EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175213 (Gene tree)
Gene ID: 79797
Gene Symbol: ZNF408
Alias: FLJ12827
Full Name: zinc finger protein 408
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 5,150 bases
Position: chr11:46,700,767-46,705,916
Accession: 20041
RBP type: canonical RBP
Summary: The protein encoded by this gene contains ten tandem zinc fingers and an N-terminal SET domain, so it is likely a DNA binding protein that interacts with other proteins. In adults, the encoded protein is expressed most highly in retina. Consequently, defects in this gene have been associated with familial exudative vitreoretinopathy (FEVR) and retinitis pigmentosa (RP). [provided by RefSeq, Dec 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000309606	zf-C2H2	PF00096.26	4.1e-40	1	8
ENSP00000309606	zf-C2H2	PF00096.26	4.1e-40	2	8
ENSP00000309606	zf-C2H2	PF00096.26	4.1e-40	3	8
ENSP00000309606	zf-C2H2	PF00096.26	4.1e-40	4	8
ENSP00000309606	zf-C2H2	PF00096.26	4.1e-40	5	8
ENSP00000309606	zf-C2H2	PF00096.26	4.1e-40	6	8
ENSP00000309606	zf-C2H2	PF00096.26	4.1e-40	7	8
ENSP00000309606	zf-C2H2	PF00096.26	4.1e-40	8	8
ENSP00000309606	zf-met	PF12874.7	7.6e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000311764	ZNF408-201	2442	-	ENSP00000309606	720 (aa)	-	Q9H9D4
ENST00000527008	ZNF408-203	699	-	-	- (aa)	-	-
ENST00000531866	ZNF408-204	575	-	-	- (aa)	-	-
ENST00000534481	ZNF408-205	529	-	-	- (aa)	-	-
ENST00000526410	ZNF408-202	539	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000175213's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000175213	Bone Density	4E-9	19801982
ENSG00000175213	Bone Density	5E-18	22504420

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175213	rs12361673	11	46702387	A	Femoral neck bone mineral density	29499414	[0.03-0.059] unit decrease	0.0446	EFO_0007785

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175213's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175213	ZNF408	100	80.854	ENSAMEG00000006904	ZNF408	98	81.180	Ailuropoda_melanoleuca
ENSG00000175213	ZNF408	99	83.310	ENSANAG00000036294	ZNF408	93	91.980	Aotus_nancymaae
ENSG00000175213	ZNF408	90	39.863	ENSAMXG00000032642	znf408	67	53.301	Astyanax_mexicanus
ENSG00000175213	ZNF408	99	90.141	ENSCJAG00000019859	ZNF408	99	90.141	Callithrix_jacchus
ENSG00000175213	ZNF408	100	81.507	ENSCAFG00000009143	ZNF408	95	81.983	Canis_familiaris
ENSG00000175213	ZNF408	100	81.370	ENSCAFG00020019155	ZNF408	95	81.844	Canis_lupus_dingo
ENSG00000175213	ZNF408	82	77.852	ENSCHIG00000025346	ZNF408	97	77.852	Capra_hircus
ENSG00000175213	ZNF408	100	81.667	ENSTSYG00000025443	ZNF408	98	82.203	Carlito_syrichta
ENSG00000175213	ZNF408	99	89.437	ENSCCAG00000029472	ZNF408	99	89.437	Cebus_capucinus
ENSG00000175213	ZNF408	56	96.564	ENSCHOG00000009909	ZNF408	75	96.564	Choloepus_hoffmanni
ENSG00000175213	ZNF408	100	70.499	ENSCGRG00001023588	Zfp408	99	70.563	Cricetulus_griseus_chok1gshd
ENSG00000175213	ZNF408	100	70.499	ENSCGRG00000017618	Zfp408	99	70.563	Cricetulus_griseus_crigri
ENSG00000175213	ZNF408	100	77.178	ENSDNOG00000047669	ZNF408	98	77.684	Dasypus_novemcinctus
ENSG00000175213	ZNF408	99	71.248	ENSDORG00000000387	Zfp408	97	72.046	Dipodomys_ordii
ENSG00000175213	ZNF408	88	63.167	ENSETEG00000017621	-	95	66.922	Echinops_telfairi
ENSG00000175213	ZNF408	100	79.201	ENSEASG00005015461	ZNF408	98	79.972	Equus_asinus_asinus
ENSG00000175213	ZNF408	100	78.788	ENSECAG00000010878	ZNF408	98	79.774	Equus_caballus
ENSG00000175213	ZNF408	94	69.367	ENSEEUG00000010466	ZNF408	94	69.514	Erinaceus_europaeus
ENSG00000175213	ZNF408	100	82.361	ENSFCAG00000029105	ZNF408	99	82.394	Felis_catus
ENSG00000175213	ZNF408	83	44.444	ENSFHEG00000016754	-	78	44.444	Fundulus_heteroclitus
ENSG00000175213	ZNF408	92	36.828	ENSGAFG00000018557	-	98	36.828	Gambusia_affinis
ENSG00000175213	ZNF408	100	98.889	ENSGGOG00000010152	ZNF408	100	98.889	Gorilla_gorilla
ENSG00000175213	ZNF408	86	79.615	ENSLAFG00000027848	ZNF408	100	79.615	Loxodonta_africana
ENSG00000175213	ZNF408	98	86.421	ENSMICG00000045320	ZNF408	98	86.421	Microcebus_murinus
ENSG00000175213	ZNF408	98	81.180	ENSMPUG00000005490	ZNF408	98	81.180	Mustela_putorius_furo
ENSG00000175213	ZNF408	99	71.548	ENSNGAG00000000309	Zfp408	98	72.057	Nannospalax_galili
ENSG00000175213	ZNF408	100	95.417	ENSNLEG00000014132	ZNF408	99	95.493	Nomascus_leucogenys
ENSG00000175213	ZNF408	99	65.315	ENSOPRG00000009225	ZNF408	95	67.158	Ochotona_princeps
ENSG00000175213	ZNF408	100	77.917	ENSOCUG00000010953	ZNF408	98	78.510	Oryctolagus_cuniculus
ENSG00000175213	ZNF408	86	84.117	ENSOGAG00000034080	ZNF408	100	84.117	Otolemur_garnettii
ENSG00000175213	ZNF408	100	99.167	ENSPPAG00000034993	ZNF408	100	99.167	Pan_paniscus
ENSG00000175213	ZNF408	100	82.083	ENSPPRG00000016866	ZNF408	99	82.113	Panthera_pardus
ENSG00000175213	ZNF408	100	81.543	ENSPTIG00000015467	ZNF408	99	81.704	Panthera_tigris_altaica
ENSG00000175213	ZNF408	100	99.167	ENSPTRG00000003551	ZNF408	100	99.167	Pan_troglodytes
ENSG00000175213	ZNF408	77	72.072	ENSPEMG00000016757	Zfp408	99	72.072	Peromyscus_maniculatus_bairdii
ENSG00000175213	ZNF408	92	36.996	ENSPFOG00000001760	-	92	49.474	Poecilia_formosa
ENSG00000175213	ZNF408	81	47.619	ENSPLAG00000019895	-	97	47.619	Poecilia_latipinna
ENSG00000175213	ZNF408	52	50.532	ENSPMEG00000021147	-	72	50.532	Poecilia_mexicana
ENSG00000175213	ZNF408	92	36.849	ENSPREG00000017068	-	98	36.951	Poecilia_reticulata
ENSG00000175213	ZNF408	100	95.694	ENSPPYG00000003318	ZNF408	100	95.840	Pongo_abelii
ENSG00000175213	ZNF408	100	75.694	ENSPCAG00000014001	ZNF408	99	75.634	Procavia_capensis
ENSG00000175213	ZNF408	98	85.614	ENSPCOG00000028698	ZNF408	98	85.614	Propithecus_coquereli
ENSG00000175213	ZNF408	98	80.845	ENSPVAG00000015791	ZNF408	99	80.252	Pteropus_vampyrus
ENSG00000175213	ZNF408	99	88.169	ENSSBOG00000033023	ZNF408	99	88.732	Saimiri_boliviensis_boliviensis
ENSG00000175213	ZNF408	100	79.339	ENSSSCG00000023097	ZNF408	96	79.330	Sus_scrofa
ENSG00000175213	ZNF408	76	91.700	ENSTBEG00000004260	ZNF408	81	91.700	Tupaia_belangeri
ENSG00000175213	ZNF408	100	81.680	ENSUAMG00000026154	ZNF408	99	81.704	Ursus_americanus
ENSG00000175213	ZNF408	100	81.543	ENSUMAG00000014405	ZNF408	99	81.145	Ursus_maritimus
ENSG00000175213	ZNF408	100	81.233	ENSVVUG00000026805	ZNF408	95	81.564	Vulpes_vulpes
ENSG00000175213	ZNF408	52	55.145	ENSXETG00000001980	znf408	100	54.090	Xenopus_tropicalis
ENSG00000175213	ZNF408	51	51.213	ENSXCOG00000002869	-	73	49.734	Xiphophorus_couchianus
ENSG00000175213	ZNF408	51	50.270	ENSXMAG00000018347	-	70	50.270	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0005515	protein binding	14667819.15231747.16189514.18255255.19060904.25416956.25910212.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	23716654.25882705.	IDA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0042802	identical protein binding	15231747.18255255.25416956.	IPI	Function
GO:0046872	metal ion binding	-	IEA	Function