EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000174231 (Gene tree)
Gene ID: 10594
Gene Symbol: PRPF8
Alias: PRPC8|Prp8|hPrp8|SNRNP220|RP13
Full Name: pre-mRNA processing factor 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 34,254 bases
Position: chr17:1,650,629-1,684,882
Accession: 17340
RBP type: canonical RBP
Summary: Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000304350	RRM_4	PF10598.9	1.2e-47	1	1
ENSP00000460348	RRM_4	PF10598.9	1.2e-47	1	1
ENSP00000458151	RRM_4	PF10598.9	4.4e-43	1	1
ENSP00000304350	U5_2-snRNA_bdg	PF10597.9	2.4e-73	1	1
ENSP00000460348	U5_2-snRNA_bdg	PF10597.9	2.4e-73	1	1
ENSP00000460849	U5_2-snRNA_bdg	PF10597.9	3e-23	1	1
ENSP00000304350	PRO8NT	PF08082.11	4.9e-86	1	1
ENSP00000460348	PRO8NT	PF08082.11	4.9e-86	1	1
ENSP00000458151	PRO8NT	PF08082.11	5.7e-43	1	2
ENSP00000458151	PRO8NT	PF08082.11	5.7e-43	2	2
ENSP00000460849	U6-snRNA_bdg	PF10596.9	2e-90	1	1
ENSP00000304350	U6-snRNA_bdg	PF10596.9	5.9e-89	1	1
ENSP00000460348	U6-snRNA_bdg	PF10596.9	5.9e-89	1	1
ENSP00000458151	PROCN	PF08083.11	1e-235	1	1
ENSP00000304350	PROCN	PF08083.11	6.4e-235	1	1
ENSP00000460348	PROCN	PF08083.11	6.4e-235	1	1
ENSP00000304350	PRP8_domainIV	PF12134.8	1.3e-129	1	1
ENSP00000460348	PRP8_domainIV	PF12134.8	1.3e-129	1	1
ENSP00000304350	PROCT	PF08084.11	5e-53	1	1
ENSP00000460348	PROCT	PF08084.11	5e-53	1	1
ENSP00000459095	PROCT	PF08084.11	4e-22	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23704370	Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8.	Science	2013 Jul 5	Mozaffari-Jovin S	doi: 10.1126/science.1237515
23393194	Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.	Nucleic Acids Res	2013 Apr 1	Li X	doi: 10.1093/nar/gkt062
27072132	Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity.	J Biol Chem	2016 Jun 3	Ledoux S	doi: 10.1074/jbc.M115.710848
26968627	Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.	RNA	2016 May	Mayerle M	doi: 10.1261/rna.055459.115
29377672	Molecular Mechanism and Evolution of Nuclear Pre-mRNA and Group II Intron Splicing: Insights from Cryo-Electron Microscopy Structures.	Chem Rev	2018 Apr 25	Galej WP	doi: 10.1021/acs.chemrev.7b00499
21441348	Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptase.	RNA	2011 May	Dlakic M	doi: 10.1261/rna.2396011

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000571346	PRPF8-202	865	-	-	- (aa)	-	-
ENST00000573716	PRPF8-208	542	-	-	- (aa)	-	-
ENST00000573681	PRPF8-207	1044	-	-	- (aa)	-	-
ENST00000574728	PRPF8-211	466	-	-	- (aa)	-	-
ENST00000576958	PRPF8-215	416	-	-	- (aa)	-	-
ENST00000572621	PRPF8-205	7445	-	ENSP00000460348	2335 (aa)	-	Q6P2Q9
ENST00000573725	PRPF8-209	749	-	ENSP00000460849	250 (aa)	-	I3L3Z8
ENST00000572445	PRPF8-204	648	-	-	- (aa)	-	-
ENST00000576585	PRPF8-214	2157	-	-	- (aa)	-	-
ENST00000576407	PRPF8-213	566	-	-	- (aa)	-	-
ENST00000572723	PRPF8-206	959	-	-	- (aa)	-	-
ENST00000575116	PRPF8-212	460	-	-	- (aa)	-	-
ENST00000574217	PRPF8-210	310	-	-	- (aa)	-	-
ENST00000577001	PRPF8-216	3274	-	ENSP00000458151	1012 (aa)	-	I3L0J9
ENST00000571958	PRPF8-203	380	-	ENSP00000459095	116 (aa)	-	I3L1T8
ENST00000304992	PRPF8-201	7295	XM_024450537	ENSP00000304350	2335 (aa)	XP_024306305	Q6P2Q9

Gene Model

Click here to download ENSG00000174231's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000174231	rs8071756	17	1671048	G	Blood protein levels	28240269	[0.49-0.69] unit increase	0.5897	EFO_0008276
ENSG00000174231	rs11867415	17	1668524	?	Stroke	29531354			EFO_0000712
ENSG00000174231	rs11867415	17	1668524	?	Ischemic stroke	29531354			HP_0002140
ENSG00000174231	rs62089970	17	1672578	C	Blood protein levels	30072576	[1.13-1.43] unit decrease	1.276	EFO_0007937
ENSG00000174231	rs11867415	17	1668524	?	Ischemic stroke	29531354			HP_0002140

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174231's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174231	PRPF8	100	97.820	ENSAPOG00000010079	prpf8	100	97.820	Acanthochromis_polyacanthus
ENSG00000174231	PRPF8	100	100.000	ENSAMEG00000007940	PRPF8	100	100.000	Ailuropoda_melanoleuca
ENSG00000174231	PRPF8	100	95.549	ENSACIG00000018280	prpf8	100	95.925	Amphilophus_citrinellus
ENSG00000174231	PRPF8	100	97.820	ENSAOCG00000010725	prpf8	100	97.820	Amphiprion_ocellaris
ENSG00000174231	PRPF8	100	97.820	ENSAPEG00000014397	prpf8	100	97.820	Amphiprion_percula
ENSG00000174231	PRPF8	100	97.263	ENSATEG00000010062	prpf8	100	97.263	Anabas_testudineus
ENSG00000174231	PRPF8	96	99.555	ENSAPLG00000010357	PRPF8	100	99.555	Anas_platyrhynchos
ENSG00000174231	PRPF8	99	93.358	ENSACAG00000014784	PRPF8	99	97.477	Anolis_carolinensis
ENSG00000174231	PRPF8	100	100.000	ENSANAG00000032629	PRPF8	100	100.000	Aotus_nancymaae
ENSG00000174231	PRPF8	100	97.447	ENSACLG00000020858	prpf8	100	97.447	Astatotilapia_calliptera
ENSG00000174231	PRPF8	100	97.731	ENSAMXG00000020291	prpf8	100	97.731	Astyanax_mexicanus
ENSG00000174231	PRPF8	100	100.000	ENSBTAG00000011488	PRPF8	100	100.000	Bos_taurus
ENSG00000174231	PRPF8	99	86.444	WBGene00004187	prp-8	99	86.529	Caenorhabditis_elegans
ENSG00000174231	PRPF8	100	100.000	ENSCJAG00000001911	PRPF8	100	100.000	Callithrix_jacchus
ENSG00000174231	PRPF8	100	100.000	ENSCAFG00000019221	PRPF8	100	100.000	Canis_familiaris
ENSG00000174231	PRPF8	96	100.000	ENSCAFG00020009943	PRPF8	100	100.000	Canis_lupus_dingo
ENSG00000174231	PRPF8	100	100.000	ENSCHIG00000017499	PRPF8	100	100.000	Capra_hircus
ENSG00000174231	PRPF8	100	100.000	ENSTSYG00000014120	PRPF8	100	100.000	Carlito_syrichta
ENSG00000174231	PRPF8	96	97.773	ENSCAPG00000009459	PRPF8	99	97.773	Cavia_aperea
ENSG00000174231	PRPF8	100	100.000	ENSCPOG00000010379	PRPF8	100	100.000	Cavia_porcellus
ENSG00000174231	PRPF8	100	100.000	ENSCCAG00000031983	-	100	100.000	Cebus_capucinus
ENSG00000174231	PRPF8	100	100.000	ENSCATG00000038595	PRPF8	100	100.000	Cercocebus_atys
ENSG00000174231	PRPF8	100	100.000	ENSCLAG00000004388	PRPF8	100	100.000	Chinchilla_lanigera
ENSG00000174231	PRPF8	100	100.000	ENSCSAG00000013929	PRPF8	100	100.000	Chlorocebus_sabaeus
ENSG00000174231	PRPF8	82	100.000	ENSCHOG00000008590	PRPF8	88	99.738	Choloepus_hoffmanni
ENSG00000174231	PRPF8	100	99.529	ENSCPBG00000020409	PRPF8	100	99.529	Chrysemys_picta_bellii
ENSG00000174231	PRPF8	99	100.000	ENSCSAVG00000007825	-	100	91.280	Ciona_savignyi
ENSG00000174231	PRPF8	100	100.000	ENSCANG00000043088	PRPF8	100	100.000	Colobus_angolensis_palliatus
ENSG00000174231	PRPF8	95	94.510	ENSCGRG00001017673	-	98	100.000	Cricetulus_griseus_chok1gshd
ENSG00000174231	PRPF8	82	100.000	ENSCGRG00000005129	Prpf8	100	99.409	Cricetulus_griseus_crigri
ENSG00000174231	PRPF8	100	97.649	ENSCSEG00000007905	prpf8	100	97.649	Cynoglossus_semilaevis
ENSG00000174231	PRPF8	100	97.609	ENSDARG00000026180	prpf8	100	97.609	Danio_rerio
ENSG00000174231	PRPF8	100	94.752	ENSDNOG00000018471	PRPF8	99	99.954	Dasypus_novemcinctus
ENSG00000174231	PRPF8	100	94.047	ENSDORG00000006185	Prpf8	96	99.432	Dipodomys_ordii
ENSG00000174231	PRPF8	99	91.549	FBgn0033688	Prp8	98	91.122	Drosophila_melanogaster
ENSG00000174231	PRPF8	100	94.518	ENSETEG00000017592	PRPF8	100	94.518	Echinops_telfairi
ENSG00000174231	PRPF8	99	93.729	ENSEBUG00000006548	prpf8	99	93.729	Eptatretus_burgeri
ENSG00000174231	PRPF8	100	100.000	ENSEASG00005009514	PRPF8	100	100.000	Equus_asinus_asinus
ENSG00000174231	PRPF8	97	100.000	ENSECAG00000021318	PRPF8	100	100.000	Equus_caballus
ENSG00000174231	PRPF8	82	91.748	ENSEEUG00000012120	-	67	100.000	Erinaceus_europaeus
ENSG00000174231	PRPF8	98	96.547	ENSELUG00000007120	prpf8	99	96.547	Esox_lucius
ENSG00000174231	PRPF8	100	100.000	ENSFCAG00000006297	PRPF8	100	100.000	Felis_catus
ENSG00000174231	PRPF8	100	99.486	ENSFALG00000006628	PRPF8	100	99.486	Ficedula_albicollis
ENSG00000174231	PRPF8	100	100.000	ENSFDAG00000004711	PRPF8	100	100.000	Fukomys_damarensis
ENSG00000174231	PRPF8	100	97.438	ENSFHEG00000021084	prpf8	100	97.438	Fundulus_heteroclitus
ENSG00000174231	PRPF8	100	95.389	ENSGMOG00000002028	prpf8	99	95.389	Gadus_morhua
ENSG00000174231	PRPF8	100	99.443	ENSGALG00000002943	PRPF8	100	99.443	Gallus_gallus
ENSG00000174231	PRPF8	99	97.520	ENSGAFG00000010337	prpf8	99	97.520	Gambusia_affinis
ENSG00000174231	PRPF8	100	97.516	ENSGACG00000008504	prpf8	100	97.516	Gasterosteus_aculeatus
ENSG00000174231	PRPF8	100	99.529	ENSGAGG00000008350	PRPF8	100	99.529	Gopherus_agassizii
ENSG00000174231	PRPF8	100	100.000	ENSGGOG00000005516	PRPF8	100	100.000	Gorilla_gorilla
ENSG00000174231	PRPF8	100	97.604	ENSHBUG00000016192	prpf8	100	97.604	Haplochromis_burtoni
ENSG00000174231	PRPF8	100	100.000	ENSHGLG00000012029	PRPF8	100	100.000	Heterocephalus_glaber_female
ENSG00000174231	PRPF8	100	100.000	ENSHGLG00100016494	PRPF8	100	100.000	Heterocephalus_glaber_male
ENSG00000174231	PRPF8	100	97.563	ENSHCOG00000016414	prpf8	100	97.563	Hippocampus_comes
ENSG00000174231	PRPF8	100	97.605	ENSIPUG00000023230	prpf8	100	97.605	Ictalurus_punctatus
ENSG00000174231	PRPF8	100	100.000	ENSSTOG00000005128	PRPF8	100	100.000	Ictidomys_tridecemlineatus
ENSG00000174231	PRPF8	100	97.816	ENSJJAG00000021159	Prpf8	100	97.816	Jaculus_jaculus
ENSG00000174231	PRPF8	99	97.977	ENSKMAG00000016118	prpf8	99	97.977	Kryptolebias_marmoratus
ENSG00000174231	PRPF8	100	97.478	ENSLBEG00000026903	prpf8	100	97.478	Labrus_bergylta
ENSG00000174231	PRPF8	100	91.839	ENSLACG00000010479	PRPF8	99	98.551	Latimeria_chalumnae
ENSG00000174231	PRPF8	99	97.731	ENSLOCG00000005409	prpf8	99	97.731	Lepisosteus_oculatus
ENSG00000174231	PRPF8	100	100.000	ENSLAFG00000015445	PRPF8	100	100.000	Loxodonta_africana
ENSG00000174231	PRPF8	100	100.000	ENSMFAG00000039995	PRPF8	100	100.000	Macaca_fascicularis
ENSG00000174231	PRPF8	100	100.000	ENSMMUG00000004820	PRPF8	100	100.000	Macaca_mulatta
ENSG00000174231	PRPF8	100	100.000	ENSMNEG00000035713	PRPF8	100	100.000	Macaca_nemestrina
ENSG00000174231	PRPF8	100	100.000	ENSMLEG00000037937	PRPF8	100	100.000	Mandrillus_leucophaeus
ENSG00000174231	PRPF8	100	97.776	ENSMAMG00000008919	prpf8	100	97.776	Mastacembelus_armatus
ENSG00000174231	PRPF8	100	97.447	ENSMZEG00005015073	prpf8	100	97.447	Maylandia_zebra
ENSG00000174231	PRPF8	100	99.443	ENSMGAG00000004769	PRPF8	100	99.443	Meleagris_gallopavo
ENSG00000174231	PRPF8	100	99.957	ENSMICG00000010320	PRPF8	100	99.957	Microcebus_murinus
ENSG00000174231	PRPF8	100	99.957	ENSMOCG00000016838	Prpf8	100	99.957	Microtus_ochrogaster
ENSG00000174231	PRPF8	100	97.305	ENSMMOG00000011887	prpf8	100	97.305	Mola_mola
ENSG00000174231	PRPF8	100	99.829	ENSMODG00000010480	PRPF8	100	99.829	Monodelphis_domestica
ENSG00000174231	PRPF8	97	97.713	ENSMALG00000003558	prpf8	100	97.713	Monopterus_albus
ENSG00000174231	PRPF8	100	100.000	MGP_CAROLIEiJ_G0016740	Prpf8	100	99.914	Mus_caroli
ENSG00000174231	PRPF8	100	100.000	ENSMUSG00000020850	Prpf8	100	99.914	Mus_musculus
ENSG00000174231	PRPF8	100	99.901	MGP_PahariEiJ_G0017877	Prpf8	100	99.829	Mus_pahari
ENSG00000174231	PRPF8	100	100.000	MGP_SPRETEiJ_G0017583	Prpf8	100	99.914	Mus_spretus
ENSG00000174231	PRPF8	100	100.000	ENSMPUG00000013227	PRPF8	100	100.000	Mustela_putorius_furo
ENSG00000174231	PRPF8	100	99.786	ENSMLUG00000002666	PRPF8	100	99.786	Myotis_lucifugus
ENSG00000174231	PRPF8	100	98.201	ENSNGAG00000005305	Prpf8	100	98.201	Nannospalax_galili
ENSG00000174231	PRPF8	100	97.489	ENSNBRG00000013127	prpf8	100	97.489	Neolamprologus_brichardi
ENSG00000174231	PRPF8	97	97.695	ENSNLEG00000000897	PRPF8	98	97.695	Nomascus_leucogenys
ENSG00000174231	PRPF8	99	98.044	ENSMEUG00000015999	PRPF8	100	98.044	Notamacropus_eugenii
ENSG00000174231	PRPF8	100	98.458	ENSOPRG00000003102	PRPF8	100	98.458	Ochotona_princeps
ENSG00000174231	PRPF8	100	100.000	ENSODEG00000008468	PRPF8	100	100.000	Octodon_degus
ENSG00000174231	PRPF8	100	97.490	ENSONIG00000008153	prpf8	100	97.490	Oreochromis_niloticus
ENSG00000174231	PRPF8	83	99.645	ENSOANG00000004250	PRPF8	97	99.720	Ornithorhynchus_anatinus
ENSG00000174231	PRPF8	100	100.000	ENSOCUG00000000081	PRPF8	100	100.000	Oryctolagus_cuniculus
ENSG00000174231	PRPF8	99	97.687	ENSORLG00000008036	prpf8	99	97.687	Oryzias_latipes
ENSG00000174231	PRPF8	99	97.646	ENSORLG00020021070	prpf8	99	97.646	Oryzias_latipes_hni
ENSG00000174231	PRPF8	99	97.687	ENSORLG00015002340	prpf8	99	97.687	Oryzias_latipes_hsok
ENSG00000174231	PRPF8	99	96.187	ENSOMEG00000016866	prpf8	99	96.187	Oryzias_melastigma
ENSG00000174231	PRPF8	100	99.872	ENSOARG00000013312	PRPF8	100	99.872	Ovis_aries
ENSG00000174231	PRPF8	100	100.000	ENSPPAG00000042753	PRPF8	100	100.000	Pan_paniscus
ENSG00000174231	PRPF8	100	100.000	ENSPPRG00000008746	PRPF8	100	100.000	Panthera_pardus
ENSG00000174231	PRPF8	100	99.914	ENSPTIG00000019200	PRPF8	100	99.914	Panthera_tigris_altaica
ENSG00000174231	PRPF8	100	100.000	ENSPTRG00000039576	PRPF8	100	100.000	Pan_troglodytes
ENSG00000174231	PRPF8	99	99.057	ENSPANG00000024607	PRPF8	99	99.057	Papio_anubis
ENSG00000174231	PRPF8	100	97.319	ENSPKIG00000011201	prpf8	100	97.319	Paramormyrops_kingsleyae
ENSG00000174231	PRPF8	100	99.486	ENSPSIG00000013393	PRPF8	100	99.486	Pelodiscus_sinensis
ENSG00000174231	PRPF8	100	99.957	ENSPEMG00000021699	Prpf8	100	99.957	Peromyscus_maniculatus_bairdii
ENSG00000174231	PRPF8	96	93.853	ENSPMAG00000005438	prpf8	100	93.898	Petromyzon_marinus
ENSG00000174231	PRPF8	100	99.829	ENSPCIG00000022603	PRPF8	100	99.866	Phascolarctos_cinereus
ENSG00000174231	PRPF8	100	96.990	ENSPFOG00000007005	prpf8	100	96.990	Poecilia_formosa
ENSG00000174231	PRPF8	100	96.403	ENSPLAG00000020777	prpf8	100	96.403	Poecilia_latipinna
ENSG00000174231	PRPF8	100	96.990	ENSPMEG00000004051	prpf8	100	96.990	Poecilia_mexicana
ENSG00000174231	PRPF8	100	97.645	ENSPREG00000021902	prpf8	100	97.645	Poecilia_reticulata
ENSG00000174231	PRPF8	100	100.000	ENSPPYG00000007777	PRPF8	100	100.000	Pongo_abelii
ENSG00000174231	PRPF8	90	99.647	ENSPCAG00000008938	PRPF8	90	99.647	Procavia_capensis
ENSG00000174231	PRPF8	100	99.957	ENSPCOG00000015182	PRPF8	100	99.957	Propithecus_coquereli
ENSG00000174231	PRPF8	93	100.000	ENSPVAG00000002134	PRPF8	93	100.000	Pteropus_vampyrus
ENSG00000174231	PRPF8	100	97.604	ENSPNYG00000016356	prpf8	100	97.604	Pundamilia_nyererei
ENSG00000174231	PRPF8	100	97.648	ENSPNAG00000009247	prpf8	100	97.648	Pygocentrus_nattereri
ENSG00000174231	PRPF8	100	99.914	ENSRNOG00000003495	Prpf8	100	99.914	Rattus_norvegicus
ENSG00000174231	PRPF8	100	100.000	ENSRBIG00000031219	PRPF8	100	100.000	Rhinopithecus_bieti
ENSG00000174231	PRPF8	100	100.000	ENSRROG00000038014	PRPF8	100	100.000	Rhinopithecus_roxellana
ENSG00000174231	PRPF8	99	79.612	YHR165C	PRP8	95	62.516	Saccharomyces_cerevisiae
ENSG00000174231	PRPF8	100	100.000	ENSSBOG00000029717	PRPF8	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000174231	PRPF8	100	99.786	ENSSHAG00000006167	PRPF8	100	99.786	Sarcophilus_harrisii
ENSG00000174231	PRPF8	100	97.523	ENSSFOG00015013905	prpf8	100	97.523	Scleropages_formosus
ENSG00000174231	PRPF8	100	97.394	ENSSMAG00000017736	prpf8	100	97.394	Scophthalmus_maximus
ENSG00000174231	PRPF8	100	97.776	ENSSDUG00000003029	prpf8	100	97.776	Seriola_dumerili
ENSG00000174231	PRPF8	82	100.000	ENSSLDG00000017096	prpf8	100	98.936	Seriola_lalandi_dorsalis
ENSG00000174231	PRPF8	87	99.395	ENSSARG00000002892	PRPF8	87	99.395	Sorex_araneus
ENSG00000174231	PRPF8	100	99.315	ENSSPUG00000007463	PRPF8	100	99.315	Sphenodon_punctatus
ENSG00000174231	PRPF8	100	97.221	ENSSPAG00000015639	prpf8	100	97.221	Stegastes_partitus
ENSG00000174231	PRPF8	100	100.000	ENSSSCG00000017817	PRPF8	100	100.000	Sus_scrofa
ENSG00000174231	PRPF8	74	99.099	ENSTGUG00000015597	-	95	99.651	Taeniopygia_guttata
ENSG00000174231	PRPF8	100	99.486	ENSTGUG00000005648	-	100	99.486	Taeniopygia_guttata
ENSG00000174231	PRPF8	100	97.563	ENSTRUG00000015906	prpf8	100	97.563	Takifugu_rubripes
ENSG00000174231	PRPF8	95	98.746	ENSTNIG00000003460	prpf8	99	98.746	Tetraodon_nigroviridis
ENSG00000174231	PRPF8	93	99.932	ENSTBEG00000006431	PRPF8	93	99.932	Tupaia_belangeri
ENSG00000174231	PRPF8	100	99.400	ENSTTRG00000006869	PRPF8	100	99.400	Tursiops_truncatus
ENSG00000174231	PRPF8	100	94.752	ENSUAMG00000015644	-	96	99.921	Ursus_americanus
ENSG00000174231	PRPF8	82	100.000	ENSUAMG00000028213	-	100	100.000	Ursus_americanus
ENSG00000174231	PRPF8	100	99.743	ENSUMAG00000009385	PRPF8	100	99.743	Ursus_maritimus
ENSG00000174231	PRPF8	71	99.505	ENSVPAG00000006063	-	71	99.505	Vicugna_pacos
ENSG00000174231	PRPF8	100	100.000	ENSVVUG00000021695	PRPF8	99	100.000	Vulpes_vulpes
ENSG00000174231	PRPF8	100	98.716	ENSXETG00000022259	prpf8	100	98.716	Xenopus_tropicalis
ENSG00000174231	PRPF8	100	97.566	ENSXCOG00000012775	prpf8	100	97.566	Xiphophorus_couchianus
ENSG00000174231	PRPF8	100	97.523	ENSXMAG00000008505	prpf8	100	97.523	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000244	spliceosomal tri-snRNP complex assembly	21873635.	IBA	Process
GO:0000244	spliceosomal tri-snRNP complex assembly	20595234.	IDA	Process
GO:0000375	RNA splicing, via transesterification reactions	9774689.	TAS	Process
GO:0000386	second spliceosomal transesterification activity	21873635.	IBA	Function
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28781166.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	9774689.18951082.20696395.22365833.22720776.23704370.23793891.26711270.	IPI	Function
GO:0005634	nucleus	22720776.28781166.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005682	U5 snRNP	21873635.	IBA	Component
GO:0006397	mRNA processing	9774689.	TAS	Process
GO:0008380	RNA splicing	9774689.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0017070	U6 snRNA binding	21873635.	IBA	Function
GO:0030619	U1 snRNA binding	21873635.	IBA	Function
GO:0030620	U2 snRNA binding	21873635.	IBA	Function
GO:0030623	U5 snRNA binding	21873635.	IBA	Function
GO:0046540	U4/U6 x U5 tri-snRNP complex	23793891.	IDA	Component
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	20595234.	IDA	Function
GO:0071005	U2-type precatalytic spliceosome	28781166.	IDA	Component
GO:0071007	U2-type catalytic step 2 spliceosome	28076346.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	21873635.	IBA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0071222	cellular response to lipopolysaccharide	-	IEA	Process
GO:0071356	cellular response to tumor necrosis factor	-	IEA	Process
GO:0097157	pre-mRNA intronic binding	21873635.	IBA	Function