EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000174780 (Gene tree)
Gene ID
6731
Gene Symbol
SRP72
Alias
N
Full Name
signal recognition particle 72
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
36,346 bases
Position
chr4:56,467,336-56,503,681
Accession
11303
RBP type
canonical RBP
Summary
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000424576SRP72PF08492.121.4e-2111
ENSP00000342181SRP72PF08492.121.6e-2111
ENSP00000495128SRP72PF08492.121.6e-2111
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
1377027Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative.Biochemistry1992 Jun 30Janiak F-
21073748Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA.BMC Mol Biol2010 Nov 13Iakhiaeva Edoi: 10.1186/1471-2199-11-83.
18347438Identification of the RNA binding regions of SRP68/72 and SRP72 by systematic mutagenesis of human SRP RNA.RNA Biol2007 NovYin J-
15588816Identification of an RNA-binding domain in human SRP72.J Mol Biol2005 Jan 28Iakhiaeva E-
16672232Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.Protein Sci2006 JunIakhiaeva E-
18441046The 5e motif of eukaryotic signal recognition particle RNA contains a conserved adenosine for the binding of SRP72.RNA2008 JunIakhiaeva Edoi: 10.1261/rna.979508
17254600Protein-induced conformational changes of RNA during the assembly of human signal recognition particle.J Mol Biol2007 Mar 16Menichelli E-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000642900SRP72-2063855XM_024454192ENSP00000495128671 (aa)XP_024309960O76094
ENST00000505314SRP72-2031006-ENSP00000425190335 (aa)-D6RDY6
ENST00000510663SRP72-2052406-ENSP00000424576610 (aa)-O76094
ENST00000646579SRP72-209766--- (aa)--
ENST00000507126SRP72-2042235--- (aa)--
ENST00000646222SRP72-207429--- (aa)--
ENST00000342756SRP72-2014136-ENSP00000342181671 (aa)-O76094
ENST00000504757SRP72-202745-ENSP00000473576220 (aa)-R4GNC1
ENST00000646537SRP72-2081496--- (aa)--
ENST00000647432SRP72-210778--- (aa)--
Gene Model
Click here to download ENSG00000174780's gene model file
Pathways
Pathway IDPathway NameSource
hsa03060Protein exportKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000174780Pulmonary Disease, Chronic Obstructive3.0600000E-00722837378
ENSG00000174780Pulmonary Disease, Chronic Obstructive5.0260000E-00722837378
ENSG00000174780Respiratory Function Tests5E-622837378
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000174780rs12505749456467946?Airflow obstruction228373781.27EFO_0003892
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174780's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000174780SRP729976.480ENSAPOG00000019438srp729776.351Acanthochromis_polyacanthus
ENSG00000174780SRP7210098.361ENSAMEG00000008469SRP729998.361Ailuropoda_melanoleuca
ENSG00000174780SRP729976.269ENSACIG00000000488srp729776.147Amphilophus_citrinellus
ENSG00000174780SRP7210077.198ENSAOCG00000011256srp729877.099Amphiprion_ocellaris
ENSG00000174780SRP7210076.900ENSAPEG00000001512srp729876.794Amphiprion_percula
ENSG00000174780SRP729973.026ENSATEG00000006781srp729978.013Anabas_testudineus
ENSG00000174780SRP729885.000ENSAPLG00000008751SRP729685.248Anas_platyrhynchos
ENSG00000174780SRP729686.090ENSACAG00000002381SRP729685.496Anolis_carolinensis
ENSG00000174780SRP7210097.541ENSANAG00000020836-10097.541Aotus_nancymaae
ENSG00000174780SRP729976.946ENSACLG00000014617srp729776.840Astatotilapia_calliptera
ENSG00000174780SRP729777.370ENSAMXG00000004011srp729777.489Astyanax_mexicanus
ENSG00000174780SRP7210097.466ENSBTAG00000010593SRP7210097.466Bos_taurus
ENSG00000174780SRP7210097.615ENSCJAG00000017998SRP7210097.615Callithrix_jacchus
ENSG00000174780SRP7210098.808ENSCAFG00000002244SRP7210098.808Canis_familiaris
ENSG00000174780SRP7210098.689ENSCAFG00020027338SRP7210098.689Canis_lupus_dingo
ENSG00000174780SRP7210096.509ENSCHIG00000021465SRP729895.282Capra_hircus
ENSG00000174780SRP729998.358ENSTSYG00000010571-9998.358Carlito_syrichta
ENSG00000174780SRP728191.260ENSCAPG00000016668SRP729391.260Cavia_aperea
ENSG00000174780SRP7210098.361ENSCPOG00000000218SRP7210098.361Cavia_porcellus
ENSG00000174780SRP729597.492ENSCCAG00000030683-9597.492Cebus_capucinus
ENSG00000174780SRP729995.946ENSCCAG00000030830-9995.946Cebus_capucinus
ENSG00000174780SRP7210099.553ENSCATG00000008072SRP7210099.553Cercocebus_atys
ENSG00000174780SRP729778.834ENSCATG00000045359-9578.737Cercocebus_atys
ENSG00000174780SRP7210097.990ENSCLAG00000003571SRP7210097.990Chinchilla_lanigera
ENSG00000174780SRP7292100.000ENSCSAG00000005079SRP729893.893Chlorocebus_sabaeus
ENSG00000174780SRP729099.153ENSCHOG00000013240SRP729099.153Choloepus_hoffmanni
ENSG00000174780SRP729686.936ENSCPBG00000015015SRP729886.128Chrysemys_picta_bellii
ENSG00000174780SRP729938.303ENSCING00000002417-9541.489Ciona_intestinalis
ENSG00000174780SRP729938.760ENSCSAVG00000011288-9940.541Ciona_savignyi
ENSG00000174780SRP729278.884ENSCANG00000037920-9881.356Colobus_angolensis_palliatus
ENSG00000174780SRP7210099.553ENSCANG00000041709SRP7210099.553Colobus_angolensis_palliatus
ENSG00000174780SRP7210097.466ENSCGRG00001013548Srp7210097.466Cricetulus_griseus_chok1gshd
ENSG00000174780SRP729497.319ENSCGRG00000003013Srp729997.319Cricetulus_griseus_crigri
ENSG00000174780SRP729977.246ENSCSEG00000003616srp729777.454Cynoglossus_semilaevis
ENSG00000174780SRP729177.997ENSCVAG00000001520srp729977.997Cyprinodon_variegatus
ENSG00000174780SRP728577.193ENSDARG00000014139srp729777.296Danio_rerio
ENSG00000174780SRP729892.237ENSDNOG00000039012SRP728192.390Dasypus_novemcinctus
ENSG00000174780SRP729996.866ENSDORG00000000171Srp729996.866Dipodomys_ordii
ENSG00000174780SRP729939.005FBgn0038810Srp729440.931Drosophila_melanogaster
ENSG00000174780SRP7210096.726ENSETEG00000005191SRP7210096.726Echinops_telfairi
ENSG00000174780SRP727361.382ENSEBUG00000003696srp729661.633Eptatretus_burgeri
ENSG00000174780SRP7210098.659ENSEASG00005017747SRP7210098.659Equus_asinus_asinus
ENSG00000174780SRP7210098.510ENSECAG00000006920SRP7210098.510Equus_caballus
ENSG00000174780SRP729975.744ENSELUG00000022415srp729775.920Esox_lucius
ENSG00000174780SRP7210098.065ENSFCAG00000027600SRP7210098.065Felis_catus
ENSG00000174780SRP729687.403ENSFALG00000006713SRP729786.239Ficedula_albicollis
ENSG00000174780SRP729767.285ENSFDAG00000009793-9566.273Fukomys_damarensis
ENSG00000174780SRP7210097.615ENSFDAG00000002014-10097.615Fukomys_damarensis
ENSG00000174780SRP729975.744ENSFHEG00000017652srp729076.220Fundulus_heteroclitus
ENSG00000174780SRP729772.881ENSGMOG00000005986srp729673.344Gadus_morhua
ENSG00000174780SRP729687.227ENSGALG00000011403SRP729886.585Gallus_gallus
ENSG00000174780SRP729976.831ENSGAFG00000017762srp729777.006Gambusia_affinis
ENSG00000174780SRP729975.149ENSGACG00000016749srp729775.762Gasterosteus_aculeatus
ENSG00000174780SRP728786.082ENSGAGG00000024611SRP729686.874Gopherus_agassizii
ENSG00000174780SRP7210099.404ENSGGOG00000013234-10099.404Gorilla_gorilla
ENSG00000174780SRP729977.096ENSHBUG00000020723srp729776.994Haplochromis_burtoni
ENSG00000174780SRP729295.567ENSHGLG00000003950-9793.450Heterocephalus_glaber_female
ENSG00000174780SRP7210098.063ENSHGLG00000009791SRP7210098.063Heterocephalus_glaber_female
ENSG00000174780SRP729891.908ENSHGLG00000005029-9891.450Heterocephalus_glaber_female
ENSG00000174780SRP729774.046ENSHGLG00000018597-9774.390Heterocephalus_glaber_female
ENSG00000174780SRP729880.467ENSHGLG00000010633-9889.247Heterocephalus_glaber_female
ENSG00000174780SRP725777.168ENSHGLG00000003496-9777.647Heterocephalus_glaber_female
ENSG00000174780SRP729287.192ENSHGLG00100009346-9779.933Heterocephalus_glaber_male
ENSG00000174780SRP729891.908ENSHGLG00100011236-9891.450Heterocephalus_glaber_male
ENSG00000174780SRP729295.074ENSHGLG00100017133-9793.013Heterocephalus_glaber_male
ENSG00000174780SRP7210098.063ENSHGLG00100009021SRP7210098.063Heterocephalus_glaber_male
ENSG00000174780SRP729976.912ENSHCOG00000013760srp729776.959Hippocampus_comes
ENSG00000174780SRP729976.612ENSIPUG00000000210srp729776.498Ictalurus_punctatus
ENSG00000174780SRP7210098.808ENSSTOG00000007305SRP7210098.808Ictidomys_tridecemlineatus
ENSG00000174780SRP7210096.731ENSJJAG00000018324Srp7210096.731Jaculus_jaculus
ENSG00000174780SRP729975.934ENSKMAG00000003776srp729776.037Kryptolebias_marmoratus
ENSG00000174780SRP729778.988ENSLOCG00000002628srp729779.109Lepisosteus_oculatus
ENSG00000174780SRP7210097.765ENSLAFG00000018307SRP7210097.765Loxodonta_africana
ENSG00000174780SRP7210099.404ENSMFAG00000031065SRP7210099.404Macaca_fascicularis
ENSG00000174780SRP729879.604ENSMFAG00000037164-9780.062Macaca_fascicularis
ENSG00000174780SRP7210099.344ENSMMUG00000016368SRP7210099.344Macaca_mulatta
ENSG00000174780SRP729472.452ENSMMUG00000021262-9572.160Macaca_mulatta
ENSG00000174780SRP7210099.404ENSMNEG00000038065-10099.404Macaca_nemestrina
ENSG00000174780SRP729597.962ENSMLEG00000030140-9597.962Mandrillus_leucophaeus
ENSG00000174780SRP729976.453ENSMAMG00000014989srp728776.336Mastacembelus_armatus
ENSG00000174780SRP729978.841ENSMZEG00005003325srp729776.994Maylandia_zebra
ENSG00000174780SRP729583.150ENSMGAG00000008567SRP729786.947Meleagris_gallopavo
ENSG00000174780SRP7210097.768ENSMAUG00000001237Srp7210097.768Mesocricetus_auratus
ENSG00000174780SRP729596.865ENSMICG00000008507-9596.865Microcebus_murinus
ENSG00000174780SRP7210097.377ENSMOCG00000020309Srp7210097.377Microtus_ochrogaster
ENSG00000174780SRP729974.850ENSMMOG00000002627srp729775.307Mola_mola
ENSG00000174780SRP729588.119ENSMODG00000020697SRP729886.718Monodelphis_domestica
ENSG00000174780SRP729976.048ENSMALG00000003747srp729776.061Monopterus_albus
ENSG00000174780SRP7210096.393MGP_CAROLIEiJ_G0027323Srp7210096.393Mus_caroli
ENSG00000174780SRP7210096.393ENSMUSG00000036323Srp7210096.393Mus_musculus
ENSG00000174780SRP7210096.405MGP_PahariEiJ_G0017103Srp7210096.405Mus_pahari
ENSG00000174780SRP7210096.393MGP_SPRETEiJ_G0028317Srp7210096.393Mus_spretus
ENSG00000174780SRP7210097.914ENSMPUG00000004828SRP7210097.914Mustela_putorius_furo
ENSG00000174780SRP7210096.741ENSMLUG00000007344SRP7210096.741Myotis_lucifugus
ENSG00000174780SRP7210096.721ENSNGAG00000012595Srp7210096.721Nannospalax_galili
ENSG00000174780SRP729973.952ENSNBRG00000014492srp729773.773Neolamprologus_brichardi
ENSG00000174780SRP7210093.145ENSNLEG00000008806-10093.145Nomascus_leucogenys
ENSG00000174780SRP729879.787ENSMEUG00000005164SRP729879.116Notamacropus_eugenii
ENSG00000174780SRP729695.483ENSOPRG00000012521SRP729795.413Ochotona_princeps
ENSG00000174780SRP729894.817ENSODEG00000012214SRP729894.817Octodon_degus
ENSG00000174780SRP729976.900ENSONIG00000001446srp729776.794Oreochromis_niloticus
ENSG00000174780SRP728980.513ENSOANG00000008562SRP729771.148Ornithorhynchus_anatinus
ENSG00000174780SRP7210097.615ENSOCUG00000012226SRP7210097.615Oryctolagus_cuniculus
ENSG00000174780SRP729975.505ENSORLG00000020418srp729775.115Oryzias_latipes
ENSG00000174780SRP729973.763ENSORLG00020009138srp729673.579Oryzias_latipes_hni
ENSG00000174780SRP729975.000ENSORLG00015018251srp729774.501Oryzias_latipes_hsok
ENSG00000174780SRP729974.513ENSOMEG00000022008srp729774.962Oryzias_melastigma
ENSG00000174780SRP7210097.466ENSOGAG00000003578SRP7210097.466Otolemur_garnettii
ENSG00000174780SRP7210097.765ENSOARG00000004329SRP7210097.765Ovis_aries
ENSG00000174780SRP728077.799ENSPPAG00000032490-9176.852Pan_paniscus
ENSG00000174780SRP72100100.000ENSPPAG00000042265SRP72100100.000Pan_paniscus
ENSG00000174780SRP729970.695ENSPPAG00000011428-9571.713Pan_paniscus
ENSG00000174780SRP7210098.212ENSPPRG00000015991SRP7210098.212Panthera_pardus
ENSG00000174780SRP7210098.212ENSPTIG00000018786SRP7210098.212Panthera_tigris_altaica
ENSG00000174780SRP72100100.000ENSPTRG00000048466-100100.000Pan_troglodytes
ENSG00000174780SRP729972.851ENSPTRG00000048100-9573.893Pan_troglodytes
ENSG00000174780SRP728077.612ENSPTRG00000043609-9276.079Pan_troglodytes
ENSG00000174780SRP729477.953ENSPANG00000030230-9778.628Papio_anubis
ENSG00000174780SRP7210099.553ENSPANG00000005495SRP7210099.553Papio_anubis
ENSG00000174780SRP729387.220ENSPSIG00000003003SRP729887.220Pelodiscus_sinensis
ENSG00000174780SRP7210096.439ENSPEMG00000012828-10096.439Peromyscus_maniculatus_bairdii
ENSG00000174780SRP729691.176ENSPCIG00000000732SRP729790.673Phascolarctos_cinereus
ENSG00000174780SRP729976.831ENSPFOG00000003480srp729777.006Poecilia_formosa
ENSG00000174780SRP729976.981ENSPLAG00000020122srp729777.160Poecilia_latipinna
ENSG00000174780SRP729976.532ENSPMEG00000019988srp729776.698Poecilia_mexicana
ENSG00000174780SRP7210075.980ENSPREG00000006218srp729776.852Poecilia_reticulata
ENSG00000174780SRP726281.414ENSPPYG00000009152-9580.105Pongo_abelii
ENSG00000174780SRP7210099.702ENSPPYG00000014752-7899.702Pongo_abelii
ENSG00000174780SRP7210096.572ENSPVAG00000005590SRP7210096.572Pteropus_vampyrus
ENSG00000174780SRP729977.395ENSPNYG00000001916srp729777.301Pundamilia_nyererei
ENSG00000174780SRP729976.981ENSPNAG00000022424srp729776.876Pygocentrus_nattereri
ENSG00000174780SRP7210094.337ENSRNOG00000002100LOC1083481809894.962Rattus_norvegicus
ENSG00000174780SRP729976.355ENSRBIG00000029328-9875.904Rhinopithecus_bieti
ENSG00000174780SRP7210097.007ENSRBIG00000042069SRP7210097.007Rhinopithecus_bieti
ENSG00000174780SRP7210099.553ENSRROG00000035704SRP7210099.553Rhinopithecus_roxellana
ENSG00000174780SRP729390.836ENSSHAG00000000614SRP729887.234Sarcophilus_harrisii
ENSG00000174780SRP729978.861ENSSFOG00015002026srp729778.802Scleropages_formosus
ENSG00000174780SRP729975.750ENSSMAG00000007639srp729775.115Scophthalmus_maximus
ENSG00000174780SRP729976.866ENSSDUG00000007345srp729677.523Seriola_dumerili
ENSG00000174780SRP729976.751ENSSLDG00000021819srp729776.923Seriola_lalandi_dorsalis
ENSG00000174780SRP728293.158ENSSARG00000005804SRP727493.158Sorex_araneus
ENSG00000174780SRP729686.760ENSSPUG00000009740SRP729785.933Sphenodon_punctatus
ENSG00000174780SRP729976.497ENSSPAG00000011565srp729777.147Stegastes_partitus
ENSG00000174780SRP729994.118ENSSSCG00000008900SRP729894.207Sus_scrofa
ENSG00000174780SRP729687.267ENSTGUG00000004767SRP729785.954Taeniopygia_guttata
ENSG00000174780SRP729975.862ENSTRUG00000009831srp729775.883Takifugu_rubripes
ENSG00000174780SRP729977.347ENSTNIG00000013073srp729777.252Tetraodon_nigroviridis
ENSG00000174780SRP729090.625ENSTBEG00000007394SRP729084.746Tupaia_belangeri
ENSG00000174780SRP729497.161ENSTTRG00000010945SRP7210097.161Tursiops_truncatus
ENSG00000174780SRP726697.750ENSUAMG00000001701SRP7210098.421Ursus_americanus
ENSG00000174780SRP7210098.063ENSUMAG00000008151SRP7210098.063Ursus_maritimus
ENSG00000174780SRP7210097.733ENSVPAG00000000458SRP7210097.733Vicugna_pacos
ENSG00000174780SRP7210098.659ENSVVUG00000006020SRP7210098.659Vulpes_vulpes
ENSG00000174780SRP729579.278ENSXETG00000010205srp729778.905Xenopus_tropicalis
ENSG00000174780SRP729976.532ENSXMAG00000018000srp729776.805Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005047signal recognition particle binding17254600.IPIFunction
GO:0005515protein binding24965446.IPIFunction
GO:0005783endoplasmic reticulum22541560.IDAComponent
GO:0005786signal recognition particle, endoplasmic reticulum targeting21873635.IBAComponent
GO:0005786signal recognition particle, endoplasmic reticulum targeting18089836.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006614SRP-dependent cotranslational protein targeting to membrane-TASProcess
GO:0006616SRP-dependent cotranslational protein targeting to membrane, translocation21873635.IBAProcess
GO:00083127S RNA binding27899666.IMPFunction
GO:0030911TPR domain binding27899666.IPIFunction
GO:0042493response to drug18089836.IDAProcess
GO:0043022ribosome binding27899666.IMPFunction
GO:0048500signal recognition particle27899666.IDAComponent

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