EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000174953 (Gene tree)
Gene ID: 170506
Gene Symbol: DHX36
Alias: MLEL1|KIAA1488|RHAU|DDX36
Full Name: DEAH-box helicase 36
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 51,952 bases
Position: chr3:154,272,546-154,324,497
Accession: 14410
RBP type: canonical RBP
Summary: This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000419862	DEAD	PF00270.29	2e-13	1	1
ENSP00000309296	DEAD	PF00270.29	3.1e-13	1	1
ENSP00000330113	DEAD	PF00270.29	3.2e-13	1	1
ENSP00000417078	DEAD	PF00270.29	3.3e-13	1	1
ENSP00000419862	HA2	PF04408.23	5.4e-20	1	1
ENSP00000330113	HA2	PF04408.23	8e-20	1	1
ENSP00000417078	HA2	PF04408.23	8.2e-20	1	1
ENSP00000309296	HA2	PF04408.23	1.8e-18	1	1
ENSP00000419761	HA2	PF04408.23	5.9e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18854321	Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain.	J Biol Chem	2008 Dec 12	Chalupnikova K	doi: 10.1074/jbc.M804857200
21846770	The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme.	Nucleic Acids Res	2011 Nov	Lattmann S	doi: 10.1093/nar/gkr630
28090421	RNA G-quadruplexes and their potential regulatory roles in translation.	Translation (Austin)	2016 Oct 4	Song J	doi: 10.1080/21690731.2016.1244031
22394195	Inhibition of hepatitis C virus NS3 helicase by manoalide.	J Nat Prod	2012 Apr 27	Salam KA	doi: 10.1021/np200883s
30977984	Post-Transcriptional Modulation of aENaC mRNA in Alveolar Epithelial Cells: Involvement of its 3' Untranslated Region.	Cell Physiol Biochem	2019	Migneault F	doi: 10.33594/000000068.
21149580	The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation.	Mol Cell Biol	2011 Feb	Sexton AN	doi: 10.1128/MCB.01033-10
18842585	G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates.	J Biol Chem	2008 Dec 12	Creacy SD	doi: 10.1074/jbc.M806277200
21703541	DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.	Immunity	2011 Jun 24	Zhang Z	doi: 10.1016/j.immuni.2011.03.027.
24151078	Binding of G-quadruplexes to the N-terminal recognition domain of the RNA helicase associated with AU-rich element (RHAU).	J Biol Chem	2013 Dec 6	Meier M	doi: 10.1074/jbc.M113.512970
26649896	Biophysical Characterization of G-Quadruplex Recognition in the PITX1 mRNA by the Specificity Domain of the Helicase RHAU.	PLoS One	2015 Dec 9	Ariyo EO	doi: 10.1371/journal.pone.0144510
26548353	Development of Fluorescent Protein Probes Specific for Parallel DNA and RNA G-Quadruplexes.	Chembiochem	2016 Jan 1	Dang DT	doi: 10.1002/cbic.201500503
31160600	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions.	Nat Commun	2019 Jun 3	Sauer M	doi: 10.1038/s41467-019-10432-5.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000477549	DHX36-207	644	-	-	- (aa)	-	-
ENST00000308361	DHX36-201	3487	-	ENSP00000309296	979 (aa)	-	Q9H2U1
ENST00000479934	DHX36-208	530	-	ENSP00000418756	119 (aa)	-	H7C514
ENST00000496811	DHX36-213	6733	-	ENSP00000417078	1008 (aa)	-	Q9H2U1
ENST00000495598	DHX36-212	719	-	-	- (aa)	-	-
ENST00000481332	DHX36-209	452	-	-	- (aa)	-	-
ENST00000460875	DHX36-204	478	-	-	- (aa)	-	-
ENST00000329463	DHX36-202	2985	-	ENSP00000330113	994 (aa)	-	Q9H2U1
ENST00000460695	DHX36-203	2306	-	-	- (aa)	-	-
ENST00000469977	DHX36-206	562	-	ENSP00000419761	187 (aa)	-	H7C5F5
ENST00000481941	DHX36-210	2612	-	ENSP00000419862	797 (aa)	-	E7EWK3
ENST00000491011	DHX36-211	833	-	-	- (aa)	-	-
ENST00000462464	DHX36-205	641	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000174953's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000174953	rs355772	3	154318917	A	Blood protein levels	29875488	[0.13-0.25] unit decrease	0.19	EFO_0007937
ENSG00000174953	rs9438	3	154301098	G	Body mass index	30108127	[NR] unit decrease	0.014	EFO_0004340
ENSG00000174953	rs355777	3	154317161	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000174953's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000174953	DHX36	95	43.602	ENSG00000135829	DHX9	59	38.501
ENSG00000174953	DHX36	95	42.105	ENSG00000134815	DHX34	53	32.357
ENSG00000174953	DHX36	95	41.232	ENSG00000132153	DHX30	63	36.869
ENSG00000174953	DHX36	98	44.538	ENSG00000047188	YTHDC2	57	43.089
ENSG00000174953	DHX36	99	36.073	ENSG00000067596	DHX8	50	43.455
ENSG00000174953	DHX36	97	50.000	ENSG00000163214	DHX57	99	40.286
ENSG00000174953	DHX36	67	30.769	ENSG00000089876	DHX32	72	30.769
ENSG00000174953	DHX36	98	46.789	ENSG00000067248	DHX29	61	40.521
ENSG00000174953	DHX36	92	34.951	ENSG00000005100	DHX33	82	36.816
ENSG00000174953	DHX36	99	32.569	ENSG00000140829	DHX38	50	31.010
ENSG00000174953	DHX36	98	31.481	ENSG00000108406	DHX40	79	42.143
ENSG00000174953	DHX36	98	35.185	ENSG00000204560	DHX16	91	39.506
ENSG00000174953	DHX36	95	34.529	ENSG00000150990	DHX37	60	30.537
ENSG00000174953	DHX36	99	34.529	ENSG00000109606	DHX15	80	31.362
ENSG00000174953	DHX36	96	34.434	ENSG00000101452	DHX35	71	31.306

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000174953	DHX36	99	75.799	ENSAPOG00000022391	dhx36	93	67.876	Acanthochromis_polyacanthus
ENSG00000174953	DHX36	98	97.436	ENSAMEG00000011721	DHX36	100	93.465	Ailuropoda_melanoleuca
ENSG00000174953	DHX36	99	76.256	ENSACIG00000016290	dhx36	97	72.588	Amphilophus_citrinellus
ENSG00000174953	DHX36	99	75.799	ENSAOCG00000000046	dhx36	92	69.128	Amphiprion_ocellaris
ENSG00000174953	DHX36	99	75.799	ENSAPEG00000001495	dhx36	92	68.776	Amphiprion_percula
ENSG00000174953	DHX36	99	75.799	ENSATEG00000015441	dhx36	95	74.670	Anabas_testudineus
ENSG00000174953	DHX36	98	91.453	ENSAPLG00000012597	DHX36	100	81.283	Anas_platyrhynchos
ENSG00000174953	DHX36	98	90.598	ENSACAG00000006905	DHX36	96	72.112	Anolis_carolinensis
ENSG00000174953	DHX36	99	99.462	ENSANAG00000020741	DHX36	99	97.937	Aotus_nancymaae
ENSG00000174953	DHX36	99	75.799	ENSACLG00000014163	dhx36	93	73.950	Astatotilapia_calliptera
ENSG00000174953	DHX36	99	79.661	ENSAMXG00000017365	dhx36	92	77.218	Astyanax_mexicanus
ENSG00000174953	DHX36	100	92.848	ENSBTAG00000006142	DHX36	100	92.186	Bos_taurus
ENSG00000174953	DHX36	100	97.616	ENSCJAG00000000986	DHX36	100	96.840	Callithrix_jacchus
ENSG00000174953	DHX36	98	97.436	ENSCAFG00000008673	DHX36	89	92.857	Canis_familiaris
ENSG00000174953	DHX36	98	97.436	ENSCAFG00020004966	DHX36	100	96.375	Canis_lupus_dingo
ENSG00000174953	DHX36	100	92.723	ENSCHIG00000017463	DHX36	100	91.988	Capra_hircus
ENSG00000174953	DHX36	100	93.852	ENSTSYG00000002377	DHX36	100	92.952	Carlito_syrichta
ENSG00000174953	DHX36	88	94.286	ENSCAPG00000006238	DHX36	96	93.103	Cavia_aperea
ENSG00000174953	DHX36	100	85.087	ENSCPOG00000007716	DHX36	100	93.033	Cavia_porcellus
ENSG00000174953	DHX36	100	95.833	ENSCCAG00000035199	DHX36	100	95.833	Cebus_capucinus
ENSG00000174953	DHX36	100	98.996	ENSCATG00000037545	DHX36	100	98.912	Cercocebus_atys
ENSG00000174953	DHX36	100	94.103	ENSCLAG00000003610	DHX36	100	91.964	Chinchilla_lanigera
ENSG00000174953	DHX36	100	98.611	ENSCSAG00000011962	DHX36	100	98.611	Chlorocebus_sabaeus
ENSG00000174953	DHX36	98	90.598	ENSCHOG00000002340	DHX36	100	88.134	Choloepus_hoffmanni
ENSG00000174953	DHX36	98	90.598	ENSCPBG00000018783	DHX36	96	81.513	Chrysemys_picta_bellii
ENSG00000174953	DHX36	92	65.455	ENSCING00000002018	-	98	67.822	Ciona_intestinalis
ENSG00000174953	DHX36	98	58.120	ENSCSAVG00000008110	-	99	53.163	Ciona_savignyi
ENSG00000174953	DHX36	100	98.468	ENSCANG00000040120	DHX36	100	98.468	Colobus_angolensis_palliatus
ENSG00000174953	DHX36	98	95.726	ENSCGRG00001013722	Dhx36	100	90.873	Cricetulus_griseus_chok1gshd
ENSG00000174953	DHX36	98	95.726	ENSCGRG00000005229	Dhx36	95	92.988	Cricetulus_griseus_crigri
ENSG00000174953	DHX36	99	74.429	ENSCSEG00000013424	dhx36	95	65.456	Cynoglossus_semilaevis
ENSG00000174953	DHX36	99	75.342	ENSCVAG00000005470	dhx36	91	67.345	Cyprinodon_variegatus
ENSG00000174953	DHX36	99	74.576	ENSDARG00000101059	dhx36	93	67.913	Danio_rerio
ENSG00000174953	DHX36	95	80.000	ENSDNOG00000001682	DHX36	100	77.224	Dasypus_novemcinctus
ENSG00000174953	DHX36	98	97.436	ENSDORG00000004848	Dhx36	98	89.820	Dipodomys_ordii
ENSG00000174953	DHX36	99	51.695	FBgn0032883	Rhau	94	39.220	Drosophila_melanogaster
ENSG00000174953	DHX36	98	94.872	ENSETEG00000009104	DHX36	96	80.252	Echinops_telfairi
ENSG00000174953	DHX36	98	72.650	ENSEBUG00000005040	-	93	66.667	Eptatretus_burgeri
ENSG00000174953	DHX36	98	96.581	ENSEASG00005020682	DHX36	92	93.586	Equus_asinus_asinus
ENSG00000174953	DHX36	98	96.581	ENSECAG00000025100	DHX36	92	92.308	Equus_caballus
ENSG00000174953	DHX36	98	96.581	ENSEEUG00000010430	DHX36	92	90.399	Erinaceus_europaeus
ENSG00000174953	DHX36	99	73.973	ENSELUG00000009181	dhx36	91	69.367	Esox_lucius
ENSG00000174953	DHX36	98	96.581	ENSFCAG00000004860	DHX36	100	93.287	Felis_catus
ENSG00000174953	DHX36	98	89.744	ENSFALG00000005045	DHX36	98	80.043	Ficedula_albicollis
ENSG00000174953	DHX36	98	94.872	ENSFDAG00000005896	DHX36	100	91.270	Fukomys_damarensis
ENSG00000174953	DHX36	98	74.359	ENSFHEG00000000896	dhx36	91	61.975	Fundulus_heteroclitus
ENSG00000174953	DHX36	99	76.712	ENSGMOG00000013947	dhx36	94	68.399	Gadus_morhua
ENSG00000174953	DHX36	98	90.598	ENSGALG00000043082	DHX36	95	81.837	Gallus_gallus
ENSG00000174953	DHX36	99	84.264	ENSGAFG00000013829	dhx36	92	72.530	Gambusia_affinis
ENSG00000174953	DHX36	99	76.256	ENSGACG00000010276	dhx36	91	70.288	Gasterosteus_aculeatus
ENSG00000174953	DHX36	98	89.744	ENSGAGG00000000294	DHX36	94	81.594	Gopherus_agassizii
ENSG00000174953	DHX36	100	99.504	ENSGGOG00000034937	DHX36	100	99.504	Gorilla_gorilla
ENSG00000174953	DHX36	99	76.256	ENSHBUG00000015199	dhx36	93	74.310	Haplochromis_burtoni
ENSG00000174953	DHX36	98	96.581	ENSHGLG00000017407	DHX36	98	90.700	Heterocephalus_glaber_female
ENSG00000174953	DHX36	98	96.581	ENSHGLG00100003204	DHX36	100	90.476	Heterocephalus_glaber_male
ENSG00000174953	DHX36	98	72.650	ENSHCOG00000003686	dhx36	94	66.068	Hippocampus_comes
ENSG00000174953	DHX36	99	80.508	ENSIPUG00000010835	dhx36	88	75.522	Ictalurus_punctatus
ENSG00000174953	DHX36	100	95.985	ENSSTOG00000003917	DHX36	100	93.651	Ictidomys_tridecemlineatus
ENSG00000174953	DHX36	100	93.852	ENSJJAG00000014564	Dhx36	96	93.908	Jaculus_jaculus
ENSG00000174953	DHX36	99	76.712	ENSKMAG00000019498	dhx36	94	69.148	Kryptolebias_marmoratus
ENSG00000174953	DHX36	99	76.256	ENSLBEG00000023465	dhx36	90	65.921	Labrus_bergylta
ENSG00000174953	DHX36	98	86.325	ENSLACG00000016218	DHX36	96	75.442	Latimeria_chalumnae
ENSG00000174953	DHX36	99	81.356	ENSLOCG00000002125	dhx36	94	73.777	Lepisosteus_oculatus
ENSG00000174953	DHX36	98	95.726	ENSLAFG00000015342	DHX36	96	91.807	Loxodonta_africana
ENSG00000174953	DHX36	100	99.206	ENSMFAG00000032288	DHX36	100	99.206	Macaca_fascicularis
ENSG00000174953	DHX36	100	99.107	ENSMMUG00000011347	DHX36	100	99.107	Macaca_mulatta
ENSG00000174953	DHX36	100	99.107	ENSMNEG00000039762	DHX36	100	99.107	Macaca_nemestrina
ENSG00000174953	DHX36	100	99.206	ENSMLEG00000032839	DHX36	100	99.206	Mandrillus_leucophaeus
ENSG00000174953	DHX36	99	73.973	ENSMAMG00000013131	dhx36	95	70.200	Mastacembelus_armatus
ENSG00000174953	DHX36	99	76.256	ENSMZEG00005001607	dhx36	96	73.404	Maylandia_zebra
ENSG00000174953	DHX36	98	90.598	ENSMGAG00000010853	DHX36	99	84.724	Meleagris_gallopavo
ENSG00000174953	DHX36	100	92.974	ENSMAUG00000000158	Dhx36	100	90.377	Mesocricetus_auratus
ENSG00000174953	DHX36	100	95.859	ENSMICG00000049093	DHX36	100	95.734	Microcebus_murinus
ENSG00000174953	DHX36	98	95.726	ENSMOCG00000006684	Dhx36	100	91.071	Microtus_ochrogaster
ENSG00000174953	DHX36	99	76.256	ENSMMOG00000013033	dhx36	94	72.418	Mola_mola
ENSG00000174953	DHX36	98	94.017	ENSMODG00000015820	DHX36	100	85.700	Monodelphis_domestica
ENSG00000174953	DHX36	99	74.886	ENSMALG00000010405	dhx36	93	63.983	Monopterus_albus
ENSG00000174953	DHX36	98	95.726	MGP_CAROLIEiJ_G0025032	Dhx36	100	90.774	Mus_caroli
ENSG00000174953	DHX36	98	95.726	ENSMUSG00000027770	Dhx36	100	90.873	Mus_musculus
ENSG00000174953	DHX36	98	95.726	MGP_PahariEiJ_G0026476	Dhx36	100	90.873	Mus_pahari
ENSG00000174953	DHX36	98	95.726	MGP_SPRETEiJ_G0025972	Dhx36	100	90.774	Mus_spretus
ENSG00000174953	DHX36	98	97.436	ENSMPUG00000002723	DHX36	100	92.899	Mustela_putorius_furo
ENSG00000174953	DHX36	98	95.726	ENSMLUG00000002318	DHX36	99	91.642	Myotis_lucifugus
ENSG00000174953	DHX36	98	97.436	ENSNGAG00000015307	Dhx36	99	91.270	Nannospalax_galili
ENSG00000174953	DHX36	99	75.342	ENSNBRG00000002239	dhx36	93	74.070	Neolamprologus_brichardi
ENSG00000174953	DHX36	100	98.996	ENSNLEG00000003640	DHX36	100	98.878	Nomascus_leucogenys
ENSG00000174953	DHX36	98	94.017	ENSMEUG00000001499	DHX36	87	71.930	Notamacropus_eugenii
ENSG00000174953	DHX36	87	93.000	ENSOPRG00000000175	DHX36	89	74.446	Ochotona_princeps
ENSG00000174953	DHX36	98	96.581	ENSODEG00000000935	DHX36	100	91.369	Octodon_degus
ENSG00000174953	DHX36	99	76.256	ENSONIG00000003546	dhx36	92	71.263	Oreochromis_niloticus
ENSG00000174953	DHX36	98	94.872	ENSOANG00000007079	-	100	86.631	Ornithorhynchus_anatinus
ENSG00000174953	DHX36	100	95.734	ENSOCUG00000001180	DHX36	100	93.849	Oryctolagus_cuniculus
ENSG00000174953	DHX36	99	76.712	ENSORLG00000005842	dhx36	96	73.077	Oryzias_latipes
ENSG00000174953	DHX36	99	76.712	ENSORLG00020004665	dhx36	96	73.317	Oryzias_latipes_hni
ENSG00000174953	DHX36	99	76.256	ENSORLG00015007188	dhx36	90	75.573	Oryzias_latipes_hsok
ENSG00000174953	DHX36	99	76.712	ENSOMEG00000011032	dhx36	94	66.169	Oryzias_melastigma
ENSG00000174953	DHX36	98	97.436	ENSOGAG00000011256	DHX36	95	93.856	Otolemur_garnettii
ENSG00000174953	DHX36	100	92.723	ENSOARG00000003508	DHX36	95	91.988	Ovis_aries
ENSG00000174953	DHX36	100	99.624	ENSPPAG00000020323	DHX36	100	99.406	Pan_paniscus
ENSG00000174953	DHX36	98	96.581	ENSPPRG00000002879	DHX36	100	93.762	Panthera_pardus
ENSG00000174953	DHX36	98	96.581	ENSPTIG00000018478	DHX36	100	91.171	Panthera_tigris_altaica
ENSG00000174953	DHX36	100	99.624	ENSPTRG00000015548	DHX36	100	99.603	Pan_troglodytes
ENSG00000174953	DHX36	100	99.206	ENSPANG00000007914	DHX36	100	99.206	Papio_anubis
ENSG00000174953	DHX36	98	77.778	ENSPKIG00000009943	dhx36	97	74.910	Paramormyrops_kingsleyae
ENSG00000174953	DHX36	98	91.453	ENSPSIG00000012755	DHX36	100	81.020	Pelodiscus_sinensis
ENSG00000174953	DHX36	99	73.394	ENSPMGG00000013858	dhx36	95	73.234	Periophthalmus_magnuspinnatus
ENSG00000174953	DHX36	100	93.350	ENSPEMG00000010012	Dhx36	100	90.972	Peromyscus_maniculatus_bairdii
ENSG00000174953	DHX36	99	70.000	ENSPMAG00000004056	-	100	69.542	Petromyzon_marinus
ENSG00000174953	DHX36	98	93.162	ENSPCIG00000000045	DHX36	94	86.743	Phascolarctos_cinereus
ENSG00000174953	DHX36	99	76.712	ENSPFOG00000009598	dhx36	91	67.975	Poecilia_formosa
ENSG00000174953	DHX36	99	76.712	ENSPLAG00000011061	dhx36	91	68.388	Poecilia_latipinna
ENSG00000174953	DHX36	99	76.712	ENSPMEG00000008396	dhx36	91	68.079	Poecilia_mexicana
ENSG00000174953	DHX36	99	76.256	ENSPREG00000002966	dhx36	91	68.323	Poecilia_reticulata
ENSG00000174953	DHX36	98	97.436	ENSPPYG00000014222	-	100	98.892	Pongo_abelii
ENSG00000174953	DHX36	99	95.763	ENSPCOG00000011695	-	99	82.857	Propithecus_coquereli
ENSG00000174953	DHX36	98	94.872	ENSPCOG00000028384	-	96	93.818	Propithecus_coquereli
ENSG00000174953	DHX36	98	94.872	ENSPVAG00000008465	DHX36	93	100.000	Pteropus_vampyrus
ENSG00000174953	DHX36	99	76.256	ENSPNYG00000007679	dhx36	91	59.599	Pundamilia_nyererei
ENSG00000174953	DHX36	99	78.082	ENSPNAG00000013972	dhx36	93	71.996	Pygocentrus_nattereri
ENSG00000174953	DHX36	98	95.726	ENSRNOG00000014599	Dhx36	100	90.476	Rattus_norvegicus
ENSG00000174953	DHX36	100	95.181	ENSRBIG00000044638	DHX36	100	95.181	Rhinopithecus_bieti
ENSG00000174953	DHX36	100	98.810	ENSRROG00000036472	DHX36	100	98.810	Rhinopithecus_roxellana
ENSG00000174953	DHX36	100	97.491	ENSSBOG00000024666	DHX36	100	96.640	Saimiri_boliviensis_boliviensis
ENSG00000174953	DHX36	98	94.017	ENSSHAG00000016292	DHX36	100	86.081	Sarcophilus_harrisii
ENSG00000174953	DHX36	98	78.632	ENSSFOG00015019533	dhx36	90	77.201	Scleropages_formosus
ENSG00000174953	DHX36	99	76.256	ENSSMAG00000011914	dhx36	80	75.831	Scophthalmus_maximus
ENSG00000174953	DHX36	99	76.256	ENSSDUG00000023657	dhx36	91	68.769	Seriola_dumerili
ENSG00000174953	DHX36	98	76.068	ENSSLDG00000015494	dhx36	94	78.280	Seriola_lalandi_dorsalis
ENSG00000174953	DHX36	98	96.581	ENSSARG00000006396	-	91	79.428	Sorex_araneus
ENSG00000174953	DHX36	98	86.325	ENSSPUG00000000785	-	99	80.858	Sphenodon_punctatus
ENSG00000174953	DHX36	99	75.799	ENSSPAG00000022168	dhx36	93	74.038	Stegastes_partitus
ENSG00000174953	DHX36	98	96.581	ENSSSCG00000024916	DHX36	100	93.926	Sus_scrofa
ENSG00000174953	DHX36	98	89.744	ENSTGUG00000011317	DHX36	100	80.386	Taeniopygia_guttata
ENSG00000174953	DHX36	99	75.799	ENSTRUG00000001230	dhx36	94	73.716	Takifugu_rubripes
ENSG00000174953	DHX36	99	74.886	ENSTNIG00000007692	dhx36	94	68.196	Tetraodon_nigroviridis
ENSG00000174953	DHX36	98	97.436	ENSTBEG00000013495	DHX36	100	89.901	Tupaia_belangeri
ENSG00000174953	DHX36	100	93.601	ENSTTRG00000016883	DHX36	100	91.609	Tursiops_truncatus
ENSG00000174953	DHX36	98	97.436	ENSUAMG00000017002	DHX36	99	93.586	Ursus_americanus
ENSG00000174953	DHX36	98	97.436	ENSUMAG00000011908	DHX36	100	95.119	Ursus_maritimus
ENSG00000174953	DHX36	98	95.726	ENSVPAG00000004046	DHX36	100	89.822	Vicugna_pacos
ENSG00000174953	DHX36	98	97.436	ENSVVUG00000024516	DHX36	100	92.956	Vulpes_vulpes
ENSG00000174953	DHX36	98	82.906	ENSXETG00000007768	dhx36	95	74.528	Xenopus_tropicalis
ENSG00000174953	DHX36	99	76.256	ENSXCOG00000011687	dhx36	90	68.577	Xiphophorus_couchianus
ENSG00000174953	DHX36	99	84.772	ENSXMAG00000001490	dhx36	92	69.388	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	16150737.21846770.	IDA	Function
GO:0000781	chromosome, telomeric region	20472641.21846770.	IDA	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	21586581.21993297.	IDA	Function
GO:0001503	ossification	-	ISS	Process
GO:0002151	G-quadruplex RNA binding	21873635.	IBA	Function
GO:0002151	G-quadruplex RNA binding	18842585.20472641.21149580.21846770.24151078.24369427.25579584.26489465.	IDA	Function
GO:0002151	G-quadruplex RNA binding	22238380.27940037.	IMP	Function
GO:0002735	positive regulation of myeloid dendritic cell cytokine production	-	IEA	Process
GO:0003697	single-stranded DNA binding	20696886.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	18854321.	IDA	Function
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	24369427.	IDA	Function
GO:0004003	ATP-dependent DNA helicase activity	21873635.	IBA	Function
GO:0004003	ATP-dependent DNA helicase activity	16150737.18842585.25579584.	IDA	Function
GO:0004004	ATP-dependent RNA helicase activity	14731398.18842585.21846770.	IDA	Function
GO:0005515	protein binding	14731398.17932509.18279852.20696886.21846770.26489465.	IPI	Function
GO:0005524	ATP binding	-	ISS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	14731398.18279852.18854321.	IDA	Component
GO:0005737	cytoplasm	14731398.18279852.18854321.20696886.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006359	regulation of transcription by RNA polymerase III	18279852.	IMP	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0008094	DNA-dependent ATPase activity	21586581.	IDA	Function
GO:0010494	cytoplasmic stress granule	18854321.	IDA	Component
GO:0010501	RNA secondary structure unwinding	18842585.20472641.21149580.21846770.22238380.	IDA	Process
GO:0010628	positive regulation of gene expression	-	ISS	Process
GO:0016607	nuclear speck	18279852.	IDA	Component
GO:0017148	negative regulation of translation	24369427.	IDA	Process
GO:0030424	axon	-	ISS	Component
GO:0030425	dendrite	-	ISS	Component
GO:0031442	positive regulation of mRNA 3'-end processing	27940037.	IMP	Process
GO:0032206	positive regulation of telomere maintenance	22238380.	IMP	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0034459	ATP-dependent 3'-5' RNA helicase activity	21873635.	IBA	Function
GO:0034605	cellular response to heat	18854321.	IDA	Process
GO:0034644	cellular response to UV	27940037.	IMP	Process
GO:0035925	mRNA 3'-UTR AU-rich region binding	14731398.26489465.	IDA	Function
GO:0042826	histone deacetylase binding	-	ISS	Function
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	ISS	Process
GO:0043204	perikaryon	-	ISS	Component
GO:0043330	response to exogenous dsRNA	-	IEA	Process
GO:0043488	regulation of mRNA stability	18279852.	IMP	Process
GO:0044212	transcription regulatory region DNA binding	-	ISS	Function
GO:0044806	G-quadruplex DNA unwinding	16150737.18842585.	IDA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0045995	regulation of embryonic development	-	ISS	Process
GO:0048027	mRNA 5'-UTR binding	26489465.	IDA	Function
GO:0051607	defense response to virus	-	IEA	Process
GO:0051880	G-quadruplex DNA binding	16150737.18842585.21586581.21993297.24151078.	IDA	Function
GO:0051891	positive regulation of cardioblast differentiation	-	ISS	Process
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	21993297.	IMP	Process
GO:0061003	positive regulation of dendritic spine morphogenesis	-	ISS	Process
GO:0061158	3'-UTR-mediated mRNA destabilization	26489465.	IMP	Process
GO:0070034	telomerase RNA binding	21149580.21846770.22238380.	IDA	Function
GO:0070062	extracellular exosome	18570454.	HDA	Component
GO:0070883	pre-miRNA binding	-	ISS	Function
GO:0090669	telomerase RNA stabilization	22238380.	IDA	Process
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	14731398.	IMP	Process
GO:1901534	positive regulation of hematopoietic progenitor cell differentiation	-	ISS	Process
GO:1902064	regulation of transcription from RNA polymerase II promoter involved in spermatogenesis	-	ISS	Process
GO:1902741	positive regulation of interferon-alpha secretion	20696886.	IMP	Process
GO:1903843	cellular response to arsenite ion	18854321.	IDA	Process
GO:1904358	positive regulation of telomere maintenance via telomere lengthening	21149580.	IMP	Process
GO:1904582	positive regulation of intracellular mRNA localization	-	ISS	Process
GO:2000767	positive regulation of cytoplasmic translation	26489465.	IMP	Process