ENSG00000173273	TNKS	100	97.059	ENSTNIG00000013232	tnksa	90	87.455	Tetraodon_nigroviridis
ENSG00000173273	TNKS	100	100.000	ENSTTRG00000007093	TNKS	94	94.573	Tursiops_truncatus
ENSG00000173273	TNKS	99	88.142	ENSUAMG00000012430	TNKS	99	84.739	Ursus_americanus
ENSG00000173273	TNKS	100	100.000	ENSUMAG00000007498	TNKS	99	99.564	Ursus_maritimus
ENSG00000173273	TNKS	100	100.000	ENSVPAG00000007821	TNKS	99	91.304	Vicugna_pacos
ENSG00000173273	TNKS	100	100.000	ENSVVUG00000019734	TNKS	100	99.020	Vulpes_vulpes
ENSG00000173273	TNKS	100	98.529	ENSXETG00000008155	tnks2	88	96.697	Xenopus_tropicalis
ENSG00000173273	TNKS	100	97.059	ENSXCOG00000015205	tnksb	92	92.622	Xiphophorus_couchianus
ENSG00000173273	TNKS	100	97.297	ENSXCOG00000005282	tnksa	99	72.393	Xiphophorus_couchianus
ENSG00000173273	TNKS	100	97.059	ENSXMAG00000002312	tnksa	98	83.768	Xiphophorus_maculatus
ENSG00000173273	TNKS	100	97.059	ENSXMAG00000004961	tnksb	92	92.622	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0000209	protein polyubiquitination	19759537.21478859.	IDA	Process
GO:0000242	pericentriolar material	11454873.	TAS	Component
GO:0000781	chromosome, telomeric region	9822378.	IDA	Component
GO:0000784	nuclear chromosome, telomeric region	9822378.11739745.	IDA	Component
GO:0003950	NAD+ ADP-ribosyltransferase activity	21873635.	IBA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	9822378.11854288.16076287.19759537.21270334.21478859.22864114.	IDA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	-	TAS	Function
GO:0005515	protein binding	9822378.11854288.12080061.12768206.14596906.15133513.16076287.17003112.19759537.20696165.21251231.21478859.22699936.22864114.25327252.26373281.26496610.26972000.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005643	nuclear pore	11454873.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005794	Golgi apparatus	22864114.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006471	protein ADP-ribosylation	21873635.	IBA	Process
GO:0006471	protein ADP-ribosylation	9822378.15133513.21270334.	IDA	Process
GO:0007052	mitotic spindle organization	17026964.	TAS	Process
GO:0008270	zinc ion binding	18436240.	IDA	Function
GO:0015031	protein transport	-	IEA	Process
GO:0016055	Wnt signaling pathway	-	IEA	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0018105	peptidyl-serine phosphorylation	17026964.	IDA	Process
GO:0018107	peptidyl-threonine phosphorylation	17026964.	IDA	Process
GO:0031670	cellular response to nutrient	-	IEA	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0031965	nuclear membrane	11454873.	TAS	Component
GO:0032210	regulation of telomere maintenance via telomerase	9822378.	IC	Process
GO:0032212	positive regulation of telomere maintenance via telomerase	12782650.18221737.	IDA	Process
GO:0032212	positive regulation of telomere maintenance via telomerase	11739745.	IMP	Process
GO:0042393	histone binding	26373281.	IPI	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	19245366.	IDA	Process
GO:0051028	mRNA transport	-	IEA	Process
GO:0051225	spindle assembly	17026964.	TAS	Process
GO:0051301	cell division	-	IEA	Process
GO:0051973	positive regulation of telomerase activity	12782650.	IDA	Process
GO:0070198	protein localization to chromosome, telomeric region	21873635.	IBA	Process
GO:0070198	protein localization to chromosome, telomeric region	15133513.18221737.	IMP	Process
GO:0070212	protein poly-ADP-ribosylation	9822378.16076287.25043379.	IDA	Process
GO:0070212	protein poly-ADP-ribosylation	25939383.	IMP	Process
GO:0070213	protein auto-ADP-ribosylation	9822378.15133513.19759537.21478859.	IDA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	21873635.	IBA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	19759537.25939383.	IMP	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0097431	mitotic spindle pole	16076287.	IDA	Component
GO:1904355	positive regulation of telomere capping	21873635.	IBA	Process
GO:1904355	positive regulation of telomere capping	21531765.	IDA	Process
GO:1904355	positive regulation of telomere capping	25939383.	IMP	Process
GO:1904357	negative regulation of telomere maintenance via telomere lengthening	25939383.	IMP	Process
GO:1904743	negative regulation of telomeric DNA binding	9822378.	IDA	Process
GO:1904743	negative regulation of telomeric DNA binding	25939383.	IMP	Process
GO:1904908	negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	26373281.	IMP	Process
GO:1990404	protein ADP-ribosylase activity	25043379.	IDA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27068743	The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.	J Biol Chem	2016 Jun 10	Croy HE	doi: 10.1074/jbc.M115.705442
26820603	Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway.	Int J Oncol	2016 Apr	Wu X	doi: 10.3892/ijo.2016.3360
18026951	Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.	Cancer Immunol Immunother	2008 Jun	Shebzukhov YV	-
23933993	Silencing tankyrase and telomerase promotes A549 human lung adenocarcinoma cell apoptosis and inhibits proliferation.	Oncol Rep	2013 Oct	Lu H	doi: 10.3892/or.2013.2665
21455637	Expression of tankyrase 1 in gastric cancer and its correlation with telomerase activity.	Pathol Oncol Res	2011 Sep	Gao J	doi: 10.1007/s12253-011-9369-8
20811689	Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors.	Oncol Rep	2010 Oct	Zhang H	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr8	9763233	Missense_Mutation	novel	V1121L	0.52	PARP
BLCA	chr8	9766421	Missense_Mutation	novel	H1246Y	0.56	PARP
BLCA	chr8	9555886	5'Flank	novel		0.18
BLCA	chr8	9763215	Missense_Mutation	novel	D1115H	0.19
BLCA	chr8	9726664	Missense_Mutation	NA	D649N	0.37
BLCA	chr8	9761602	Missense_Mutation	rs768586368	I1080M	0.09
BLCA	chr8	9720446	Missense_Mutation	novel	R608G	0.11
BLCA	chr8	9556355	Missense_Mutation	rs772995748	S139L	0.36
BRCA	chr8	9556143	Silent	novel	G68G	0.64
BRCA	chr8	9776916	3'UTR	novel		0.67
BRCA	chr8	9776917	3'UTR	novel		0.67
BRCA	chr8	9770219	Missense_Mutation	rs767692118	N1285S	0.4	PARP
BRCA	chr8	9704702	Nonsense_Mutation	rs747680650	R383*	0.13
BRCA	chr8	9730958	Silent	rs575224152	F690F	0.3
BRCA	chr8	9764788	Nonsense_Mutation	NA	R1149*	0.22	PARP
BRCA	chr8	9761602	Silent	NA	I1080I	0.27
BRCA	chr8	9556215	Silent	novel	T92T	0.18
BRCA	chr8	9556340	Missense_Mutation	NA	S134F	0.11
BRCA	chr8	9556605	Silent	novel	F222F	0.27
CESC	chr8	9777196	3'UTR	rs576516934		0.36
CESC	chr8	9680756	Silent	NA	L355L	0.18
CESC	chr8	9776709	Silent	rs750083974	T1319T	0.43
CESC	chr8	9733421	Missense_Mutation	novel	E764Q	0.06
CESC	chr8	9748078	Missense_Mutation	NA	D900Y	0.67
CESC	chr8	9615615	Missense_Mutation	rs753349258	R311Q	0.19
CESC	chr8	9730975	Missense_Mutation	novel	R696H	0.33
CESC	chr8	9765726	Missense_Mutation	novel	R1161Q	0.4	PARP
CESC	chr8	9706224	Missense_Mutation	NA	H414Y	0.41
CESC	chr8	9778155	3'UTR	novel		0.22
CESC	chr8	9781945	3'UTR	novel		0.08
CESC	chr8	9776730	Missense_Mutation	rs372614885	K1326N	0.29
COAD	chr8	9751650	Silent	rs200640807	P958P	0.1
COAD	chr8	9679968	Missense_Mutation	novel	E338K	0.11
COAD	chr8	9556289	Missense_Mutation	novel	A117D	0.37
COAD	chr8	9735453	Silent	novel	G870G	0.19
COAD	chr8	9704702	Nonsense_Mutation	rs747680650	R383*	0.17
COAD	chr8	9730963	Missense_Mutation	novel	A692V	0.19
COAD	chr8	9556564	Missense_Mutation	NA	A209T	0.49
COAD	chr8	9708430	Frame_Shift_Del	NA	*T508Hfs33**	0.43
COAD	chr8	9720399	Missense_Mutation	novel	Q592R	0.22
COAD	chr8	9752621	Missense_Mutation	novel	E1050K	0.1
COAD	chr8	9556287	Silent	novel	V116V	0.54
COAD	chr8	9556174	Nonsense_Mutation	NA	R79*	0.6
COAD	chr8	9706828	Silent	NA	N429N	0.18
COAD	chr8	9770215	Missense_Mutation	rs762090867	V1284I	0.29	PARP
COAD	chr8	9708471	Silent	rs370231803	P519P	0.22
COAD	chr8	9710033	Frame_Shift_Ins	NA	*N555Kfs2**	0.29
COAD	chr8	9556140	Silent	novel	E67E	0.16
COAD	chr8	9556571	Missense_Mutation	novel	D211G	0.2
COAD	chr8	9556572	Missense_Mutation	novel	D211E	0.16
COAD	chr8	9751609	Missense_Mutation	novel	A945T	0.18
COAD	chr8	9748127	Missense_Mutation	novel	T916M	0.2
COAD	chr8	9710313	Intron	novel		0.52
COAD	chr8	9704702	Nonsense_Mutation	rs747680650	R383*	0.31
COAD	chr8	9776664	Nonsense_Mutation	novel	Y1304*	0.24	PARP
COAD	chr8	9766424	Missense_Mutation	NA	R1247G	0.34	PARP
COAD	chr8	9748193	Missense_Mutation	rs756350259	T938M	0.07
DLBC	chr8	9710198	Missense_Mutation	novel	V576G	0.24
ESCA	chr8	9777196	3'UTR	rs576516934		0.24
ESCA	chr8	9555936	5'UTR	novel		0.16
GBM	chr8	9752627	Splice_Site	novel	X1051_splice	0.13
GBM	chr8	9741765	Intron	novel		0.29
GBM	chr8	9704685	Missense_Mutation	rs373493403	A377V	0.4
GBM	chr8	9615595	Silent	rs761562375	H304H	0.28
GBM	chr8	9706964	Missense_Mutation	novel	A475T	0.07
HNSC	chr8	9710275	Intron	rs766043640		0.23
HNSC	chr8	9556334	Missense_Mutation	rs774407820	S132F	0.19
HNSC	chr8	9706862	Missense_Mutation	novel	E441K	0.23
HNSC	chr8	9751813	Missense_Mutation	novel	G1013C	0.3
HNSC	chr8	9770156	Missense_Mutation	novel	S1264N	0.44	PARP
HNSC	chr8	9730977	Missense_Mutation	novel	V697M	0.85
HNSC	chr8	9580218	Missense_Mutation	rs773491393	R245C	0.25
HNSC	chr8	9748089	Silent	rs35491087	A903A	0.19
KIRC	chr8	9766301	Missense_Mutation	NA	G1206R	0.06	PARP
KIRC	chr8	9731014	Missense_Mutation	NA	D709A	0.54
KIRC	chr8	9556023	Silent	NA	P28P	0.56
KIRC	chr8	9720488	Missense_Mutation	novel	L622I	0.3
KIRP	chr8	9556174	Missense_Mutation	rs764665125	R79G	0.27
KIRP	chr8	9706918	Silent	novel	A459A	0.39
LGG	chr8	9730949	Silent	rs372527063	P687P	0.39
LIHC	chr8	9720500	Missense_Mutation	NA	T626A	0.27
LIHC	chr8	9680736	Missense_Mutation	NA	E348V	0.38
LIHC	chr8	9710340	Intron	novel		0.71
LIHC	chr8	9770104	Splice_Site	NA	X1247_splice	0.54
LUAD	chr8	9741674	Intron	rs548843321		0.42
LUAD	chr8	9776716	Missense_Mutation	NA	A1322P	0.71
LUAD	chr8	9748155	Missense_Mutation	NA	H925Q	0.23
LUAD	chr8	9751753	Missense_Mutation	novel	D993H	0.24
LUAD	chr8	9765708	Missense_Mutation	NA	N1155I	0.08	PARP
LUAD	chr8	9735068	Silent	rs774830242	T839T	0.26
LUAD	chr8	9751702	Missense_Mutation	novel	L976V	0.06
LUAD	chr8	9709961	Missense_Mutation	novel	A529S	0.53
LUAD	chr8	9555961	Nonsense_Mutation	novel	Q8*	0.46
LUAD	chr8	9748126	Missense_Mutation	novel	T916S	0.76
LUAD	chr8	9770203	Missense_Mutation	novel	G1280C	0.72	PARP
LUAD	chr8	9556287	Silent	novel	V116V	0.26
LUAD	chr8	9751795	Missense_Mutation	NA	A1007P	0.1
LUAD	chr8	9751626	Silent	NA	A950A	0.26
LUSC	chr8	9735043	Missense_Mutation	novel	R831K	0.29
LUSC	chr8	9748038	Silent	novel	A886A	0.35
LUSC	chr8	9580181	Silent	novel	V232V	0.21
LUSC	chr8	9765718	Missense_Mutation	NA	L1158F	0.09	PARP
LUSC	chr8	9733364	Missense_Mutation	novel	V745M	0.34
LUSC	chr8	9748056	Silent	NA	Y892Y	0.39
LUSC	chr8	9615633	Missense_Mutation	novel	S317L	0.19
LUSC	chr8	9770118	Missense_Mutation	novel	F1251L	0.28	PARP
LUSC	chr8	9770170	Missense_Mutation	novel	A1269S	0.24	PARP
LUSC	chr8	9733331	Missense_Mutation	NA	E734Q	0.12
LUSC	chr8	9735045	Missense_Mutation	NA	D832Y	0.26
LUSC	chr8	9580281	Missense_Mutation	novel	S266C	0.11
LUSC	chr8	9580278	Missense_Mutation	novel	V265L	0.19
LUSC	chr8	9761628	Missense_Mutation	novel	G1089V	0.44
LUSC	chr8	9704676	Missense_Mutation	NA	H374R	0.27
LUSC	chr8	9776692	Missense_Mutation	rs763765832	E1314K	0.12
LUSC	chr8	9556175	Missense_Mutation	NA	R79L	0.73
LUSC	chr8	9748105	Missense_Mutation	novel	E909K	0.18
OV	chr8	9555918	5'UTR	novel		0.31
OV	chr8	9556149	Silent	novel	G70G	0.16
OV	chr8	9776969	3'UTR	novel		0.3
OV	chr8	9709977	Missense_Mutation	novel	H534L	0.07
OV	chr8	9556352	Missense_Mutation	novel	S138F	0.1
OV	chr8	9752603	Missense_Mutation	NA	R1044W	0.37
OV	chr8	9706974	Missense_Mutation	rs140760765	P478L	0.42
OV	chr8	9776745	3'UTR	novel		0.28
PAAD	chr8	9680750	Missense_Mutation	rs765516903	A353T	0.17
PAAD	chr8	9748194	Silent	rs376610791	T938T	0.22
PAAD	chr8	9765739	Silent	novel	R1165R	0.14
PAAD	chr8	9766284	Missense_Mutation	rs762718942	R1200Q	0.17	PARP
PAAD	chr8	9770182	Missense_Mutation	novel	P1273S	0.19	PARP
PRAD	chr8	9748093	Missense_Mutation	NA	T905S	0.63
PRAD	chr8	9766411	Frame_Shift_Ins	novel	*C1245Yfs11**	0.08	PARP
PRAD	chr8	9556416	Silent	novel	V159V	0.37
PRAD	chr8	9731022	Missense_Mutation	novel	A712T	0.46
READ	chr8	9710034	Frame_Shift_Del	novel	*N555Ifs5**	0.32
READ	chr8	9770243	Missense_Mutation	novel	V1293D	0.67	PARP
READ	chr8	9726677	Missense_Mutation	NA	R653Q	0.44
READ	chr8	9766421	Missense_Mutation	novel	H1246Y	0.37	PARP
SARC	chr8	9777978	3'UTR	novel		0.25
SARC	chr8	9778184	3'UTR	novel		0.31
SARC	chr8	9776961	3'UTR	novel		0.32
SKCM	chr8	9766315	Silent	rs373127636	A1210A	0.39
SKCM	chr8	9735004	Missense_Mutation	NA	R818T	0.17
SKCM	chr8	9751675	Missense_Mutation	NA	P967S	0.16
SKCM	chr8	9766305	Missense_Mutation	NA	M1207R	0.3	PARP
SKCM	chr8	9766388	Missense_Mutation	NA	P1235S	0.18	PARP
SKCM	chr8	9741704	Intron	novel		0.43
SKCM	chr8	9741705	Intron	novel		0.43
SKCM	chr8	9752546	Missense_Mutation	NA	A1025S	0.38
SKCM	chr8	9580197	Missense_Mutation	NA	M238L	0.43
SKCM	chr8	9706203	Missense_Mutation	NA	H407Y	0.36
SKCM	chr8	9555881	5'Flank	novel		0.27
SKCM	chr8	9708419	Missense_Mutation	NA	L502S	0.09
SKCM	chr8	9751641	Silent	NA	A955A	0.37
SKCM	chr8	9733391	Missense_Mutation	novel	L754V	0.45
SKCM	chr8	9710007	Nonsense_Mutation	novel	L544*	0.35
SKCM	chr8	9752594	Missense_Mutation	NA	E1041K	0.17
SKCM	chr8	9770141	Missense_Mutation	NA	S1259F	0.23	PARP
SKCM	chr8	9730976	Silent	rs376984415	R696R	0.65
STAD	chr8	9708430	Frame_Shift_Del	NA	*T508Hfs33**	0.33
STAD	chr8	9710034	Frame_Shift_Del	novel	*N555Ifs5**	0.31
STAD	chr8	9763189	Missense_Mutation	rs150495385	T1106M	0.12
STAD	chr8	9764740	Missense_Mutation	NA	R1133G	0.1	PARP
STAD	chr8	9733363	Silent	rs749980147	N744N	0.04
STAD	chr8	9751785	Silent	rs201607807	A1003A	0.07
STAD	chr8	9704702	Nonsense_Mutation	rs747680650	R383*	0.34
STAD	chr8	9556406	Missense_Mutation	novel	A156V	0.29
STAD	chr8	9761589	Missense_Mutation	NA	R1076H	0.22
STAD	chr8	9764718	Missense_Mutation	novel	M1125I	0.28	PARP
STAD	chr8	9556029	Silent	NA	P30P	0.16
STAD	chr8	9731009	Silent	NA	G707G	0.05
STAD	chr8	9766332	Frame_Shift_Del	novel	*N1217Tfs38**	0.2	PARP
STAD	chr8	9708430	Frame_Shift_Del	NA	*T508Hfs33**	0.17
STAD	chr8	9776718	Silent	rs370002383	A1322A	0.44
STAD	chr8	9735082	Missense_Mutation	novel	A844V	0.09
STAD	chr8	9748176	Missense_Mutation	novel	K932N	0.07
STAD	chr8	9710254	Intron	rs774449552		0.24
STAD	chr8	9710034	Frame_Shift_Del	novel	*N555Ifs5**	0.18
STAD	chr8	9764724	Silent	NA	S1127S	0.11
STAD	chr8	9580241	Silent	rs759481250	P252P	0.09
STAD	chr8	9706865	Missense_Mutation	NA	A442T	0.07
STAD	chr8	9710034	Frame_Shift_Del	novel	*N555Ifs5**	0.31
STAD	chr8	9751784	Missense_Mutation	NA	A1003V	0.37
STAD	chr8	9751689	Silent	NA	V971V	0.2
STAD	chr8	9766381	Silent	rs747152187	T1232T	0.12
STAD	chr8	9751618	Missense_Mutation	NA	I948V	0.19
STAD	chr8	9751676	Missense_Mutation	NA	P967H	0.1
STAD	chr8	9706926	Missense_Mutation	rs551035523	T462I	0.1
STAD	chr8	9709962	Missense_Mutation	NA	A529V	0.33
TGCT	chr8	9766395	Frame_Shift_Del	novel	*H1237Pfs18**	0.17	PARP
THYM	chr8	9777196	3'UTR	rs576516934		0.23
UCEC	chr8	9731013	Missense_Mutation	rs775055887	D709N	0.26
UCEC	chr8	9765783	Missense_Mutation	rs764619026	R1180H	0.05	PARP
UCEC	chr8	9748193	Missense_Mutation	rs756350259	T938M	0.21
UCEC	chr8	9580384	Splice_Site	NA	X300_splice	0.34
UCEC	chr8	9710339	Intron	rs774392522		0.23
UCEC	chr8	9730946	Silent	rs545887745	T686T	0.37
UCEC	chr8	9752603	Missense_Mutation	NA	R1044W	0.32
UCEC	chr8	9555739	5'Flank	novel		0.32
UCEC	chr8	9764788	Nonsense_Mutation	NA	R1149*	0.2	PARP
UCEC	chr8	9706863	Missense_Mutation	novel	E441G	0.33
UCEC	chr8	9708416	Missense_Mutation	novel	D501A	0.29
UCEC	chr8	9779124	3'UTR	novel		0.3
UCEC	chr8	9782116	3'UTR	novel		0.44
UCEC	chr8	9766382	Missense_Mutation	novel	G1233C	0.23	PARP
UCEC	chr8	9781729	3'UTR	novel		0.32
UCEC	chr8	9555939	5'UTR	rs781149091		0.26
UCEC	chr8	9708430	Frame_Shift_Del	NA	*T508Hfs33**	0.43
UCEC	chr8	9706835	Missense_Mutation	novel	D432Y	0.32
UCEC	chr8	9734967	Missense_Mutation	novel	A806T	0.4
UCEC	chr8	9763147	Missense_Mutation	novel	G1092D	0.43
UCEC	chr8	9734893	Missense_Mutation	novel	R781I	0.36
UCEC	chr8	9777181	3'UTR	novel		0.5
UCEC	chr8	9778319	3'UTR	novel		0.3
UCEC	chr8	9781873	3'UTR	novel		0.45
UCEC	chr8	9704703	Missense_Mutation	rs777314477	R383Q	0.21
UCEC	chr8	9710289	Intron	novel		0.33
UCEC	chr8	9764792	Splice_Site	NA	X1149_splice	0.05
UCEC	chr8	9777861	3'UTR	novel		0.45
UCEC	chr8	9782070	3'UTR	novel		0.42
UCEC	chr8	9580215	Missense_Mutation	novel	A244T	0.08
UCEC	chr8	9708398	Missense_Mutation	novel	Q495P	0.06
UCEC	chr8	9735072	Missense_Mutation	novel	L841M	0.14
UCEC	chr8	9741749	Intron	rs368118876		0.29
UCEC	chr8	9751627	Missense_Mutation	NA	L951V	0.29
UCEC	chr8	9778677	3'UTR	novel		0.26
UCEC	chr8	9706239	Nonsense_Mutation	novel	E419*	0.34
UCEC	chr8	9782186	3'UTR	rs191674330		0.27
UCEC	chr8	9556026	Silent	novel	P29P	0.39
UCEC	chr8	9556564	Missense_Mutation	NA	A209T	0.32
UCEC	chr8	9731006	Silent	rs745412373	H706H	0.29
UCEC	chr8	9763190	Silent	rs138329640	T1106T	0.4
UCEC	chr8	9778390	3'UTR	novel		0.18
UCEC	chr8	9777196	3'UTR	rs576516934		0.7
UCEC	chr8	9776718	Silent	rs370002383	A1322A	0.39
UCEC	chr8	9764789	Missense_Mutation	rs139110221	R1149Q	0.31	PARP
UCEC	chr8	9706830	Missense_Mutation	novel	A430V	0.33
UCEC	chr8	9751707	Silent	novel	I977I	0.43
UCEC	chr8	9765754	Silent	novel	S1170S	0.46
UCEC	chr8	9730937	Silent	novel	R683R	0.29
UCEC	chr8	9734931	Missense_Mutation	novel	D794Y	0.6
UCEC	chr8	9761552	Nonsense_Mutation	novel	E1064*	0.54
UCEC	chr8	9776665	Missense_Mutation	novel	L1305I	0.35	PARP
UCEC	chr8	9781728	3'UTR	novel		0.55
UCEC	chr8	9781829	3'UTR	novel		0.59
UCEC	chr8	9770211	Silent	rs144079466	P1282P	0.39
UCEC	chr8	9710151	Frame_Shift_Ins	novel	*L562Pfs10**	0.44
UCEC	chr8	9735049	Missense_Mutation	NA	T833I	0.32
UCEC	chr8	9706868	Missense_Mutation	NA	A443T	0.09
UCEC	chr8	9709954	Splice_Site	NA	X527_splice	0.27
UCEC	chr8	9710142	Splice_Region	novel	D557D	0.38
UCEC	chr8	9741676	Intron	novel		0.34
UCEC	chr8	9741762	Intron	novel		0.34
UCEC	chr8	9765740	Nonsense_Mutation	novel	Q1166*	0.34	PARP
UCEC	chr8	9778677	3'UTR	novel		0.22
UCEC	chr8	9704703	Missense_Mutation	rs777314477	R383Q	0.13
UCEC	chr8	9752603	Missense_Mutation	NA	R1044W	0.08
UCEC	chr8	9781851	3'UTR	novel		0.1
UCEC	chr8	9706976	Missense_Mutation	novel	E479K	0.41
UCEC	chr8	9730959	Missense_Mutation	novel	A691T	0.46
UCEC	chr8	9779359	3'UTR	novel		0.56
UCEC	chr8	9776967	3'UTR	novel		0.4
UCEC	chr8	9763166	Frame_Shift_Del	novel	*H1100Tfs59**	0.12
UCEC	chr8	9704703	Missense_Mutation	rs777314477	R383Q	0.32
UCEC	chr8	9751624	Missense_Mutation	novel	A950S	0.43
UCEC	chr8	9766284	Missense_Mutation	rs762718942	R1200Q	0.39	PARP
UCEC	chr8	9776882	3'UTR	novel		0.4
UCEC	chr8	9777314	3'UTR	novel		0.27
UCEC	chr8	9778338	3'UTR	novel		0.4
UCEC	chr8	9781845	3'UTR	novel		0.11
UCEC	chr8	9778088	3'UTR	novel		0.44
UCEC	chr8	9777083	3'UTR	novel		0.29
UCEC	chr8	9708430	Frame_Shift_Del	NA	*T508Hfs33**	0.32
UCEC	chr8	9764789	Missense_Mutation	rs139110221	R1149Q	0.27	PARP
UCEC	chr8	9580383	Missense_Mutation	novel	V300M	0.23
UCEC	chr8	9761573	Missense_Mutation	novel	N1071D	0.31
UCEC	chr8	9766290	Missense_Mutation	novel	A1202V	0.33	PARP
UCEC	chr8	9777206	3'UTR	novel		0.58
UCEC	chr8	9704689	Silent	novel	G378G	0.31
UCEC	chr8	9777890	3'UTR	novel		0.23
UCEC	chr8	9764763	Silent	NA	G1140G	0.25
UCEC	chr8	9778111	3'UTR	novel		0.46
UCEC	chr8	9708430	Frame_Shift_Del	NA	*T508Hfs33**	0.11
UCEC	chr8	9761589	Missense_Mutation	NA	R1076H	0.45
UCEC	chr8	9776870	3'UTR	novel		0.29
UCEC	chr8	9706198	Missense_Mutation	novel	P405L	0.17
UCEC	chr8	9706940	Missense_Mutation	rs758754437	H467Y	0.26
UCEC	chr8	9710022	Missense_Mutation	novel	A549V	0.15
UCEC	chr8	9730965	Missense_Mutation	novel	G693C	0.25
UCEC	chr8	9761589	Missense_Mutation	NA	R1076H	0.41
UCEC	chr8	9776709	Silent	rs750083974	T1319T	0.33
UCEC	chr8	9770176	Missense_Mutation	NA	A1271T	0.53	PARP
UCEC	chr8	9555768	5'Flank	novel		1
UCEC	chr8	9778245	3'UTR	novel		0.64
UCEC	chr8	9720442	Silent	novel	T606T	0.42
UCEC	chr8	9770215	Missense_Mutation	rs762090867	V1284I	0.45	PARP
UCS	chr8	9731026	Missense_Mutation	novel	K713T	0.18

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.5417	4.5185e-08
DLBC	DEL	0.2083	0.15679
PAAD	DEL	0.2446	0.050455
UCS	DEL	0.5357	0.0031922

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00038	Kaplan-Meier Survival Analysis
HNSC	0.041	Kaplan-Meier Survival Analysis
COAD	0.00045	Kaplan-Meier Survival Analysis
CESC	0.0057	Kaplan-Meier Survival Analysis
READ	0.0068	Kaplan-Meier Survival Analysis
LAML	0.029	Kaplan-Meier Survival Analysis
KICH	0.014	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742