EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000174840 (Gene tree)
Gene ID: 201626
Gene Symbol: PDE12
Alias: DKFZp667B1218|2'-PDE|3635
Full Name: phosphodiesterase 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 98,728 bases
Position: chr3:57,556,252-57,654,979
Accession: 25386
RBP type: canonical RBP
Summary: (Phosphodiesterase 12) is a Protein Coding gene. Diseases associated with PDE12 include Microphthalmia With Limb Anomalies. Gene Ontology (GO) annotations related to this gene include poly(A)-specific ribonuclease activity. An important paralog of this gene is ANGEL1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000309142	Exo_endo_phos	PF03372.23	5.7e-19	1	1
ENSP00000420626	Exo_endo_phos	PF03372.23	4.3e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000487257	PDE12-202	3040	-	ENSP00000420626	472 (aa)	-	F6T1Q0
ENST00000311180	PDE12-201	8773	-	ENSP00000309142	609 (aa)	-	Q6L8Q7

Gene Model

Click here to download ENSG00000174840's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000174840	rs7618684	3	57560266	?	Reaction time	29844566	[0.0053-0.0122] unit decrease	0.0087343	EFO_0008393

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174840's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174840	PDE12	96	57.023	ENSAPOG00000018806	pde12	96	57.023	Acanthochromis_polyacanthus
ENSG00000174840	PDE12	100	92.282	ENSAMEG00000011802	PDE12	100	92.348	Ailuropoda_melanoleuca
ENSG00000174840	PDE12	99	58.388	ENSACIG00000014918	pde12	99	57.566	Amphilophus_citrinellus
ENSG00000174840	PDE12	96	57.458	ENSAOCG00000016376	pde12	99	56.230	Amphiprion_ocellaris
ENSG00000174840	PDE12	94	58.131	ENSAPEG00000000756	pde12	94	58.131	Amphiprion_percula
ENSG00000174840	PDE12	94	58.232	ENSATEG00000003072	pde12	97	57.785	Anabas_testudineus
ENSG00000174840	PDE12	100	62.075	ENSACAG00000003067	PDE12	100	62.399	Anolis_carolinensis
ENSG00000174840	PDE12	100	95.567	ENSANAG00000011815	PDE12	100	95.731	Aotus_nancymaae
ENSG00000174840	PDE12	96	57.458	ENSACLG00000010127	pde12	96	57.612	Astatotilapia_calliptera
ENSG00000174840	PDE12	94	59.829	ENSAMXG00000020765	pde12	95	59.589	Astyanax_mexicanus
ENSG00000174840	PDE12	100	91.626	ENSBTAG00000015563	PDE12	100	91.626	Bos_taurus
ENSG00000174840	PDE12	52	30.149	WBGene00011268	pde-12	52	30.149	Caenorhabditis_elegans
ENSG00000174840	PDE12	100	95.895	ENSCJAG00000019905	PDE12	100	96.059	Callithrix_jacchus
ENSG00000174840	PDE12	100	91.396	ENSCAFG00000007792	PDE12	100	92.370	Canis_familiaris
ENSG00000174840	PDE12	100	91.558	ENSCAFG00020006692	PDE12	100	92.532	Canis_lupus_dingo
ENSG00000174840	PDE12	100	91.817	ENSCHIG00000014202	PDE12	100	91.817	Capra_hircus
ENSG00000174840	PDE12	100	93.596	ENSTSYG00000025750	PDE12	100	93.596	Carlito_syrichta
ENSG00000174840	PDE12	100	89.819	ENSCPOG00000001620	PDE12	100	89.819	Cavia_porcellus
ENSG00000174840	PDE12	94	93.454	ENSCCAG00000031290	PDE12	100	82.594	Cebus_capucinus
ENSG00000174840	PDE12	100	98.686	ENSCATG00000044539	PDE12	100	98.686	Cercocebus_atys
ENSG00000174840	PDE12	100	87.685	ENSCLAG00000004864	PDE12	100	87.685	Chinchilla_lanigera
ENSG00000174840	PDE12	100	98.358	ENSCSAG00000012275	PDE12	100	98.358	Chlorocebus_sabaeus
ENSG00000174840	PDE12	89	95.616	ENSCHOG00000002188	-	89	95.616	Choloepus_hoffmanni
ENSG00000174840	PDE12	68	92.736	ENSCHOG00000012173	-	100	92.736	Choloepus_hoffmanni
ENSG00000174840	PDE12	95	73.150	ENSCPBG00000012353	PDE12	91	72.852	Chrysemys_picta_bellii
ENSG00000174840	PDE12	93	35.456	ENSCING00000006903	-	99	39.669	Ciona_intestinalis
ENSG00000174840	PDE12	100	98.686	ENSCANG00000038723	PDE12	100	98.686	Colobus_angolensis_palliatus
ENSG00000174840	PDE12	100	89.491	ENSCGRG00001021836	Pde12	100	89.491	Cricetulus_griseus_chok1gshd
ENSG00000174840	PDE12	100	88.998	ENSCGRG00000012319	Pde12	100	88.998	Cricetulus_griseus_crigri
ENSG00000174840	PDE12	94	57.487	ENSCSEG00000018538	pde12	99	57.487	Cynoglossus_semilaevis
ENSG00000174840	PDE12	95	49.741	ENSCVAG00000003624	pde12	94	49.398	Cyprinodon_variegatus
ENSG00000174840	PDE12	94	57.192	ENSDARG00000030964	pde12	93	56.499	Danio_rerio
ENSG00000174840	PDE12	100	87.844	ENSDNOG00000048413	PDE12	100	87.844	Dasypus_novemcinctus
ENSG00000174840	PDE12	100	90.969	ENSDORG00000004313	Pde12	100	90.969	Dipodomys_ordii
ENSG00000174840	PDE12	94	33.389	FBgn0051759	CG31759	99	32.013	Drosophila_melanogaster
ENSG00000174840	PDE12	64	49.315	ENSEBUG00000004803	pde12	71	49.315	Eptatretus_burgeri
ENSG00000174840	PDE12	100	93.924	ENSEASG00005000644	PDE12	100	93.924	Equus_asinus_asinus
ENSG00000174840	PDE12	100	93.924	ENSECAG00000005326	PDE12	100	93.924	Equus_caballus
ENSG00000174840	PDE12	64	94.220	ENSEEUG00000010406	-	63	94.220	Erinaceus_europaeus
ENSG00000174840	PDE12	94	60.659	ENSELUG00000014391	pde12	92	61.005	Esox_lucius
ENSG00000174840	PDE12	100	92.611	ENSFCAG00000031696	PDE12	100	92.611	Felis_catus
ENSG00000174840	PDE12	79	74.327	ENSFALG00000008401	PDE12	99	74.534	Ficedula_albicollis
ENSG00000174840	PDE12	100	91.297	ENSFDAG00000021278	PDE12	100	91.297	Fukomys_damarensis
ENSG00000174840	PDE12	99	54.545	ENSFHEG00000018967	pde12	90	55.226	Fundulus_heteroclitus
ENSG00000174840	PDE12	94	56.055	ENSGMOG00000018041	pde12	98	54.639	Gadus_morhua
ENSG00000174840	PDE12	98	67.980	ENSGALG00000052355	PDE12	99	67.652	Gallus_gallus
ENSG00000174840	PDE12	98	55.408	ENSGAFG00000002045	pde12	98	55.075	Gambusia_affinis
ENSG00000174840	PDE12	99	56.721	ENSGACG00000003914	pde12	99	56.721	Gasterosteus_aculeatus
ENSG00000174840	PDE12	100	69.790	ENSGAGG00000010266	PDE12	98	69.516	Gopherus_agassizii
ENSG00000174840	PDE12	100	99.507	ENSGGOG00000003312	PDE12	100	99.507	Gorilla_gorilla
ENSG00000174840	PDE12	96	57.868	ENSHBUG00000023370	pde12	96	57.458	Haplochromis_burtoni
ENSG00000174840	PDE12	100	90.969	ENSHGLG00000005661	PDE12	100	90.969	Heterocephalus_glaber_female
ENSG00000174840	PDE12	100	90.969	ENSHGLG00100001136	PDE12	100	90.969	Heterocephalus_glaber_male
ENSG00000174840	PDE12	95	56.729	ENSHCOG00000013749	pde12	94	57.240	Hippocampus_comes
ENSG00000174840	PDE12	94	61.005	ENSIPUG00000007123	Pde12	94	61.005	Ictalurus_punctatus
ENSG00000174840	PDE12	100	92.447	ENSSTOG00000007861	PDE12	100	92.447	Ictidomys_tridecemlineatus
ENSG00000174840	PDE12	100	87.520	ENSJJAG00000006038	Pde12	100	87.662	Jaculus_jaculus
ENSG00000174840	PDE12	96	58.545	ENSKMAG00000018523	pde12	96	58.895	Kryptolebias_marmoratus
ENSG00000174840	PDE12	94	59.552	ENSLBEG00000009762	PDE12	94	59.897	Labrus_bergylta
ENSG00000174840	PDE12	94	57.659	ENSLBEG00000026775	pde12	97	56.126	Labrus_bergylta
ENSG00000174840	PDE12	94	67.591	ENSLACG00000015492	PDE12	94	67.703	Latimeria_chalumnae
ENSG00000174840	PDE12	95	63.731	ENSLOCG00000013277	pde12	93	63.731	Lepisosteus_oculatus
ENSG00000174840	PDE12	92	92.540	ENSLAFG00000002821	PDE12	100	92.895	Loxodonta_africana
ENSG00000174840	PDE12	100	98.851	ENSMFAG00000030966	PDE12	100	98.851	Macaca_fascicularis
ENSG00000174840	PDE12	100	98.851	ENSMMUG00000004052	PDE12	100	98.851	Macaca_mulatta
ENSG00000174840	PDE12	100	98.851	ENSMNEG00000030068	PDE12	100	98.851	Macaca_nemestrina
ENSG00000174840	PDE12	100	98.851	ENSMLEG00000036137	PDE12	100	98.851	Mandrillus_leucophaeus
ENSG00000174840	PDE12	99	58.444	ENSMAMG00000014415	pde12	99	58.113	Mastacembelus_armatus
ENSG00000174840	PDE12	94	55.440	ENSMZEG00005028202	-	98	54.844	Maylandia_zebra
ENSG00000174840	PDE12	96	57.360	ENSMZEG00005016132	pde12	96	58.377	Maylandia_zebra
ENSG00000174840	PDE12	52	80.251	ENSMGAG00000006449	PDE12	99	80.251	Meleagris_gallopavo
ENSG00000174840	PDE12	100	80.914	ENSMAUG00000000442	Pde12	100	81.403	Mesocricetus_auratus
ENSG00000174840	PDE12	100	91.626	ENSMICG00000005723	PDE12	100	91.626	Microcebus_murinus
ENSG00000174840	PDE12	100	89.163	ENSMOCG00000020734	Pde12	100	89.327	Microtus_ochrogaster
ENSG00000174840	PDE12	95	59.310	ENSMMOG00000013636	pde12	94	58.722	Mola_mola
ENSG00000174840	PDE12	100	74.634	ENSMODG00000000155	PDE12	100	74.146	Monodelphis_domestica
ENSG00000174840	PDE12	96	56.780	ENSMALG00000022647	pde12	96	56.176	Monopterus_albus
ENSG00000174840	PDE12	100	88.670	MGP_CAROLIEiJ_G0019032	Pde12	100	88.670	Mus_caroli
ENSG00000174840	PDE12	100	88.342	ENSMUSG00000043702	Pde12	100	88.342	Mus_musculus
ENSG00000174840	PDE12	100	88.506	MGP_PahariEiJ_G0030049	Pde12	100	88.506	Mus_pahari
ENSG00000174840	PDE12	100	88.342	MGP_SPRETEiJ_G0019916	Pde12	100	88.342	Mus_spretus
ENSG00000174840	PDE12	100	92.775	ENSMPUG00000016869	PDE12	100	92.775	Mustela_putorius_furo
ENSG00000174840	PDE12	100	91.626	ENSMLUG00000026487	PDE12	100	91.626	Myotis_lucifugus
ENSG00000174840	PDE12	100	87.685	ENSNGAG00000001228	Pde12	100	87.685	Nannospalax_galili
ENSG00000174840	PDE12	96	53.051	ENSNBRG00000015769	pde12	66	52.292	Neolamprologus_brichardi
ENSG00000174840	PDE12	100	99.015	ENSNLEG00000007269	-	100	99.015	Nomascus_leucogenys
ENSG00000174840	PDE12	100	90.701	ENSNLEG00000034833	-	100	90.212	Nomascus_leucogenys
ENSG00000174840	PDE12	100	72.995	ENSMEUG00000006786	PDE12	100	74.346	Notamacropus_eugenii
ENSG00000174840	PDE12	100	87.948	ENSOPRG00000015273	PDE12	100	88.274	Ochotona_princeps
ENSG00000174840	PDE12	100	91.461	ENSODEG00000006268	PDE12	100	91.461	Octodon_degus
ENSG00000174840	PDE12	94	58.204	ENSONIG00000004293	pde12	100	57.785	Oreochromis_niloticus
ENSG00000174840	PDE12	94	75.893	ENSOANG00000012885	PDE12	99	77.858	Ornithorhynchus_anatinus
ENSG00000174840	PDE12	100	92.623	ENSOCUG00000000823	PDE12	100	92.295	Oryctolagus_cuniculus
ENSG00000174840	PDE12	97	57.022	ENSORLG00000017444	pde12	96	55.668	Oryzias_latipes
ENSG00000174840	PDE12	99	56.457	ENSORLG00020010469	pde12	99	54.801	Oryzias_latipes_hni
ENSG00000174840	PDE12	97	56.684	ENSORLG00015004093	pde12	96	55.499	Oryzias_latipes_hsok
ENSG00000174840	PDE12	96	56.229	ENSOMEG00000020900	pde12	97	56.229	Oryzias_melastigma
ENSG00000174840	PDE12	100	91.954	ENSOGAG00000024093	PDE12	100	91.954	Otolemur_garnettii
ENSG00000174840	PDE12	90	92.405	ENSOARG00000013642	PDE12	100	92.405	Ovis_aries
ENSG00000174840	PDE12	100	99.015	ENSPPAG00000034712	PDE12	100	99.015	Pan_paniscus
ENSG00000174840	PDE12	100	92.611	ENSPPRG00000011738	PDE12	100	92.611	Panthera_pardus
ENSG00000174840	PDE12	83	91.389	ENSPTIG00000019166	PDE12	97	91.389	Panthera_tigris_altaica
ENSG00000174840	PDE12	100	99.179	ENSPTRG00000030221	PDE12	100	99.179	Pan_troglodytes
ENSG00000174840	PDE12	100	98.686	ENSPANG00000007324	PDE12	100	98.686	Papio_anubis
ENSG00000174840	PDE12	99	59.211	ENSPKIG00000025354	pde12	98	59.500	Paramormyrops_kingsleyae
ENSG00000174840	PDE12	95	74.010	ENSPSIG00000004926	PDE12	92	73.711	Pelodiscus_sinensis
ENSG00000174840	PDE12	99	53.846	ENSPMGG00000006742	pde12	99	54.806	Periophthalmus_magnuspinnatus
ENSG00000174840	PDE12	86	91.647	ENSPEMG00000007259	Pde12	97	91.647	Peromyscus_maniculatus_bairdii
ENSG00000174840	PDE12	95	59.107	ENSPFOG00000011864	pde12	94	58.348	Poecilia_formosa
ENSG00000174840	PDE12	72	61.765	ENSPLAG00000023871	pde12	81	61.348	Poecilia_latipinna
ENSG00000174840	PDE12	95	58.448	ENSPMEG00000005674	pde12	95	58.148	Poecilia_mexicana
ENSG00000174840	PDE12	95	58.276	ENSPREG00000022831	pde12	95	58.319	Poecilia_reticulata
ENSG00000174840	PDE12	100	98.851	ENSPPYG00000013769	PDE12	100	98.851	Pongo_abelii
ENSG00000174840	PDE12	100	92.282	ENSPCOG00000026004	PDE12	100	92.282	Propithecus_coquereli
ENSG00000174840	PDE12	100	92.118	ENSPVAG00000008885	PDE12	100	92.118	Pteropus_vampyrus
ENSG00000174840	PDE12	96	58.037	ENSPNYG00000013258	pde12	96	57.627	Pundamilia_nyererei
ENSG00000174840	PDE12	94	62.912	ENSPNAG00000029032	pde12	95	63.432	Pygocentrus_nattereri
ENSG00000174840	PDE12	100	89.491	ENSRNOG00000059442	Pde12	100	89.491	Rattus_norvegicus
ENSG00000174840	PDE12	100	98.358	ENSRBIG00000040704	PDE12	100	98.358	Rhinopithecus_bieti
ENSG00000174840	PDE12	100	98.358	ENSRROG00000031279	PDE12	100	98.358	Rhinopithecus_roxellana
ENSG00000174840	PDE12	100	94.910	ENSSBOG00000023974	PDE12	100	95.074	Saimiri_boliviensis_boliviensis
ENSG00000174840	PDE12	84	64.776	ENSSFOG00015003468	pde12	93	64.776	Scleropages_formosus
ENSG00000174840	PDE12	95	56.552	ENSSMAG00000003258	pde12	95	57.070	Scophthalmus_maximus
ENSG00000174840	PDE12	95	59.725	ENSSDUG00000020470	pde12	94	59.585	Seriola_dumerili
ENSG00000174840	PDE12	95	60.104	ENSSLDG00000019833	pde12	94	59.931	Seriola_lalandi_dorsalis
ENSG00000174840	PDE12	100	88.361	ENSSARG00000007201	PDE12	100	87.869	Sorex_araneus
ENSG00000174840	PDE12	96	58.277	ENSSPAG00000014980	pde12	99	56.766	Stegastes_partitus
ENSG00000174840	PDE12	52	84.543	ENSSSCG00000034476	-	74	84.543	Sus_scrofa
ENSG00000174840	PDE12	100	92.611	ENSSSCG00000011465	-	100	92.611	Sus_scrofa
ENSG00000174840	PDE12	60	79.730	ENSTGUG00000007290	PDE12	100	79.730	Taeniopygia_guttata
ENSG00000174840	PDE12	96	58.206	ENSTRUG00000005159	pde12	96	58.037	Takifugu_rubripes
ENSG00000174840	PDE12	97	57.264	ENSTNIG00000017497	pde12	97	56.926	Tetraodon_nigroviridis
ENSG00000174840	PDE12	82	96.053	ENSTBEG00000008202	PDE12	82	96.053	Tupaia_belangeri
ENSG00000174840	PDE12	100	92.282	ENSTTRG00000014707	PDE12	100	92.282	Tursiops_truncatus
ENSG00000174840	PDE12	100	93.103	ENSUAMG00000020634	-	100	93.103	Ursus_americanus
ENSG00000174840	PDE12	98	78.618	ENSUAMG00000008368	-	98	78.618	Ursus_americanus
ENSG00000174840	PDE12	72	94.725	ENSUMAG00000021906	PDE12	100	94.725	Ursus_maritimus
ENSG00000174840	PDE12	100	91.040	ENSVVUG00000020335	PDE12	100	91.040	Vulpes_vulpes
ENSG00000174840	PDE12	97	55.312	ENSXETG00000008653	pde12	99	54.392	Xenopus_tropicalis
ENSG00000174840	PDE12	95	57.414	ENSXCOG00000000407	pde12	97	57.265	Xiphophorus_couchianus
ENSG00000174840	PDE12	99	56.322	ENSXMAG00000013370	pde12	99	55.863	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	21245038.21666256.	IMP	Function
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	21245038.	IMP	Process
GO:0000958	mitochondrial mRNA catabolic process	21245038.21666256.	IMP	Process
GO:0004527	exonuclease activity	22285541.	IDA	Function
GO:0004527	exonuclease activity	15231837.	IMP	Function
GO:0004535	poly(A)-specific ribonuclease activity	-	IEA	Function
GO:0005759	mitochondrial matrix	21666256.	IDA	Component
GO:0005759	mitochondrial matrix	21245038.	IMP	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0034611	oligoribonucleotidase activity	-	TAS	Function
GO:0035457	cellular response to interferon-alpha	15231837.	IMP	Process
GO:0044528	regulation of mitochondrial mRNA stability	21666256.	IMP	Process
GO:0045070	positive regulation of viral genome replication	15231837.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051607	defense response to virus	-	TAS	Process
GO:0060548	negative regulation of cell death	15231837.	IDA	Process
GO:0071346	cellular response to interferon-gamma	15231837.	IDA	Process
GO:0071359	cellular response to dsRNA	15231837.	IDA	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	22285541.	IDA	Process
GO:0090324	negative regulation of oxidative phosphorylation	21666256.	IMP	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	21245038.21666256.	IMP	Process