EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173786 (Gene tree)
Gene ID: 1267
Gene Symbol: CNP
Alias: N
Full Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 10,996 bases
Position: chr17:41,966,741-41,977,736
Accession: 2158
RBP type: canonical RBP
Summary: (2',3'-Cyclic Nucleotide 3' Phosphodiesterase) is a Protein Coding gene. Diseases associated with CNP include Isolated Optic Neuritis and Multiple Sclerosis. Among its related pathways are Glial Cell Differentiation and Neuroscience. Gene Ontology (GO) annotations related to this gene include RNA binding and cyclic nucleotide binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000377470	CNPase	PF05881.12	2.4e-123	1	1
ENSP00000377466	CNPase	PF05881.12	2.7e-123	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19021295	2',3'-Cyclic nucleotide 3'-phosphodiesterase: a novel RNA-binding protein that inhibits protein synthesis.	J Neurosci Res	2009 Apr	Gravel M	doi: 10.1002/jnr.21939.
22928743	The N-terminal domain of the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase: direct molecular interaction with the calcium sensor calmodulin.	J Neurochem	2012 Nov	Myllykoski M	doi: 10.1111/jnc.12000
22393399	Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation.	PLoS One	2012	Myllykoski M	doi: 10.1371/journal.pone.0032336

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000592446	CNP-211	587	-	-	- (aa)	-	-
ENST00000587679	CNP-207	581	-	ENSP00000468198	164 (aa)	-	K7ERC4
ENST00000592861	CNP-212	1517	-	-	- (aa)	-	-
ENST00000486438	CNP-205	911	-	-	- (aa)	-	-
ENST00000585452	CNP-206	689	-	ENSP00000468471	153 (aa)	-	K7ERZ0
ENST00000592105	CNP-210	572	-	-	- (aa)	-	-
ENST00000591945	CNP-209	576	-	-	- (aa)	-	-
ENST00000589772	CNP-208	516	-	ENSP00000466807	120 (aa)	-	K7EN66
ENST00000393892	CNP-202	5217	-	ENSP00000377470	421 (aa)	-	P09543
ENST00000393888	CNP-201	2583	XM_011524340	ENSP00000377466	401 (aa)	XP_011522642	P09543
ENST00000441615	CNP-203	622	-	ENSP00000413104	144 (aa)	-	C9K0L8
ENST00000472031	CNP-204	1019	-	ENSP00000467641	49 (aa)	-	K7EQ27

Gene Model

Click here to download ENSG00000173786's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000173786	rs12602950	17	41971811	A	Blood protein levels	30072576	[0.13-0.24] unit increase	0.187	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173786's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173786	CNP	97	43.478	ENSAPOG00000000586	CNP	81	43.832	Acanthochromis_polyacanthus
ENSG00000173786	CNP	100	89.583	ENSAMEG00000005894	CNP	99	85.071	Ailuropoda_melanoleuca
ENSG00000173786	CNP	97	44.836	ENSACIG00000010353	CNP	96	44.332	Amphilophus_citrinellus
ENSG00000173786	CNP	92	44.892	ENSAOCG00000012107	CNP	57	43.766	Amphiprion_ocellaris
ENSG00000173786	CNP	92	44.892	ENSAPEG00000004626	CNP	60	43.766	Amphiprion_percula
ENSG00000173786	CNP	97	44.836	ENSATEG00000001565	CNP	59	44.836	Anabas_testudineus
ENSG00000173786	CNP	100	67.822	ENSAPLG00000002170	CNP	99	68.558	Anas_platyrhynchos
ENSG00000173786	CNP	100	63.119	ENSACAG00000016984	CNP	99	64.066	Anolis_carolinensis
ENSG00000173786	CNP	93	75.603	ENSANAG00000033053	CNP	96	75.603	Aotus_nancymaae
ENSG00000173786	CNP	97	43.970	ENSACLG00000002493	CNP	62	43.970	Astatotilapia_calliptera
ENSG00000173786	CNP	55	46.018	ENSAMXG00000032037	cnp	58	43.902	Astyanax_mexicanus
ENSG00000173786	CNP	100	92.810	ENSBTAG00000025762	CNP	100	90.274	Bos_taurus
ENSG00000173786	CNP	100	99.346	ENSCJAG00000014973	CNP	100	96.200	Callithrix_jacchus
ENSG00000173786	CNP	100	94.444	ENSCAFG00000015757	CNP	100	90.974	Canis_familiaris
ENSG00000173786	CNP	100	94.444	ENSCAFG00020013999	CNP	100	90.974	Canis_lupus_dingo
ENSG00000173786	CNP	100	94.118	ENSCHIG00000007203	CNP	100	90.499	Capra_hircus
ENSG00000173786	CNP	100	96.732	ENSTSYG00000035746	CNP	100	93.267	Carlito_syrichta
ENSG00000173786	CNP	100	84.289	ENSCAPG00000010221	CNP	99	84.048	Cavia_aperea
ENSG00000173786	CNP	100	83.791	ENSCPOG00000020940	CNP	100	83.610	Cavia_porcellus
ENSG00000173786	CNP	100	99.346	ENSCCAG00000017532	CNP	89	95.724	Cebus_capucinus
ENSG00000173786	CNP	100	98.693	ENSCATG00000034358	CNP	100	97.862	Cercocebus_atys
ENSG00000173786	CNP	99	87.730	ENSCLAG00000015883	CNP	100	86.284	Chinchilla_lanigera
ENSG00000173786	CNP	100	98.693	ENSCSAG00000003059	CNP	100	98.100	Chlorocebus_sabaeus
ENSG00000173786	CNP	100	66.667	ENSCPBG00000006750	CNP	91	66.588	Chrysemys_picta_bellii
ENSG00000173786	CNP	100	98.693	ENSCANG00000030259	CNP	100	97.756	Colobus_angolensis_palliatus
ENSG00000173786	CNP	100	91.667	ENSCGRG00001019037	Cnp	100	87.886	Cricetulus_griseus_chok1gshd
ENSG00000173786	CNP	100	91.667	ENSCGRG00000006510	Cnp	100	87.886	Cricetulus_griseus_crigri
ENSG00000173786	CNP	97	41.730	ENSCSEG00000016323	CNP	90	43.514	Cynoglossus_semilaevis
ENSG00000173786	CNP	92	44.947	ENSCVAG00000009329	CNP	55	43.577	Cyprinodon_variegatus
ENSG00000173786	CNP	59	46.311	ENSDARG00000070822	cnp	60	45.594	Danio_rerio
ENSG00000173786	CNP	100	88.194	ENSDNOG00000004854	CNP	97	86.429	Dasypus_novemcinctus
ENSG00000173786	CNP	100	92.810	ENSDORG00000001913	Cnp	100	88.836	Dipodomys_ordii
ENSG00000173786	CNP	100	84.722	ENSETEG00000018949	CNP	100	81.297	Echinops_telfairi
ENSG00000173786	CNP	98	36.196	ENSEBUG00000007530	CNP	94	40.104	Eptatretus_burgeri
ENSG00000173786	CNP	100	90.024	ENSEASG00005008413	CNP	100	90.024	Equus_asinus_asinus
ENSG00000173786	CNP	95	43.871	ENSELUG00000018311	-	53	44.961	Esox_lucius
ENSG00000173786	CNP	100	93.750	ENSFCAG00000022165	CNP	100	90.524	Felis_catus
ENSG00000173786	CNP	100	67.689	ENSFALG00000000635	CNP	100	67.689	Ficedula_albicollis
ENSG00000173786	CNP	99	89.571	ENSFDAG00000013782	CNP	100	85.748	Fukomys_damarensis
ENSG00000173786	CNP	95	44.516	ENSFHEG00000012297	CNP	55	46.257	Fundulus_heteroclitus
ENSG00000173786	CNP	99	36.301	ENSGMOG00000000075	cnp	91	42.091	Gadus_morhua
ENSG00000173786	CNP	99	67.299	ENSGALG00000003457	CNP	99	67.299	Gallus_gallus
ENSG00000173786	CNP	92	45.213	ENSGAFG00000001088	CNP	59	44.961	Gambusia_affinis
ENSG00000173786	CNP	92	45.676	ENSGACG00000008810	cnp	92	45.676	Gasterosteus_aculeatus
ENSG00000173786	CNP	100	66.667	ENSGAGG00000000759	CNP	94	66.667	Gopherus_agassizii
ENSG00000173786	CNP	100	99.525	ENSGGOG00000038251	CNP	100	99.525	Gorilla_gorilla
ENSG00000173786	CNP	97	44.444	ENSHBUG00000001895	CNP	62	44.444	Haplochromis_burtoni
ENSG00000173786	CNP	100	80.798	ENSHGLG00000016638	CNP	100	80.285	Heterocephalus_glaber_female
ENSG00000173786	CNP	100	80.798	ENSHGLG00100012266	CNP	100	80.285	Heterocephalus_glaber_male
ENSG00000173786	CNP	97	42.424	ENSHCOG00000005023	CNP	92	41.919	Hippocampus_comes
ENSG00000173786	CNP	54	45.778	ENSIPUG00000017367	CNP	56	43.725	Ictalurus_punctatus
ENSG00000173786	CNP	100	93.464	ENSSTOG00000006116	CNP	100	89.311	Ictidomys_tridecemlineatus
ENSG00000173786	CNP	100	92.157	ENSJJAG00000021905	Cnp	100	87.648	Jaculus_jaculus
ENSG00000173786	CNP	97	42.317	ENSKMAG00000020217	CNP	61	42.317	Kryptolebias_marmoratus
ENSG00000173786	CNP	99	47.531	ENSLACG00000008233	CNP	99	46.809	Latimeria_chalumnae
ENSG00000173786	CNP	98	49.375	ENSLOCG00000012633	cnp	89	46.959	Lepisosteus_oculatus
ENSG00000173786	CNP	100	91.667	ENSLAFG00000013941	CNP	98	88.378	Loxodonta_africana
ENSG00000173786	CNP	100	98.693	ENSMFAG00000000621	CNP	100	97.862	Macaca_fascicularis
ENSG00000173786	CNP	100	98.693	ENSMMUG00000016114	CNP	100	97.862	Macaca_mulatta
ENSG00000173786	CNP	100	98.693	ENSMNEG00000035343	CNP	100	97.862	Macaca_nemestrina
ENSG00000173786	CNP	100	98.693	ENSMLEG00000043126	CNP	100	97.756	Mandrillus_leucophaeus
ENSG00000173786	CNP	97	44.081	ENSMAMG00000022301	CNP	58	44.081	Mastacembelus_armatus
ENSG00000173786	CNP	97	43.970	ENSMZEG00005022756	CNP	62	43.970	Maylandia_zebra
ENSG00000173786	CNP	100	66.253	ENSMGAG00000003273	CNP	99	67.062	Meleagris_gallopavo
ENSG00000173786	CNP	100	90.972	ENSMAUG00000013752	Cnp	100	87.173	Mesocricetus_auratus
ENSG00000173786	CNP	100	97.386	ENSMICG00000011903	CNP	100	93.824	Microcebus_murinus
ENSG00000173786	CNP	100	91.667	ENSMOCG00000015043	Cnp	100	88.361	Microtus_ochrogaster
ENSG00000173786	CNP	59	46.025	ENSMMOG00000020722	cnp	63	42.754	Mola_mola
ENSG00000173786	CNP	100	79.739	ENSMODG00000014742	CNP	79	78.622	Monodelphis_domestica
ENSG00000173786	CNP	97	44.192	ENSMALG00000006914	CNP	57	44.192	Monopterus_albus
ENSG00000173786	CNP	99	91.411	MGP_CAROLIEiJ_G0017177	Cnp	100	84.798	Mus_caroli
ENSG00000173786	CNP	99	91.411	ENSMUSG00000006782	Cnp	100	84.798	Mus_musculus
ENSG00000173786	CNP	100	90.196	MGP_PahariEiJ_G0018307	Cnp	100	84.798	Mus_pahari
ENSG00000173786	CNP	99	91.411	MGP_SPRETEiJ_G0018020	Cnp	100	84.798	Mus_spretus
ENSG00000173786	CNP	100	93.464	ENSMPUG00000010608	CNP	99	90.952	Mustela_putorius_furo
ENSG00000173786	CNP	100	88.889	ENSMLUG00000011961	CNP	99	87.828	Myotis_lucifugus
ENSG00000173786	CNP	100	92.810	ENSNGAG00000006656	Cnp	100	88.361	Nannospalax_galili
ENSG00000173786	CNP	93	44.974	ENSNBRG00000018997	CNP	60	44.560	Neolamprologus_brichardi
ENSG00000173786	CNP	100	99.525	ENSNLEG00000011217	CNP	100	99.525	Nomascus_leucogenys
ENSG00000173786	CNP	82	76.453	ENSMEUG00000008895	CNP	99	76.453	Notamacropus_eugenii
ENSG00000173786	CNP	99	89.571	ENSODEG00000017962	CNP	100	86.223	Octodon_degus
ENSG00000173786	CNP	97	43.719	ENSONIG00000001073	CNP	64	44.238	Oreochromis_niloticus
ENSG00000173786	CNP	100	89.583	ENSOCUG00000013253	CNP	99	81.190	Oryctolagus_cuniculus
ENSG00000173786	CNP	95	45.223	ENSORLG00000026570	CNP	62	43.829	Oryzias_latipes
ENSG00000173786	CNP	95	45.860	ENSORLG00020008668	CNP	62	44.332	Oryzias_latipes_hni
ENSG00000173786	CNP	95	44.586	ENSORLG00015000871	CNP	62	43.577	Oryzias_latipes_hsok
ENSG00000173786	CNP	95	44.586	ENSOMEG00000022908	CNP	62	43.325	Oryzias_melastigma
ENSG00000173786	CNP	100	92.361	ENSOGAG00000024241	CNP	99	89.762	Otolemur_garnettii
ENSG00000173786	CNP	100	92.500	ENSOARG00000018154	CNP	99	80.998	Ovis_aries
ENSG00000173786	CNP	100	100.000	ENSPPAG00000041028	CNP	96	99.757	Pan_paniscus
ENSG00000173786	CNP	100	93.750	ENSPPRG00000002512	CNP	100	90.024	Panthera_pardus
ENSG00000173786	CNP	100	92.361	ENSPTIG00000007387	CNP	99	78.759	Panthera_tigris_altaica
ENSG00000173786	CNP	100	100.000	ENSPTRG00000009187	CNP	100	100.000	Pan_troglodytes
ENSG00000173786	CNP	100	98.693	ENSPANG00000021479	CNP	100	97.862	Papio_anubis
ENSG00000173786	CNP	93	43.935	ENSPKIG00000020351	-	64	43.299	Paramormyrops_kingsleyae
ENSG00000173786	CNP	99	40.741	ENSPKIG00000001465	-	94	43.455	Paramormyrops_kingsleyae
ENSG00000173786	CNP	99	67.062	ENSPSIG00000009860	CNP	99	67.062	Pelodiscus_sinensis
ENSG00000173786	CNP	97	40.909	ENSPMGG00000009693	cnp	95	40.909	Periophthalmus_magnuspinnatus
ENSG00000173786	CNP	100	91.667	ENSPEMG00000011807	Cnp	100	87.531	Peromyscus_maniculatus_bairdii
ENSG00000173786	CNP	70	43.007	ENSPMAG00000002593	CNP	96	42.561	Petromyzon_marinus
ENSG00000173786	CNP	100	78.147	ENSPCIG00000020254	CNP	100	78.147	Phascolarctos_cinereus
ENSG00000173786	CNP	92	45.479	ENSPFOG00000023789	CNP	55	45.479	Poecilia_formosa
ENSG00000173786	CNP	92	45.479	ENSPLAG00000021778	CNP	55	45.479	Poecilia_latipinna
ENSG00000173786	CNP	92	45.479	ENSPMEG00000011481	CNP	55	45.479	Poecilia_mexicana
ENSG00000173786	CNP	92	45.213	ENSPREG00000010590	CNP	56	44.947	Poecilia_reticulata
ENSG00000173786	CNP	100	99.050	ENSPPYG00000008403	CNP	100	99.050	Pongo_abelii
ENSG00000173786	CNP	91	88.187	ENSPCAG00000015702	CNP	86	88.187	Procavia_capensis
ENSG00000173786	CNP	100	97.386	ENSPCOG00000022353	CNP	100	93.587	Propithecus_coquereli
ENSG00000173786	CNP	100	86.111	ENSPVAG00000003848	CNP	99	86.190	Pteropus_vampyrus
ENSG00000173786	CNP	97	44.221	ENSPNYG00000011312	CNP	62	44.221	Pundamilia_nyererei
ENSG00000173786	CNP	55	46.018	ENSPNAG00000005391	cnp	57	44.309	Pygocentrus_nattereri
ENSG00000173786	CNP	100	90.972	ENSRNOG00000017496	Cnp	100	86.223	Rattus_norvegicus
ENSG00000173786	CNP	100	98.693	ENSRBIG00000033849	CNP	100	97.756	Rhinopithecus_bieti
ENSG00000173786	CNP	100	98.693	ENSRROG00000029955	CNP	100	97.862	Rhinopithecus_roxellana
ENSG00000173786	CNP	100	98.693	ENSSBOG00000022946	CNP	100	95.962	Saimiri_boliviensis_boliviensis
ENSG00000173786	CNP	100	81.046	ENSSHAG00000007750	CNP	100	80.235	Sarcophilus_harrisii
ENSG00000173786	CNP	96	43.038	ENSSFOG00015010233	cnp	55	42.328	Scleropages_formosus
ENSG00000173786	CNP	99	44.913	ENSSFOG00015023161	CNP	99	44.681	Scleropages_formosus
ENSG00000173786	CNP	97	42.821	ENSSMAG00000007666	-	53	42.821	Scophthalmus_maximus
ENSG00000173786	CNP	95	41.401	ENSSDUG00000022943	-	54	42.821	Seriola_dumerili
ENSG00000173786	CNP	92	44.149	ENSSLDG00000017502	-	54	42.821	Seriola_lalandi_dorsalis
ENSG00000173786	CNP	99	88.028	ENSSARG00000004530	-	99	70.916	Sorex_araneus
ENSG00000173786	CNP	100	67.059	ENSSPUG00000013203	CNP	100	67.059	Sphenodon_punctatus
ENSG00000173786	CNP	97	43.467	ENSSPAG00000006727	cnp	62	43.467	Stegastes_partitus
ENSG00000173786	CNP	100	93.056	ENSSSCG00000017420	CNP	100	90.261	Sus_scrofa
ENSG00000173786	CNP	99	67.849	ENSTGUG00000002478	CNP	100	67.849	Taeniopygia_guttata
ENSG00000173786	CNP	99	42.317	ENSTRUG00000022019	CNP	65	42.317	Takifugu_rubripes
ENSG00000173786	CNP	97	43.766	ENSTNIG00000011344	cnp	97	43.766	Tetraodon_nigroviridis
ENSG00000173786	CNP	100	93.750	ENSTBEG00000000234	CNP	100	80.798	Tupaia_belangeri
ENSG00000173786	CNP	100	92.810	ENSTTRG00000006607	CNP	100	90.261	Tursiops_truncatus
ENSG00000173786	CNP	100	89.583	ENSUAMG00000024608	CNP	100	89.027	Ursus_americanus
ENSG00000173786	CNP	57	78.355	ENSUMAG00000022870	-	82	78.355	Ursus_maritimus
ENSG00000173786	CNP	100	94.444	ENSVVUG00000019121	CNP	100	90.974	Vulpes_vulpes
ENSG00000173786	CNP	92	45.867	ENSXMAG00000008845	-	52	45.867	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	-	IEA	Process
GO:0003723	RNA binding	-	IEA	Function
GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	21873635.	IBA	Function
GO:0005615	extracellular space	12379507.	IDA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	12379507.	IDA	Component
GO:0005741	mitochondrial outer membrane	-	IEA	Component
GO:0005743	mitochondrial inner membrane	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005902	microvillus	-	IEA	Component
GO:0007268	chemical synaptic transmission	1322358.	TAS	Process
GO:0007409	axonogenesis	-	IEA	Process
GO:0007568	aging	-	IEA	Process
GO:0008344	adult locomotory behavior	-	IEA	Process
GO:0009214	cyclic nucleotide catabolic process	-	IEA	Process
GO:0009636	response to toxic substance	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0030551	cyclic nucleotide binding	-	IEA	Function
GO:0030900	forebrain development	-	IEA	Process
GO:0031143	pseudopodium	-	IEA	Component
GO:0032496	response to lipopolysaccharide	-	IEA	Process
GO:0035748	myelin sheath abaxonal region	-	IEA	Component
GO:0035749	myelin sheath adaxonal region	-	IEA	Component
GO:0042470	melanosome	-	IEA	Component
GO:0046902	regulation of mitochondrial membrane permeability	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0048709	oligodendrocyte differentiation	-	IEA	Process
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	41971951	Frame_Shift_Del	novel	*P247Qfs28**	0.33	CNPase
BLCA	chr17	41973704	Frame_Shift_Ins	novel	*E350Rfs60**	0.32	CNPase
BLCA	chr17	41977209	3'UTR	novel		0.6
BRCA	chr17	41971949	Missense_Mutation	NA	R245K	0.36	CNPase
BRCA	chr17	41968658	Silent	rs781905642	S198S	0.21
BRCA	chr17	41973558	In_Frame_Del	novel	E301_E304del	0.09	CNPase
BRCA	chr17	41973612	Silent	NA	S318S	0.32
BRCA	chr17	41977392	3'UTR	novel		0.38
BRCA	chr17	41977439	3'UTR	novel		0.27
BRCA	chr17	41976652	3'UTR	novel		0.04
CESC	chr17	41968112	Silent	novel	I16I	0.29
CESC	chr17	41971930	Missense_Mutation	novel	V239I	0.47	CNPase
CESC	chr17	41974197	3'UTR	rs568092515		0.33
CESC	chr17	41976317	3'UTR	novel		0.43
CESC	chr17	41974114	3'UTR	rs577501094		0.15
CESC	chr17	41968628	Silent	NA	L188L	0.44
COAD	chr17	41968714	Missense_Mutation	NA	K217R	0.48	CNPase
COAD	chr17	41968310	Silent	rs782433665	S82S	0.31
COAD	chr17	41968609	In_Frame_Del	NA	K183del	0.78	CNPase
COAD	chr17	41976660	3'UTR	novel		0.26
COAD	chr17	41973631	Missense_Mutation	rs199970993	R325W	0.32	CNPase
COAD	chr17	41973506	Missense_Mutation	rs782078035	T283M	0.16	CNPase
COAD	chr17	41973552	Silent	NA	A298A	0.38
COAD	chr17	41968679	Silent	NA	A205A	0.27
COAD	chr17	41976828	3'UTR	novel		0.24
COAD	chr17	41968693	Missense_Mutation	NA	L210P	0.41	CNPase
COAD	chr17	41968084	Missense_Mutation	NA	R7Q	0.08
COAD	chr17	41968735	Missense_Mutation	NA	R224Q	0.26	CNPase
ESCA	chr17	41976658	3'UTR	novel		0.31
GBM	chr17	41973775	Missense_Mutation	novel	Y373N	0.1	CNPase
HNSC	chr17	41976832	3'UTR	novel		0.11
LGG	chr17	41968316	Silent	rs782683469	D84D	0.46
LIHC	chr17	41968692	Missense_Mutation	novel	L210V	0.24	CNPase
LUAD	chr17	41968084	Missense_Mutation	NA	R7Q	0.06
LUAD	chr17	41973763	Missense_Mutation	rs202171457	R369W	0.13	CNPase
LUSC	chr17	41973536	Missense_Mutation	novel	P293L	0.06	CNPase
LUSC	chr17	41973631	Silent	novel	R325R	0.32
OV	chr17	41976824	3'UTR	novel		0.09
OV	chr17	41973513	Silent	novel	T285T	0.1
PAAD	chr17	41968242	Missense_Mutation	novel	G60R	0.13
PAAD	chr17	41973643	Missense_Mutation	rs782481884	A329T	0.19	CNPase
READ	chr17	41968444	Missense_Mutation	novel	E127A	0.17
SARC	chr17	41968342	Missense_Mutation	rs374975038	R93Q	0.49
STAD	chr17	41968379	Silent	NA	E105E	0.13
STAD	chr17	41968203	Missense_Mutation	NA	L47I	0.33
STAD	chr17	41973899	Missense_Mutation	NA	A414G	0.13
STAD	chr17	41968324	Missense_Mutation	NA	K87R	0.22
STAD	chr17	41968316	Silent	rs782683469	D84D	0.13
STAD	chr17	41968622	Silent	novel	L186L	0.39
TGCT	chr17	41977129	3'UTR	novel		0.18
UCEC	chr17	41976462	3'UTR	novel		0.25
UCEC	chr17	41973726	Frame_Shift_Del	novel	*G358Afs10**	0.47	CNPase
UCEC	chr17	41968153	Missense_Mutation	novel	P30L	0.24
UCEC	chr17	41973475	Missense_Mutation	novel	V273M	0.11	CNPase
UCEC	chr17	41975429	3'UTR	novel		0.4
UCEC	chr17	41968652	Missense_Mutation	novel	K196N	0.22	CNPase
UCEC	chr17	41973483	Missense_Mutation	NA	K275N	0.2	CNPase
UCEC	chr17	41977014	3'UTR	novel		0.5
UCEC	chr17	41968625	Silent	rs377381620	P187P	0.29
UCEC	chr17	41977368	3'UTR	novel		0.12
UCEC	chr17	41976462	3'UTR	novel		0.45
UCEC	chr17	41976552	3'UTR	novel		0.26
UCEC	chr17	41973764	Missense_Mutation	novel	R369Q	0.1	CNPase
UCEC	chr17	41976876	3'UTR	novel		0.52
UCEC	chr17	41977387	3'UTR	novel		0.3
UCEC	chr17	41973578	Missense_Mutation	novel	L307P	0.35	CNPase
UCEC	chr17	41976462	3'UTR	novel		0.43
UCEC	chr17	41968371	Missense_Mutation	novel	L103I	0.48
UCEC	chr17	41976552	3'UTR	novel		0.27
UCEC	chr17	41973567	Silent	rs371108522	S303S	0.25
UCEC	chr17	41968259	Silent	novel	T65T	0.38
UCEC	chr17	41976462	3'UTR	novel		0.54
UCEC	chr17	41976594	3'UTR	novel		0.44
UCEC	chr17	41976462	3'UTR	novel		0.43
UCEC	chr17	41968668	In_Frame_Del	NA	R203_L213del	0.49	CNPase
UCEC	chr17	41976432	3'UTR	novel		0.14
UCEC	chr17	41977192	3'UTR	novel		0.5
UCEC	chr17	41976462	3'UTR	novel		0.5
UCEC	chr17	41968157	Silent	novel	E31E	0.11
UCEC	chr17	41973632	Frame_Shift_Del	novel	*S327Afs13**	0.33	CNPase
UCEC	chr17	41977148	3'UTR	novel		0.48
UCEC	chr17	41968145	Missense_Mutation	novel	K27N	0.2
UCEC	chr17	41968625	Silent	rs377381620	P187P	0.18
UCEC	chr17	41973754	Missense_Mutation	novel	E366K	0.22	CNPase
UCEC	chr17	41976978	3'UTR	novel		0.22
UCEC	chr17	41973804	Silent	novel	L382L	0.36
UCEC	chr17	41972008	Missense_Mutation	NA	A265T	0.29	CNPase
UCEC	chr17	41973643	Missense_Mutation	rs782481884	A329T	0.3	CNPase
UCEC	chr17	41976680	3'UTR	novel		0.22
UCEC	chr17	41977231	3'UTR	novel		0.48
UCEC	chr17	41977582	3'UTR	novel		0.28
UCEC	chr17	41977382	3'UTR	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2778	0.0017784
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
UCEC	DEL	0.1929	5.8317e-06
UCS	DEL	0.3929	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0023	Kaplan-Meier Survival Analysis
SARC	0.015	Kaplan-Meier Survival Analysis
ESCA	0.048	Kaplan-Meier Survival Analysis
KIRP	0.0087	Kaplan-Meier Survival Analysis
PAAD	0.005	Kaplan-Meier Survival Analysis
BLCA	0.0043	Kaplan-Meier Survival Analysis
CESC	0.031	Kaplan-Meier Survival Analysis
READ	0.04	Kaplan-Meier Survival Analysis
LIHC	0.00065	Kaplan-Meier Survival Analysis
UVM	0.019	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742