EuRBPDB

Description

Ensembl ID: ENSG00000173821 (Gene tree)
Gene ID: 57674
Gene Symbol: RNF213
Alias: KIAA1554|NET57|ALO17|C17orf27|KIAA1618|MYMY2
Full Name: ring finger protein 213
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 137,947 bases
Position: chr17:80,260,840-80,398,786
Accession: 14539
RBP type: non-canonical RBP
Summary: This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000559070	RNF213-207	4644	-	-	- (aa)	-	-
ENST00000572622	RNF213-214	320	-	-	- (aa)	-	-
ENST00000427003	RNF213-203	3552	-	-	- (aa)	-	-
ENST00000573919	RNF213-217	899	-	-	- (aa)	-	-
ENST00000571908	RNF213-213	624	-	-	- (aa)	-	-
ENST00000582970	RNF213-220	21055	XM_017024905	ENSP00000464087	5207 (aa)	XP_016880394	A0A0A0MTR7
ENST00000574909	RNF213-219	298	-	-	- (aa)	-	-
ENST00000508628	RNF213-204	17730	XM_005257545	ENSP00000425956	5256 (aa)	XP_005257602	A0A0A0MTC1
ENST00000560083	RNF213-210	4212	-	-	- (aa)	-	-
ENST00000560694	RNF213-211	639	-	-	- (aa)	-	-
ENST00000573548	RNF213-216	616	-	-	- (aa)	-	-
ENST00000411702	RNF213-202	6428	-	-	- (aa)	-	-
ENST00000574060	RNF213-218	540	-	-	- (aa)	-	-
ENST00000559603	RNF213-208	765	-	-	- (aa)	-	-
ENST00000570776	RNF213-212	544	-	-	- (aa)	-	-
ENST00000573038	RNF213-215	699	-	ENSP00000460462	106 (aa)	-	I3L3H9
ENST00000559864	RNF213-209	594	-	-	- (aa)	-	-
ENST00000558116	RNF213-205	3768	-	-	- (aa)	-	-
ENST00000319921	RNF213-201	5316	-	ENSP00000324392	1063 (aa)	-	Q63HN8
ENST00000558488	RNF213-206	526	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000173821	Platelet Function Tests	2.6600000E-015	-
ENSG00000173821	Platelet Function Tests	2.4400000E-015	-
ENSG00000173821	Moyamoya Disease	2E-8	21048783
ENSG00000173821	1-Alkyl-2-acetylglycerophosphocholine Esterase	3E-6	23118302
ENSG00000173821	Migraine Disorders	5E-10	27182965
ENSG00000173821	Migraine Disorders	5E-10	27322543

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000173821	rs17857135	17	80288362	C	Migraine	27322543	[1.04-1.08]	1.06	EFO_0003821
ENSG00000173821	rs12051723	17	80350459	T	Lipoprotein-associated phospholipase A2 activity change in response to statin therapy	23118302	[1.22-3.18] percent increase	2.2	EFO_0004746
ENSG00000173821	rs9916351	17	80265733	A	Moyamoya disease	29273593	[NR]	1.96	Orphanet_2573
ENSG00000173821	rs11869363	17	80292960	A	Moyamoya disease	29273593	[NR]	1.7857143	Orphanet_2573
ENSG00000173821	rs9907978	17	80327580	A	Moyamoya disease	29273593	[NR]	1.5873016	Orphanet_2573
ENSG00000173821	rs10782008	17	80332071	G	Moyamoya disease	29273593	[NR]	2	Orphanet_2573
ENSG00000173821	rs6565681	17	80374694	A	Moyamoya disease	21048783	[2.73-8.49]	4.82	Orphanet_2573
ENSG00000173821	rs7220465	17	80286212	?	Migraine	27182965	[1.04-1.08]	1.0582011	EFO_0003821
ENSG00000173821	rs17857135	17	80288362	T	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	28090653	[1.03-1.59]	1.2820514	EFO_0004735\|EFO_0007965\|EFO_0000220

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173821	RNF213	100	66.495	ENSMUSG00000070327	Rnf213	100	72.930	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0001525	angiogenesis	26126547.26278786.	IMP	Process
GO:0002040	sprouting angiogenesis	21873635.	IBA	Process
GO:0002040	sprouting angiogenesis	26766444.	IMP	Process
GO:0004842	ubiquitin-protein transferase activity	21873635.	IBA	Function
GO:0004842	ubiquitin-protein transferase activity	21799892.	IDA	Function
GO:0004842	ubiquitin-protein transferase activity	26766444.	TAS	Function
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	21799892.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	26766444.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016567	protein ubiquitination	21799892.	IDA	Process
GO:0016887	ATPase activity	21799892.24658080.26126547.	IDA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051260	protein homooligomerization	24658080.26126547.	IDA	Process
GO:0051865	protein autoubiquitination	21799892.	IDA	Process
GO:2000051	negative regulation of non-canonical Wnt signaling pathway	21873635.	IBA	Process
GO:2000051	negative regulation of non-canonical Wnt signaling pathway	26766444.	IMP	Process