EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000174547 (Gene tree)
Gene ID: 65003
Gene Symbol: MRPL11
Alias: N
Full Name: mitochondrial ribosomal protein L11
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 31,664 bases
Position: chr11:66,435,075-66,466,738
Accession: 14042
RBP type: canonical RBP
Summary: This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000415356	Ribosomal_L11	PF00298.19	3.2e-24	1	1
ENSP00000329630	Ribosomal_L11	PF00298.19	4.1e-24	1	1
ENSP00000308897	Ribosomal_L11	PF00298.19	4.7e-24	1	1
ENSP00000431405	Ribosomal_L11	PF00298.19	2.4e-07	1	1
ENSP00000329630	Ribosomal_L11_N	PF03946.14	2.7e-24	1	1
ENSP00000308897	Ribosomal_L11_N	PF03946.14	3.3e-24	1	1
ENSP00000415356	Ribosomal_L11_N	PF03946.14	8.3e-12	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000534488	MRPL11-206	812	-	ENSP00000436904	75 (aa)	-	E9PQB6
ENST00000430466	MRPL11-203	1527	-	ENSP00000415356	166 (aa)	-	Q9Y3B7
ENST00000310999	MRPL11-201	1605	-	ENSP00000308897	192 (aa)	-	Q9Y3B7
ENST00000528272	MRPL11-205	506	-	ENSP00000431405	63 (aa)	-	H0YCD5
ENST00000329819	MRPL11-202	922	XM_017018135	ENSP00000329630	181 (aa)	XP_016873624	Q9Y3B7
ENST00000524576	MRPL11-204	2209	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000174547's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000174547	Alzheimer Disease	1.0753533E-004	17998437

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000174547	rs35313216	11	66456724	G	Corneal astigmatism	30306274	[0.016-0.036] dioptres increase	0.026	EFO_1002040

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174547's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174547	MRPL11	97	65.753	ENSAPOG00000005713	mrpl11	99	59.694	Acanthochromis_polyacanthus
ENSG00000174547	MRPL11	100	93.229	ENSAMEG00000011350	MRPL11	100	93.229	Ailuropoda_melanoleuca
ENSG00000174547	MRPL11	97	65.753	ENSACIG00000010480	mrpl11	93	59.239	Amphilophus_citrinellus
ENSG00000174547	MRPL11	97	65.753	ENSAOCG00000007308	mrpl11	97	61.376	Amphiprion_ocellaris
ENSG00000174547	MRPL11	97	65.753	ENSAPEG00000008704	mrpl11	97	61.376	Amphiprion_percula
ENSG00000174547	MRPL11	97	67.123	ENSATEG00000015240	mrpl11	99	61.458	Anabas_testudineus
ENSG00000174547	MRPL11	100	92.708	ENSANAG00000021898	MRPL11	100	92.708	Aotus_nancymaae
ENSG00000174547	MRPL11	97	64.384	ENSACLG00000018663	mrpl11	97	59.788	Astatotilapia_calliptera
ENSG00000174547	MRPL11	97	69.863	ENSAMXG00000036903	mrpl11	99	64.062	Astyanax_mexicanus
ENSG00000174547	MRPL11	94	91.667	ENSBTAG00000053687	MRPL11	100	91.667	Bos_taurus
ENSG00000174547	MRPL11	95	46.032	WBGene00015133	mrpl-11	94	46.032	Caenorhabditis_elegans
ENSG00000174547	MRPL11	100	90.625	ENSCJAG00000001470	MRPL11	98	90.625	Callithrix_jacchus
ENSG00000174547	MRPL11	94	93.333	ENSCAFG00000012706	MRPL11	100	93.229	Canis_familiaris
ENSG00000174547	MRPL11	94	93.333	ENSCAFG00020015432	MRPL11	100	93.229	Canis_lupus_dingo
ENSG00000174547	MRPL11	94	90.556	ENSCHIG00000014851	MRPL11	100	90.625	Capra_hircus
ENSG00000174547	MRPL11	100	93.750	ENSTSYG00000008712	MRPL11	100	93.750	Carlito_syrichta
ENSG00000174547	MRPL11	94	92.778	ENSCPOG00000000687	MRPL11	100	92.708	Cavia_porcellus
ENSG00000174547	MRPL11	100	93.229	ENSCCAG00000030195	MRPL11	100	93.229	Cebus_capucinus
ENSG00000174547	MRPL11	100	96.354	ENSCATG00000029345	MRPL11	100	96.354	Cercocebus_atys
ENSG00000174547	MRPL11	94	90.000	ENSCLAG00000016161	MRPL11	100	90.104	Chinchilla_lanigera
ENSG00000174547	MRPL11	100	97.396	ENSCSAG00000008217	MRPL11	100	97.396	Chlorocebus_sabaeus
ENSG00000174547	MRPL11	97	84.932	ENSCHOG00000010471	MRPL11	100	91.720	Choloepus_hoffmanni
ENSG00000174547	MRPL11	96	50.000	ENSCING00000004394	-	95	39.894	Ciona_intestinalis
ENSG00000174547	MRPL11	100	97.396	ENSCANG00000029750	MRPL11	100	97.396	Colobus_angolensis_palliatus
ENSG00000174547	MRPL11	100	88.021	ENSCGRG00001012748	Mrpl11	100	88.021	Cricetulus_griseus_chok1gshd
ENSG00000174547	MRPL11	100	88.021	ENSCGRG00000017537	Mrpl11	100	88.021	Cricetulus_griseus_crigri
ENSG00000174547	MRPL11	97	61.644	ENSCSEG00000004826	mrpl11	97	56.614	Cynoglossus_semilaevis
ENSG00000174547	MRPL11	97	65.753	ENSCVAG00000018209	mrpl11	97	61.579	Cyprinodon_variegatus
ENSG00000174547	MRPL11	97	67.123	ENSDARG00000013075	mrpl11	96	66.316	Danio_rerio
ENSG00000174547	MRPL11	93	92.135	ENSDNOG00000037861	MRPL11	100	91.667	Dasypus_novemcinctus
ENSG00000174547	MRPL11	97	82.286	ENSDORG00000023531	Mrpl11	100	89.809	Dipodomys_ordii
ENSG00000174547	MRPL11	83	43.750	FBgn0038234	mRpL11	81	43.750	Drosophila_melanogaster
ENSG00000174547	MRPL11	100	90.104	ENSETEG00000015216	MRPL11	100	90.104	Echinops_telfairi
ENSG00000174547	MRPL11	84	56.429	ENSEBUG00000008014	mrpl11	97	50.847	Eptatretus_burgeri
ENSG00000174547	MRPL11	97	87.671	ENSEASG00005004988	MRPL11	100	86.458	Equus_asinus_asinus
ENSG00000174547	MRPL11	100	93.229	ENSECAG00000013737	MRPL11	100	93.229	Equus_caballus
ENSG00000174547	MRPL11	98	85.714	ENSEEUG00000011113	MRPL11	98	85.714	Erinaceus_europaeus
ENSG00000174547	MRPL11	97	73.973	ENSELUG00000002807	mrpl11	95	66.851	Esox_lucius
ENSG00000174547	MRPL11	93	91.620	ENSFCAG00000028353	MRPL11	100	91.146	Felis_catus
ENSG00000174547	MRPL11	100	88.542	ENSFDAG00000011509	MRPL11	100	88.542	Fukomys_damarensis
ENSG00000174547	MRPL11	97	65.753	ENSFHEG00000015521	mrpl11	97	61.053	Fundulus_heteroclitus
ENSG00000174547	MRPL11	97	64.384	ENSGMOG00000004943	mrpl11	100	62.366	Gadus_morhua
ENSG00000174547	MRPL11	97	64.384	ENSGAFG00000019857	mrpl11	99	59.278	Gambusia_affinis
ENSG00000174547	MRPL11	97	65.753	ENSGACG00000017077	mrpl11	97	60.106	Gasterosteus_aculeatus
ENSG00000174547	MRPL11	97	71.233	ENSGAGG00000013814	MRPL11	99	64.767	Gopherus_agassizii
ENSG00000174547	MRPL11	100	99.479	ENSGGOG00000001300	MRPL11	100	99.479	Gorilla_gorilla
ENSG00000174547	MRPL11	97	64.384	ENSHBUG00000013559	mrpl11	97	60.317	Haplochromis_burtoni
ENSG00000174547	MRPL11	94	89.444	ENSHGLG00000016487	MRPL11	100	89.583	Heterocephalus_glaber_female
ENSG00000174547	MRPL11	94	89.444	ENSHGLG00100017113	MRPL11	100	89.583	Heterocephalus_glaber_male
ENSG00000174547	MRPL11	97	68.493	ENSHCOG00000004011	mrpl11	99	60.204	Hippocampus_comes
ENSG00000174547	MRPL11	97	68.493	ENSIPUG00000021526	MRPL11	97	63.784	Ictalurus_punctatus
ENSG00000174547	MRPL11	97	84.932	ENSSTOG00000025971	MRPL11	100	89.241	Ictidomys_tridecemlineatus
ENSG00000174547	MRPL11	97	86.301	ENSJJAG00000020430	Mrpl11	100	89.062	Jaculus_jaculus
ENSG00000174547	MRPL11	97	65.753	ENSKMAG00000003125	mrpl11	94	63.784	Kryptolebias_marmoratus
ENSG00000174547	MRPL11	97	67.123	ENSLBEG00000007638	mrpl11	97	61.905	Labrus_bergylta
ENSG00000174547	MRPL11	79	54.198	ENSLACG00000005779	MRPL11	86	54.962	Latimeria_chalumnae
ENSG00000174547	MRPL11	97	71.233	ENSLOCG00000000617	mrpl11	99	63.402	Lepisosteus_oculatus
ENSG00000174547	MRPL11	100	90.625	ENSLAFG00000011143	MRPL11	100	90.625	Loxodonta_africana
ENSG00000174547	MRPL11	100	97.396	ENSMFAG00000042321	MRPL11	100	97.396	Macaca_fascicularis
ENSG00000174547	MRPL11	100	97.396	ENSMMUG00000008876	MRPL11	100	97.396	Macaca_mulatta
ENSG00000174547	MRPL11	100	96.875	ENSMNEG00000041903	MRPL11	100	96.875	Macaca_nemestrina
ENSG00000174547	MRPL11	100	96.354	ENSMLEG00000044104	MRPL11	100	96.354	Mandrillus_leucophaeus
ENSG00000174547	MRPL11	97	65.753	ENSMAMG00000021038	mrpl11	97	61.579	Mastacembelus_armatus
ENSG00000174547	MRPL11	97	64.384	ENSMZEG00005005523	mrpl11	97	60.317	Maylandia_zebra
ENSG00000174547	MRPL11	100	88.021	ENSMAUG00000006941	Mrpl11	100	88.021	Mesocricetus_auratus
ENSG00000174547	MRPL11	100	90.625	ENSMICG00000003759	MRPL11	100	90.625	Microcebus_murinus
ENSG00000174547	MRPL11	100	86.458	ENSMOCG00000018594	Mrpl11	100	86.458	Microtus_ochrogaster
ENSG00000174547	MRPL11	95	45.070	ENSMMOG00000002541	mrpl11	96	49.080	Mola_mola
ENSG00000174547	MRPL11	97	80.822	ENSMODG00000008273	MRPL11	100	79.793	Monodelphis_domestica
ENSG00000174547	MRPL11	97	65.753	ENSMALG00000011049	mrpl11	99	62.983	Monopterus_albus
ENSG00000174547	MRPL11	100	87.500	MGP_CAROLIEiJ_G0022526	Mrpl11	100	87.500	Mus_caroli
ENSG00000174547	MRPL11	100	87.500	ENSMUSG00000024902	Mrpl11	100	87.500	Mus_musculus
ENSG00000174547	MRPL11	100	86.979	MGP_PahariEiJ_G0014023	Mrpl11	100	86.979	Mus_pahari
ENSG00000174547	MRPL11	100	87.500	MGP_SPRETEiJ_G0023440	Mrpl11	100	87.500	Mus_spretus
ENSG00000174547	MRPL11	94	92.222	ENSMPUG00000003047	MRPL11	100	92.188	Mustela_putorius_furo
ENSG00000174547	MRPL11	97	87.671	ENSMLUG00000004047	MRPL11	98	90.526	Myotis_lucifugus
ENSG00000174547	MRPL11	100	89.062	ENSNGAG00000005875	Mrpl11	100	89.062	Nannospalax_galili
ENSG00000174547	MRPL11	97	64.384	ENSNBRG00000023089	mrpl11	97	60.317	Neolamprologus_brichardi
ENSG00000174547	MRPL11	100	98.895	ENSNLEG00000028893	MRPL11	100	98.895	Nomascus_leucogenys
ENSG00000174547	MRPL11	93	82.584	ENSMEUG00000010291	MRPL11	100	80.829	Notamacropus_eugenii
ENSG00000174547	MRPL11	97	86.301	ENSODEG00000014340	-	85	89.773	Octodon_degus
ENSG00000174547	MRPL11	97	86.301	ENSODEG00000017704	-	100	90.960	Octodon_degus
ENSG00000174547	MRPL11	79	63.359	ENSONIG00000005480	mrpl11	95	58.750	Oreochromis_niloticus
ENSG00000174547	MRPL11	100	89.062	ENSOCUG00000020926	MRPL11	100	89.062	Oryctolagus_cuniculus
ENSG00000174547	MRPL11	97	65.753	ENSORLG00000001990	mrpl11	97	62.632	Oryzias_latipes
ENSG00000174547	MRPL11	97	65.753	ENSORLG00020020145	mrpl11	97	62.632	Oryzias_latipes_hni
ENSG00000174547	MRPL11	97	65.753	ENSORLG00015009657	mrpl11	97	62.632	Oryzias_latipes_hsok
ENSG00000174547	MRPL11	97	65.753	ENSOMEG00000017598	mrpl11	97	62.105	Oryzias_melastigma
ENSG00000174547	MRPL11	94	89.503	ENSOGAG00000010448	MRPL11	91	89.503	Otolemur_garnettii
ENSG00000174547	MRPL11	94	90.556	ENSOARG00000005178	MRPL11	100	90.625	Ovis_aries
ENSG00000174547	MRPL11	100	100.000	ENSPPAG00000028194	MRPL11	100	100.000	Pan_paniscus
ENSG00000174547	MRPL11	100	92.708	ENSPPRG00000006994	MRPL11	100	92.708	Panthera_pardus
ENSG00000174547	MRPL11	100	92.708	ENSPTIG00000007086	MRPL11	100	92.708	Panthera_tigris_altaica
ENSG00000174547	MRPL11	100	100.000	ENSPTRG00000003924	MRPL11	100	100.000	Pan_troglodytes
ENSG00000174547	MRPL11	100	96.875	ENSPANG00000018675	MRPL11	100	96.875	Papio_anubis
ENSG00000174547	MRPL11	97	71.233	ENSPKIG00000024583	mrpl11	100	64.583	Paramormyrops_kingsleyae
ENSG00000174547	MRPL11	97	69.863	ENSPSIG00000003131	MRPL11	99	64.767	Pelodiscus_sinensis
ENSG00000174547	MRPL11	97	65.753	ENSPMGG00000017736	mrpl11	99	60.825	Periophthalmus_magnuspinnatus
ENSG00000174547	MRPL11	100	85.938	ENSPEMG00000013254	Mrpl11	100	85.938	Peromyscus_maniculatus_bairdii
ENSG00000174547	MRPL11	97	79.452	ENSPCIG00000008435	MRPL11	100	80.829	Phascolarctos_cinereus
ENSG00000174547	MRPL11	97	64.384	ENSPFOG00000009559	mrpl11	94	62.162	Poecilia_formosa
ENSG00000174547	MRPL11	97	64.384	ENSPLAG00000011291	mrpl11	94	61.622	Poecilia_latipinna
ENSG00000174547	MRPL11	64	61.321	ENSPMEG00000018314	mrpl11	85	58.333	Poecilia_mexicana
ENSG00000174547	MRPL11	95	45.070	ENSPREG00000008953	mrpl11	99	50.000	Poecilia_reticulata
ENSG00000174547	MRPL11	100	97.396	ENSPPYG00000003025	MRPL11	100	97.396	Pongo_abelii
ENSG00000174547	MRPL11	100	93.229	ENSPCAG00000008371	MRPL11	100	93.229	Procavia_capensis
ENSG00000174547	MRPL11	100	93.229	ENSPCOG00000013514	MRPL11	100	93.229	Propithecus_coquereli
ENSG00000174547	MRPL11	97	64.384	ENSPNYG00000013744	mrpl11	97	60.317	Pundamilia_nyererei
ENSG00000174547	MRPL11	97	67.123	ENSPNAG00000020525	mrpl11	99	63.021	Pygocentrus_nattereri
ENSG00000174547	MRPL11	100	87.500	ENSRNOG00000019970	mrpl11	100	87.500	Rattus_norvegicus
ENSG00000174547	MRPL11	100	97.396	ENSRBIG00000030370	MRPL11	100	97.396	Rhinopithecus_bieti
ENSG00000174547	MRPL11	100	97.396	ENSRROG00000041021	-	100	97.396	Rhinopithecus_roxellana
ENSG00000174547	MRPL11	95	97.452	ENSRROG00000036860	-	95	96.721	Rhinopithecus_roxellana
ENSG00000174547	MRPL11	73	45.455	YNL185C	MRPL19	94	40.397	Saccharomyces_cerevisiae
ENSG00000174547	MRPL11	100	92.708	ENSSBOG00000019968	MRPL11	100	92.708	Saimiri_boliviensis_boliviensis
ENSG00000174547	MRPL11	97	78.082	ENSSHAG00000009446	MRPL11	100	82.383	Sarcophilus_harrisii
ENSG00000174547	MRPL11	97	72.603	ENSSFOG00015009200	mrpl11	99	65.104	Scleropages_formosus
ENSG00000174547	MRPL11	97	64.384	ENSSMAG00000016343	mrpl11	88	61.404	Scophthalmus_maximus
ENSG00000174547	MRPL11	97	67.123	ENSSDUG00000018338	mrpl11	97	60.317	Seriola_dumerili
ENSG00000174547	MRPL11	97	67.123	ENSSLDG00000022855	mrpl11	97	60.317	Seriola_lalandi_dorsalis
ENSG00000174547	MRPL11	97	64.384	ENSSPAG00000006573	mrpl11	99	61.458	Stegastes_partitus
ENSG00000174547	MRPL11	100	90.625	ENSSSCG00000012943	MRPL11	100	90.625	Sus_scrofa
ENSG00000174547	MRPL11	86	61.379	ENSTRUG00000011804	mrpl11	95	58.084	Takifugu_rubripes
ENSG00000174547	MRPL11	79	63.359	ENSTNIG00000016824	mrpl11	99	59.868	Tetraodon_nigroviridis
ENSG00000174547	MRPL11	100	92.708	ENSTTRG00000002678	MRPL11	100	92.708	Tursiops_truncatus
ENSG00000174547	MRPL11	100	92.708	ENSUAMG00000014879	MRPL11	100	92.708	Ursus_americanus
ENSG00000174547	MRPL11	100	92.708	ENSUMAG00000011244	MRPL11	100	92.708	Ursus_maritimus
ENSG00000174547	MRPL11	94	87.222	ENSVPAG00000003170	MRPL11	100	86.387	Vicugna_pacos
ENSG00000174547	MRPL11	97	86.301	ENSVVUG00000027010	MRPL11	100	91.667	Vulpes_vulpes
ENSG00000174547	MRPL11	97	71.233	ENSXETG00000020574	mrpl11	99	66.146	Xenopus_tropicalis
ENSG00000174547	MRPL11	85	61.702	ENSXCOG00000015719	mrpl11	95	58.537	Xiphophorus_couchianus
ENSG00000174547	MRPL11	97	65.753	ENSXMAG00000023368	mrpl11	98	60.309	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000027	ribosomal large subunit assembly	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	11543634.	NAS	Function
GO:0005515	protein binding	22190034.25416956.27107012.	IPI	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	11543634.	NAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0006412	translation	11543634.	NAS	Process
GO:0015934	large ribosomal subunit	21873635.	IBA	Component
GO:0019843	rRNA binding	21873635.	IBA	Function
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process
GO:0070180	large ribosomal subunit rRNA binding	21873635.	IBA	Function