EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000174740 (Gene tree)
Gene ID: 140886
Gene Symbol: PABPC5
Alias: PABP5
Full Name: poly(A) binding protein cytoplasmic 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 3,990 bases
Position: chrX:91,434,595-91,438,584
Accession: 13629
RBP type: canonical RBP
Summary: This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000308012	RRM_5	PF13893.6	1.6e-12	1	2
ENSP00000308012	RRM_5	PF13893.6	1.6e-12	2	2
ENSP00000362197	RRM_5	PF13893.6	9e-06	1	2
ENSP00000362197	RRM_5	PF13893.6	9e-06	2	2
ENSP00000308012	RRM_1	PF00076.22	8.5e-77	1	4
ENSP00000308012	RRM_1	PF00076.22	8.5e-77	2	4
ENSP00000308012	RRM_1	PF00076.22	8.5e-77	3	4
ENSP00000308012	RRM_1	PF00076.22	8.5e-77	4	4
ENSP00000362197	RRM_1	PF00076.22	4.9e-42	1	2
ENSP00000362197	RRM_1	PF00076.22	4.9e-42	2	2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23275553	Alternative translation initiation augments the human mitochondrial proteome.	Nucleic Acids Res	2013 Feb 1	Kazak L	doi: 10.1093/nar/gks1347

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000312600	PABPC5-201	3221	-	ENSP00000308012	382 (aa)	-	Q96DU9
ENST00000373105	PABPC5-202	1262	-	ENSP00000362197	218 (aa)	-	Q5JQF3

Gene Model

Click here to download ENSG00000174740's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000174740	3-hydroxy-1-methylpropylmercapturic acid	7E-7	26053186
ENSG00000174740	Smoking	7E-7	26053186
ENSG00000174740	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	4E-8	22808956

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174740's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000174740	PABPC5	92	33.803	ENSG00000151923	TIAL1	98	34.783
ENSG00000174740	PABPC5	74	30.508	ENSG00000180098	TRNAU1AP	58	30.409
ENSG00000174740	PABPC5	74	30.952	ENSG00000135486	HNRNPA1	74	30.952
ENSG00000174740	PABPC5	93	59.694	ENSG00000186288	PABPC1L2A	98	59.375
ENSG00000174740	PABPC5	96	31.356	ENSG00000179950	PUF60	63	31.447
ENSG00000174740	PABPC5	100	59.155	ENSG00000151846	PABPC3	58	62.360
ENSG00000174740	PABPC5	98	64.690	ENSG00000070756	PABPC1	99	74.766
ENSG00000174740	PABPC5	100	64.319	ENSG00000090621	PABPC4	99	72.973
ENSG00000174740	PABPC5	96	59.504	ENSG00000101104	PABPC1L	95	57.235
ENSG00000174740	PABPC5	81	35.135	ENSG00000101489	CELF4	51	35.135
ENSG00000174740	PABPC5	97	35.802	ENSG00000107105	ELAVL2	89	35.802
ENSG00000174740	PABPC5	99	59.624	ENSG00000254535	PABPC4L	98	61.798
ENSG00000174740	PABPC5	93	59.694	ENSG00000184388	PABPC1L2B	98	59.375
ENSG00000174740	PABPC5	78	34.524	ENSG00000122566	HNRNPA2B1	62	37.500
ENSG00000174740	PABPC5	93	40.769	ENSG00000143368	SF3B4	72	40.152
ENSG00000174740	PABPC5	93	33.333	ENSG00000116001	TIA1	97	30.201
ENSG00000174740	PABPC5	87	30.939	ENSG00000147140	NONO	70	30.939
ENSG00000174740	PABPC5	69	35.616	ENSG00000159409	CELF3	53	35.616
ENSG00000174740	PABPC5	80	37.349	ENSG00000104177	MYEF2	66	37.805

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174740	PABPC5	99	97.375	ENSAMEG00000020114	PABPC5	100	97.375	Ailuropoda_melanoleuca
ENSG00000174740	PABPC5	100	100.000	ENSANAG00000005063	PABPC5	100	100.000	Aotus_nancymaae
ENSG00000174740	PABPC5	99	96.850	ENSBTAG00000019942	PABPC5	99	96.850	Bos_taurus
ENSG00000174740	PABPC5	100	99.476	ENSCJAG00000003665	PABPC5	100	99.476	Callithrix_jacchus
ENSG00000174740	PABPC5	99	96.850	ENSCAFG00000017452	PABPC5	99	96.850	Canis_familiaris
ENSG00000174740	PABPC5	99	96.850	ENSCHIG00000019004	PABPC5	99	96.850	Capra_hircus
ENSG00000174740	PABPC5	99	97.900	ENSTSYG00000036351	PABPC5	99	97.900	Carlito_syrichta
ENSG00000174740	PABPC5	100	87.958	ENSCAPG00000010714	PABPC5	99	88.421	Cavia_aperea
ENSG00000174740	PABPC5	99	94.488	ENSCPOG00000002555	PABPC5	99	94.488	Cavia_porcellus
ENSG00000174740	PABPC5	100	100.000	ENSCCAG00000032154	PABPC5	100	100.000	Cebus_capucinus
ENSG00000174740	PABPC5	100	99.738	ENSCATG00000043083	PABPC5	100	99.738	Cercocebus_atys
ENSG00000174740	PABPC5	99	95.801	ENSCLAG00000000647	PABPC5	99	95.801	Chinchilla_lanigera
ENSG00000174740	PABPC5	100	99.738	ENSCSAG00000000065	PABPC5	100	99.738	Chlorocebus_sabaeus
ENSG00000174740	PABPC5	100	99.738	ENSCANG00000011473	PABPC5	100	99.738	Colobus_angolensis_palliatus
ENSG00000174740	PABPC5	99	94.226	ENSCGRG00000018699	Pabpc5	99	94.226	Cricetulus_griseus_crigri
ENSG00000174740	PABPC5	100	91.584	ENSETEG00000011832	PABPC5	99	78.796	Echinops_telfairi
ENSG00000174740	PABPC5	99	97.638	ENSEASG00005014396	PABPC5	99	97.638	Equus_asinus_asinus
ENSG00000174740	PABPC5	99	97.638	ENSECAG00000003452	PABPC5	99	97.638	Equus_caballus
ENSG00000174740	PABPC5	99	97.113	ENSFCAG00000004998	PABPC5	99	97.113	Felis_catus
ENSG00000174740	PABPC5	99	96.325	ENSFDAG00000000126	PABPC5	99	96.325	Fukomys_damarensis
ENSG00000174740	PABPC5	100	100.000	ENSGGOG00000007622	PABPC5	100	100.000	Gorilla_gorilla
ENSG00000174740	PABPC5	100	96.330	ENSJJAG00000011960	Pabpc5	100	96.330	Jaculus_jaculus
ENSG00000174740	PABPC5	100	99.738	ENSMFAG00000024561	PABPC5	100	99.738	Macaca_fascicularis
ENSG00000174740	PABPC5	100	99.738	ENSMMUG00000011562	PABPC5	100	99.738	Macaca_mulatta
ENSG00000174740	PABPC5	100	99.738	ENSMNEG00000037604	PABPC5	100	99.738	Macaca_nemestrina
ENSG00000174740	PABPC5	100	99.738	ENSMLEG00000028318	PABPC5	100	99.738	Mandrillus_leucophaeus
ENSG00000174740	PABPC5	99	96.588	ENSMICG00000041706	PABPC5	99	96.588	Microcebus_murinus
ENSG00000174740	PABPC5	99	95.538	ENSMOCG00000001554	Pabpc5	99	95.538	Microtus_ochrogaster
ENSG00000174740	PABPC5	99	94.987	MGP_CAROLIEiJ_G0033367	Pabpc5	99	94.987	Mus_caroli
ENSG00000174740	PABPC5	99	95.515	ENSMUSG00000034732	Pabpc5	99	95.515	Mus_musculus
ENSG00000174740	PABPC5	99	95.801	MGP_PahariEiJ_G0031908	Pabpc5	99	95.801	Mus_pahari
ENSG00000174740	PABPC5	99	95.515	MGP_SPRETEiJ_G0034533	Pabpc5	99	95.515	Mus_spretus
ENSG00000174740	PABPC5	99	96.588	ENSMPUG00000018465	PABPC5	99	96.588	Mustela_putorius_furo
ENSG00000174740	PABPC5	99	96.063	ENSMLUG00000008244	PABPC5	99	96.063	Myotis_lucifugus
ENSG00000174740	PABPC5	100	95.413	ENSNGAG00000004371	Pabpc5	100	95.413	Nannospalax_galili
ENSG00000174740	PABPC5	100	100.000	ENSNLEG00000035086	PABPC5	100	100.000	Nomascus_leucogenys
ENSG00000174740	PABPC5	98	97.285	ENSOPRG00000000856	PABPC5	100	97.285	Ochotona_princeps
ENSG00000174740	PABPC5	99	97.900	ENSOCUG00000010919	PABPC5	99	97.900	Oryctolagus_cuniculus
ENSG00000174740	PABPC5	99	96.850	ENSOGAG00000006882	PABPC5	99	96.850	Otolemur_garnettii
ENSG00000174740	PABPC5	99	97.113	ENSOARG00000010260	PABPC5	99	97.113	Ovis_aries
ENSG00000174740	PABPC5	100	99.738	ENSPPAG00000007378	PABPC5	100	99.738	Pan_paniscus
ENSG00000174740	PABPC5	99	97.113	ENSPPRG00000010742	PABPC5	99	97.113	Panthera_pardus
ENSG00000174740	PABPC5	99	97.113	ENSPTIG00000001480	PABPC5	99	97.113	Panthera_tigris_altaica
ENSG00000174740	PABPC5	100	100.000	ENSPTRG00000022078	PABPC5	100	100.000	Pan_troglodytes
ENSG00000174740	PABPC5	100	99.738	ENSPANG00000018282	PABPC5	100	99.738	Papio_anubis
ENSG00000174740	PABPC5	99	95.013	ENSPEMG00000000171	Pabpc5	99	95.013	Peromyscus_maniculatus_bairdii
ENSG00000174740	PABPC5	100	100.000	ENSPPYG00000020526	PABPC5	100	100.000	Pongo_abelii
ENSG00000174740	PABPC5	99	97.091	ENSPCAG00000015577	PABPC5	100	97.091	Procavia_capensis
ENSG00000174740	PABPC5	99	97.375	ENSPCOG00000000676	PABPC5	99	97.375	Propithecus_coquereli
ENSG00000174740	PABPC5	99	97.375	ENSPVAG00000006465	PABPC5	99	97.375	Pteropus_vampyrus
ENSG00000174740	PABPC5	99	95.538	ENSRNOG00000003354	Pabpc5	99	95.538	Rattus_norvegicus
ENSG00000174740	PABPC5	100	99.738	ENSRBIG00000011760	PABPC5	100	99.738	Rhinopithecus_bieti
ENSG00000174740	PABPC5	100	99.738	ENSRROG00000036708	PABPC5	100	99.738	Rhinopithecus_roxellana
ENSG00000174740	PABPC5	100	99.738	ENSSBOG00000008658	PABPC5	100	99.738	Saimiri_boliviensis_boliviensis
ENSG00000174740	PABPC5	99	94.226	ENSSARG00000014012	PABPC5	99	94.226	Sorex_araneus
ENSG00000174740	PABPC5	99	96.850	ENSSSCG00000040194	PABPC5	99	96.850	Sus_scrofa
ENSG00000174740	PABPC5	99	98.163	ENSTBEG00000016482	PABPC5	99	98.163	Tupaia_belangeri
ENSG00000174740	PABPC5	99	96.850	ENSUAMG00000013627	PABPC5	99	96.850	Ursus_americanus
ENSG00000174740	PABPC5	99	96.588	ENSUMAG00000023934	PABPC5	99	96.588	Ursus_maritimus
ENSG00000174740	PABPC5	99	97.375	ENSVPAG00000001063	PABPC5	99	97.375	Vicugna_pacos
ENSG00000174740	PABPC5	99	97.113	ENSVVUG00000013172	PABPC5	99	97.113	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0008143	poly(A) binding	21873635.	IBA	Function
GO:0008266	poly(U) RNA binding	21873635.	IBA	Function
GO:0010494	cytoplasmic stress granule	21873635.	IBA	Component
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chrX	91434673	5'Flank	novel		0.47
BLCA	chrX	91436283	Missense_Mutation	novel	G236R	0.39
BLCA	chrX	91436284	Missense_Mutation	NA	G236V	0.38
BLCA	chrX	91436531	Silent	novel	L318L	0.13
BLCA	chrX	91435803	Silent	novel	L76L	0.32
BLCA	chrX	91436636	Silent	rs759967355	E353E	0.94
BLCA	chrX	91436593	Missense_Mutation	novel	Q339P	0.24
BRCA	chrX	91435650	Missense_Mutation	novel	L25V	0.18
BRCA	chrX	91436256	Missense_Mutation	novel	S227G	0.34
BRCA	chrX	91435559	5'UTR	novel		0.22
BRCA	chrX	91435699	Missense_Mutation	NA	A41D	0.19
BRCA	chrX	91436599	Missense_Mutation	NA	K341R	0.36
CESC	chrX	91435710	Silent	novel	R45R	0.38
CESC	chrX	91435735	Missense_Mutation	NA	P53L	0.42
CESC	chrX	91435974	Silent	NA	L133L	0.19
CESC	chrX	91436513	Silent	novel	T312T	0.07
CESC	chrX	91435780	Missense_Mutation	NA	F68S	0.47
CESC	chrX	91434780	5'Flank	novel		0.18
CESC	chrX	91435685	Silent	rs761484590	K36K	0.42
CESC	chrX	91436409	Frame_Shift_Ins	novel	*I278Sfs5**	0.15
CESC	chrX	91436974	3'UTR	novel		0.46
CESC	chrX	91437743	3'UTR	novel		0.47
CESC	chrX	91435787	Silent	rs747339331	A70A	0.18
CESC	chrX	91436652	Missense_Mutation	novel	D359N	0.39
CESC	chrX	91437417	3'UTR	novel		0.27
CESC	chrX	91436629	Missense_Mutation	NA	F351S	0.1
CESC	chrX	91434885	5'UTR	novel		0.32
CESC	chrX	91435907	Missense_Mutation	NA	I110M	0.12
CESC	chrX	91434884	5'UTR	novel		0.37
CESC	chrX	91436820	3'UTR	novel		0.54
CESC	chrX	91437061	3'UTR	novel		0.16
CESC	chrX	91435590	Missense_Mutation	rs779583126	E5K	0.24
CESC	chrX	91436096	Silent	NA	R173R	0.21
CESC	chrX	91436588	Silent	novel	V337V	0.15
CESC	chrX	91437778	3'UTR	novel		0.15
COAD	chrX	91435743	Missense_Mutation	NA	R56C	0.55
COAD	chrX	91435491	5'UTR	novel		0.52
COAD	chrX	91436592	Nonsense_Mutation	NA	Q339*	0.5
COAD	chrX	91438264	3'UTR	novel		0.19
COAD	chrX	91437426	3'UTR	novel		0.51
COAD	chrX	91436339	Missense_Mutation	novel	K254N	0.07
COAD	chrX	91436874	3'UTR	novel		0.22
COAD	chrX	91437211	3'UTR	novel		0.12
COAD	chrX	91436019	Missense_Mutation	novel	A148T	0.32	RRM_5
COAD	chrX	91438035	3'UTR	novel		0.87
COAD	chrX	91436445	Missense_Mutation	rs772523316	R290W	0.73
COAD	chrX	91437860	3'UTR	novel		0.13
COAD	chrX	91438239	3'UTR	novel		0.34
COAD	chrX	91435695	Missense_Mutation	rs767399259	P40S	0.44
COAD	chrX	91437732	3'UTR	novel		0.25
COAD	chrX	91436137	Missense_Mutation	rs779221642	A187E	0.22	RRM_5
COAD	chrX	91435721	Silent	rs760880235	R48R	0.2
COAD	chrX	91437852	3'UTR	novel		0.6
COAD	chrX	91436196	Missense_Mutation	novel	G207R	0.08	RRM_5
COAD	chrX	91434779	5'Flank	novel		0.33
COAD	chrX	91435899	Missense_Mutation	novel	I108V	0.27
COAD	chrX	91438395	3'UTR	novel		0.72
COAD	chrX	91434827	5'UTR	novel		0.11
COAD	chrX	91435786	Missense_Mutation	NA	A70V	0.17
COAD	chrX	91436820	3'UTR	novel		1
COAD	chrX	91437508	3'UTR	novel		0.36
COAD	chrX	91436820	3'UTR	novel		0.48
COAD	chrX	91436925	3'UTR	novel		0.42
COAD	chrX	91437852	3'UTR	novel		0.06
COAD	chrX	91435842	Missense_Mutation	NA	F89L	0.34
COAD	chrX	91438213	3'UTR	novel		0.56
COAD	chrX	91437899	3'UTR	novel		0.07
COAD	chrX	91436134	Missense_Mutation	novel	R186Q	0.71	RRM_5
COAD	chrX	91437238	3'UTR	novel		0.3
COAD	chrX	91437989	3'UTR	novel		0.43
COAD	chrX	91438460	3'UTR	novel		0.58
COAD	chrX	91435829	Missense_Mutation	novel	I84M	0.29
COAD	chrX	91436437	Missense_Mutation	novel	R287I	0.25
COAD	chrX	91436947	3'UTR	novel		0.15
COAD	chrX	91437683	3'UTR	novel		0.17
COAD	chrX	91438328	3'UTR	novel		0.21
COAD	chrX	91437998	3'UTR	novel		0.5
COAD	chrX	91436095	Missense_Mutation	novel	R173H	0.06	RRM_5
COAD	chrX	91437560	3'UTR	rs190034364		0.23
COAD	chrX	91436241	Frame_Shift_Ins	novel	*Y222Ffs6**	0.06
COAD	chrX	91437420	3'UTR	novel		0.03
COAD	chrX	91437421	3'UTR	novel		0.03
COAD	chrX	91438485	3'UTR	novel		0.02
COAD	chrX	91438306	3'UTR	novel		0.19
COAD	chrX	91436557	Nonsense_Mutation	novel	S327*	0.21
COAD	chrX	91437211	3'UTR	novel		0.44
DLBC	chrX	91437176	3'UTR	novel		0.36
ESCA	chrX	91435544	5'UTR	novel		0.61
ESCA	chrX	91436925	3'UTR	novel		0.16
ESCA	chrX	91435714	Missense_Mutation	novel	F46C	0.76
ESCA	chrX	91436008	Missense_Mutation	novel	S144C	0.68	RRM_5
ESCA	chrX	91435521	5'UTR	novel		0.12
ESCA	chrX	91435687	Missense_Mutation	NA	K37T	0.63
ESCA	chrX	91437397	3'UTR	novel		0.13
ESCA	chrX	91436870	3'UTR	novel		0.37
ESCA	chrX	91434757	5'Flank	novel		0.75
ESCA	chrX	91437826	3'UTR	novel		0.79
ESCA	chrX	91437383	3'UTR	novel		0.77
ESCA	chrX	91435650	Missense_Mutation	novel	L25V	0.88
ESCA	chrX	91437660	3'UTR	novel		0.81
ESCA	chrX	91437247	3'UTR	novel		0.26
GBM	chrX	91435989	Missense_Mutation	NA	V138I	0.35
HNSC	chrX	91435671	Missense_Mutation	novel	D32Y	0.32
HNSC	chrX	91436442	Missense_Mutation	novel	E289Q	0.32
HNSC	chrX	91436202	Missense_Mutation	NA	D209N	0.15
HNSC	chrX	91435744	Missense_Mutation	novel	R56L	0.64
HNSC	chrX	91435656	Missense_Mutation	novel	P27T	0.79
HNSC	chrX	91435657	Missense_Mutation	novel	P27Q	0.79
HNSC	chrX	91436156	Silent	novel	R193R	0.47
HNSC	chrX	91436538	Missense_Mutation	rs755927278	E321K	0.32
HNSC	chrX	91435907	Missense_Mutation	NA	I110M	0.07
HNSC	chrX	91435580	Translation_Start_Site	novel	M1?	0.59
HNSC	chrX	91435737	Missense_Mutation	novel	V54L	0.45
HNSC	chrX	91436386	Missense_Mutation	rs367670485	Y270C	0.25
HNSC	chrX	91436046	Missense_Mutation	novel	A157S	0.13	RRM_5
KIRC	chrX	91436351	Silent	NA	D258D	0.25
KIRC	chrX	91436445	Missense_Mutation	NA	R290G	0.39
KIRC	chrX	91436475	Frame_Shift_Del	novel	*P300Ifs14**	0.06
LGG	chrX	91436274	Missense_Mutation	novel	D233Y	0.32
LGG	chrX	91436184	Missense_Mutation	NA	V203I	0.04	RRM_5
LIHC	chrX	91437612	3'UTR	novel		0.34
LIHC	chrX	91437241	3'UTR	novel		0.21
LIHC	chrX	91435561	5'UTR	novel		0.33
LIHC	chrX	91436481	Missense_Mutation	novel	V302L	0.31
LIHC	chrX	91435700	Silent	NA	A41A	0.63
LIHC	chrX	91437660	3'UTR	novel		0.11
LIHC	chrX	91435656	Missense_Mutation	NA	P27S	0.25
LIHC	chrX	91436013	Missense_Mutation	NA	G146C	0.69	RRM_5
LUAD	chrX	91436733	3'UTR	novel		0.22
LUAD	chrX	91435698	Missense_Mutation	novel	A41S	0.9
LUAD	chrX	91436534	Missense_Mutation	novel	K319N	0.1
LUAD	chrX	91436566	Missense_Mutation	rs779133384	R330Q	0.66
LUAD	chrX	91435872	Missense_Mutation	NA	R99S	0.22
LUAD	chrX	91436099	Silent	NA	Q174Q	0.31
LUAD	chrX	91435788	Missense_Mutation	novel	D71Y	0.7
LUAD	chrX	91435529	5'UTR	novel		0.23
LUAD	chrX	91436685	Missense_Mutation	NA	P370T	0.62
LUAD	chrX	91435939	Missense_Mutation	novel	A121D	0.18
LUAD	chrX	91435796	Missense_Mutation	rs769429858	E73D	0.17
LUAD	chrX	91436249	Silent	NA	P224P	0.4
LUAD	chrX	91436152	Missense_Mutation	NA	T192N	0.22	RRM_5
LUAD	chrX	91435754	Silent	novel	L59L	0.8
LUAD	chrX	91435840	Missense_Mutation	NA	P88L	0.17
LUAD	chrX	91435949	Nonsense_Mutation	NA	Y124*	0.17
LUAD	chrX	91435802	Silent	NA	A75A	0.36
LUAD	chrX	91436553	Frame_Shift_Del	novel	*S327Qfs7**	0.12
LUAD	chrX	91436716	Missense_Mutation	NA	R380P	0.29
LUAD	chrX	91435777	Missense_Mutation	novel	R67L	0.16
LUAD	chrX	91436083	Missense_Mutation	NA	R169L	0.48	RRM_5
LUAD	chrX	91436475	Missense_Mutation	NA	P300T	0.42
LUAD	chrX	91436645	Missense_Mutation	NA	K356N	0.89
LUAD	chrX	91436597	Silent	NA	G340G	0.13
LUAD	chrX	91436664	Missense_Mutation	NA	G363C	0.2
LUAD	chrX	91436484	Missense_Mutation	novel	P303T	0.12
LUAD	chrX	91436233	Missense_Mutation	rs763059925	F219S	0.52
LUSC	chrX	91436336	Silent	novel	Q253Q	0.24
LUSC	chrX	91436407	Missense_Mutation	novel	K277I	0.8
LUSC	chrX	91436647	Missense_Mutation	NA	A357V	0.39
LUSC	chrX	91435600	Missense_Mutation	novel	P8H	0.24
LUSC	chrX	91436004	Missense_Mutation	novel	G143C	0.47	RRM_5
LUSC	chrX	91436328	Missense_Mutation	novel	A251S	0.39
LUSC	chrX	91436562	Missense_Mutation	rs749117182	S329C	0.65
LUSC	chrX	91436157	Missense_Mutation	novel	D194N	0.67	RRM_5
LUSC	chrX	91435606	Missense_Mutation	novel	G10V	0.28
LUSC	chrX	91436478	Missense_Mutation	novel	G301W	0.24
LUSC	chrX	91436126	Silent	novel	P183P	0.18
LUSC	chrX	91436788	3'UTR	novel		0.88
LUSC	chrX	91436034	Missense_Mutation	novel	D153Y	0.73	RRM_5
LUSC	chrX	91436373	Nonsense_Mutation	NA	G266*	0.3
LUSC	chrX	91436384	Silent	novel	L269L	0.25
LUSC	chrX	91436538	Nonsense_Mutation	novel	E321*	0.69
LUSC	chrX	91436004	Missense_Mutation	novel	G143C	0.11	RRM_5
LUSC	chrX	91436005	Missense_Mutation	novel	G143V	0.11	RRM_5
LUSC	chrX	91436681	Silent	novel	S368S	0.79
LUSC	chrX	91436255	Missense_Mutation	novel	E226D	0.53
LUSC	chrX	91435735	Missense_Mutation	NA	P53Q	0.48
LUSC	chrX	91436545	Missense_Mutation	novel	S323F	0.2
OV	chrX	91436014	Missense_Mutation	NA	G146A	0.23	RRM_5
OV	chrX	91436626	Missense_Mutation	novel	S350Y	0.11
OV	chrX	91436274	Missense_Mutation	novel	D233N	0.05
OV	chrX	91436050	Missense_Mutation	NA	A158D	0.13	RRM_5
OV	chrX	91436331	Missense_Mutation	novel	A252T	0.09
OV	chrX	91437869	3'UTR	novel		0.2
OV	chrX	91435891	Missense_Mutation	NA	V105E	0.12
PAAD	chrX	91436095	Missense_Mutation	novel	R173H	0.26	RRM_5
PAAD	chrX	91436367	Missense_Mutation	novel	I264F	0.32
PRAD	chrX	91436470	Missense_Mutation	NA	R298Q	0.11
PRAD	chrX	91435631	Silent	rs745592341	A18A	0.79
READ	chrX	91436977	3'UTR	novel		0.21
READ	chrX	91437589	3'UTR	novel		0.17
READ	chrX	91437200	3'UTR	novel		0.64
READ	chrX	91437212	3'UTR	novel		0.82
READ	chrX	91435720	Missense_Mutation	NA	R48Q	0.29
READ	chrX	91436445	Missense_Mutation	rs772523316	R290W	0.7
READ	chrX	91435929	Missense_Mutation	NA	D118Y	0.73
READ	chrX	91436752	3'UTR	novel		0.83
READ	chrX	91435913	Missense_Mutation	NA	N112K	0.65
READ	chrX	91436595	Missense_Mutation	novel	G340S	0.1
READ	chrX	91436045	Silent	rs770896837	A156A	0.28
SARC	chrX	91434891	5'UTR	novel		0.42
SARC	chrX	91434890	5'UTR	novel		0.18
SARC	chrX	91437443	3'UTR	novel		0.77
SKCM	chrX	91436349	Missense_Mutation	NA	D258H	0.17
SKCM	chrX	91435557	5'UTR	novel		0.38
SKCM	chrX	91436565	Missense_Mutation	rs768706643	R330W	0.73
SKCM	chrX	91436123	Silent	NA	F182F	0.37
SKCM	chrX	91436124	Missense_Mutation	novel	P183S	0.37	RRM_5
STAD	chrX	91436204	Silent	NA	D209D	0.18
STAD	chrX	91436701	Missense_Mutation	novel	L375P	0.4
STAD	chrX	91435959	Missense_Mutation	NA	A128S	0.77
STAD	chrX	91435586	Silent	NA	S3S	0.75
STAD	chrX	91435845	Missense_Mutation	novel	R90C	0.66
STAD	chrX	91436416	Missense_Mutation	NA	R280H	0.26
STAD	chrX	91435623	Missense_Mutation	NA	L16F	0.21
STAD	chrX	91435786	Missense_Mutation	NA	A70V	0.24
STAD	chrX	91436324	Silent	rs752338428	H249H	0.15
STAD	chrX	91435640	Silent	NA	Y21Y	0.36
STAD	chrX	91436446	Missense_Mutation	NA	R290Q	0.17
STAD	chrX	91436230	Missense_Mutation	novel	L218R	0.66
STAD	chrX	91435691	Missense_Mutation	NA	F38L	0.76
STAD	chrX	91435692	Missense_Mutation	NA	R39G	0.76
STAD	chrX	91435586	Silent	NA	S3S	0.21
STAD	chrX	91435989	Missense_Mutation	NA	V138I	0.28
THYM	chrX	91436714	Missense_Mutation	novel	R379S	0.45
UCEC	chrX	91436312	Missense_Mutation	novel	R245S	0.07
UCEC	chrX	91436636	Missense_Mutation	NA	E353D	0.36
UCEC	chrX	91435445	5'UTR	novel		0.15
UCEC	chrX	91437821	3'UTR	novel		0.32
UCEC	chrX	91435474	5'UTR	novel		0.42
UCEC	chrX	91435924	Missense_Mutation	novel	S116F	0.3
UCEC	chrX	91437426	3'UTR	novel		0.42
UCEC	chrX	91436723	Silent	NA	C382C	0.08
UCEC	chrX	91436601	Nonsense_Mutation	NA	G342*	0.59
UCEC	chrX	91438264	3'UTR	novel		0.49
UCEC	chrX	91437288	3'UTR	novel		0.23
UCEC	chrX	91436211	Missense_Mutation	novel	D212Y	0.38
UCEC	chrX	91435553	5'UTR	novel		0.11
UCEC	chrX	91435479	5'UTR	novel		0.42
UCEC	chrX	91435890	Missense_Mutation	NA	V105L	0.1
UCEC	chrX	91437346	3'UTR	novel		0.22
UCEC	chrX	91434800	5'Flank	novel		0.12
UCEC	chrX	91436820	3'UTR	novel		0.38
UCEC	chrX	91435737	Missense_Mutation	novel	V54M	0.51
UCEC	chrX	91435814	Missense_Mutation	NA	M79I	0.28
UCEC	chrX	91436133	Missense_Mutation	NA	R186W	0.19	RRM_5
UCEC	chrX	91437602	3'UTR	novel		0.34
UCEC	chrX	91436370	Missense_Mutation	novel	D265N	0.33
UCEC	chrX	91436339	Silent	NA	K254K	0.25
UCEC	chrX	91436333	Silent	novel	A252A	0.43
UCEC	chrX	91437049	3'UTR	rs779421267		0.47
UCEC	chrX	91436849	3'UTR	novel		0.39
UCEC	chrX	91437967	3'UTR	novel		0.12
UCEC	chrX	91435616	Missense_Mutation	novel	K13N	0.18
UCEC	chrX	91436432	Silent	novel	R285R	0.44
UCEC	chrX	91436549	Silent	novel	S324S	0.42
UCEC	chrX	91438547	3'UTR	novel		0.24
UCEC	chrX	91437351	3'UTR	novel		0.28
UCEC	chrX	91437852	3'UTR	novel		0.35
UCEC	chrX	91436415	Missense_Mutation	novel	R280C	0.27
UCEC	chrX	91437205	3'UTR	novel		0.31
UCEC	chrX	91436820	3'UTR	novel		0.46
UCEC	chrX	91436201	Silent	rs770843647	D208D	0.43
UCEC	chrX	91436538	Nonsense_Mutation	novel	E321*	0.45
UCEC	chrX	91436369	Silent	rs781301174	I264I	0.13
UCEC	chrX	91436574	Missense_Mutation	novel	V333M	0.14
UCEC	chrX	91437346	3'UTR	novel		0.11
UCEC	chrX	91437768	3'UTR	novel		0.41
UCEC	chrX	91436324	Silent	rs752338428	H249H	0.43
UCEC	chrX	91436890	3'UTR	novel		0.42
UCEC	chrX	91436820	3'UTR	novel		0.27
UCEC	chrX	91434780	5'Flank	novel		0.47
UCEC	chrX	91435526	5'UTR	novel		0.43
UCEC	chrX	91436003	Silent	novel	N142N	0.43
UCEC	chrX	91436274	Missense_Mutation	novel	D233N	0.5
UCEC	chrX	91435553	5'UTR	novel		0.39
UCEC	chrX	91436820	3'UTR	novel		0.39
UCEC	chrX	91436184	Missense_Mutation	NA	V203I	0.05	RRM_5
UCEC	chrX	91436191	Missense_Mutation	NA	N205S	0.47	RRM_5
UCEC	chrX	91436820	3'UTR	novel		0.26
UCEC	chrX	91435586	Silent	NA	S3S	0.31
UCEC	chrX	91436202	Missense_Mutation	NA	D209N	0.38
UCEC	chrX	91436818	3'UTR	novel		0.43
UCEC	chrX	91434751	5'Flank	novel		0.31
UCEC	chrX	91437211	3'UTR	novel		0.24
UCEC	chrX	91437852	3'UTR	novel		0.46
UCEC	chrX	91436820	3'UTR	novel		0.45
UCEC	chrX	91437852	3'UTR	novel		0.36
UCEC	chrX	91436214	Missense_Mutation	rs770093157	E213K	0.21
UCEC	chrX	91437106	3'UTR	novel		0.19
UCEC	chrX	91435673	Silent	novel	D32D	0.33
UCEC	chrX	91436566	Missense_Mutation	NA	R330L	0.42
UCEC	chrX	91436978	3'UTR	novel		0.41
UCEC	chrX	91436460	Nonsense_Mutation	novel	E295*	0.3
UCEC	chrX	91437450	3'UTR	novel		0.12
UCEC	chrX	91437665	3'UTR	novel		0.34
UCEC	chrX	91435491	5'UTR	novel		0.31
UCEC	chrX	91436469	Missense_Mutation	novel	R298W	0.29
UCEC	chrX	91436911	3'UTR	novel		0.49
UCEC	chrX	91437669	3'UTR	novel		0.34
UCEC	chrX	91438356	3'UTR	novel		0.38
UCEC	chrX	91436978	3'UTR	novel		0.34
UCEC	chrX	91434689	5'Flank	novel		0.5
UCEC	chrX	91434855	5'UTR	novel		0.36
UCEC	chrX	91435735	Missense_Mutation	NA	P53L	0.39
UCEC	chrX	91436021	Silent	novel	A148A	0.14
UCEC	chrX	91436820	3'UTR	novel		0.34
UCEC	chrX	91436978	3'UTR	novel		0.27
UCEC	chrX	91438329	3'UTR	novel		0.17
UCEC	chrX	91435479	5'UTR	novel		0.35
UCEC	chrX	91436082	Missense_Mutation	NA	R169W	0.34	RRM_5
UCEC	chrX	91436782	3'UTR	novel		0.43
UCEC	chrX	91438082	3'UTR	novel		0.33
UCEC	chrX	91436472	Missense_Mutation	novel	P299S	0.33
UCEC	chrX	91435684	Missense_Mutation	novel	K36R	0.5
UCEC	chrX	91437244	3'UTR	novel		0.45
UCEC	chrX	91437730	3'UTR	rs770615407		0.13
UCEC	chrX	91438156	3'UTR	novel		0.31
UCEC	chrX	91436214	Missense_Mutation	rs770093157	E213K	0.17
UCEC	chrX	91437021	3'UTR	novel		0.11
UCEC	chrX	91438067	3'UTR	novel		0.15
UCEC	chrX	91438145	3'UTR	novel		0.61
UCEC	chrX	91436820	3'UTR	novel		0.48
UCEC	chrX	91438224	3'UTR	novel		0.21
UCEC	chrX	91438380	3'UTR	novel		0.28
UCEC	chrX	91436820	3'UTR	novel		0.24
UCEC	chrX	91435485	5'UTR	novel		0.62
UCEC	chrX	91435641	Missense_Mutation	NA	V22M	0.09
UCEC	chrX	91435587	Frame_Shift_Del	novel	*E5Sfs50**	0.27
UCEC	chrX	91436978	3'UTR	novel		0.12
UCEC	chrX	91437439	3'UTR	novel		0.29
UCEC	chrX	91436820	3'UTR	novel		0.27
UCEC	chrX	91435961	Silent	NA	A128A	0.46
UCEC	chrX	91436820	3'UTR	novel		0.24
UCEC	chrX	91436668	Missense_Mutation	rs751297464	R364H	0.5
UCEC	chrX	91436498	Missense_Mutation	NA	K307N	0.32
UCEC	chrX	91437662	3'UTR	novel		0.27
UCEC	chrX	91437805	3'UTR	novel		0.38
UCEC	chrX	91435496	5'UTR	novel		0.43
UCEC	chrX	91437106	3'UTR	novel		0.51
UCEC	chrX	91435623	Missense_Mutation	NA	L16I	0.24
UCEC	chrX	91436297	Silent	NA	G240G	0.28
UCEC	chrX	91436819	3'UTR	novel		0.24
UCEC	chrX	91436820	3'UTR	novel		0.3
UCEC	chrX	91434803	5'Flank	novel		0.21
UCEC	chrX	91437050	3'UTR	rs750743717		0.41
UCEC	chrX	91435577	5'UTR	novel		0.29
UCEC	chrX	91436402	Silent	rs371461611	Q275Q	0.37
UCEC	chrX	91436801	3'UTR	novel		0.11
UCEC	chrX	91437079	3'UTR	novel		0.4
UCEC	chrX	91437665	3'UTR	novel		0.35
UCEC	chrX	91434894	Splice_Region	novel		0.4
UCEC	chrX	91435788	Missense_Mutation	novel	D71N	0.3
UCEC	chrX	91436161	Missense_Mutation	novel	R195K	0.4	RRM_5
UCEC	chrX	91437495	3'UTR	novel		0.35
UCEC	chrX	91438451	3'UTR	novel		0.46
UCS	chrX	91435677	Missense_Mutation	novel	L34F	0.52
UCS	chrX	91435526	5'UTR	novel		0.2
UCS	chrX	91435890	Missense_Mutation	NA	V105L	0.08
UCS	chrX	91436339	Missense_Mutation	novel	K254N	0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0051	Kaplan-Meier Survival Analysis
STAD	0.01	Kaplan-Meier Survival Analysis
MESO	0.036	Kaplan-Meier Survival Analysis
LUSC	0.049	Kaplan-Meier Survival Analysis
KIRP	0.0099	Kaplan-Meier Survival Analysis
PAAD	0.025	Kaplan-Meier Survival Analysis
LAML	0.0075	Kaplan-Meier Survival Analysis
LGG	0.00016	Kaplan-Meier Survival Analysis
CHOL	0.021	Kaplan-Meier Survival Analysis
UVM	0.033	Kaplan-Meier Survival Analysis