EuRBPDB

Description

Ensembl ID: ENSG00000175221 (Gene tree)
Gene ID: 10025
Gene Symbol: MED16
Alias: DRIP92|TRAP95|THRAP5
Full Name: mediator complex subunit 16
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 25,589 bases
Position: chr19:867,630-893,218
Accession: 17556
RBP type: non-canonical RBP
Summary: (Mediator Complex Subunit 16) is a Protein Coding gene. Among its related pathways are Developmental Biology and Metabolism. Gene Ontology (GO) annotations related to this gene include transcription coregulator activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000586017	MED16-205	1403	-	ENSP00000465762	462 (aa)	-	K7EKS6
ENST00000395808	MED16-204	3420	-	ENSP00000379153	841 (aa)	-	Q9Y2X0
ENST00000325464	MED16-203	2922	XM_017026120	ENSP00000325612	877 (aa)	XP_016881609	Q9Y2X0
ENST00000589119	MED16-207	2772	-	ENSP00000464810	877 (aa)	-	Q9Y2X0
ENST00000616387	MED16-213	1078	-	ENSP00000479411	219 (aa)	-	B9TX11
ENST00000312090	MED16-202	3229	-	ENSP00000308528	860 (aa)	-	Q9Y2X0
ENST00000606248	MED16-210	3181	-	ENSP00000475528	663 (aa)	-	U3KQ43
ENST00000606828	MED16-211	599	-	ENSP00000480766	194 (aa)	-	B9TX03
ENST00000269814	MED16-201	1199	-	ENSP00000269814	218 (aa)	-	B9TX12
ENST00000617672	MED16-214	554	-	ENSP00000483533	135 (aa)	-	B9TX21
ENST00000592373	MED16-208	927	-	ENSP00000465823	74 (aa)	-	K7EKX2
ENST00000586342	MED16-206	635	-	ENSP00000465827	49 (aa)	-	K7EKX6
ENST00000607471	MED16-212	2004	-	ENSP00000475725	505 (aa)	-	U3KQB4
ENST00000621073	MED16-215	492	-	ENSP00000478286	79 (aa)	-	A0A087WU12
ENST00000592943	MED16-209	1628	-	ENSP00000466868	537 (aa)	-	B9TWZ6

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04919	Thyroid hormone signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000175221	Platelet Function Tests	9.9130000E-006	-
ENSG00000175221	Platelet Function Tests	1.6422900E-005	-
ENSG00000175221	Platelet Function Tests	7.2132700E-006	-
ENSG00000175221	Platelet Function Tests	3.3023016E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175221	rs891206	19	872255	G	Blood protein levels	30072576	[0.073-0.175] unit increase	0.124	EFO_0007937
ENSG00000175221	rs1617214	19	877437	G	Blood protein levels	30072576	[0.1-0.22] unit increase	0.16	EFO_0007937

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003712	transcription coregulator activity	12218053.	IDA	Function
GO:0003713	transcription coactivator activity	10198638.	TAS	Function
GO:0003824	catalytic activity	-	IEA	Function
GO:0005515	protein binding	24882805.	IPI	Function
GO:0005634	nucleus	10198638.	NAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006357	regulation of transcription by RNA polymerase II	10198638.	NAS	Process
GO:0006366	transcription by RNA polymerase II	10198638.	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	12218053.	IDA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016592	mediator complex	21873635.	IBA	Component
GO:0016592	mediator complex	10198638.	IDA	Component
GO:0030375	thyroid hormone receptor coactivator activity	10198638.	IDA	Function
GO:0042809	vitamin D receptor binding	10235266.	NAS	Function
GO:0045893	positive regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045893	positive regulation of transcription, DNA-templated	10198638.	IDA	Process
GO:0046966	thyroid hormone receptor binding	10198638.	IDA	Function