EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173692 (Gene tree)
Gene ID: 5707
Gene Symbol: PSMD1
Alias: S1|P112|Rpn2
Full Name: proteasome 26S subunit, non-ATPase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 115,964 bases
Position: chr2:231,056,864-231,172,827
Accession: 9554
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000619128	PSMD1-213	3161	-	ENSP00000479986	953 (aa)	-	A0A087WW66
ENST00000444007	PSMD1-206	491	-	ENSP00000390967	164 (aa)	-	H7BZR6
ENST00000373635	PSMD1-202	3230	-	ENSP00000362738	922 (aa)	-	Q99460
ENST00000491229	PSMD1-212	546	-	-	- (aa)	-	-
ENST00000409643	PSMD1-203	2901	XM_017004517	ENSP00000386932	922 (aa)	XP_016860006	Q99460
ENST00000477120	PSMD1-209	723	-	-	- (aa)	-	-
ENST00000440838	PSMD1-205	761	-	ENSP00000406141	203 (aa)	-	C9J9M4
ENST00000488354	PSMD1-211	659	-	-	- (aa)	-	-
ENST00000467792	PSMD1-208	444	-	-	- (aa)	-	-
ENST00000431051	PSMD1-204	2506	-	ENSP00000400483	48 (aa)	-	F8WCE3
ENST00000308696	PSMD1-201	3326	-	ENSP00000309474	953 (aa)	-	Q99460
ENST00000447633	PSMD1-207	696	-	ENSP00000410061	192 (aa)	-	H7C378
ENST00000481003	PSMD1-210	352	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000173692's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000173692	von Willebrand Factor	4.36987119341037E-5	17903294
ENSG00000173692	von Willebrand Factor	1.97233327876578E-5	17903294
ENSG00000173692	Cholesterol, HDL	6.864e-005	19060910

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173692's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173692	PSMD1	81	83.333	FBgn0028692	Rpn2	98	61.477	Drosophila_melanogaster
ENSG00000173692	PSMD1	81	58.974	YIL075C	RPN2	97	40.745	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0004175	endopeptidase activity	21873635.	IBA	Function
GO:0005515	protein binding	29804830.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005838	proteasome regulatory particle	8816993.	TAS	Component
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008540	proteasome regulatory particle, base subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0030234	enzyme regulator activity	-	IEA	Function
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0031625	ubiquitin protein ligase binding	16207813.	IPI	Function
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0034515	proteasome storage granule	21873635.	IBA	Component
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0042176	regulation of protein catabolic process	-	IEA	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050790	regulation of catalytic activity	-	IEA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process