EuRBPDB

Ensembl ID

ENSG00000175110 (Gene tree)

Gene ID

56945

Gene Symbol

MRPS22

Alias

MRP-S22|GK002|C3orf5|GIBT

Full Name

mitochondrial ribosomal protein S22

Gene Type

protein_coding

Species

Homo_sapiens

Status

putative

Strand

Plus strand

Length

351,418 bases

Position

chr3:139,005,806-139,357,223

Accession

14508

RBP type

canonical RBP

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]