EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175183 (Gene tree)
Gene ID: 1466
Gene Symbol: CSRP2
Alias: SmLIM|CRP2|LMO5
Full Name: cysteine and glycine rich protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 20,346 bases
Position: chr12:76,858,715-76,879,060
Accession: 2470
RBP type: non-canonical RBP
Summary: CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000546966	CSRP2-202	754	-	ENSP00000450056	193 (aa)	-	Q16527
ENST00000547435	CSRP2-203	632	-	ENSP00000450143	187 (aa)	-	F8VQR7
ENST00000547557	CSRP2-204	628	-	-	- (aa)	-	-
ENST00000552330	CSRP2-207	910	-	ENSP00000449824	243 (aa)	-	F8VW96
ENST00000551725	CSRP2-206	194	-	-	- (aa)	-	-
ENST00000548783	CSRP2-205	5078	-	-	- (aa)	-	-
ENST00000311083	CSRP2-201	943	-	ENSP00000310901	193 (aa)	-	Q16527

Gene Model

Click here to download ENSG00000175183's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000175183	Asthma	2E-6	27611488

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175183's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175183	CSRP2	100	99.482	ENSMUSG00000020186	Csrp2	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	8626582.	NAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0030154	cell differentiation	8626582.	NAS	Process
GO:0046872	metal ion binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	76860348	Missense_Mutation	novel	A116D	0.28
BLCA	chr12	76859627	Missense_Mutation	novel	N142S	0.15
BRCA	chr12	76860409	Nonsense_Mutation	NA	Q96*	0.21
CESC	chr12	76859599	Missense_Mutation	NA	K151N	0.1
COAD	chr12	76863310	Silent	NA	V49V	0.33
COAD	chr12	76863228	Missense_Mutation	rs548686771	A77T	0.36
COAD	chr12	76866166	Missense_Mutation	NA	R32H	0.31
COAD	chr12	76863229	Silent	novel	G76G	0.42
COAD	chr12	76858837	3'UTR	novel		0.35
COAD	chr12	76866219	Silent	novel	G14G	0.09
GBM	chr12	76858986	Missense_Mutation	novel	G183D	0.2
KIRC	chr12	76863327	Silent	NA	L44L	0.34
LIHC	chr12	76859554	Silent	rs202057442	Y166Y	0.47
LUSC	chr12	76859574	Missense_Mutation	novel	E160K	0.45
OV	chr12	76858966	Missense_Mutation	NA	V190F	0.18
OV	chr12	76858900	3'UTR	novel		0.14
READ	chr12	76858929	3'UTR	novel		0.13
SARC	chr12	76863187	Missense_Mutation	novel	I90M	0.03
SKCM	chr12	76863273	Missense_Mutation	NA	Y62N	0.55
SKCM	chr12	76860282	Splice_Site	NA	X137_splice	0.42
STAD	chr12	76860282	Splice_Site	NA	X137_splice	0.33
STAD	chr12	76866155	Missense_Mutation	NA	L36V	0.1
STAD	chr12	76858912	3'UTR	novel		0.27
STAD	chr12	76860386	Silent	NA	N103N	0.18
STAD	chr12	76859618	Missense_Mutation	NA	R145Q	0.23
STAD	chr12	76859006	Silent	NA	G176G	0.1
STAD	chr12	76858837	3'UTR	novel		0.42
UCEC	chr12	76863292	Missense_Mutation	NA	E55D	0.34
UCEC	chr12	76859015	Missense_Mutation	NA	K173N	0.35
UCEC	chr12	76858945	3'UTR	novel		0.35
UCEC	chr12	76863292	Missense_Mutation	NA	E55D	0.22
UCEC	chr12	76863328	Frame_Shift_Ins	novel	*N43Kfs4**	0.29
UCEC	chr12	76860390	Frame_Shift_Ins	novel	*T102Kfs14**	0.03
UCEC	chr12	76858838	3'UTR	rs190992421		0.34
UCEC	chr12	76859582	Missense_Mutation	novel	T157N	0.19
UCEC	chr12	76859015	Missense_Mutation	NA	K173N	0.29
UCEC	chr12	76863177	Missense_Mutation	NA	S94G	0.16
UCEC	chr12	76866166	Missense_Mutation	NA	R32H	0.32
UCEC	chr12	76858837	3'UTR	novel		0.28
UCEC	chr12	76859639	Missense_Mutation	novel	P138L	0.48
UCEC	chr12	76863270	Missense_Mutation	rs750932703	G63R	0.41
UCEC	chr12	76860324	Missense_Mutation	novel	D124G	0.18
UCEC	chr12	76860391	Missense_Mutation	novel	T102P	0.44
UCEC	chr12	76859560	Missense_Mutation	NA	E164D	0.49
UCEC	chr12	76858787	3'UTR	novel		0.48
UCEC	chr12	76863190	Silent	novel	G89G	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0222	0.20414
DLBC	AMP	0.1875	0.085003
ESCA	DEL	0.1902	0.045584
HNSC	DEL	0.0747	0.22646
LUAD	DEL	0.1318	0.0059643
PAAD	DEL	0.1739	0.0030251
PRAD	AMP	0.0508	0.016187
READ	DEL	0.1091	0.064633
SKCM	DEL	0.1771	0.00079981

Survival Analysis

Cancer	P-value	Q-value
STAD	0.037	Kaplan-Meier Survival Analysis
MESO	0.0011	Kaplan-Meier Survival Analysis
ACC	0.00064	Kaplan-Meier Survival Analysis
HNSC	0.0027	Kaplan-Meier Survival Analysis
SKCM	0.03	Kaplan-Meier Survival Analysis
PRAD	0.0097	Kaplan-Meier Survival Analysis
BRCA	0.029	Kaplan-Meier Survival Analysis
KIRP	0.00023	Kaplan-Meier Survival Analysis
COAD	0.0026	Kaplan-Meier Survival Analysis
CESC	0.016	Kaplan-Meier Survival Analysis
LAML	0.03	Kaplan-Meier Survival Analysis
DLBC	0.033	Kaplan-Meier Survival Analysis
LGG	0.0021	Kaplan-Meier Survival Analysis
LUAD	0.029	Kaplan-Meier Survival Analysis
UVM	0.028	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742