EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173431 (Gene tree)
Gene ID: 122665
Gene Symbol: RNASE8
Alias: RAE2
Full Name: ribonuclease A family member 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 634 bases
Position: chr14:21,057,822-21,058,455
Accession: 19277
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000311398	RnaseA	PF00074.20	2.3e-37	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000308227	RNASE8-201	634	-	ENSP00000311398	154 (aa)	-	Q8TDE3

Gene Model

Click here to download ENSG00000173431's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000173431	Platelet Function Tests	1.5991650E-012	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173431's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000173431	RNASE8	100	75.641	ENSG00000165799	RNASE7	100	76.282
ENSG00000173431	RNASE8	87	41.844	ENSG00000169385	RNASE2	88	41.844
ENSG00000173431	RNASE8	68	41.818	ENSG00000129538	RNASE1	89	41.228
ENSG00000173431	RNASE8	95	55.102	ENSG00000169413	RNASE6	98	55.102
ENSG00000173431	RNASE8	87	37.143	ENSG00000169397	RNASE3	88	37.143
ENSG00000173431	RNASE8	75	36.885	ENSG00000258818	RNASE4	77	36.066

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173431	RNASE8	100	78.065	ENSANAG00000010473	RNASE8	100	78.065	Aotus_nancymaae
ENSG00000173431	RNASE8	100	58.974	ENSTSYG00000009702	-	100	59.615	Carlito_syrichta
ENSG00000173431	RNASE8	100	88.961	ENSCSAG00000000341	RNASE8	100	88.961	Chlorocebus_sabaeus
ENSG00000173431	RNASE8	86	58.865	ENSFCAG00000038708	-	87	57.447	Felis_catus
ENSG00000173431	RNASE8	100	77.564	ENSGGOG00000042974	RNASE7	100	78.205	Gorilla_gorilla
ENSG00000173431	RNASE8	100	71.795	ENSSTOG00000021538	-	100	73.718	Ictidomys_tridecemlineatus
ENSG00000173431	RNASE8	100	73.418	ENSOGAG00000001147	-	100	73.418	Otolemur_garnettii
ENSG00000173431	RNASE8	100	96.129	ENSPPAG00000022422	RNASE8	100	96.129	Pan_paniscus
ENSG00000173431	RNASE8	100	77.564	ENSPPAG00000033312	RNASE7	100	78.205	Pan_paniscus
ENSG00000173431	RNASE8	100	95.541	ENSPTRG00000030802	RNASE8	100	95.541	Pan_troglodytes
ENSG00000173431	RNASE8	100	77.564	ENSPTRG00000048912	RNASE7	100	78.205	Pan_troglodytes
ENSG00000173431	RNASE8	100	76.923	ENSPPYG00000005587	RNASE7	100	77.564	Pongo_abelii
ENSG00000173431	RNASE8	100	87.662	ENSPPYG00000005588	RNASE8	100	87.662	Pongo_abelii
ENSG00000173431	RNASE8	100	88.961	ENSRBIG00000034590	RNASE8	100	88.961	Rhinopithecus_bieti
ENSG00000173431	RNASE8	100	88.961	ENSRROG00000025981	RNASE8	100	88.961	Rhinopithecus_roxellana
ENSG00000173431	RNASE8	100	78.205	ENSSBOG00000035350	RNASE8	86	78.846	Saimiri_boliviensis_boliviensis
ENSG00000173431	RNASE8	97	71.053	ENSTBEG00000005176	-	98	70.395	Tupaia_belangeri
ENSG00000173431	RNASE8	84	53.846	ENSUAMG00000011106	-	63	62.136	Ursus_americanus
ENSG00000173431	RNASE8	99	58.599	ENSVPAG00000005213	-	99	59.236	Vicugna_pacos

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004522	ribonuclease A activity	11861908.	IDA	Function
GO:0004540	ribonuclease activity	21873635.	IBA	Function
GO:0005576	extracellular region	-	IEA	Component
GO:0045087	innate immune response	16940129.	IMP	Process
GO:0050829	defense response to Gram-negative bacterium	16940129.	IDA	Process
GO:0050829	defense response to Gram-negative bacterium	16940129.	IMP	Process
GO:0050830	defense response to Gram-positive bacterium	16940129.	IDA	Process
GO:0061760	antifungal innate immune response	16940129.	IDA	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process