EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173809 (Gene tree)
Gene ID: 91646
Gene Symbol: TDRD12
Alias: ECAT8|FLJ13072
Full Name: tudor domain containing 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 109,828 bases
Position: chr19:32,719,753-32,829,580
Accession: 25044
RBP type: canonical RBP
Summary: (Tudor Domain Containing 12) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is TDRD1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000416248	TUDOR	PF00567.24	2e-30	1	2
ENSP00000416248	TUDOR	PF00567.24	2e-30	2	2
ENSP00000496698	TUDOR	PF00567.24	2.9e-30	1	2
ENSP00000496698	TUDOR	PF00567.24	2.9e-30	2	2
ENSP00000390621	TUDOR	PF00567.24	1.5e-20	1	1
ENSP00000489971	TUDOR	PF00567.24	0.00014	1	1
ENSP00000416248	DEAD	PF00270.29	3.4e-06	1	1
ENSP00000496698	DEAD	PF00270.29	4.2e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000637289	TDRD12-204	3267	-	ENSP00000489971	350 (aa)	-	A0A1B0GU57
ENST00000421545	TDRD12-201	1317	-	ENSP00000390621	395 (aa)	-	Q587J7
ENST00000564769	TDRD12-203	3176	-	ENSP00000457498	112 (aa)	-	H3BU70
ENST00000647536	TDRD12-206	4215	XM_011527471	ENSP00000496698	1335 (aa)	XP_011525773	A0A2R8Y872
ENST00000444215	TDRD12-202	3934	XM_011527476	ENSP00000416248	1177 (aa)	XP_011525778	Q587J7
ENST00000639142	TDRD12-205	503	-	ENSP00000492643	167 (aa)	-	A0A1W2PRK2

Gene Model

Click here to download ENSG00000173809's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173809's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173809	TDRD12	64	82.470	ENSAMEG00000009847	TDRD12	98	82.470	Ailuropoda_melanoleuca
ENSG00000173809	TDRD12	70	39.209	ENSACLG00000003249	-	88	39.209	Astatotilapia_calliptera
ENSG00000173809	TDRD12	99	80.711	ENSFCAG00000014913	TDRD12	100	80.506	Felis_catus
ENSG00000173809	TDRD12	56	41.964	ENSMZEG00005022688	-	88	41.964	Maylandia_zebra
ENSG00000173809	TDRD12	99	76.093	ENSMUSG00000030491	Tdrd12	100	76.093	Mus_musculus
ENSG00000173809	TDRD12	98	80.829	ENSPTIG00000011285	TDRD12	100	80.620	Panthera_tigris_altaica
ENSG00000173809	TDRD12	65	40.299	ENSXETG00000025568	TDRD12	88	41.379	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005575	cellular_component	-	ND	Component
GO:0007140	male meiotic nuclear division	-	ISS	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0009566	fertilization	-	ISS	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0031047	gene silencing by RNA	-	ISS	Process
GO:0034587	piRNA metabolic process	-	ISS	Process
GO:0043046	DNA methylation involved in gamete generation	-	ISS	Process
GO:1990923	PET complex	-	ISS	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BRCA	chr19	32731767	Missense_Mutation	NA	S23G	0.33
BRCA	chr19	32742879	Missense_Mutation	NA	C140F	0.17
BRCA	chr19	32802972	Silent	NA	L794L	0.14
BRCA	chr19	32826137	3'Flank	novel		0.09
BRCA	chr19	32731829	Nonsense_Mutation	novel	Y43*	0.26
BRCA	chr19	32772814	Silent	NA	K309K	0.2
BRCA	chr19	32772776	Missense_Mutation	NA	D297N	0.04
CESC	chr19	32772780	Missense_Mutation	novel	S298L	0.38
CESC	chr19	32802960	Silent	novel	S790S	0.15
CESC	chr19	32801839	Missense_Mutation	novel	K721N	0.14
CESC	chr19	32818138	Missense_Mutation	novel	E1122Q	0.31
CESC	chr19	32731837	Missense_Mutation	rs750956233	T46M	0.34
CESC	chr19	32803005	Silent	novel	V805V	0.25
CESC	chr19	32826215	3'Flank	novel		0.09
CESC	chr19	32756021	Missense_Mutation	novel	K204N	0.32
CESC	chr19	32800335	Missense_Mutation	novel	A643S	0.06
CESC	chr19	32807572	Missense_Mutation	rs777809222	R859Q	0.4
CHOL	chr19	32815601	Missense_Mutation	novel	E1099K	0.45
COAD	chr19	32772842	Missense_Mutation	novel	T319A	0.31
COAD	chr19	32749861	Missense_Mutation	novel	D192Y	0.2
COAD	chr19	32742789	Missense_Mutation	novel	V110D	0.07
COAD	chr19	32748511	Missense_Mutation	rs570756261	Y159C	0.48
COAD	chr19	32772757	Missense_Mutation	novel	K290N	0.04
COAD	chr19	32772843	Missense_Mutation	NA	T319K	0.1
COAD	chr19	32790742	Intron	rs769248097		0.41
COAD	chr19	32748512	Silent	novel	Y159Y	0.22
COAD	chr19	32757040	Missense_Mutation	novel	S259P	0.27
ESCA	chr19	32798307	Splice_Site	novel	X544_splice	0.28
ESCA	chr19	32756007	Missense_Mutation	novel	D200H	0.07
KIRP	chr19	32790747	Intron	novel		0.06
LIHC	chr19	32742843	Missense_Mutation	rs775908730	Y128C	0.18
LIHC	chr19	32719952	5'UTR	novel		0.29
READ	chr19	32731745	Frame_Shift_Ins	novel	*W16Cfs6**	0.06
READ	chr19	32742785	Nonsense_Mutation	novel	R109*	0.41
SARC	chr19	32790556	Missense_Mutation	novel	P383S	0.32
SARC	chr19	32821185	3'UTR	novel		0.45
SARC	chr19	32756055	Frame_Shift_Del	novel	*N217Tfs5**	0.46
SARC	chr19	32803134	Frame_Shift_Del	novel	*C850Afs36**	0.42
SARC	chr19	32790707	Intron	novel		0.2
TGCT	chr19	32757066	Silent	rs772530801	Q267Q	0.08
UCEC	chr19	32738994	Splice_Site	NA	X107_splice	0.32
UCEC	chr19	32800191	Frame_Shift_Del	NA	*N597Ifs25**	0.38
UCEC	chr19	32755995	Missense_Mutation	NA	C196S	0.31
UCEC	chr19	32749827	Silent	novel	D180D	0.35
UCEC	chr19	32777172	Missense_Mutation	novel	E355G	0.07
UCEC	chr19	32790571	Missense_Mutation	NA	G388R	0.67
UCEC	chr19	32803108	Missense_Mutation	novel	L840I	0.41
UCEC	chr19	32811300	Silent	novel	L976L	0.23
UCEC	chr19	32811399	Silent	novel	N1009N	0.3
UCEC	chr19	32742806	Missense_Mutation	novel	M116V	0.17
UCEC	chr19	32772839	Missense_Mutation	novel	D318Y	0.21
UCEC	chr19	32803072	Missense_Mutation	rs192579479	L828M	0.35
UCEC	chr19	32772839	Missense_Mutation	novel	D318Y	0.22
UCEC	chr19	32797798	Nonsense_Mutation	novel	E513*	0.23	TUDOR
UCEC	chr19	32757104	Missense_Mutation	novel	D280V	0.14
UCEC	chr19	32731793	Silent	NA	D31D	0.49
UCEC	chr19	32800191	Frame_Shift_Del	NA	*N597Ifs25**	0.32
UCEC	chr19	32738986	Missense_Mutation	novel	S105Y	0.13
UCEC	chr19	32790690	Intron	novel		0.17
UCEC	chr19	32794719	Missense_Mutation	novel	S460Y	0.31
UCEC	chr19	32800193	Missense_Mutation	novel	K595N	0.37	TUDOR
UCEC	chr19	32801798	Nonsense_Mutation	novel	E708*	0.4
UCEC	chr19	32811244	Missense_Mutation	novel	A958T	0.26
UCEC	chr19	32800673	Missense_Mutation	novel	K660N	0.38
UCEC	chr19	32801801	Missense_Mutation	novel	M709L	0.41
UCEC	chr19	32810100	Frame_Shift_Ins	novel	*Y889Lfs14**	0.41
UCEC	chr19	32731737	Missense_Mutation	novel	G13S	0.33
UCEC	chr19	32807576	Silent	novel	H860H	0.23
UCEC	chr19	32810255	Missense_Mutation	novel	A939S	0.2
UCEC	chr19	32803002	Silent	rs541196125	G804G	0.35
UCEC	chr19	32791047	Silent	rs754241258	P422P	0.35
UCEC	chr19	32800191	Frame_Shift_Del	NA	*N597Ifs25**	0.53
UCEC	chr19	32742833	Missense_Mutation	novel	F125V	0.45
UCEC	chr19	32790709	Intron	novel		0.58
UCEC	chr19	32800358	Missense_Mutation	novel	Q650H	0.63
UCEC	chr19	32802974	Missense_Mutation	novel	T795M	0.45
UCEC	chr19	32756051	Missense_Mutation	novel	K214N	0.35
UCEC	chr19	32742881	Nonsense_Mutation	NA	R141*	0.3
UCEC	chr19	32756051	Missense_Mutation	novel	K214N	0.25
UCEC	chr19	32826210	3'Flank	novel		0.44
UCEC	chr19	32756142	Missense_Mutation	novel	P245S	0.41
UCEC	chr19	32800676	Silent	novel	T661T	0.35
UCEC	chr19	32801828	Missense_Mutation	novel	E718K	0.1
UCEC	chr19	32756002	Missense_Mutation	novel	N198T	0.38
UCEC	chr19	32803009	Missense_Mutation	rs745891404	R807C	0.29
UCEC	chr19	32807642	Silent	novel	Y882Y	0.38
UCEC	chr19	32756158	Missense_Mutation	novel	G250V	0.36
UCEC	chr19	32813709	Missense_Mutation	novel	I1025S	0.15
UCEC	chr19	32731773	Frame_Shift_Del	novel	L26*	0.15
UCEC	chr19	32742829	Missense_Mutation	novel	K123N	0.1
UCEC	chr19	32756062	Missense_Mutation	novel	L218R	0.14
UCEC	chr19	32821044	Missense_Mutation	novel	A1132E	0.54
UCEC	chr19	32731837	Missense_Mutation	rs750956233	T46M	0.35
UCEC	chr19	32818146	Frame_Shift_Del	novel	*Q1127Rfs47**	0.3
UCEC	chr19	32772839	Missense_Mutation	novel	D318H	0.35
UCEC	chr19	32807617	Missense_Mutation	novel	S874N	0.08
UCEC	chr19	32826227	3'Flank	novel		0.2
UCEC	chr19	32731739	Silent	NA	G13G	0.45
UCEC	chr19	32772829	Silent	NA	I314I	0.38
UCEC	chr19	32749839	Silent	NA	V184V	0.33
UCEC	chr19	32756051	Missense_Mutation	novel	K214N	0.4
UCEC	chr19	32790742	Intron	rs769248097		0.44
UCEC	chr19	32821064	Nonsense_Mutation	novel	Q1139*	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.0182	0.23023
STAD	DEL	0.1247	0.1243

Survival Analysis

Cancer	P-value	Q-value
SARC	0.034	Kaplan-Meier Survival Analysis
MESO	0.0026	Kaplan-Meier Survival Analysis
ACC	0.0023	Kaplan-Meier Survival Analysis
KIRP	0.00015	Kaplan-Meier Survival Analysis
PCPG	0.032	Kaplan-Meier Survival Analysis
BLCA	0.045	Kaplan-Meier Survival Analysis
LAML	0.0017	Kaplan-Meier Survival Analysis
UCEC	0.00094	Kaplan-Meier Survival Analysis
LGG	0.018	Kaplan-Meier Survival Analysis
UVM	0.024	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742