EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000175130 (Gene tree)
Gene ID: 65108
Gene Symbol: MARCKSL1
Alias: F52|MacMARCKS|MLP1|MLP
Full Name: MARCKS like 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 2,551 bases
Position: chr1:32,333,829-32,336,379
Accession: 7142
RBP type: non-canonical RBP
Summary: This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10523674	Mutagenesis of SNM1, which encodes a protein component of the yeast RNase MRP, reveals a role for this ribonucleoprotein endoribonuclease in plasmid segregation.	Mol Cell Biol	1999 Nov	Cai T	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000329421	MARCKSL1-201	1699	-	ENSP00000362638	195 (aa)	-	P49006

Gene Model

Click here to download ENSG00000175130's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa05140	Leishmaniasis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175130's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	-	IEA	Function
GO:0005515	protein binding	24863880.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0008284	positive regulation of cell proliferation	-	IEA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29588366	The long noncoding RNA lncZic2 drives the self-renewal of liver tumor-initiating cells via the protein kinase C substrates MARCKS and MARCKSL1.	J Biol Chem	2018 May 25	Chen Z	doi: 10.1074/jbc.RA117.001321
22751924	c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.	Mol Cell Biol	2012 Sep	Bjrkblom B	doi: 10.1128/MCB.00713-12

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	32334792	Silent	novel	I131I	0.48
BLCA	chr1	32334903	Silent	novel	F94F	0.14
BRCA	chr1	32335011	Silent	rs142561179	A58A	0.55
BRCA	chr1	32334829	Missense_Mutation	NA	S119C	0.41
COAD	chr1	32334853	Frame_Shift_Del	novel	*E111Gfs87**	0.17
COAD	chr1	32334705	Missense_Mutation	novel	E160D	0.5
COAD	chr1	32334875	Missense_Mutation	NA	S104P	0.3
COAD	chr1	32334705	Missense_Mutation	novel	E160D	0.46
COAD	chr1	32334939	Frame_Shift_Del	NA	*K83Rfs18**	0.38
COAD	chr1	32334538	3'UTR	novel		0.2
COAD	chr1	32334994	Missense_Mutation	NA	A64V	0.4
DLBC	chr1	32336091	5'UTR	novel		0.35
DLBC	chr1	32334853	Missense_Mutation	novel	E111V	0.27
ESCA	chr1	32334683	Missense_Mutation	novel	E168Q	0.06
GBM	chr1	32336049	5'UTR	novel		0.14
GBM	chr1	32334543	3'UTR	novel		0.48
HNSC	chr1	32334637	Missense_Mutation	novel	E183V	0.29
HNSC	chr1	32334638	Missense_Mutation	novel	E183Q	0.3
LGG	chr1	32335036	Missense_Mutation	rs757947035	P50L	0.7
LGG	chr1	32334835	Missense_Mutation	novel	S117Y	0.4
LIHC	chr1	32334863	Frame_Shift_Del	novel	*F105Efs6**	0.8
LUAD	chr1	32334577	3'UTR	novel		0.31
LUSC	chr1	32334882	Missense_Mutation	NA	S101R	0.27
OV	chr1	32334923	Missense_Mutation	novel	K88Q	0.07
OV	chr1	32334809	Nonsense_Mutation	NA	Q126*	0.39
OV	chr1	32334740	Missense_Mutation	novel	P149S	0.22
READ	chr1	32334558	3'UTR	novel		0.26
SARC	chr1	32334703	Missense_Mutation	novel	A161D	0.14
SKCM	chr1	32334708	Silent	NA	A159A	0.06
SKCM	chr1	32334650	Missense_Mutation	NA	P179S	0.17
SKCM	chr1	32334832	Missense_Mutation	novel	A118V	0.24
SKCM	chr1	32335063	Missense_Mutation	rs374147732	S41F	0.24
STAD	chr1	32335979	Missense_Mutation	NA	A19T	0.17
STAD	chr1	32334875	Missense_Mutation	NA	S104P	0.16
STAD	chr1	32334530	3'UTR	novel		0.22
STAD	chr1	32336036	5'UTR	novel		0.17
THCA	chr1	32334578	3'UTR	novel		0.25
UCEC	chr1	32334555	3'UTR	novel		0.12
UCEC	chr1	32334909	Missense_Mutation	rs770620654	F92L	0.11
UCEC	chr1	32334865	Missense_Mutation	NA	R107I	0.25
UCEC	chr1	32334123	3'UTR	novel		0.24
UCEC	chr1	32333879	3'UTR	novel		0.53
UCEC	chr1	32334266	3'UTR	novel		0.48
UCEC	chr1	32334620	Missense_Mutation	novel	A189T	0.08
UCEC	chr1	32334938	Frame_Shift_Ins	rs749563695	*K83Qfs33**	0.39
UCEC	chr1	32334441	3'UTR	novel		0.15
UCEC	chr1	32334575	3'UTR	novel		0.19
UCEC	chr1	32334909	Missense_Mutation	rs770620654	F92L	0.5
UCEC	chr1	32334909	Missense_Mutation	rs770620654	F92L	0.77
UCEC	chr1	32334921	Silent	novel	K88K	0.24
UCEC	chr1	32333989	3'UTR	novel		0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.125	0.011841
LIHC	DEL	0.3216	1.6679e-20
TGCT	DEL	0.14	0.00046313

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.023	Kaplan-Meier Survival Analysis
SARC	0.00011	Kaplan-Meier Survival Analysis
ACC	0.0024	Kaplan-Meier Survival Analysis
TGCT	0.047	Kaplan-Meier Survival Analysis
COAD	0.032	Kaplan-Meier Survival Analysis
PCPG	0.034	Kaplan-Meier Survival Analysis
LAML	0.0088	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0075	Kaplan-Meier Survival Analysis
OV	0.015	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742