EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175376 (Gene tree)
Gene ID: 84285
Gene Symbol: EIF1AD
Alias: MGC11102|haponin
Full Name: eukaryotic translation initiation factor 1A domain containing
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 5,632 bases
Position: chr11:65,996,545-66,002,176
Accession: 28147
RBP type: canonical RBP
Summary: (Eukaryotic Translation Initiation Factor 1A Domain Containing) is a Protein Coding gene. Diseases associated with EIF1AD include Nestor-Guillermo Progeria Syndrome. Gene Ontology (GO) annotations related to this gene include RNA binding and translation initiation factor activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000433320	eIF-1a	PF01176.19	2.6e-18	1	1
ENSP00000435891	eIF-1a	PF01176.19	2.7e-18	1	1
ENSP00000309175	eIF-1a	PF01176.19	6.5e-18	1	1
ENSP00000434056	eIF-1a	PF01176.19	6.5e-18	1	1
ENSP00000435439	eIF-1a	PF01176.19	6.5e-18	1	1
ENSP00000435942	eIF-1a	PF01176.19	6.5e-18	1	1
ENSP00000436644	eIF-1a	PF01176.19	6.5e-18	1	1
ENSP00000432135	eIF-1a	PF01176.19	3.3e-17	1	1
ENSP00000434796	eIF-1a	PF01176.19	2.1e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000530462	EIF1AD-209	580	-	ENSP00000435891	114 (aa)	-	E9PS76
ENST00000529964	EIF1AD-207	808	-	ENSP00000435942	165 (aa)	-	Q8N9N8
ENST00000527051	EIF1AD-205	588	-	ENSP00000432135	78 (aa)	-	E9PS30
ENST00000532707	EIF1AD-210	584	-	ENSP00000433320	113 (aa)	-	E9PLI6
ENST00000526451	EIF1AD-204	2761	-	ENSP00000436644	165 (aa)	-	Q8N9N8
ENST00000525767	EIF1AD-202	743	-	ENSP00000434796	113 (aa)	-	E9PNH5
ENST00000526449	EIF1AD-203	561	-	-	- (aa)	-	-
ENST00000312234	EIF1AD-201	2887	-	ENSP00000309175	165 (aa)	-	Q8N9N8
ENST00000533544	EIF1AD-211	965	XM_017018412	ENSP00000434056	165 (aa)	XP_016873901	Q8N9N8
ENST00000527249	EIF1AD-206	889	-	ENSP00000435439	165 (aa)	-	Q8N9N8
ENST00000529973	EIF1AD-208	530	-	ENSP00000436876	64 (aa)	-	E9PQD0

Gene Model

Click here to download ENSG00000175376's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175376	rs3825068	11	66000622	G	Blood protein levels	29875488	[0.41-0.73] unit increase	0.57	EFO_0007937
ENSG00000175376	rs3825068	11	66000622	G	Blood protein levels	29875488	[0.44-0.76] unit increase	0.6	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175376's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175376	EIF1AD	100	74.359	ENSAPOG00000008699	eif1ad	88	59.494	Acanthochromis_polyacanthus
ENSG00000175376	EIF1AD	100	98.718	ENSAMEG00000017252	EIF1AD	100	95.181	Ailuropoda_melanoleuca
ENSG00000175376	EIF1AD	100	74.359	ENSACIG00000005456	eif1ad	85	60.000	Amphilophus_citrinellus
ENSG00000175376	EIF1AD	100	74.359	ENSAOCG00000014631	eif1ad	86	59.740	Amphiprion_ocellaris
ENSG00000175376	EIF1AD	100	74.359	ENSAPEG00000008313	eif1ad	86	60.526	Amphiprion_percula
ENSG00000175376	EIF1AD	100	75.641	ENSATEG00000018376	eif1ad	83	62.092	Anabas_testudineus
ENSG00000175376	EIF1AD	100	97.436	ENSANAG00000034384	EIF1AD	93	95.425	Aotus_nancymaae
ENSG00000175376	EIF1AD	100	73.077	ENSACLG00000022444	eif1ad	84	60.784	Astatotilapia_calliptera
ENSG00000175376	EIF1AD	100	67.949	ENSAMXG00000010537	eif1ad	87	58.599	Astyanax_mexicanus
ENSG00000175376	EIF1AD	100	98.718	ENSBTAG00000020186	EIF1AD	100	95.181	Bos_taurus
ENSG00000175376	EIF1AD	100	42.308	WBGene00014112	ZK856.11	69	40.496	Caenorhabditis_elegans
ENSG00000175376	EIF1AD	100	97.436	ENSCJAG00000001732	EIF1AD	92	94.771	Callithrix_jacchus
ENSG00000175376	EIF1AD	100	98.718	ENSCAFG00000031896	EIF1AD	100	96.988	Canis_familiaris
ENSG00000175376	EIF1AD	100	98.718	ENSCAFG00020015352	EIF1AD	100	96.988	Canis_lupus_dingo
ENSG00000175376	EIF1AD	100	98.718	ENSCHIG00000013617	EIF1AD	100	96.386	Capra_hircus
ENSG00000175376	EIF1AD	100	94.872	ENSTSYG00000037118	EIF1AD	100	93.333	Carlito_syrichta
ENSG00000175376	EIF1AD	87	98.529	ENSCAPG00000007505	EIF1AD	100	84.076	Cavia_aperea
ENSG00000175376	EIF1AD	100	98.718	ENSCPOG00000038958	EIF1AD	100	95.758	Cavia_porcellus
ENSG00000175376	EIF1AD	100	97.436	ENSCCAG00000026301	EIF1AD	93	96.078	Cebus_capucinus
ENSG00000175376	EIF1AD	100	100.000	ENSCATG00000038000	EIF1AD	100	100.000	Cercocebus_atys
ENSG00000175376	EIF1AD	100	98.718	ENSCLAG00000016596	EIF1AD	100	96.386	Chinchilla_lanigera
ENSG00000175376	EIF1AD	100	100.000	ENSCSAG00000008082	EIF1AD	100	100.000	Chlorocebus_sabaeus
ENSG00000175376	EIF1AD	100	87.179	ENSCPBG00000023432	EIF1AD	86	73.026	Chrysemys_picta_bellii
ENSG00000175376	EIF1AD	100	60.256	ENSCING00000001828	-	90	46.667	Ciona_intestinalis
ENSG00000175376	EIF1AD	100	55.128	ENSCSAVG00000002564	-	63	48.598	Ciona_savignyi
ENSG00000175376	EIF1AD	100	100.000	ENSCANG00000040586	EIF1AD	100	99.394	Colobus_angolensis_palliatus
ENSG00000175376	EIF1AD	100	96.154	ENSCGRG00001002718	Eif1ad	89	92.157	Cricetulus_griseus_chok1gshd
ENSG00000175376	EIF1AD	100	96.154	ENSCGRG00000015253	Eif1ad	89	92.157	Cricetulus_griseus_crigri
ENSG00000175376	EIF1AD	100	70.513	ENSCSEG00000016964	eif1ad	90	59.477	Cynoglossus_semilaevis
ENSG00000175376	EIF1AD	100	74.359	ENSCVAG00000020949	eif1ad	86	61.688	Cyprinodon_variegatus
ENSG00000175376	EIF1AD	99	70.130	ENSDARG00000016280	eif1ad	87	60.000	Danio_rerio
ENSG00000175376	EIF1AD	100	95.575	ENSDORG00000025552	Eif1ad	100	95.575	Dipodomys_ordii
ENSG00000175376	EIF1AD	95	56.000	FBgn0051957	CG31957	74	48.305	Drosophila_melanogaster
ENSG00000175376	EIF1AD	100	78.481	ENSEBUG00000011023	eif1ad	68	72.277	Eptatretus_burgeri
ENSG00000175376	EIF1AD	88	93.000	ENSEASG00005004471	EIF1AD	88	93.000	Equus_asinus_asinus
ENSG00000175376	EIF1AD	100	97.436	ENSECAG00000024304	EIF1AD	93	94.771	Equus_caballus
ENSG00000175376	EIF1AD	99	87.013	ENSEEUG00000009605	-	100	80.198	Erinaceus_europaeus
ENSG00000175376	EIF1AD	100	70.886	ENSELUG00000008619	eif1ad	87	54.717	Esox_lucius
ENSG00000175376	EIF1AD	100	98.718	ENSFCAG00000038474	EIF1AD	100	96.386	Felis_catus
ENSG00000175376	EIF1AD	100	98.246	ENSFDAG00000007002	EIF1AD	100	94.578	Fukomys_damarensis
ENSG00000175376	EIF1AD	100	76.923	ENSFHEG00000016633	eif1ad	88	60.131	Fundulus_heteroclitus
ENSG00000175376	EIF1AD	100	66.667	ENSGMOG00000005604	eif1ad	95	51.899	Gadus_morhua
ENSG00000175376	EIF1AD	100	74.359	ENSGAFG00000000415	eif1ad	85	60.131	Gambusia_affinis
ENSG00000175376	EIF1AD	100	69.231	ENSGACG00000018684	eif1ad	88	57.516	Gasterosteus_aculeatus
ENSG00000175376	EIF1AD	100	100.000	ENSGGOG00000011792	EIF1AD	100	98.795	Gorilla_gorilla
ENSG00000175376	EIF1AD	100	73.077	ENSHBUG00000001624	eif1ad	84	60.131	Haplochromis_burtoni
ENSG00000175376	EIF1AD	100	96.154	ENSHGLG00000013679	EIF1AD	100	93.976	Heterocephalus_glaber_female
ENSG00000175376	EIF1AD	100	96.154	ENSHGLG00100018086	EIF1AD	100	93.976	Heterocephalus_glaber_male
ENSG00000175376	EIF1AD	100	75.641	ENSHCOG00000003468	eif1ad	88	61.842	Hippocampus_comes
ENSG00000175376	EIF1AD	100	70.513	ENSIPUG00000002466	eif1ad	85	56.954	Ictalurus_punctatus
ENSG00000175376	EIF1AD	100	98.718	ENSSTOG00000008124	EIF1AD	100	96.364	Ictidomys_tridecemlineatus
ENSG00000175376	EIF1AD	100	93.590	ENSJJAG00000020452	Eif1ad	93	91.503	Jaculus_jaculus
ENSG00000175376	EIF1AD	100	71.795	ENSKMAG00000014110	eif1ad	84	58.442	Kryptolebias_marmoratus
ENSG00000175376	EIF1AD	100	70.513	ENSLBEG00000000411	eif1ad	85	58.170	Labrus_bergylta
ENSG00000175376	EIF1AD	100	83.333	ENSLACG00000011475	EIF1AD	89	67.516	Latimeria_chalumnae
ENSG00000175376	EIF1AD	100	80.769	ENSLOCG00000001883	eif1ad	89	61.818	Lepisosteus_oculatus
ENSG00000175376	EIF1AD	100	96.491	ENSLAFG00000027234	EIF1AD	100	95.783	Loxodonta_africana
ENSG00000175376	EIF1AD	100	100.000	ENSMFAG00000038170	EIF1AD	100	100.000	Macaca_fascicularis
ENSG00000175376	EIF1AD	100	100.000	ENSMMUG00000019115	EIF1AD	100	99.394	Macaca_mulatta
ENSG00000175376	EIF1AD	100	100.000	ENSMNEG00000038258	EIF1AD	100	100.000	Macaca_nemestrina
ENSG00000175376	EIF1AD	100	100.000	ENSMLEG00000032238	EIF1AD	100	100.000	Mandrillus_leucophaeus
ENSG00000175376	EIF1AD	100	71.795	ENSMAMG00000015258	eif1ad	84	58.170	Mastacembelus_armatus
ENSG00000175376	EIF1AD	100	73.077	ENSMZEG00005005915	eif1ad	83	60.784	Maylandia_zebra
ENSG00000175376	EIF1AD	100	96.154	ENSMAUG00000015627	Eif1ad	91	92.810	Mesocricetus_auratus
ENSG00000175376	EIF1AD	100	98.718	ENSMICG00000038645	EIF1AD	100	96.988	Microcebus_murinus
ENSG00000175376	EIF1AD	100	94.872	ENSMOCG00000018056	Eif1ad	91	91.503	Microtus_ochrogaster
ENSG00000175376	EIF1AD	100	74.359	ENSMMOG00000009710	eif1ad	87	58.974	Mola_mola
ENSG00000175376	EIF1AD	100	96.154	ENSMODG00000008964	-	94	88.961	Monodelphis_domestica
ENSG00000175376	EIF1AD	100	94.872	ENSMODG00000024851	-	93	88.235	Monodelphis_domestica
ENSG00000175376	EIF1AD	100	74.359	ENSMALG00000011700	eif1ad	85	58.824	Monopterus_albus
ENSG00000175376	EIF1AD	100	93.590	MGP_CAROLIEiJ_G0022544	Eif1ad	90	91.503	Mus_caroli
ENSG00000175376	EIF1AD	100	93.590	ENSMUSG00000024841	Eif1ad	90	91.503	Mus_musculus
ENSG00000175376	EIF1AD	100	94.872	MGP_PahariEiJ_G0014041	Eif1ad	88	91.558	Mus_pahari
ENSG00000175376	EIF1AD	100	93.590	MGP_SPRETEiJ_G0023458	Eif1ad	90	91.503	Mus_spretus
ENSG00000175376	EIF1AD	100	98.718	ENSMPUG00000011390	EIF1AD	100	98.182	Mustela_putorius_furo
ENSG00000175376	EIF1AD	100	97.436	ENSMLUG00000011116	EIF1AD	93	93.548	Myotis_lucifugus
ENSG00000175376	EIF1AD	100	93.590	ENSNGAG00000007977	Eif1ad	92	88.889	Nannospalax_galili
ENSG00000175376	EIF1AD	100	73.077	ENSNBRG00000021601	eif1ad	82	62.092	Neolamprologus_brichardi
ENSG00000175376	EIF1AD	100	94.872	ENSMEUG00000004948	EIF1AD	94	87.582	Notamacropus_eugenii
ENSG00000175376	EIF1AD	100	98.718	ENSODEG00000018064	EIF1AD	100	94.578	Octodon_degus
ENSG00000175376	EIF1AD	100	73.077	ENSONIG00000015765	eif1ad	82	60.403	Oreochromis_niloticus
ENSG00000175376	EIF1AD	74	88.095	ENSOANG00000009919	-	88	74.400	Ornithorhynchus_anatinus
ENSG00000175376	EIF1AD	89	86.408	ENSOCUG00000021968	EIF1AD	91	88.189	Oryctolagus_cuniculus
ENSG00000175376	EIF1AD	100	75.641	ENSORLG00000009647	eif1ad	87	65.132	Oryzias_latipes
ENSG00000175376	EIF1AD	100	75.641	ENSORLG00020019508	eif1ad	87	65.132	Oryzias_latipes_hni
ENSG00000175376	EIF1AD	100	75.641	ENSORLG00015014448	eif1ad	87	65.132	Oryzias_latipes_hsok
ENSG00000175376	EIF1AD	100	74.359	ENSOMEG00000016251	eif1ad	85	63.816	Oryzias_melastigma
ENSG00000175376	EIF1AD	100	96.154	ENSOGAG00000016528	EIF1AD	93	95.425	Otolemur_garnettii
ENSG00000175376	EIF1AD	100	97.436	ENSOARG00000001128	EIF1AD	100	95.783	Ovis_aries
ENSG00000175376	EIF1AD	100	100.000	ENSPPAG00000002124	EIF1AD	100	99.398	Pan_paniscus
ENSG00000175376	EIF1AD	100	98.718	ENSPPRG00000014886	EIF1AD	100	95.783	Panthera_pardus
ENSG00000175376	EIF1AD	100	98.718	ENSPTIG00000017618	EIF1AD	100	95.783	Panthera_tigris_altaica
ENSG00000175376	EIF1AD	100	100.000	ENSPTRG00000042604	EIF1AD	100	99.398	Pan_troglodytes
ENSG00000175376	EIF1AD	100	100.000	ENSPANG00000011370	EIF1AD	100	100.000	Papio_anubis
ENSG00000175376	EIF1AD	100	78.205	ENSPKIG00000025136	eif1ad	82	66.234	Paramormyrops_kingsleyae
ENSG00000175376	EIF1AD	100	87.179	ENSPSIG00000002790	EIF1AD	86	71.053	Pelodiscus_sinensis
ENSG00000175376	EIF1AD	100	74.359	ENSPMGG00000008364	eif1ad	85	62.025	Periophthalmus_magnuspinnatus
ENSG00000175376	EIF1AD	100	76.923	ENSPMAG00000000805	eif1ad	77	57.792	Petromyzon_marinus
ENSG00000175376	EIF1AD	100	93.805	ENSPCIG00000008327	-	58	87.662	Phascolarctos_cinereus
ENSG00000175376	EIF1AD	100	75.641	ENSPFOG00000002981	eif1ad	85	61.935	Poecilia_formosa
ENSG00000175376	EIF1AD	100	75.641	ENSPLAG00000007974	eif1ad	85	61.935	Poecilia_latipinna
ENSG00000175376	EIF1AD	100	74.359	ENSPMEG00000014448	eif1ad	85	61.688	Poecilia_mexicana
ENSG00000175376	EIF1AD	100	75.641	ENSPREG00000004120	eif1ad	85	61.935	Poecilia_reticulata
ENSG00000175376	EIF1AD	100	100.000	ENSPPYG00000004111	EIF1AD	100	98.795	Pongo_abelii
ENSG00000175376	EIF1AD	100	96.154	ENSPCAG00000011408	EIF1AD	92	91.503	Procavia_capensis
ENSG00000175376	EIF1AD	100	98.718	ENSPCOG00000026199	EIF1AD	100	96.988	Propithecus_coquereli
ENSG00000175376	EIF1AD	100	98.718	ENSPVAG00000016970	EIF1AD	93	96.732	Pteropus_vampyrus
ENSG00000175376	EIF1AD	100	73.077	ENSPNYG00000000067	eif1ad	84	60.131	Pundamilia_nyererei
ENSG00000175376	EIF1AD	100	67.949	ENSPNAG00000008505	eif1ad	86	56.688	Pygocentrus_nattereri
ENSG00000175376	EIF1AD	100	94.872	ENSRNOG00000020463	Eif1ad	92	91.503	Rattus_norvegicus
ENSG00000175376	EIF1AD	100	100.000	ENSRBIG00000032221	EIF1AD	100	100.000	Rhinopithecus_bieti
ENSG00000175376	EIF1AD	100	100.000	ENSRROG00000045125	EIF1AD	100	100.000	Rhinopithecus_roxellana
ENSG00000175376	EIF1AD	100	97.436	ENSSBOG00000023159	EIF1AD	93	96.078	Saimiri_boliviensis_boliviensis
ENSG00000175376	EIF1AD	100	93.805	ENSSHAG00000011448	EIF1AD	94	87.662	Sarcophilus_harrisii
ENSG00000175376	EIF1AD	100	83.333	ENSSFOG00015007777	eif1ad	90	65.806	Scleropages_formosus
ENSG00000175376	EIF1AD	100	70.513	ENSSMAG00000012910	eif1ad	87	57.764	Scophthalmus_maximus
ENSG00000175376	EIF1AD	100	74.359	ENSSDUG00000013175	eif1ad	92	61.438	Seriola_dumerili
ENSG00000175376	EIF1AD	100	74.359	ENSSLDG00000022957	eif1ad	90	62.092	Seriola_lalandi_dorsalis
ENSG00000175376	EIF1AD	100	83.333	ENSSPUG00000009425	EIF1AD	90	71.242	Sphenodon_punctatus
ENSG00000175376	EIF1AD	100	74.359	ENSSPAG00000022943	eif1ad	84	59.355	Stegastes_partitus
ENSG00000175376	EIF1AD	100	96.154	ENSSSCG00000027334	EIF1AD	100	90.964	Sus_scrofa
ENSG00000175376	EIF1AD	100	74.359	ENSTRUG00000025381	eif1ad	91	61.350	Takifugu_rubripes
ENSG00000175376	EIF1AD	100	66.667	ENSTNIG00000001342	eif1ad	90	56.863	Tetraodon_nigroviridis
ENSG00000175376	EIF1AD	100	97.436	ENSTBEG00000001781	EIF1AD	93	96.104	Tupaia_belangeri
ENSG00000175376	EIF1AD	100	97.368	ENSTTRG00000008745	EIF1AD	93	94.118	Tursiops_truncatus
ENSG00000175376	EIF1AD	100	98.718	ENSUAMG00000020763	EIF1AD	100	96.386	Ursus_americanus
ENSG00000175376	EIF1AD	100	98.718	ENSUMAG00000010976	EIF1AD	100	96.386	Ursus_maritimus
ENSG00000175376	EIF1AD	100	98.718	ENSVPAG00000008692	EIF1AD	100	95.783	Vicugna_pacos
ENSG00000175376	EIF1AD	100	98.718	ENSVVUG00000027034	EIF1AD	100	96.988	Vulpes_vulpes
ENSG00000175376	EIF1AD	100	75.641	ENSXETG00000011431	eif1ad	88	62.658	Xenopus_tropicalis
ENSG00000175376	EIF1AD	87	72.464	ENSXCOG00000012570	eif1ad	100	72.464	Xiphophorus_couchianus
ENSG00000175376	EIF1AD	100	75.641	ENSXMAG00000028859	eif1ad	85	60.784	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003743	translation initiation factor activity	-	IEA	Function
GO:0005515	protein binding	16189514.21516116.25416956.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0006413	translational initiation	-	IEA	Process