EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000173933 (Gene tree)
Gene ID: 5936
Gene Symbol: RBM4
Alias: LARK|RBM4A|ZCRB3A|ZCCHC21
Full Name: RNA binding motif protein 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 29,769 bases
Position: chr11:66,638,617-66,668,385
Accession: 9901
RBP type: canonical RBP
Summary: (RNA Binding Motif Protein 4) is a Protein Coding gene. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM4B.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000309166	zf-CCHC	PF00098.23	6.7e-07	1	1
ENSP00000386561	zf-CCHC	PF00098.23	6.7e-07	1	1
ENSP00000386894	zf-CCHC	PF00098.23	6.7e-07	1	1
ENSP00000422301	RRM_5	PF13893.6	3.6e-08	1	2
ENSP00000422301	RRM_5	PF13893.6	3.6e-08	2	2
ENSP00000309166	RRM_5	PF13893.6	1.4e-07	1	2
ENSP00000309166	RRM_5	PF13893.6	1.4e-07	2	2
ENSP00000386561	RRM_5	PF13893.6	1.4e-07	1	2
ENSP00000386561	RRM_5	PF13893.6	1.4e-07	2	2
ENSP00000386894	RRM_5	PF13893.6	1.4e-07	1	2
ENSP00000386894	RRM_5	PF13893.6	1.4e-07	2	2
ENSP00000413497	RRM_5	PF13893.6	3.5e-06	1	1
ENSP00000423572	RRM_5	PF13893.6	3.8e-06	1	1
ENSP00000381680	RRM_5	PF13893.6	6.1e-06	1	1
ENSP00000432150	RRM_5	PF13893.6	6.1e-06	1	1
ENSP00000432020	RRM_5	PF13893.6	6.4e-06	1	1
ENSP00000435821	RRM_5	PF13893.6	6.4e-06	1	1
ENSP00000464349	RRM_5	PF13893.6	1.4e-05	1	1
ENSP00000422301	RRM_1	PF00076.22	2.2e-34	1	2
ENSP00000422301	RRM_1	PF00076.22	2.2e-34	2	2
ENSP00000413497	RRM_1	PF00076.22	3.4e-34	1	2
ENSP00000413497	RRM_1	PF00076.22	3.4e-34	2	2
ENSP00000381680	RRM_1	PF00076.22	5.3e-34	1	2
ENSP00000381680	RRM_1	PF00076.22	5.3e-34	2	2
ENSP00000432150	RRM_1	PF00076.22	5.3e-34	1	2
ENSP00000432150	RRM_1	PF00076.22	5.3e-34	2	2
ENSP00000432020	RRM_1	PF00076.22	6e-34	1	2
ENSP00000432020	RRM_1	PF00076.22	6e-34	2	2
ENSP00000435821	RRM_1	PF00076.22	6e-34	1	2
ENSP00000435821	RRM_1	PF00076.22	6e-34	2	2
ENSP00000309166	RRM_1	PF00076.22	6.9e-34	1	2
ENSP00000309166	RRM_1	PF00076.22	6.9e-34	2	2
ENSP00000386561	RRM_1	PF00076.22	6.9e-34	1	2
ENSP00000386561	RRM_1	PF00076.22	6.9e-34	2	2
ENSP00000386894	RRM_1	PF00076.22	6.9e-34	1	2
ENSP00000386894	RRM_1	PF00076.22	6.9e-34	2	2
ENSP00000423572	RRM_1	PF00076.22	9.5e-34	1	2
ENSP00000423572	RRM_1	PF00076.22	9.5e-34	2	2
ENSP00000464349	RRM_1	PF00076.22	2.2e-33	1	2
ENSP00000464349	RRM_1	PF00076.22	2.2e-33	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14528909	Decreased brain levels of Lupus La protein and increased U5 small ribonucleoprotein-specific 40 kDa protein in fetal Down syndrome.	Cell Mol Biol (Noisy-le-grand)	2003 Jul	Gulesserian T	-
23129807	RBM4 promotes pancreas cell differentiation and insulin expression.	Mol Cell Biol	2013 Jan	Lin JC	doi: 10.1128/MCB.01266-12
23897118	MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes.	Immunol Cell Biol	2013 Sep	Brudecki L	doi: 10.1038/icb.2013.37
17068759	Identification and analysis of altered alpha1,6-fucosylated glycoproteins associated with hepatocellular carcinoma metastasis.	Proteomics	2006 Nov	Dai Z	-
26216489	Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs.	Tissue Antigens	2015 Sep	Yamada E	doi: 10.1111/tan.12607
28754317	Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4.	Int J Biochem Cell Biol	2017 Sep	Huang GW	doi: 10.1016/j.biocel.2017.07.017
16212419	Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).	J Proteome Res	2005 Sep-Oct	Amanchy R	-
12628928	A novel splicing regulator shares a nuclear import pathway with SR proteins.	EMBO J	2003 Mar 17	Lai MC	-
16260624	Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.	Mol Cell Biol	2005 Nov	Lin JC	-
16777844	RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.	J Biol Chem	2006 Aug 25	Kar A	-
19801630	RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.	J Biol Chem	2009 Dec 11	Lin JC	doi: 10.1074/jbc.M109.032946
18708123	The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.	Neurosci Lett	2008 Oct 17	Pfuhl T	doi: 10.1016/j.neulet.2008.08.017
18064391	Gene expression profiling in apoptotic k562 cells treated by homoharringtonine.	Acta Biochim Biophys Sin (Shanghai)	2007 Dec	Jin W	-
17932509	Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.	EMBO Rep	2007 Nov	Hock J	-
17284590	Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.	Proc Natl Acad Sci U S A	2007 Feb 13	Lin JC	-
25414336	Alanine repeats influence protein localization in splicing speckles and paraspeckles.	Nucleic Acids Res	2014 Dec 16	Chang SH	doi: 10.1093/nar/gku1159
25140042	Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.	RNA	2014 Oct	Lin JC	doi: 10.1261/rna.045583.114
24389249	Emerging role for RNA binding motif protein 4 in the development of brown adipocytes.	Biochim Biophys Acta	2014 Apr	Lin JC	doi: 10.1016/j.bbamcr.2013.12.018
26506517	The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells.	Oncotarget	2015 Nov 10	Liang YC	doi: 10.18632/oncotarget.5710.
25998849	Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages.	J Innate Immun	2015	McClure C	doi: 10.1159/000381915
29138007	RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell.	Biochim Biophys Acta Mol Cell Res	2018 Feb	Lin JC	doi: 10.1016/j.bbamcr.2017.11.005
30200638	RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.	Int J Mol Sci	2018 Sep 6	Peng HY	doi: 10.3390/ijms19092646.
18723113	RBM4: a multifunctional RNA-binding protein.	Int J Biochem Cell Biol	2009 Apr	Markus MA	doi: 10.1016/j.biocel.2008.05.027
28138257	Decrease of RBM4 indicates poor prognosis in patients with hepatocellular carcinoma after hepatectomy.	Onco Targets Ther	2017 Jan 11	Chen JY	doi: 10.2147/OTT.S125250
22678294	An oxygen-regulated switch in the protein synthesis machinery.	Nature	2012 May 6	Uniacke J	doi: 10.1038/nature11055.
22202052	Multiple roles of RBM4 in muscle cell differentiation.	Front Biosci (Schol Ed)	2012 Jan 1	Lin JC	-
21562054	MicroRNA-146a regulates both transcription silencing and translation disruption of TNF--and-alpha; during TLR4-induced gene reprogramming.	J Leukoc Biol	2011 Sep	El Gazzar M	doi: 10.1189/jlb.0211074
21518792	RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing.	J Cell Biol	2011 May 2	Lin JC	doi: 10.1083/jcb.201007131
25211129	Translational regulation of the DOUBLETIME/CKIdelta/-epsilon kinase by LARK contributes to circadian period modulation.	PLoS Genet	2014 Sep 11	Huang Y	doi: 10.1371/journal.pgen.1004536
27662615	Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements.	PLoS Genet	2016 Sep 23	Swain A	doi: 10.1371/journal.pgen.1006331
23825193	Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes.	Clin Vaccine Immunol	2013 Sep	Brudecki L	doi: 10.1128/CVI.00264-13
23527094	Phylogenetic and molecular characterization of the splicing factor RBM4.	PLoS One	2013	Lu CC	doi: 10.1371/journal.pone.0059092
26857472	RBM4a-regulated splicing cascade modulates the differentiation and metabolic activities of brown adipocytes.	Sci Rep	2016 Feb 9	Lin JC	doi: 10.1038/srep20665.
27324405	Prognostic value of decreased expression of RBM4 in human gastric cancer.	Sci Rep	2016 Jun 21	Yong H	doi: 10.1038/srep28222.
26565589	A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells.	Elife	2015 Nov 13	Gowen BG	doi: 10.7554/eLife.08474.
29581187	RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.	Mol Cell Biol	2018 May 29	D D	doi: 10.1128/MCB.00007-18
31145716	RNA-Binding Motif 4 (RBM4) Suppresses Tumor Growth and Metastasis in Human Gastric Cancer.	Med Sci Monit	2019 May 30	Yong H	doi: 10.12659/MSM.914513.
31234575	Berberine Promotes Beige Adipogenic Signatures of 3T3-L1 Cells by Regulating Post-transcriptional Events.	Cells	2019 Jun 23	Lin YC	doi: 10.3390/cells8060632.
20617199	RNAcontext: a new method for learning the sequence and structure binding preferences of RNA-binding proteins.	PLoS Comput Biol	2010 Jul 1	Kazan H	doi: 10.1371/journal.pcbi.1000832.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000398692	RBM4-203	921	-	ENSP00000381680	143 (aa)	-	Q9BWF3
ENST00000310092	RBM4-201	1694	-	ENSP00000309166	364 (aa)	-	Q9BWF3
ENST00000578778	RBM4-213	582	-	ENSP00000464349	155 (aa)	-	J3QRR5
ENST00000510173	RBM4-208	782	-	ENSP00000422301	240 (aa)	-	E9PB51
ENST00000396053	RBM4-202	3029	-	ENSP00000413497	173 (aa)	-	Q9BWF3
ENST00000532968	RBM4-212	757	-	ENSP00000432020	177 (aa)	-	Q9BWF3
ENST00000506523	RBM4-207	654	-	ENSP00000423572	150 (aa)	-	D6R9K7
ENST00000409406	RBM4-205	2321	-	ENSP00000386894	364 (aa)	-	Q9BWF3
ENST00000408993	RBM4-204	1763	-	ENSP00000386561	364 (aa)	-	Q9BWF3
ENST00000530235	RBM4-211	1011	-	ENSP00000432150	143 (aa)	-	Q9BWF3
ENST00000528039	RBM4-210	764	-	-	- (aa)	-	-
ENST00000515838	RBM4-209	943	-	-	- (aa)	-	-
ENST00000483858	RBM4-206	1548	-	ENSP00000435821	177 (aa)	-	Q9BWF3

Gene Model

Click here to download ENSG00000173933's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000173933's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000173933	RBM4	98	30.625	ENSG00000116001	TIA1	85	31.081
ENSG00000173933	RBM4	97	30.128	ENSG00000101489	CELF4	52	30.065
ENSG00000173933	RBM4	88	38.983	ENSG00000115875	SRSF7	83	35.780
ENSG00000173933	RBM4	97	98.551	ENSG00000173914	RBM4B	98	97.857
ENSG00000173933	RBM4	77	35.714	ENSG00000147140	NONO	60	32.857
ENSG00000173933	RBM4	50	33.750	ENSG00000213516	RBMXL1	91	33.750
ENSG00000173933	RBM4	90	30.464	ENSG00000135486	HNRNPA1	65	30.464
ENSG00000173933	RBM4	94	31.034	ENSG00000151923	TIAL1	84	30.973
ENSG00000173933	RBM4	59	32.143	ENSG00000124193	SRSF6	62	32.143
ENSG00000173933	RBM4	97	48.529	ENSG00000239306	RBM14	94	48.529
ENSG00000173933	RBM4	77	30.952	ENSG00000149187	CELF1	79	33.333

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000173933	RBM4	100	100.000	ENSAMEG00000010914	RBM4	100	99.178	Ailuropoda_melanoleuca
ENSG00000173933	RBM4	100	98.780	ENSAMEG00000010906	RBM4B	96	98.780	Ailuropoda_melanoleuca
ENSG00000173933	RBM4	100	96.129	ENSANAG00000023478	RBM4B	100	96.129	Aotus_nancymaae
ENSG00000173933	RBM4	100	96.503	ENSANAG00000033986	-	96	88.679	Aotus_nancymaae
ENSG00000173933	RBM4	97	98.551	ENSBTAG00000000423	RBM4B	96	98.780	Bos_taurus
ENSG00000173933	RBM4	100	97.253	ENSBTAG00000031688	RBM4	100	97.253	Bos_taurus
ENSG00000173933	RBM4	100	96.774	ENSCJAG00000013666	RBM4B	100	96.774	Callithrix_jacchus
ENSG00000173933	RBM4	100	100.000	ENSCAFG00000012388	RBM4	100	99.178	Canis_familiaris
ENSG00000173933	RBM4	100	98.780	ENSCAFG00000012378	RBM4B	96	98.780	Canis_familiaris
ENSG00000173933	RBM4	100	98.780	ENSCAFG00020015519	RBM4B	96	98.780	Canis_lupus_dingo
ENSG00000173933	RBM4	100	100.000	ENSCAFG00020015515	RBM4	100	99.178	Canis_lupus_dingo
ENSG00000173933	RBM4	100	97.253	ENSCHIG00000020613	RBM4	100	97.253	Capra_hircus
ENSG00000173933	RBM4	97	98.551	ENSCHIG00000008907	RBM4B	96	98.780	Capra_hircus
ENSG00000173933	RBM4	66	79.583	ENSTSYG00000009580	RBM4B	96	79.668	Carlito_syrichta
ENSG00000173933	RBM4	94	87.850	ENSTSYG00000036168	-	100	82.400	Carlito_syrichta
ENSG00000173933	RBM4	100	99.301	ENSCAPG00000016600	RBM4	100	99.301	Cavia_aperea
ENSG00000173933	RBM4	97	98.551	ENSCAPG00000009570	RBM4B	96	98.780	Cavia_aperea
ENSG00000173933	RBM4	100	99.301	ENSCPOG00000013194	RBM4	100	99.301	Cavia_porcellus
ENSG00000173933	RBM4	97	98.551	ENSCPOG00000013689	RBM4B	96	98.780	Cavia_porcellus
ENSG00000173933	RBM4	97	98.551	ENSCCAG00000016501	RBM4B	98	97.857	Cebus_capucinus
ENSG00000173933	RBM4	99	72.535	ENSCCAG00000023319	-	100	74.129	Cebus_capucinus
ENSG00000173933	RBM4	100	97.203	ENSCCAG00000007508	-	100	97.203	Cebus_capucinus
ENSG00000173933	RBM4	97	98.551	ENSCATG00000035353	RBM4B	98	97.857	Cercocebus_atys
ENSG00000173933	RBM4	100	99.301	ENSCLAG00000014756	RBM4	100	99.301	Chinchilla_lanigera
ENSG00000173933	RBM4	100	98.780	ENSCLAG00000015287	RBM4B	96	98.780	Chinchilla_lanigera
ENSG00000173933	RBM4	97	98.551	ENSCSAG00000008361	RBM4B	96	98.780	Chlorocebus_sabaeus
ENSG00000173933	RBM4	97	98.551	ENSCHOG00000002892	RBM4B	96	98.780	Choloepus_hoffmanni
ENSG00000173933	RBM4	62	97.357	ENSCHOG00000009753	RBM14-RBM4	100	97.357	Choloepus_hoffmanni
ENSG00000173933	RBM4	100	96.341	ENSCPBG00000023800	-	100	74.278	Chrysemys_picta_bellii
ENSG00000173933	RBM4	97	98.551	ENSCANG00000021868	RBM4B	98	97.857	Colobus_angolensis_palliatus
ENSG00000173933	RBM4	100	98.601	ENSCGRG00001016609	-	100	98.601	Cricetulus_griseus_chok1gshd
ENSG00000173933	RBM4	97	98.551	ENSCGRG00001024693	Rbm4b	96	98.780	Cricetulus_griseus_chok1gshd
ENSG00000173933	RBM4	97	98.551	ENSCGRG00000012112	Rbm4b	96	98.780	Cricetulus_griseus_crigri
ENSG00000173933	RBM4	100	98.601	ENSCGRG00000010183	-	100	98.601	Cricetulus_griseus_crigri
ENSG00000173933	RBM4	97	98.551	ENSDNOG00000019500	-	96	98.780	Dasypus_novemcinctus
ENSG00000173933	RBM4	100	99.390	ENSDNOG00000032390	RBM4	100	98.630	Dasypus_novemcinctus
ENSG00000173933	RBM4	100	97.561	ENSDNOG00000045639	-	96	97.561	Dasypus_novemcinctus
ENSG00000173933	RBM4	97	98.551	ENSDORG00000029108	Rbm4b	96	98.780	Dipodomys_ordii
ENSG00000173933	RBM4	100	98.171	ENSDORG00000004538	-	100	97.902	Dipodomys_ordii
ENSG00000173933	RBM4	62	63.717	ENSETEG00000018142	-	100	64.159	Echinops_telfairi
ENSG00000173933	RBM4	100	98.780	ENSEASG00005005068	RBM4B	96	98.780	Equus_asinus_asinus
ENSG00000173933	RBM4	100	100.000	ENSEASG00005005064	RBM4	100	97.802	Equus_asinus_asinus
ENSG00000173933	RBM4	100	98.780	ENSECAG00000022987	RBM4B	96	98.780	Equus_caballus
ENSG00000173933	RBM4	100	100.000	ENSECAG00000022940	RBM4	100	97.802	Equus_caballus
ENSG00000173933	RBM4	97	99.275	ENSEEUG00000000058	RBM4B	96	99.390	Erinaceus_europaeus
ENSG00000173933	RBM4	97	98.551	ENSFCAG00000007394	RBM4B	98	97.857	Felis_catus
ENSG00000173933	RBM4	100	100.000	ENSFCAG00000029651	RBM4	100	100.000	Felis_catus
ENSG00000173933	RBM4	97	97.101	ENSFALG00000002073	-	100	68.108	Ficedula_albicollis
ENSG00000173933	RBM4	100	98.780	ENSFDAG00000015530	RBM4B	96	98.780	Fukomys_damarensis
ENSG00000173933	RBM4	99	92.366	ENSFDAG00000013661	-	96	92.366	Fukomys_damarensis
ENSG00000173933	RBM4	100	99.301	ENSFDAG00000005447	RBM4	100	99.301	Fukomys_damarensis
ENSG00000173933	RBM4	97	97.101	ENSGALG00000037946	-	100	76.000	Gallus_gallus
ENSG00000173933	RBM4	97	97.101	ENSGALG00000040489	-	86	95.745	Gallus_gallus
ENSG00000173933	RBM4	100	96.341	ENSGAGG00000008553	-	100	74.607	Gopherus_agassizii
ENSG00000173933	RBM4	98	78.571	ENSGGOG00000043023	-	98	79.562	Gorilla_gorilla
ENSG00000173933	RBM4	100	95.804	ENSGGOG00000011698	RBM4B	98	97.857	Gorilla_gorilla
ENSG00000173933	RBM4	97	65.942	ENSHGLG00000000117	-	95	66.027	Heterocephalus_glaber_female
ENSG00000173933	RBM4	100	85.976	ENSHGLG00000002853	-	99	85.976	Heterocephalus_glaber_female
ENSG00000173933	RBM4	100	98.601	ENSHGLG00000009991	RBM4	100	98.601	Heterocephalus_glaber_female
ENSG00000173933	RBM4	100	98.780	ENSHGLG00000016412	-	96	98.780	Heterocephalus_glaber_female
ENSG00000173933	RBM4	100	98.780	ENSHGLG00100003978	-	96	98.780	Heterocephalus_glaber_male
ENSG00000173933	RBM4	100	98.601	ENSHGLG00100003854	RBM4	100	98.601	Heterocephalus_glaber_male
ENSG00000173933	RBM4	97	88.406	ENSHGLG00100020033	-	100	85.976	Heterocephalus_glaber_male
ENSG00000173933	RBM4	97	98.551	ENSSTOG00000011226	RBM4B	96	98.780	Ictidomys_tridecemlineatus
ENSG00000173933	RBM4	100	100.000	ENSSTOG00000022811	RBM4	100	100.000	Ictidomys_tridecemlineatus
ENSG00000173933	RBM4	93	75.188	ENSJJAG00000003168	-	98	72.340	Jaculus_jaculus
ENSG00000173933	RBM4	100	94.512	ENSJJAG00000020870	Rbm4b	96	94.512	Jaculus_jaculus
ENSG00000173933	RBM4	97	98.551	ENSLAFG00000002285	RBM4B	96	98.780	Loxodonta_africana
ENSG00000173933	RBM4	97	98.551	ENSLAFG00000028147	-	100	94.795	Loxodonta_africana
ENSG00000173933	RBM4	100	96.503	ENSMFAG00000033927	RBM4B	97	98.551	Macaca_fascicularis
ENSG00000173933	RBM4	97	98.551	ENSMNEG00000043371	RBM4B	98	97.857	Macaca_nemestrina
ENSG00000173933	RBM4	100	96.503	ENSMLEG00000028563	RBM4B	98	97.857	Mandrillus_leucophaeus
ENSG00000173933	RBM4	97	98.551	ENSMAUG00000017027	Rbm4b	96	98.780	Mesocricetus_auratus
ENSG00000173933	RBM4	100	97.902	ENSMICG00000047975	-	99	97.902	Microcebus_murinus
ENSG00000173933	RBM4	100	95.804	ENSMICG00000003817	-	100	95.804	Microcebus_murinus
ENSG00000173933	RBM4	100	98.780	ENSMICG00000003820	RBM4B	98	97.857	Microcebus_murinus
ENSG00000173933	RBM4	97	98.551	ENSMOCG00000001835	Rbm4b	96	98.780	Microtus_ochrogaster
ENSG00000173933	RBM4	100	96.951	ENSMODG00000008056	-	100	90.489	Monodelphis_domestica
ENSG00000173933	RBM4	100	98.601	MGP_CAROLIEiJ_G0022516	-	100	98.601	Mus_caroli
ENSG00000173933	RBM4	97	98.551	MGP_CAROLIEiJ_G0022515	Rbm4b	96	98.780	Mus_caroli
ENSG00000173933	RBM4	99	87.013	MGP_CAROLIEiJ_G0022514	-	100	71.038	Mus_caroli
ENSG00000173933	RBM4	100	95.890	ENSMUSG00000096370	Gm21992	100	95.890	Mus_musculus
ENSG00000173933	RBM4	100	95.804	ENSMUSG00000033760	Rbm4b	96	98.780	Mus_musculus
ENSG00000173933	RBM4	100	98.601	ENSMUSG00000094936	Rbm4	100	98.837	Mus_musculus
ENSG00000173933	RBM4	97	98.551	MGP_PahariEiJ_G0014012	Rbm4b	96	98.780	Mus_pahari
ENSG00000173933	RBM4	100	96.164	MGP_PahariEiJ_G0014011	-	100	96.164	Mus_pahari
ENSG00000173933	RBM4	100	98.601	MGP_PahariEiJ_G0014013	-	100	98.601	Mus_pahari
ENSG00000173933	RBM4	100	73.868	MGP_SPRETEiJ_G0023429	-	100	75.694	Mus_spretus
ENSG00000173933	RBM4	100	87.013	MGP_SPRETEiJ_G0023428	-	94	79.511	Mus_spretus
ENSG00000173933	RBM4	100	87.013	MGP_SPRETEiJ_G0023430	-	100	79.511	Mus_spretus
ENSG00000173933	RBM4	97	98.551	ENSMPUG00000003450	RBM4B	96	98.780	Mustela_putorius_furo
ENSG00000173933	RBM4	100	100.000	ENSMPUG00000003443	RBM4	100	98.904	Mustela_putorius_furo
ENSG00000173933	RBM4	100	99.390	ENSMLUG00000004076	RBM4	95	96.961	Myotis_lucifugus
ENSG00000173933	RBM4	100	98.780	ENSMLUG00000001290	RBM4B	96	98.780	Myotis_lucifugus
ENSG00000173933	RBM4	97	98.551	ENSNGAG00000016292	Rbm4b	96	98.780	Nannospalax_galili
ENSG00000173933	RBM4	100	100.000	ENSNLEG00000035021	RBM4	100	100.000	Nomascus_leucogenys
ENSG00000173933	RBM4	100	95.804	ENSNLEG00000006213	RBM4B	98	97.857	Nomascus_leucogenys
ENSG00000173933	RBM4	100	98.171	ENSMEUG00000001445	-	96	98.171	Notamacropus_eugenii
ENSG00000173933	RBM4	62	86.344	ENSMEUG00000005739	-	100	86.404	Notamacropus_eugenii
ENSG00000173933	RBM4	100	98.780	ENSOPRG00000009158	RBM4B	96	98.780	Ochotona_princeps
ENSG00000173933	RBM4	100	98.356	ENSOPRG00000009149	RBM4	100	98.356	Ochotona_princeps
ENSG00000173933	RBM4	100	95.804	ENSODEG00000019143	-	100	95.804	Octodon_degus
ENSG00000173933	RBM4	97	99.275	ENSODEG00000017696	-	96	99.390	Octodon_degus
ENSG00000173933	RBM4	100	85.366	ENSODEG00000001866	-	96	85.366	Octodon_degus
ENSG00000173933	RBM4	100	97.203	ENSODEG00000020039	-	100	97.203	Octodon_degus
ENSG00000173933	RBM4	100	76.923	ENSODEG00000006635	-	100	76.923	Octodon_degus
ENSG00000173933	RBM4	100	98.780	ENSOANG00000003143	-	81	98.780	Ornithorhynchus_anatinus
ENSG00000173933	RBM4	100	98.780	ENSOANG00000011036	-	96	98.780	Ornithorhynchus_anatinus
ENSG00000173933	RBM4	100	99.452	ENSOCUG00000004731	RBM4	100	99.452	Oryctolagus_cuniculus
ENSG00000173933	RBM4	97	98.551	ENSOCUG00000006695	LARK	96	98.780	Oryctolagus_cuniculus
ENSG00000173933	RBM4	97	98.551	ENSOGAG00000015648	RBM4B	96	98.780	Otolemur_garnettii
ENSG00000173933	RBM4	100	99.452	ENSOGAG00000015647	RBM4	100	99.452	Otolemur_garnettii
ENSG00000173933	RBM4	97	98.551	ENSOARG00000007759	RBM4B	96	98.780	Ovis_aries
ENSG00000173933	RBM4	97	100.000	ENSOARG00000007700	RBM4	96	100.000	Ovis_aries
ENSG00000173933	RBM4	100	95.804	ENSPPAG00000015125	RBM4B	98	97.857	Pan_paniscus
ENSG00000173933	RBM4	97	98.551	ENSPPRG00000003388	RBM4B	98	97.857	Panthera_pardus
ENSG00000173933	RBM4	100	100.000	ENSPPRG00000003533	RBM4	100	100.000	Panthera_pardus
ENSG00000173933	RBM4	97	98.551	ENSPTIG00000015426	RBM4B	98	97.857	Panthera_tigris_altaica
ENSG00000173933	RBM4	100	99.301	ENSPTIG00000016180	RBM4	100	99.301	Panthera_tigris_altaica
ENSG00000173933	RBM4	100	95.804	ENSPTRG00000003935	RBM4B	98	97.857	Pan_troglodytes
ENSG00000173933	RBM4	97	98.551	ENSPANG00000020672	RBM4B	98	97.857	Papio_anubis
ENSG00000173933	RBM4	97	95.652	ENSPSIG00000003477	-	95	77.740	Pelodiscus_sinensis
ENSG00000173933	RBM4	100	95.732	ENSPSIG00000003430	-	96	95.732	Pelodiscus_sinensis
ENSG00000173933	RBM4	97	98.551	ENSPEMG00000009144	Rbm4b	96	98.780	Peromyscus_maniculatus_bairdii
ENSG00000173933	RBM4	97	98.551	ENSPPYG00000003010	RBM4B	96	98.780	Pongo_abelii
ENSG00000173933	RBM4	100	100.000	ENSPPYG00000003012	RBM4	100	98.901	Pongo_abelii
ENSG00000173933	RBM4	100	96.438	ENSPCAG00000003393	-	100	96.438	Procavia_capensis
ENSG00000173933	RBM4	97	98.551	ENSPCOG00000027885	RBM4B	99	98.561	Propithecus_coquereli
ENSG00000173933	RBM4	97	98.551	ENSPVAG00000010487	RBM4B	96	98.780	Pteropus_vampyrus
ENSG00000173933	RBM4	100	100.000	ENSPVAG00000010486	RBM4	100	98.356	Pteropus_vampyrus
ENSG00000173933	RBM4	97	98.551	ENSRNOG00000061795	Rbm4b	96	98.780	Rattus_norvegicus
ENSG00000173933	RBM4	100	98.601	ENSRNOG00000050741	Rbm4	100	98.601	Rattus_norvegicus
ENSG00000173933	RBM4	97	98.551	ENSRBIG00000019394	RBM4B	98	97.857	Rhinopithecus_bieti
ENSG00000173933	RBM4	97	100.000	ENSRROG00000032796	-	90	100.000	Rhinopithecus_roxellana
ENSG00000173933	RBM4	97	98.551	ENSRROG00000032850	RBM4B	98	97.857	Rhinopithecus_roxellana
ENSG00000173933	RBM4	97	97.826	ENSSBOG00000034474	RBM4B	98	97.143	Saimiri_boliviensis_boliviensis
ENSG00000173933	RBM4	100	98.780	ENSSHAG00000008386	-	100	87.945	Sarcophilus_harrisii
ENSG00000173933	RBM4	97	98.551	ENSSARG00000010710	RBM4B	96	98.780	Sorex_araneus
ENSG00000173933	RBM4	100	100.000	ENSSSCG00000032437	RBM4	100	99.178	Sus_scrofa
ENSG00000173933	RBM4	97	96.377	ENSTGUG00000016779	-	94	77.740	Taeniopygia_guttata
ENSG00000173933	RBM4	96	100.000	ENSTBEG00000003727	-	70	100.000	Tupaia_belangeri
ENSG00000173933	RBM4	100	98.780	ENSTBEG00000003748	RBM4B	96	98.780	Tupaia_belangeri
ENSG00000173933	RBM4	100	97.260	ENSTTRG00000011164	RBM4	100	97.260	Tursiops_truncatus
ENSG00000173933	RBM4	100	98.171	ENSTTRG00000011166	RBM4B	96	98.171	Tursiops_truncatus
ENSG00000173933	RBM4	100	100.000	ENSUAMG00000014882	RBM4	100	100.000	Ursus_americanus
ENSG00000173933	RBM4	100	98.780	ENSUAMG00000004745	RBM4B	96	98.780	Ursus_americanus
ENSG00000173933	RBM4	100	99.301	ENSUMAG00000011738	-	100	99.301	Ursus_maritimus
ENSG00000173933	RBM4	100	100.000	ENSVPAG00000001949	RBM4	100	96.712	Vicugna_pacos
ENSG00000173933	RBM4	97	97.826	ENSVPAG00000001950	RBM4B	96	98.171	Vicugna_pacos
ENSG00000173933	RBM4	99	89.362	ENSVVUG00000011717	-	100	85.714	Vulpes_vulpes
ENSG00000173933	RBM4	100	98.780	ENSVVUG00000010619	RBM4B	96	98.780	Vulpes_vulpes
ENSG00000173933	RBM4	100	98.780	ENSVVUG00000010622	RBM4	100	98.630	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	12628928.16260624.16777844.16934801.21518792.	IDA	Process
GO:0002190	cap-independent translational initiation	17284590.	IDA	Process
GO:0002192	IRES-dependent translational initiation of linear mRNA	17284590.	IDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	19561594.	IDA	Function
GO:0003729	mRNA binding	21518792.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	-	ISS	Function
GO:0005515	protein binding	12628928.16934801.17284590.19801630.21343338.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	16777844.16907643.17284590.	IDA	Component
GO:0005654	nucleoplasm	12628928.	IDA	Component
GO:0005730	nucleolus	12628928.16907643.	IDA	Component
GO:0005737	cytoplasm	12628928.16777844.16907643.17284590.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006396	RNA processing	9169144.	TAS	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0010494	cytoplasmic stress granule	17284590.	IDA	Component
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	12628928.16907643.	IDA	Component
GO:0017148	negative regulation of translation	17284590.	IDA	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0030332	cyclin binding	15159402.	IPI	Function
GO:0032055	negative regulation of translation in response to stress	17284590.	IDA	Process
GO:0035198	miRNA binding	19801630.	IDA	Function
GO:0035278	miRNA mediated inhibition of translation	19801630.	IDA	Process
GO:0043153	entrainment of circadian clock by photoperiod	-	ISS	Process
GO:0045292	mRNA cis splicing, via spliceosome	21873635.	IBA	Process
GO:0045947	negative regulation of translational initiation	19801630.	IDA	Process
GO:0046685	response to arsenic-containing substance	17284590.	IDA	Process
GO:0046822	regulation of nucleocytoplasmic transport	12628928.17284590.	IDA	Process
GO:0051149	positive regulation of muscle cell differentiation	21518792.	IDA	Process
GO:0097157	pre-mRNA intronic binding	16260624.	IDA	Function
GO:0097158	pre-mRNA intronic pyrimidine-rich binding	16260624.16777844.	IDA	Function
GO:0097167	circadian regulation of translation	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25203323	The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.	Cancer Cell	2014 Sep 8	Wang Y	doi: 10.1016/j.ccr.2014.07.010.
16934801	WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.	Exp Cell Res	2006 Oct 15	Markus MA	-
26506517	The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells.	Oncotarget	2015 Nov 10	Liang YC	doi: 10.18632/oncotarget.5710.
25140042	Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.	RNA	2014 Oct	Lin JC	doi: 10.1261/rna.045583.114
19416963	Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation.	J Biol Chem	2009 Jul 3	Brooks YS	doi: 10.1074/jbc.M109.006999
28754317	Natural antisense transcript TPM1-AS regulates the alternative splicing of tropomyosin I through an interaction with RNA-binding motif protein 4.	Int J Biochem Cell Biol	2017 Sep	Huang GW	doi: 10.1016/j.biocel.2017.07.017
29138007	RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell.	Biochim Biophys Acta Mol Cell Res	2018 Feb	Lin JC	doi: 10.1016/j.bbamcr.2017.11.005
27324405	Prognostic value of decreased expression of RBM4 in human gastric cancer.	Sci Rep	2016 Jun 21	Yong H	doi: 10.1038/srep28222.
28276498	The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells.	Sci Rep	2017 Mar 9	Lin JC	doi: 10.1038/srep44204.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr11	66639924	Silent	novel	K71K	0.26
BLCA	chr11	66643527	Silent	NA	R164R	0.12
BLCA	chr11	66644082	Missense_Mutation	novel	R349G	0.1
BRCA	chr11	66644187	Intron	novel		0.19
BRCA	chr11	66639750	Silent	NA	A13A	0.17
BRCA	chr11	66644420	Intron	novel		0.17
BRCA	chr11	66643757	Silent	rs372104227	S240S	0.1
BRCA	chr11	66639997	Missense_Mutation	novel	A96T	0.09	zf-CCHC
BRCA	chr11	66643514	Missense_Mutation	NA	Q159H	0.3
CESC	chr11	66639628	Intron	novel		0.1
CESC	chr11	66640038	Silent	novel	I109I	0.28
CESC	chr11	66643758	Missense_Mutation	rs752990000	V241M	0.31
CESC	chr11	66639636	Intron	novel		0.31
CESC	chr11	66646084	3'UTR	novel		0.4
CHOL	chr11	66643474	Missense_Mutation	novel	S146F	0.42
CHOL	chr11	66639937	Missense_Mutation	novel	T76P	0.07
COAD	chr11	66639869	Missense_Mutation	rs765301901	R53H	0.38
COAD	chr11	66639591	Intron	novel		0.33
COAD	chr11	66643793	Silent	NA	L252L	0.49
COAD	chr11	66643901	Silent	rs746731288	A288A	0.27
COAD	chr11	66639598	Intron	novel		0.67
COAD	chr11	66644192	Intron	novel		0.28
COAD	chr11	66643587	Missense_Mutation	NA	A184T	0.46
COAD	chr11	66643950	Missense_Mutation	rs767778848	G305R	0.32
COAD	chr11	66639956	Missense_Mutation	novel	V82A	0.35	zf-CCHC
COAD	chr11	66640070	Missense_Mutation	novel	R120Q	0.13	zf-CCHC
COAD	chr11	66639511	Intron	novel		0.09
COAD	chr11	66639513	Intron	novel		0.09
COAD	chr11	66639693	Splice_Region	novel		0.12
COAD	chr11	66639640	Intron	novel		0.38
COAD	chr11	66644083	Missense_Mutation	NA	R349Q	0.28
DLBC	chr11	66643848	Missense_Mutation	rs767766638	P271S	0.14
ESCA	chr11	66639663	Intron	novel		0.35
ESCA	chr11	66639760	Missense_Mutation	novel	E17Q	0.4
ESCA	chr11	66643630	Missense_Mutation	rs577949918	R198H	0.38
ESCA	chr11	66646100	3'UTR	novel		0.45
GBM	chr11	66643994	Silent	rs777485002	P319P	0.41
GBM	chr11	66640017	Silent	NA	G102G	0.07
GBM	chr11	66644056	Missense_Mutation	rs766435416	A340V	0.7
GBM	chr11	66643495	Missense_Mutation	NA	A153V	0.39
HNSC	chr11	66639869	Missense_Mutation	rs765301901	R53H	0.31
HNSC	chr11	66643565	Silent	rs373465062	P176P	0.07
HNSC	chr11	66640232	Intron	novel		0.18
HNSC	chr11	66640234	Intron	novel		0.18
HNSC	chr11	66640006	Missense_Mutation	novel	E99Q	0.24	zf-CCHC
HNSC	chr11	66639876	Silent	novel	L55L	0.11
HNSC	chr11	66643767	Missense_Mutation	novel	Y244H	0.21
KIRP	chr11	66643979	Silent	NA	A314A	0.38
LAML	chr11	66643743	Missense_Mutation	novel	A236T	0.1
LGG	chr11	66640175	Intron	novel		0.13
LGG	chr11	66643563	Frame_Shift_Ins	novel	S180*	0.44
LIHC	chr11	66643757	Silent	rs372104227	S240S	0.52
LUAD	chr11	66639569	Intron	novel		0.31
LUAD	chr11	66643845	Missense_Mutation	rs751773381	D270N	0.11
LUAD	chr11	66644148	Splice_Region	novel		0.47
LUAD	chr11	66640219	Intron	novel		0.67
LUAD	chr11	66644130	Nonstop_Mutation	novel	365Kext75	0.34
LUAD	chr11	66643583	Silent	rs751146254	R182R	0.21
LUAD	chr11	66640057	Missense_Mutation	NA	V116L	0.1	zf-CCHC
LUAD	chr11	66640261	Intron	novel		0.21
LUAD	chr11	66643938	Missense_Mutation	novel	T301S	0.8
LUSC	chr11	66639668	Intron	novel		0.48
LUSC	chr11	66643943	Silent	NA	S302S	0.21
LUSC	chr11	66643893	In_Frame_Del	rs773057844	A289_A295del	0.34
LUSC	chr11	66639780	Silent	novel	E23E	0.2
OV	chr11	66640273	Intron	novel		0.12
OV	chr11	66640136	Intron	novel		0.47
OV	chr11	66643798	Missense_Mutation	novel	Q254R	0.07
OV	chr11	66644112	Missense_Mutation	NA	A359T	0.23
READ	chr11	66643456	Missense_Mutation	NA	R140Q	0.15
READ	chr11	66640038	Silent	NA	I109I	0.17
READ	chr11	66639668	Intron	novel		0.41
READ	chr11	66639994	Nonsense_Mutation	NA	R95*	0.45	zf-CCHC
READ	chr11	66640388	Intron	novel		0.5
READ	chr11	66639801	Missense_Mutation	NA	E30D	0.32
SARC	chr11	66644058	Missense_Mutation	novel	R341G	0.09
SARC	chr11	66646184	3'UTR	novel		0.09
SARC	chr11	66644127	Missense_Mutation	novel	F364L	0.08
SKCM	chr11	66644161	Intron	novel		0.75
SKCM	chr11	66639970	Missense_Mutation	novel	P87S	0.38	zf-CCHC
SKCM	chr11	66643802	Silent	novel	V255V	0.42
SKCM	chr11	66644180	Intron	novel		0.38
SKCM	chr11	66643474	Missense_Mutation	novel	S146F	0.45
STAD	chr11	66640017	Silent	NA	G102G	0.1
STAD	chr11	66643494	Missense_Mutation	NA	A153T	0.19
STAD	chr11	66643499	Silent	NA	P154P	0.11
STAD	chr11	66643904	Silent	NA	A289A	0.29
STAD	chr11	66643722	Missense_Mutation	NA	R229W	0.35
STAD	chr11	66643629	Missense_Mutation	rs748197738	R198C	0.28
STAD	chr11	66643696	Missense_Mutation	NA	A220V	0.18
STAD	chr11	66640057	Missense_Mutation	rs368114061	V116I	0.23	zf-CCHC
STAD	chr11	66643723	Missense_Mutation	rs768616980	R229Q	0.19
STAD	chr11	66643704	Missense_Mutation	NA	K223E	0.21
TGCT	chr11	66643715	Silent	novel	R226R	0.22
THCA	chr11	66640126	Splice_Region	NA		0.13
UCEC	chr11	66644118	Missense_Mutation	NA	Y361H	0.13
UCEC	chr11	66643863	Missense_Mutation	novel	L276M	0.39
UCEC	chr11	66646103	3'UTR	novel		0.06
UCEC	chr11	66643949	Silent	rs777866630	Y304Y	0.44
UCEC	chr11	66644056	Missense_Mutation	novel	A340G	0.18
UCEC	chr11	66643912	Missense_Mutation	novel	A292V	0.43
UCEC	chr11	66643714	Missense_Mutation	novel	R226H	0.38
UCEC	chr11	66639860	Missense_Mutation	novel	D50G	0.1
UCEC	chr11	66639588	Intron	novel		0.31
UCEC	chr11	66639849	Silent	NA	T46T	0.13
UCEC	chr11	66640038	Silent	NA	I109I	0.09
UCEC	chr11	66643914	Missense_Mutation	rs763486340	A293T	0.48
UCEC	chr11	66646197	3'UTR	novel		0.29
UCEC	chr11	66640111	Missense_Mutation	novel	T134P	0.5	zf-CCHC
UCEC	chr11	66643914	Missense_Mutation	rs763486340	A293T	0.42
UCEC	chr11	66643766	Silent	NA	N243N	0.37
UCEC	chr11	66639903	Silent	novel	N64N	0.11
UCEC	chr11	66639987	Silent	novel	K92K	0.05
UCEC	chr11	66643949	Silent	rs777866630	Y304Y	0.24
UCEC	chr11	66640291	Intron	novel		0.19
UCEC	chr11	66639766	Missense_Mutation	NA	R19C	0.3
UCEC	chr11	66639994	Nonsense_Mutation	NA	R95*	0.3	zf-CCHC
UCEC	chr11	66643565	Silent	rs373465062	P176P	0.27
UCEC	chr11	66643890	Missense_Mutation	novel	T285A	0.36
UCEC	chr11	66640026	Silent	novel	I105I	0.14
UCEC	chr11	66639615	Intron	novel		0.29
UCEC	chr11	66643527	Missense_Mutation	NA	R164W	0.13
UCEC	chr11	66646355	3'UTR	novel		0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.2554	0.018342
TGCT	DEL	0.7	0.21504

Survival Analysis

Cancer	P-value	Q-value
ACC	0.0054	Kaplan-Meier Survival Analysis
UCS	0.03	Kaplan-Meier Survival Analysis
PRAD	0.031	Kaplan-Meier Survival Analysis
PCPG	0.014	Kaplan-Meier Survival Analysis
BLCA	0.0094	Kaplan-Meier Survival Analysis
READ	0.022	Kaplan-Meier Survival Analysis
LAML	0.00033	Kaplan-Meier Survival Analysis
KICH	0.016	Kaplan-Meier Survival Analysis
UCEC	0.016	Kaplan-Meier Survival Analysis
GBM	0.033	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.049	Kaplan-Meier Survival Analysis
UVM	0.0087	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742