EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175166 (Gene tree)
Gene ID: 5708
Gene Symbol: PSMD2
Alias: S2|P97|TRAP2|MGC14274|Rpn1
Full Name: proteasome 26S subunit, non-ATPase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 10,346 bases
Position: chr3:184,298,709-184,309,054
Accession: 9559
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000463602	PSMD2-210	576	-	-	- (aa)	-	-
ENST00000460628	PSMD2-209	565	-	-	- (aa)	-	-
ENST00000417952	PSMD2-202	721	-	ENSP00000414061	217 (aa)	-	C9JPC0
ENST00000473991	PSMD2-212	590	-	-	- (aa)	-	-
ENST00000445558	PSMD2-207	825	-	ENSP00000407259	143 (aa)	-	H7C2Q3
ENST00000491494	PSMD2-218	371	-	-	- (aa)	-	-
ENST00000310118	PSMD2-201	3449	-	ENSP00000310129	908 (aa)	-	Q13200
ENST00000433010	PSMD2-204	942	-	ENSP00000411494	59 (aa)	-	F8WBS8
ENST00000459910	PSMD2-208	676	-	-	- (aa)	-	-
ENST00000476461	PSMD2-213	816	-	-	- (aa)	-	-
ENST00000488085	PSMD2-216	543	-	-	- (aa)	-	-
ENST00000435761	PSMD2-205	2574	-	ENSP00000402618	749 (aa)	-	Q13200
ENST00000432855	PSMD2-203	609	-	ENSP00000400330	203 (aa)	-	H7C1H2
ENST00000491149	PSMD2-217	895	-	-	- (aa)	-	-
ENST00000485937	PSMD2-214	603	-	-	- (aa)	-	-
ENST00000496925	PSMD2-220	723	-	-	- (aa)	-	-
ENST00000492191	PSMD2-219	581	-	-	- (aa)	-	-
ENST00000466987	PSMD2-211	530	-	-	- (aa)	-	-
ENST00000487475	PSMD2-215	910	-	-	- (aa)	-	-
ENST00000439383	PSMD2-206	2633	-	ENSP00000416028	778 (aa)	-	Q13200

Gene Model

Click here to download ENSG00000175166's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175166	rs11545169	3	184302754	G	Self-reported math ability	30038396	[0.01-0.021] unit increase	0.0153	EFO_0004875
ENSG00000175166	rs11545169	3	184302754	T	Educational attainment (MTAG)	30038396	[0.0071-0.0141] unit decrease	0.0106	EFO_0004784
ENSG00000175166	rs11545169	3	184302754	T	Self-reported math ability (MTAG)	30038396	[0.011-0.021] unit decrease	0.0158	EFO_0004875
ENSG00000175166	rs11545169	3	184302754	T	Cognitive performance (MTAG)	30038396	[0.011-0.023] unit decrease	0.0173	EFO_0008354
ENSG00000175166	rs7618629	3	184305273	G	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0054-0.0114] unit increase	0.00842028	EFO_0007878

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175166's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175166	PSMD2	99	63.553	FBgn0028695	Rpn1	99	61.304	Drosophila_melanogaster
ENSG00000175166	PSMD2	83	58.947	YHR027C	RPN1	87	55.118	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0004175	endopeptidase activity	21873635.	IBA	Function
GO:0005515	protein binding	11278995.16189514.16763564.16990800.18457437.18922472.19060904.19490896.19615732.22901813.25036637.25416956.26496610.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005838	proteasome regulatory particle	8774743.	TAS	Component
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008540	proteasome regulatory particle, base subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0030234	enzyme regulator activity	-	IEA	Function
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0034515	proteasome storage granule	21873635.	IBA	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0042176	regulation of protein catabolic process	-	IEA	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050790	regulation of catalytic activity	-	IEA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component