EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175324 (Gene tree)
Gene ID: 27257
Gene Symbol: LSM1
Alias: CASM|YJL124C
Full Name: LSM1 homolog, mRNA degradation associated
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 13,410 bases
Position: chr8:38,163,321-38,176,730
Accession: 20472
RBP type: canonical RBP
Summary: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000310596	LSM	PF01423.22	7.3e-15	1	1
ENSP00000430021	LSM	PF01423.22	8.9e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26092942	The Lsm1-7-Pat1 complex promotes viral RNA translation and replication by differential mechanisms.	RNA	2015 Aug	Jungfleisch J	doi: 10.1261/rna.052209.115
25035297	Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex.	RNA	2014 Sep	Chowdhury A	doi: 10.1261/rna.045252.114
19643916	Activation of decapping involves binding of the mRNA and facilitation of the post-binding steps by the Lsm1-7-Pat1 complex.	RNA	2009 Oct	Chowdhury A	doi: 10.1261/rna.1650109
22450758	Both Sm-domain and C-terminal extension of Lsm1 are important for the RNA-binding activity of the Lsm1-7-Pat1 complex.	RNA	2012 May	Chowdhury A	doi: 10.1261/rna.029876.111
24139796	Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover.	Cell Rep	2013 Oct 31	Sharif H	doi: 10.1016/j.celrep.2013.10.004
27434131	Mutagenic Analysis of the C-Terminal Extension of Lsm1.	PLoS One	2016 Jul 19	Chowdhury A	doi: 10.1371/journal.pone.0158876
25872476	LSm1 binds to the Dengue virus RNA 3' UTR and is a positive regulator of Dengue virus replication.	Int J Mol Med	2015 Jun	Dong Y	doi: 10.3892/ijmm.2015.2169

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000520286	LSM1-202	776	NR_045493	-	- (aa)	-	-
ENST00000522515	LSM1-204	1568	-	-	- (aa)	-	-
ENST00000523511	LSM1-205	700	-	ENSP00000428307	44 (aa)	-	E5RJ47
ENST00000311351	LSM1-201	1147	-	ENSP00000310596	133 (aa)	-	O15116
ENST00000520755	LSM1-203	975	-	ENSP00000430021	44 (aa)	-	E5RH18

Gene Model

Click here to download ENSG00000175324's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000175324	Schizophrenia	1E-10	22037555

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175324	rs5891007	8	38163493	?	Schizophrenia	28991256	[1.07-1.15]	1.1086475	EFO_0000692
ENSG00000175324	rs16887244	8	38173827	?	Schizophrenia	22037555	[1.14-1.27]	1.19	EFO_0000692
ENSG00000175324	rs145151767	8	38167993	?	Systolic blood pressure	30595370			EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175324's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000175324	LSM1	65	34.091	ENSG00000128534	LSM8	99	33.333

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175324	LSM1	100	85.714	ENSAPOG00000010833	lsm1	100	85.714	Acanthochromis_polyacanthus
ENSG00000175324	LSM1	100	100.000	ENSAMEG00000011141	LSM1	100	100.000	Ailuropoda_melanoleuca
ENSG00000175324	LSM1	89	89.744	ENSACIG00000019593	lsm1	64	92.208	Amphilophus_citrinellus
ENSG00000175324	LSM1	100	85.714	ENSAOCG00000017096	lsm1	100	85.714	Amphiprion_ocellaris
ENSG00000175324	LSM1	100	85.714	ENSAOCG00000017997	-	100	85.714	Amphiprion_ocellaris
ENSG00000175324	LSM1	100	85.714	ENSAPEG00000011669	lsm1	100	85.714	Amphiprion_percula
ENSG00000175324	LSM1	100	84.211	ENSATEG00000022266	lsm1	100	84.211	Anabas_testudineus
ENSG00000175324	LSM1	100	100.000	ENSANAG00000027785	LSM1	100	100.000	Aotus_nancymaae
ENSG00000175324	LSM1	100	84.211	ENSACLG00000011400	lsm1	100	84.211	Astatotilapia_calliptera
ENSG00000175324	LSM1	100	86.466	ENSAMXG00000005441	lsm1	100	86.466	Astyanax_mexicanus
ENSG00000175324	LSM1	100	99.248	ENSBTAG00000001612	LSM1	100	99.248	Bos_taurus
ENSG00000175324	LSM1	86	71.053	WBGene00003076	lsm-1	73	58.065	Caenorhabditis_elegans
ENSG00000175324	LSM1	100	100.000	ENSCJAG00000048015	LSM1	100	100.000	Callithrix_jacchus
ENSG00000175324	LSM1	100	100.000	ENSCAFG00000006113	LSM1	100	100.000	Canis_familiaris
ENSG00000175324	LSM1	100	100.000	ENSCAFG00020001822	LSM1	100	100.000	Canis_lupus_dingo
ENSG00000175324	LSM1	100	100.000	ENSCHIG00000013194	LSM1	100	100.000	Capra_hircus
ENSG00000175324	LSM1	100	100.000	ENSTSYG00000010394	LSM1	100	100.000	Carlito_syrichta
ENSG00000175324	LSM1	100	100.000	ENSCPOG00000032671	LSM1	100	100.000	Cavia_porcellus
ENSG00000175324	LSM1	100	100.000	ENSCCAG00000037171	LSM1	100	100.000	Cebus_capucinus
ENSG00000175324	LSM1	100	100.000	ENSCATG00000020377	LSM1	100	100.000	Cercocebus_atys
ENSG00000175324	LSM1	100	98.496	ENSCLAG00000001137	LSM1	100	98.496	Chinchilla_lanigera
ENSG00000175324	LSM1	100	100.000	ENSCSAG00000015485	LSM1	100	100.000	Chlorocebus_sabaeus
ENSG00000175324	LSM1	100	99.248	ENSCHOG00000006030	LSM1	100	99.248	Choloepus_hoffmanni
ENSG00000175324	LSM1	95	88.976	ENSCPBG00000006569	LSM1	86	88.976	Chrysemys_picta_bellii
ENSG00000175324	LSM1	89	82.051	ENSCING00000013536	-	99	67.424	Ciona_intestinalis
ENSG00000175324	LSM1	100	100.000	ENSCANG00000019173	LSM1	100	100.000	Colobus_angolensis_palliatus
ENSG00000175324	LSM1	100	99.248	ENSCGRG00001024560	-	100	99.248	Cricetulus_griseus_chok1gshd
ENSG00000175324	LSM1	70	93.548	ENSCGRG00001002259	-	97	81.982	Cricetulus_griseus_chok1gshd
ENSG00000175324	LSM1	100	99.248	ENSCGRG00000006554	-	100	99.248	Cricetulus_griseus_crigri
ENSG00000175324	LSM1	70	93.548	ENSCGRG00000013603	-	97	81.982	Cricetulus_griseus_crigri
ENSG00000175324	LSM1	100	82.707	ENSCSEG00000008319	lsm1	92	82.707	Cynoglossus_semilaevis
ENSG00000175324	LSM1	100	83.459	ENSCSEG00000010570	lsm1	92	83.459	Cynoglossus_semilaevis
ENSG00000175324	LSM1	100	83.459	ENSCVAG00000003871	lsm1	100	83.459	Cyprinodon_variegatus
ENSG00000175324	LSM1	100	85.714	ENSDARG00000043177	lsm1	100	85.714	Danio_rerio
ENSG00000175324	LSM1	100	93.985	ENSDNOG00000030989	-	100	93.985	Dasypus_novemcinctus
ENSG00000175324	LSM1	100	99.248	ENSDNOG00000032911	-	100	99.248	Dasypus_novemcinctus
ENSG00000175324	LSM1	100	100.000	ENSDNOG00000046387	-	100	100.000	Dasypus_novemcinctus
ENSG00000175324	LSM1	89	79.832	ENSDNOG00000046620	-	100	79.832	Dasypus_novemcinctus
ENSG00000175324	LSM1	100	100.000	ENSDORG00000028172	Lsm1	100	100.000	Dipodomys_ordii
ENSG00000175324	LSM1	93	63.710	FBgn0261067	LSm1	91	63.710	Drosophila_melanogaster
ENSG00000175324	LSM1	100	98.496	ENSEASG00005016677	LSM1	100	98.496	Equus_asinus_asinus
ENSG00000175324	LSM1	100	98.496	ENSECAG00000010461	LSM1	100	98.496	Equus_caballus
ENSG00000175324	LSM1	89	97.436	ENSEEUG00000015181	LSM1	100	69.925	Erinaceus_europaeus
ENSG00000175324	LSM1	89	97.436	ENSELUG00000023374	lsm1	100	84.211	Esox_lucius
ENSG00000175324	LSM1	100	86.466	ENSELUG00000002322	lsm1	100	86.466	Esox_lucius
ENSG00000175324	LSM1	100	100.000	ENSFCAG00000039335	LSM1	100	100.000	Felis_catus
ENSG00000175324	LSM1	89	94.915	ENSFALG00000006723	LSM1	100	94.915	Ficedula_albicollis
ENSG00000175324	LSM1	100	100.000	ENSFDAG00000007658	LSM1	100	100.000	Fukomys_damarensis
ENSG00000175324	LSM1	100	83.459	ENSFHEG00000009556	lsm1	100	83.459	Fundulus_heteroclitus
ENSG00000175324	LSM1	100	83.459	ENSGMOG00000016651	lsm1	98	83.459	Gadus_morhua
ENSG00000175324	LSM1	100	93.233	ENSGALG00000003245	LSM1	100	93.233	Gallus_gallus
ENSG00000175324	LSM1	100	83.459	ENSGAFG00000011355	lsm1	100	83.459	Gambusia_affinis
ENSG00000175324	LSM1	100	84.211	ENSGACG00000011763	lsm1	98	84.211	Gasterosteus_aculeatus
ENSG00000175324	LSM1	100	95.489	ENSGAGG00000024065	LSM1	100	95.489	Gopherus_agassizii
ENSG00000175324	LSM1	100	100.000	ENSGGOG00000022658	LSM1	100	100.000	Gorilla_gorilla
ENSG00000175324	LSM1	100	84.211	ENSHBUG00000010897	lsm1	100	84.211	Haplochromis_burtoni
ENSG00000175324	LSM1	100	79.699	ENSHGLG00000017574	-	100	79.699	Heterocephalus_glaber_female
ENSG00000175324	LSM1	100	100.000	ENSHGLG00000005711	LSM1	100	100.000	Heterocephalus_glaber_female
ENSG00000175324	LSM1	100	79.699	ENSHGLG00100012152	-	100	79.699	Heterocephalus_glaber_male
ENSG00000175324	LSM1	100	100.000	ENSHGLG00100017660	LSM1	100	100.000	Heterocephalus_glaber_male
ENSG00000175324	LSM1	100	84.211	ENSHCOG00000017233	lsm1	100	84.211	Hippocampus_comes
ENSG00000175324	LSM1	100	84.962	ENSIPUG00000002312	LSM1	100	84.962	Ictalurus_punctatus
ENSG00000175324	LSM1	89	97.436	ENSSTOG00000026870	LSM1	94	100.000	Ictidomys_tridecemlineatus
ENSG00000175324	LSM1	100	98.496	ENSJJAG00000014605	-	100	98.496	Jaculus_jaculus
ENSG00000175324	LSM1	100	84.211	ENSKMAG00000003016	lsm1	100	84.211	Kryptolebias_marmoratus
ENSG00000175324	LSM1	100	84.211	ENSLBEG00000022352	lsm1	100	84.211	Labrus_bergylta
ENSG00000175324	LSM1	89	90.678	ENSLACG00000010947	LSM1	98	90.678	Latimeria_chalumnae
ENSG00000175324	LSM1	100	94.737	ENSLOCG00000015149	lsm1	100	94.737	Lepisosteus_oculatus
ENSG00000175324	LSM1	100	100.000	ENSLAFG00000003534	LSM1	100	100.000	Loxodonta_africana
ENSG00000175324	LSM1	100	100.000	ENSMFAG00000032661	LSM1	100	100.000	Macaca_fascicularis
ENSG00000175324	LSM1	100	100.000	ENSMLEG00000034535	LSM1	100	100.000	Mandrillus_leucophaeus
ENSG00000175324	LSM1	100	84.211	ENSMAMG00000007464	lsm1	100	84.211	Mastacembelus_armatus
ENSG00000175324	LSM1	100	84.211	ENSMZEG00005010321	lsm1	100	84.211	Maylandia_zebra
ENSG00000175324	LSM1	100	93.233	ENSMGAG00000002125	LSM1	100	93.233	Meleagris_gallopavo
ENSG00000175324	LSM1	100	100.000	ENSMICG00000030726	LSM1	100	100.000	Microcebus_murinus
ENSG00000175324	LSM1	100	99.248	ENSMOCG00000022817	Lsm1	100	99.248	Microtus_ochrogaster
ENSG00000175324	LSM1	100	84.962	ENSMMOG00000015466	lsm1	100	84.962	Mola_mola
ENSG00000175324	LSM1	100	97.744	ENSMODG00000010732	-	100	97.744	Monodelphis_domestica
ENSG00000175324	LSM1	89	89.744	ENSMALG00000001478	lsm1	82	92.208	Monopterus_albus
ENSG00000175324	LSM1	100	97.744	MGP_CAROLIEiJ_G0030930	Lsm1	100	97.744	Mus_caroli
ENSG00000175324	LSM1	100	97.744	ENSMUSG00000037296	Lsm1	100	97.744	Mus_musculus
ENSG00000175324	LSM1	100	97.744	MGP_PahariEiJ_G0021400	Lsm1	100	97.744	Mus_pahari
ENSG00000175324	LSM1	100	97.744	MGP_SPRETEiJ_G0032049	Lsm1	100	97.744	Mus_spretus
ENSG00000175324	LSM1	100	99.248	ENSMPUG00000009883	LSM1	100	99.248	Mustela_putorius_furo
ENSG00000175324	LSM1	100	99.248	ENSMLUG00000003734	LSM1	100	99.248	Myotis_lucifugus
ENSG00000175324	LSM1	100	99.248	ENSNGAG00000003753	Lsm1	100	99.248	Nannospalax_galili
ENSG00000175324	LSM1	89	89.744	ENSNBRG00000017370	lsm1	66	92.208	Neolamprologus_brichardi
ENSG00000175324	LSM1	100	100.000	ENSNLEG00000029390	LSM1	100	100.000	Nomascus_leucogenys
ENSG00000175324	LSM1	100	97.744	ENSMEUG00000014077	LSM1	100	97.744	Notamacropus_eugenii
ENSG00000175324	LSM1	88	94.017	ENSOPRG00000000333	LSM1	100	94.017	Ochotona_princeps
ENSG00000175324	LSM1	100	100.000	ENSODEG00000004834	LSM1	100	100.000	Octodon_degus
ENSG00000175324	LSM1	100	84.211	ENSONIG00000010782	lsm1	100	84.211	Oreochromis_niloticus
ENSG00000175324	LSM1	100	96.992	ENSOANG00000003256	LSM1	100	96.992	Ornithorhynchus_anatinus
ENSG00000175324	LSM1	100	100.000	ENSOCUG00000015399	LSM1	100	100.000	Oryctolagus_cuniculus
ENSG00000175324	LSM1	100	85.714	ENSORLG00000030288	lsm1	100	85.714	Oryzias_latipes
ENSG00000175324	LSM1	100	85.714	ENSORLG00020003941	lsm1	100	85.714	Oryzias_latipes_hni
ENSG00000175324	LSM1	100	84.211	ENSORLG00020006213	-	86	84.211	Oryzias_latipes_hni
ENSG00000175324	LSM1	100	85.714	ENSORLG00015018350	lsm1	100	85.714	Oryzias_latipes_hsok
ENSG00000175324	LSM1	100	84.211	ENSOMEG00000012454	lsm1	100	84.211	Oryzias_melastigma
ENSG00000175324	LSM1	100	100.000	ENSOGAG00000015161	LSM1	100	100.000	Otolemur_garnettii
ENSG00000175324	LSM1	100	100.000	ENSOARG00000001317	LSM1	100	100.000	Ovis_aries
ENSG00000175324	LSM1	100	100.000	ENSPPAG00000032279	LSM1	100	100.000	Pan_paniscus
ENSG00000175324	LSM1	100	100.000	ENSPPRG00000014172	-	100	100.000	Panthera_pardus
ENSG00000175324	LSM1	100	100.000	ENSPTIG00000010289	LSM1	100	100.000	Panthera_tigris_altaica
ENSG00000175324	LSM1	100	100.000	ENSPTRG00000020169	LSM1	100	100.000	Pan_troglodytes
ENSG00000175324	LSM1	100	100.000	ENSPANG00000008814	LSM1	100	100.000	Papio_anubis
ENSG00000175324	LSM1	100	90.226	ENSPKIG00000001839	lsm1	100	90.226	Paramormyrops_kingsleyae
ENSG00000175324	LSM1	100	82.707	ENSPKIG00000019409	LSM1	99	82.707	Paramormyrops_kingsleyae
ENSG00000175324	LSM1	98	89.231	ENSPSIG00000012563	LSM1	99	89.231	Pelodiscus_sinensis
ENSG00000175324	LSM1	89	89.744	ENSPMGG00000022999	lsm1	73	92.208	Periophthalmus_magnuspinnatus
ENSG00000175324	LSM1	85	80.531	ENSPMAG00000002671	lsm1	100	80.531	Petromyzon_marinus
ENSG00000175324	LSM1	100	96.241	ENSPCIG00000008880	LSM1	100	96.241	Phascolarctos_cinereus
ENSG00000175324	LSM1	100	83.459	ENSPFOG00000016029	lsm1	100	83.459	Poecilia_formosa
ENSG00000175324	LSM1	100	83.459	ENSPLAG00000007879	lsm1	100	83.459	Poecilia_latipinna
ENSG00000175324	LSM1	100	83.459	ENSPMEG00000023550	lsm1	100	83.459	Poecilia_mexicana
ENSG00000175324	LSM1	100	83.459	ENSPREG00000009574	lsm1	100	83.459	Poecilia_reticulata
ENSG00000175324	LSM1	100	100.000	ENSPPYG00000018521	LSM1	100	100.000	Pongo_abelii
ENSG00000175324	LSM1	100	100.000	ENSPCOG00000020901	-	100	100.000	Propithecus_coquereli
ENSG00000175324	LSM1	100	100.000	ENSPVAG00000006016	LSM1	100	100.000	Pteropus_vampyrus
ENSG00000175324	LSM1	100	84.211	ENSPNYG00000018067	lsm1	100	84.211	Pundamilia_nyererei
ENSG00000175324	LSM1	100	85.714	ENSPNAG00000013707	lsm1	100	85.714	Pygocentrus_nattereri
ENSG00000175324	LSM1	100	97.744	ENSRNOG00000015375	Lsm1	100	97.744	Rattus_norvegicus
ENSG00000175324	LSM1	100	100.000	ENSRBIG00000027449	LSM1	100	100.000	Rhinopithecus_bieti
ENSG00000175324	LSM1	100	100.000	ENSRROG00000036074	LSM1	100	100.000	Rhinopithecus_roxellana
ENSG00000175324	LSM1	100	97.744	ENSSHAG00000017260	LSM1	100	97.744	Sarcophilus_harrisii
ENSG00000175324	LSM1	100	91.729	ENSSFOG00015019528	lsm1	100	91.729	Scleropages_formosus
ENSG00000175324	LSM1	100	84.211	ENSSMAG00000004930	lsm1	100	84.211	Scophthalmus_maximus
ENSG00000175324	LSM1	100	84.211	ENSSDUG00000021823	lsm1	100	84.211	Seriola_dumerili
ENSG00000175324	LSM1	100	84.211	ENSSLDG00000012154	lsm1	100	84.211	Seriola_lalandi_dorsalis
ENSG00000175324	LSM1	100	95.489	ENSSPUG00000014878	LSM1	100	95.489	Sphenodon_punctatus
ENSG00000175324	LSM1	100	84.962	ENSSPAG00000020548	lsm1	100	84.962	Stegastes_partitus
ENSG00000175324	LSM1	100	98.496	ENSSSCG00000039058	LSM1	100	98.496	Sus_scrofa
ENSG00000175324	LSM1	100	94.737	ENSTGUG00000004793	LSM1	100	94.737	Taeniopygia_guttata
ENSG00000175324	LSM1	100	86.466	ENSTRUG00000025239	lsm1	100	86.466	Takifugu_rubripes
ENSG00000175324	LSM1	100	86.466	ENSTNIG00000004055	lsm1	100	86.466	Tetraodon_nigroviridis
ENSG00000175324	LSM1	88	97.436	ENSTBEG00000015884	LSM1	100	97.436	Tupaia_belangeri
ENSG00000175324	LSM1	100	100.000	ENSTTRG00000004482	LSM1	100	100.000	Tursiops_truncatus
ENSG00000175324	LSM1	100	100.000	ENSUAMG00000004103	LSM1	100	100.000	Ursus_americanus
ENSG00000175324	LSM1	100	100.000	ENSUMAG00000009132	LSM1	100	100.000	Ursus_maritimus
ENSG00000175324	LSM1	89	94.872	ENSVPAG00000011593	LSM1	100	98.701	Vicugna_pacos
ENSG00000175324	LSM1	89	61.538	ENSVVUG00000014880	-	91	69.767	Vulpes_vulpes
ENSG00000175324	LSM1	100	100.000	ENSVVUG00000020191	LSM1	100	100.000	Vulpes_vulpes
ENSG00000175324	LSM1	100	92.701	ENSXETG00000009004	lsm1	100	92.701	Xenopus_tropicalis
ENSG00000175324	LSM1	100	82.707	ENSXCOG00000015631	lsm1	100	82.707	Xiphophorus_couchianus
ENSG00000175324	LSM1	100	82.707	ENSXMAG00000026637	lsm1	100	82.707	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	21873635.	IBA	Process
GO:0000339	RNA cap binding	21873635.	IBA	Function
GO:0000375	RNA splicing, via transesterification reactions	10369684.	TAS	Process
GO:0000932	P-body	21873635.	IBA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	-	IEA	Function
GO:0005515	protein binding	15231747.18172165.19628699.20584987.20852261.25416956.26871637.	IPI	Function
GO:0005634	nucleus	18559850.	IDA	Component
GO:0005737	cytoplasm	18559850.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0008380	RNA splicing	10369684.	TAS	Process
GO:0016070	RNA metabolic process	21873635.	IBA	Process
GO:0019827	stem cell population maintenance	-	IEA	Process
GO:0030424	axon	-	IEA	Component
GO:0030425	dendrite	-	IEA	Component
GO:0036002	pre-mRNA binding	-	IEA	Function
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0045665	negative regulation of neuron differentiation	-	IEA	Process
GO:0071044	histone mRNA catabolic process	18172165.	IMP	Process
GO:1990124	messenger ribonucleoprotein complex	-	IEA	Component
GO:1990726	Lsm1-7-Pat1 complex	21873635.	IBA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18218995	CaSm (LSm-1) overexpression in lung cancer and mesothelioma is required for transformed phenotypes.	Am J Respir Cell Mol Biol	2008 Jun	Watson PM	doi: 10.1165/rcmb.2007-0205OC
17001308	Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon.	Oncogene	2007 Mar 29	Streicher KL	-
11953827	Down-regulation of Lsm1 is involved in human prostate cancer progression.	Br J Cancer	2002 Mar 18	Takahashi S	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr8	38163736	Silent	NA	L112L	0.23
BRCA	chr8	38163579	3'UTR	novel		0.83
BRCA	chr8	38171982	Missense_Mutation	NA	R33K	0.33	LSM
BRCA	chr8	38176288	Silent	NA	I11I	0.38
BRCA	chr8	38163552	3'UTR	novel		0.07
COAD	chr8	38163708	Missense_Mutation	novel	L122I	0.29
COAD	chr8	38169887	Missense_Mutation	NA	R49H	0.3
COAD	chr8	38169891	Nonsense_Mutation	NA	E48*	0.4
COAD	chr8	38163619	3'UTR	novel		0.15
COAD	chr8	38169868	Frame_Shift_Del	NA	*K55Nfs20**	0.32
COAD	chr8	38169857	Missense_Mutation	NA	I59S	0.2
ESCA	chr8	38163495	3'UTR	novel		0.32
ESCA	chr8	38176446	5'UTR	novel		0.38
ESCA	chr8	38163546	3'UTR	novel		0.2
ESCA	chr8	38163516	3'UTR	novel		0.08
HNSC	chr8	38163813	Missense_Mutation	novel	L87I	0.08
HNSC	chr8	38163689	Missense_Mutation	novel	D128G	0.43
KIRC	chr8	38171997	Missense_Mutation	NA	L28P	0.1	LSM
KIRC	chr8	38169865	Silent	rs769909686	Y56Y	0.08
KIRP	chr8	38169918	Splice_Site	novel	X39_splice	0.26
LIHC	chr8	38171983	Missense_Mutation	novel	R33G	0.12	LSM
LUSC	chr8	38169912	Silent	novel	L41L	0.37
LUSC	chr8	38163589	3'UTR	novel		0.4
LUSC	chr8	38171994	Missense_Mutation	rs201992884	I29T	0.29	LSM
LUSC	chr8	38163795	Missense_Mutation	novel	E93Q	0.43
LUSC	chr8	38163833	Missense_Mutation	novel	E80V	0.24
READ	chr8	38169814	Silent	NA	L73L	0.31
SKCM	chr8	38176379	5'UTR	novel		0.57
SKCM	chr8	38169848	Missense_Mutation	novel	G62E	0.31
SKCM	chr8	38163678	Missense_Mutation	NA	E132Q	0.21
STAD	chr8	38169817	Silent	NA	V72V	0.06
STAD	chr8	38169918	Splice_Site	novel	X39_splice	0.31
THCA	chr8	38163609	3'UTR	novel		0.48
UCEC	chr8	38163495	3'UTR	novel		0.4
UCEC	chr8	38176393	5'UTR	novel		0.14
UCEC	chr8	38163809	Missense_Mutation	NA	Q88R	0.44
UCEC	chr8	38171985	Frame_Shift_Del	novel	L32*	0.34	LSM
UCEC	chr8	38163760	Missense_Mutation	novel	Q104H	0.33
UCEC	chr8	38163786	Missense_Mutation	novel	L96I	0.06
UCEC	chr8	38163690	Missense_Mutation	novel	D128N	0.07
UCEC	chr8	38176409	5'UTR	novel		0.5
UCEC	chr8	38169865	Silent	rs769909686	Y56Y	0.16
UCEC	chr8	38169888	Missense_Mutation	novel	R49C	0.3
UCEC	chr8	38176324	5'UTR	novel		0.36
UCEC	chr8	38163834	Missense_Mutation	novel	E80K	0.22
UVM	chr8	38163727	Missense_Mutation	novel	Q115H	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	DEL	0.2554	0.060925
PAAD	AMP	0.0924	0.021017
PRAD	AMP	0.1118	0.00020824
READ	DEL	0.2727	0.20625
SARC	AMP	0.2374	0.16281

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0004	Kaplan-Meier Survival Analysis
MESO	0.00076	Kaplan-Meier Survival Analysis
ACC	0.014	Kaplan-Meier Survival Analysis
PRAD	0.017	Kaplan-Meier Survival Analysis
LUSC	0.0023	Kaplan-Meier Survival Analysis
PAAD	0.037	Kaplan-Meier Survival Analysis
LAML	0.0088	Kaplan-Meier Survival Analysis
LIHC	0.022	Kaplan-Meier Survival Analysis
OV	0.028	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742