EuRBPDB

Description

Ensembl ID: ENSG00000174197 (Gene tree)
Gene ID: 23269
Gene Symbol: MGA
Alias: KIAA0518|MAD5|MXD5|FLJ12634
Full Name: MAX dimerization protein MGA
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 151,858 bases
Position: chr15:41,621,224-41,773,081
Accession: 14010
RBP type: non-canonical RBP
Summary: (MAX Dimerization Protein MGA) is a Protein Coding gene. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is TBX3.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000564190	MGA-205	3521	XM_005254254	ENSP00000457474	1174 (aa)	XP_005254311	H3BU53
ENST00000570161	MGA-211	11859	XM_005254244	ENSP00000457035	3065 (aa)	XP_005254301	Q8IWI9
ENST00000566718	MGA-208	3439	-	ENSP00000455155	1086 (aa)	-	H3BP52
ENST00000619521	MGA-212	1496	-	ENSP00000483990	61 (aa)	-	A0A087X194
ENST00000566586	MGA-207	14439	-	ENSP00000456141	2856 (aa)	-	Q8IWI9
ENST00000568630	MGA-210	584	-	-	- (aa)	-	-
ENST00000563576	MGA-204	3537	-	ENSP00000457151	1138 (aa)	-	H3BTF4
ENST00000561532	MGA-203	532	-	ENSP00000457250	83 (aa)	-	H3BTN2
ENST00000568255	MGA-209	724	-	-	- (aa)	-	-
ENST00000219905	MGA-201	12042	XM_005254243	ENSP00000219905	3065 (aa)	XP_005254300	Q8IWI9
ENST00000566288	MGA-206	3405	-	-	- (aa)	-	-
ENST00000545763	MGA-202	11413	XM_005254253	ENSP00000442467	2856 (aa)	XP_005254310	Q8IWI9

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000174197	Blood Pressure	1.3378440E-006	-
ENSG00000174197	Blood Pressure	7.9468079E-006	-
ENSG00000174197	Lung Volume Measurements	1E-9	28166213

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000174197	rs117618307	15	41738651	A	Feeling nervous	29500382	z score decrease	5.68	EFO_0009597
ENSG00000174197	rs72724130	15	41685492	T	Lung function (FEV1/FVC)	28166213	[0.038-0.074] unit decrease	0.056	EFO_0004713
ENSG00000174197	rs4924570	15	41682462	?	Age at menopause	30595370			EFO_0004704
ENSG00000174197	rs56383987	15	41661013	T	Lung function (FEV1/FVC)	30804560	[0.026-0.047] unit decrease	0.0364	EFO_0004713
ENSG00000174197	rs17677991	15	41740185	G	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.01-0.02] unit increase	0.015	EFO_0007788
ENSG00000174197	rs17677991	15	41740185	G	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.012-0.022] unit increase	0.0171	EFO_0007788
ENSG00000174197	rs17677991	15	41740185	G	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.01-0.024] unit increase	0.0169	EFO_0007788
ENSG00000174197	rs17677991	15	41740185	G	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.01-0.023] unit increase	0.0165	EFO_0007788
ENSG00000174197	rs17677991	15	41740185	G	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.0088-0.021] unit increase	0.0149	EFO_0007788
ENSG00000174197	rs17677991	15	41740185	G	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.0083-0.0205] unit increase	0.0144	EFO_0007788

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174197	MGA	100	87.042	ENSMUSG00000033943	Mga	100	85.089	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0005515	protein binding	20936779.21988832.25609649.27705803.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046983	protein dimerization activity	-	IEA	Function
GO:0070317	negative regulation of G0 to G1 transition	-	TAS	Process
GO:0071339	MLL1 complex	15960975.	IDA	Component