EuRBPDB

Description

Ensembl ID: ENSG00000174106 (Gene tree)
Gene ID: 23592
Gene Symbol: LEMD3
Alias: MAN1
Full Name: LEM domain containing 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 78,791 bases
Position: chr12:65,169,571-65,248,361
Accession: 28887
RBP type: non-canonical RBP
Summary: This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20036230	The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins.	Dev Biol	2010 Mar 1	Wagner N	doi: 10.1016/j.ydbio.2009.11.036

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000308330	LEMD3-201	4764	-	ENSP00000308369	911 (aa)	-	Q9Y2U8
ENST00000541171	LEMD3-203	856	-	-	- (aa)	-	-
ENST00000545026	LEMD3-206	619	-	-	- (aa)	-	-
ENST00000539442	LEMD3-202	932	-	-	- (aa)	-	-
ENST00000542032	LEMD3-204	645	-	-	- (aa)	-	-
ENST00000544506	LEMD3-205	412	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000174106	monocyte chemoattractant protein 1 (66-77)	3.7620000E-005	-
ENSG00000174106	Venous Thromboembolism	1E-8	28203683

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000174106	rs138916004	12	65188408	G	Venous thromboembolism adjusted for sickle cell variant rs77121243-T	28203683	[2.131-4.719]	3.171	EFO_0004286

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001525	angiogenesis	-	IEA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0005515	protein binding	15231748.15647271.24407287.	IPI	Function
GO:0005637	nuclear inner membrane	15647271.	IDA	Component
GO:0005639	integral component of nuclear inner membrane	21873635.	IBA	Component
GO:0006998	nuclear envelope organization	21873635.	IBA	Process
GO:0016020	membrane	10671519.	TAS	Component
GO:0016021	integral component of membrane	10671519.	IDA	Component
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	15647271.	IDA	Process
GO:0030514	negative regulation of BMP signaling pathway	21873635.	IBA	Process
GO:0030514	negative regulation of BMP signaling pathway	15647271.	IDA	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0032926	negative regulation of activin receptor signaling pathway	15647271.	IDA	Process
GO:1902531	regulation of intracellular signal transduction	-	IEA	Process