EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175467 (Gene tree)
Gene ID: 9092
Gene Symbol: SART1
Alias: Ara1|Snu66|SNRNP110|HAF
Full Name: spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 18,448 bases
Position: chr11:65,961,689-65,980,136
Accession: 10538
RBP type: canonical RBP
Summary: This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000310448	SART-1	PF03343.13	2.9e-150	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000529532	SART1-204	1471	-	-	- (aa)	-	-
ENST00000528137	SART1-202	403	-	-	- (aa)	-	-
ENST00000529580	SART1-205	390	-	-	- (aa)	-	-
ENST00000530251	SART1-206	753	-	ENSP00000436218	164 (aa)	-	E9PQI8
ENST00000532333	SART1-207	873	-	-	- (aa)	-	-
ENST00000533386	SART1-208	586	-	-	- (aa)	-	-
ENST00000528573	SART1-203	585	-	-	- (aa)	-	-
ENST00000312397	SART1-201	3293	XM_011545344	ENSP00000310448	800 (aa)	XP_011543646	O43290

Gene Model

Click here to download ENSG00000175467's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175467's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175467	SART1	87	94.017	ENSAMEG00000017260	SART1	100	95.442	Ailuropoda_melanoleuca
ENSG00000175467	SART1	100	98.002	ENSANAG00000037219	SART1	99	100.000	Aotus_nancymaae
ENSG00000175467	SART1	100	94.293	ENSBTAG00000003094	SART1	100	93.921	Bos_taurus
ENSG00000175467	SART1	100	98.377	ENSCJAG00000001741	SART1	100	98.377	Callithrix_jacchus
ENSG00000175467	SART1	100	95.658	ENSCAFG00000013103	SART1	100	95.658	Canis_familiaris
ENSG00000175467	SART1	100	96.154	ENSCAFG00020015337	SART1	100	96.154	Canis_lupus_dingo
ENSG00000175467	SART1	100	92.432	ENSCHIG00000016364	SART1	100	91.935	Capra_hircus
ENSG00000175467	SART1	87	85.206	ENSTSYG00000029994	SART1	93	84.211	Carlito_syrichta
ENSG00000175467	SART1	85	96.898	ENSCAPG00000016369	SART1	96	96.898	Cavia_aperea
ENSG00000175467	SART1	86	93.000	ENSCPOG00000020882	SART1	99	92.143	Cavia_porcellus
ENSG00000175467	SART1	100	98.627	ENSCCAG00000037852	SART1	99	100.000	Cebus_capucinus
ENSG00000175467	SART1	100	98.875	ENSCATG00000032953	SART1	99	100.000	Cercocebus_atys
ENSG00000175467	SART1	100	96.125	ENSCLAG00000016593	SART1	100	95.875	Chinchilla_lanigera
ENSG00000175467	SART1	100	99.125	ENSCSAG00000008081	SART1	100	99.125	Chlorocebus_sabaeus
ENSG00000175467	SART1	100	72.857	ENSCPBG00000023434	SART1	100	75.604	Chrysemys_picta_bellii
ENSG00000175467	SART1	85	38.561	ENSCING00000009048	-	82	39.024	Ciona_intestinalis
ENSG00000175467	SART1	91	35.606	ENSCSAVG00000009337	-	86	38.061	Ciona_savignyi
ENSG00000175467	SART1	94	91.534	ENSCANG00000043164	SART1	96	91.667	Colobus_angolensis_palliatus
ENSG00000175467	SART1	100	95.043	ENSCGRG00001021367	Sart1	100	95.043	Cricetulus_griseus_chok1gshd
ENSG00000175467	SART1	87	95.559	ENSCGRG00000015292	Sart1	99	94.150	Cricetulus_griseus_crigri
ENSG00000175467	SART1	100	64.548	ENSCVAG00000009800	SART1	100	64.663	Cyprinodon_variegatus
ENSG00000175467	SART1	88	89.041	ENSDNOG00000038920	-	89	93.640	Dasypus_novemcinctus
ENSG00000175467	SART1	84	84.024	ENSDNOG00000041860	-	100	83.580	Dasypus_novemcinctus
ENSG00000175467	SART1	100	86.973	ENSDORG00000011887	Sart1	100	87.097	Dipodomys_ordii
ENSG00000175467	SART1	66	52.890	ENSEBUG00000006203	SART1	78	61.417	Eptatretus_burgeri
ENSG00000175467	SART1	100	96.168	ENSEASG00005004465	SART1	100	96.168	Equus_asinus_asinus
ENSG00000175467	SART1	100	96.287	ENSECAG00000023491	TSGA10IP	93	96.287	Equus_caballus
ENSG00000175467	SART1	100	95.906	ENSFCAG00000013278	SART1	100	95.906	Felis_catus
ENSG00000175467	SART1	100	93.250	ENSFDAG00000008891	SART1	100	92.875	Fukomys_damarensis
ENSG00000175467	SART1	100	64.338	ENSFHEG00000010334	SART1	100	64.049	Fundulus_heteroclitus
ENSG00000175467	SART1	100	64.822	ENSGAFG00000013919	SART1	100	64.039	Gambusia_affinis
ENSG00000175467	SART1	99	62.145	ENSGACG00000016951	SART1	100	61.834	Gasterosteus_aculeatus
ENSG00000175467	SART1	100	74.163	ENSGAGG00000022783	SART1	100	76.942	Gopherus_agassizii
ENSG00000175467	SART1	100	99.750	ENSGGOG00000009457	SART1	100	99.750	Gorilla_gorilla
ENSG00000175467	SART1	56	54.545	ENSHBUG00000020412	-	70	52.074	Haplochromis_burtoni
ENSG00000175467	SART1	100	95.125	ENSHGLG00000015022	SART1	100	95.000	Heterocephalus_glaber_female
ENSG00000175467	SART1	100	94.500	ENSHGLG00100018346	SART1	100	94.125	Heterocephalus_glaber_male
ENSG00000175467	SART1	100	63.725	ENSHCOG00000007259	SART1	100	62.895	Hippocampus_comes
ENSG00000175467	SART1	100	64.982	ENSIPUG00000021117	sart1	100	65.926	Ictalurus_punctatus
ENSG00000175467	SART1	100	96.875	ENSSTOG00000023375	SART1	100	96.875	Ictidomys_tridecemlineatus
ENSG00000175467	SART1	100	94.888	ENSJJAG00000019103	Sart1	100	94.888	Jaculus_jaculus
ENSG00000175467	SART1	82	68.381	ENSLACG00000011165	SART1	99	67.470	Latimeria_chalumnae
ENSG00000175467	SART1	59	72.050	ENSLOCG00000001871	SART1	95	69.231	Lepisosteus_oculatus
ENSG00000175467	SART1	99	94.271	ENSLAFG00000001768	SART1	100	94.271	Loxodonta_africana
ENSG00000175467	SART1	100	99.000	ENSMFAG00000002484	SART1	100	99.000	Macaca_fascicularis
ENSG00000175467	SART1	88	97.931	ENSMMUG00000008065	SART1	99	100.000	Macaca_mulatta
ENSG00000175467	SART1	100	99.000	ENSMNEG00000035507	SART1	100	99.000	Macaca_nemestrina
ENSG00000175467	SART1	91	99.040	ENSMLEG00000036259	SART1	100	99.040	Mandrillus_leucophaeus
ENSG00000175467	SART1	100	96.000	ENSMAUG00000016274	Sart1	100	96.000	Mesocricetus_auratus
ENSG00000175467	SART1	100	95.556	ENSMICG00000030096	SART1	100	95.556	Microcebus_murinus
ENSG00000175467	SART1	100	96.375	ENSMOCG00000019815	Sart1	100	96.375	Microtus_ochrogaster
ENSG00000175467	SART1	90	68.587	ENSMMOG00000004019	SART1	97	67.255	Mola_mola
ENSG00000175467	SART1	100	77.467	ENSMODG00000009047	SART1	100	77.223	Monodelphis_domestica
ENSG00000175467	SART1	100	94.169	MGP_CAROLIEiJ_G0022545	Sart1	100	94.169	Mus_caroli
ENSG00000175467	SART1	100	94.417	ENSMUSG00000039148	Sart1	100	94.417	Mus_musculus
ENSG00000175467	SART1	100	94.169	MGP_PahariEiJ_G0014042	Sart1	100	94.169	Mus_pahari
ENSG00000175467	SART1	100	94.417	MGP_SPRETEiJ_G0023459	Sart1	100	94.417	Mus_spretus
ENSG00000175467	SART1	100	95.906	ENSMPUG00000011394	SART1	100	95.906	Mustela_putorius_furo
ENSG00000175467	SART1	100	94.052	ENSMLUG00000011078	SART1	100	93.804	Myotis_lucifugus
ENSG00000175467	SART1	100	90.706	ENSNGAG00000004727	Sart1	100	89.839	Nannospalax_galili
ENSG00000175467	SART1	100	95.500	ENSNLEG00000005961	SART1	99	100.000	Nomascus_leucogenys
ENSG00000175467	SART1	100	82.389	ENSMEUG00000004918	SART1	100	82.244	Notamacropus_eugenii
ENSG00000175467	SART1	100	96.125	ENSODEG00000017777	SART1	100	95.875	Octodon_degus
ENSG00000175467	SART1	100	65.884	ENSONIG00000021283	SART1	100	65.760	Oreochromis_niloticus
ENSG00000175467	SART1	100	63.321	ENSORLG00000028400	SART1	100	63.569	Oryzias_latipes
ENSG00000175467	SART1	100	63.073	ENSORLG00020014721	SART1	100	63.321	Oryzias_latipes_hni
ENSG00000175467	SART1	100	63.445	ENSORLG00015014467	SART1	100	62.949	Oryzias_latipes_hsok
ENSG00000175467	SART1	100	64.560	ENSOMEG00000002508	SART1	100	63.569	Oryzias_melastigma
ENSG00000175467	SART1	100	97.129	ENSOGAG00000016523	SART1	100	97.129	Otolemur_garnettii
ENSG00000175467	SART1	87	92.593	ENSOARG00000000694	SART1	100	92.023	Ovis_aries
ENSG00000175467	SART1	100	99.875	ENSPPAG00000030167	SART1	100	99.875	Pan_paniscus
ENSG00000175467	SART1	100	95.250	ENSPPRG00000015794	SART1	100	95.250	Panthera_pardus
ENSG00000175467	SART1	79	75.791	ENSPTIG00000017833	SART1	98	75.911	Panthera_tigris_altaica
ENSG00000175467	SART1	100	99.875	ENSPTRG00000003905	SART1	100	99.875	Pan_troglodytes
ENSG00000175467	SART1	100	98.875	ENSPANG00000023502	SART1	99	100.000	Papio_anubis
ENSG00000175467	SART1	91	78.619	ENSPSIG00000002712	SART1	92	77.025	Pelodiscus_sinensis
ENSG00000175467	SART1	100	87.841	ENSPEMG00000012166	Sart1	98	97.561	Peromyscus_maniculatus_bairdii
ENSG00000175467	SART1	100	88.127	ENSPCIG00000008311	SART1	100	87.760	Phascolarctos_cinereus
ENSG00000175467	SART1	100	64.865	ENSPFOG00000019883	SART1	100	64.453	Poecilia_formosa
ENSG00000175467	SART1	100	64.988	ENSPLAG00000019633	SART1	100	64.576	Poecilia_latipinna
ENSG00000175467	SART1	100	64.742	ENSPMEG00000013621	SART1	100	64.330	Poecilia_mexicana
ENSG00000175467	SART1	100	63.469	ENSPREG00000000100	SART1	100	63.054	Poecilia_reticulata
ENSG00000175467	SART1	100	97.250	ENSPPYG00000003039	SART1	100	97.250	Pongo_abelii
ENSG00000175467	SART1	88	90.411	ENSPCAG00000011262	SART1	73	98.684	Procavia_capensis
ENSG00000175467	SART1	100	97.000	ENSPCOG00000008448	SART1	100	97.000	Propithecus_coquereli
ENSG00000175467	SART1	100	88.903	ENSPVAG00000016969	SART1	100	88.903	Pteropus_vampyrus
ENSG00000175467	SART1	100	66.007	ENSPNYG00000014765	SART1	100	65.884	Pundamilia_nyererei
ENSG00000175467	SART1	100	93.928	ENSRNOG00000020475	Sart1	100	93.928	Rattus_norvegicus
ENSG00000175467	SART1	100	98.750	ENSRBIG00000044079	SART1	99	100.000	Rhinopithecus_bieti
ENSG00000175467	SART1	100	98.750	ENSRROG00000045251	SART1	99	100.000	Rhinopithecus_roxellana
ENSG00000175467	SART1	100	97.753	ENSSBOG00000023102	SART1	100	97.753	Saimiri_boliviensis_boliviensis
ENSG00000175467	SART1	100	84.464	ENSSHAG00000011437	SART1	100	84.464	Sarcophilus_harrisii
ENSG00000175467	SART1	100	61.595	ENSSFOG00015018792	SART1	100	61.397	Scleropages_formosus
ENSG00000175467	SART1	100	63.081	ENSSMAG00000001043	SART1	100	63.035	Scophthalmus_maximus
ENSG00000175467	SART1	90	69.918	ENSSDUG00000019131	SART1	99	66.624	Seriola_dumerili
ENSG00000175467	SART1	100	65.389	ENSSLDG00000024307	SART1	100	65.513	Seriola_lalandi_dorsalis
ENSG00000175467	SART1	100	75.577	ENSSPUG00000009399	SART1	100	75.182	Sphenodon_punctatus
ENSG00000175467	SART1	100	66.131	ENSSPAG00000013156	SART1	100	65.760	Stegastes_partitus
ENSG00000175467	SART1	100	94.789	ENSSSCG00000012963	SART1	100	94.417	Sus_scrofa
ENSG00000175467	SART1	100	63.906	ENSTRUG00000025047	SART1	100	62.454	Takifugu_rubripes
ENSG00000175467	SART1	99	70.260	ENSTBEG00000002397	-	99	69.517	Tupaia_belangeri
ENSG00000175467	SART1	79	100.000	ENSTBEG00000010864	-	83	100.000	Tupaia_belangeri
ENSG00000175467	SART1	71	74.211	ENSTBEG00000010370	-	100	73.860	Tupaia_belangeri
ENSG00000175467	SART1	100	90.886	ENSTTRG00000008751	SART1	100	91.011	Tursiops_truncatus
ENSG00000175467	SART1	100	90.125	ENSUAMG00000020770	SART1	100	92.125	Ursus_americanus
ENSG00000175467	SART1	73	95.540	ENSUMAG00000010903	SART1	91	95.540	Ursus_maritimus
ENSG00000175467	SART1	100	96.402	ENSVVUG00000027041	SART1	100	96.402	Vulpes_vulpes
ENSG00000175467	SART1	89	73.427	ENSXETG00000011429	sart1	100	70.260	Xenopus_tropicalis
ENSG00000175467	SART1	100	65.356	ENSXCOG00000005296	SART1	100	65.148	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000387	spliceosomal snRNP assembly	16687569.	TAS	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28781166.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000481	maturation of 5S rRNA	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	15620657.17000644.20467437.22365833.25092792.	IPI	Function
GO:0005634	nucleus	28781166.	IDA	Component
GO:0005654	nucleoplasm	16687569.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	9856836.	TAS	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005829	cytosol	10929426.	TAS	Component
GO:0015030	Cajal body	16687569.	IDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0045292	mRNA cis splicing, via spliceosome	21873635.	IBA	Process
GO:0045585	positive regulation of cytotoxic T cell differentiation	10209962.	IDA	Process
GO:0046540	U4/U6 x U5 tri-snRNP complex	21873635.	IBA	Component
GO:0071005	U2-type precatalytic spliceosome	28781166.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component