EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000175792 (Gene tree)
Gene ID: 8607
Gene Symbol: RUVBL1
Alias: TIP49|NMP238|RVB1|TIP49a|Pontin52|ECP54|TIH1|Rvb1|INO80H
Full Name: RuvB like AAA ATPase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 89,137 bases
Position: chr3:128,064,778-128,153,914
Accession: 10474
RBP type: non-canonical RBP
Summary: This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10787406	The Saccharomyces cerevisiae RuvB-like protein, Tih2p, is required for cell cycle progression and RNA polymerase II-directed transcription.	J Biol Chem	2000 Jul 21	Lim CR	-
18548265	Pontin is localized in nucleolar fibrillar centers.	Chromosoma	2008 Oct	Cvackova Z	doi: 10.1007/s00412-008-0170-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000478892	RUVBL1-205	872	-	ENSP00000417254	267 (aa)	-	H7C4G5
ENST00000582176	RUVBL1-207	4062	-	-	- (aa)	-	-
ENST00000322623	RUVBL1-201	1761	XM_005247841	ENSP00000318297	456 (aa)	XP_005247898	Q9Y265
ENST00000478243	RUVBL1-204	395	-	-	- (aa)	-	-
ENST00000472125	RUVBL1-203	913	-	ENSP00000417370	222 (aa)	-	H7C4I3
ENST00000464873	RUVBL1-202	2126	XM_011513249	ENSP00000420738	315 (aa)	XP_011511551	E7ETR0
ENST00000480616	RUVBL1-206	564	-	-	- (aa)	-	-
ENST00000585057	RUVBL1-208	1113	-	ENSP00000463669	131 (aa)	-	J3QLR1

Gene Model

Click here to download ENSG00000175792's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04310	Wnt signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	4E-6	26634245
ENSG00000175792	Lung Volume Measurements	4E-6	26634245
ENSG00000175792	Bronchodilator Agents	7E-7	26634245
ENSG00000175792	Forced Expiratory Volume	7E-7	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	4E-7	26634245
ENSG00000175792	Forced Expiratory Volume	4E-7	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	4E-6	26634245
ENSG00000175792	Forced Expiratory Volume	4E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	1E-6	26634245
ENSG00000175792	Lung Volume Measurements	1E-6	26634245
ENSG00000175792	Bronchodilator Agents	5E-6	26634245
ENSG00000175792	Lung Volume Measurements	5E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	4E-7	26634245
ENSG00000175792	Forced Expiratory Volume	4E-7	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	8E-7	26634245
ENSG00000175792	Forced Expiratory Volume	8E-7	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	6E-7	26634245
ENSG00000175792	Forced Expiratory Volume	6E-7	26634245
ENSG00000175792	Bronchodilator Agents	4E-7	26634245
ENSG00000175792	Forced Expiratory Volume	4E-7	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	1E-6	26634245
ENSG00000175792	Lung Volume Measurements	1E-6	26634245
ENSG00000175792	Bronchodilator Agents	1E-6	26634245
ENSG00000175792	Lung Volume Measurements	1E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	7E-7	26634245
ENSG00000175792	Forced Expiratory Volume	7E-7	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Lung Volume Measurements	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	8E-7	26634245
ENSG00000175792	Forced Expiratory Volume	8E-7	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	4E-6	26634245
ENSG00000175792	Forced Expiratory Volume	4E-6	26634245
ENSG00000175792	Bronchodilator Agents	6E-7	26634245
ENSG00000175792	Forced Expiratory Volume	6E-7	26634245
ENSG00000175792	Bronchodilator Agents	1E-6	26634245
ENSG00000175792	Lung Volume Measurements	1E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Lung Volume Measurements	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	5E-6	26634245
ENSG00000175792	Lung Volume Measurements	5E-6	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-7	26634245
ENSG00000175792	Forced Expiratory Volume	3E-7	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Forced Expiratory Volume	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	4E-6	26634245
ENSG00000175792	Lung Volume Measurements	4E-6	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	4E-7	26634245
ENSG00000175792	Forced Expiratory Volume	4E-7	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	1E-6	26634245
ENSG00000175792	Lung Volume Measurements	1E-6	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	3E-6	26634245
ENSG00000175792	Forced Expiratory Volume	3E-6	26634245
ENSG00000175792	Bronchodilator Agents	5E-7	26634245
ENSG00000175792	Forced Expiratory Volume	5E-7	26634245
ENSG00000175792	Bronchodilator Agents	6E-7	26634245
ENSG00000175792	Forced Expiratory Volume	6E-7	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245
ENSG00000175792	Bronchodilator Agents	2E-6	26634245
ENSG00000175792	Lung Volume Measurements	2E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175792	rs11709725	3	128139090	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs2687723	3	128146716	C	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs34689870	3	128141636	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs6439116	3	128130224	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs13069054	3	128137139	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000175792	rs34817706	3	128142215	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs6800225	3	128143335	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs73192979	3	128149478	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs6797834	3	128137557	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs6783253	3	128132718	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs73192978	3	128149432	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs34174370	3	128130901	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs35347185	3	128135684	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs11714619	3	128131233	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs13059975	3	128130841	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs13095660	3	128129313	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs6788497	3	128129545	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs66987356	3	128122255	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs35421223	3	128111036	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs11714052	3	128095614	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs35515217	3	128094968	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000175792	rs35804055	3	128107736	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs11709725	3	128139090	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs34689870	3	128141636	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs2687723	3	128146716	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs6439116	3	128130224	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs13062252	3	128109788	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.06	EFO_0004314\|GO_0097366
ENSG00000175792	rs6784159	3	128124535	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs33998546	3	128112195	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs35145572	3	128128575	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs55777628	3	128103178	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs34955225	3	128106235	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs11719079	3	128105206	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs60464856	3	128123377	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs34228187	3	128097590	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs13082038	3	128109613	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs112434347	3	128121604	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs138573550	3	128121182	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs35947214	3	128114388	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs67940364	3	128114510	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs6785535	3	128115852	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs11720239	3	128099112	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs36059338	3	128097084	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs34403909	3	128091602	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs35724792	3	128090773	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs13060453	3	128091895	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs11719546	3	128153759	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.056	EFO_0004314\|GO_0097366
ENSG00000175792	rs67674204	3	128105935	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.056	EFO_0004314\|GO_0097366
ENSG00000175792	rs11711710	3	128153663	T	Post bronchodilator FEV1	26634245	NR unit increase	0.056	EFO_0004314\|GO_0097366
ENSG00000175792	rs34749881	3	128151426	T	Post bronchodilator FEV1	26634245	NR unit increase	0.056	EFO_0004314\|GO_0097366
ENSG00000175792	rs60387553	3	128110125	A	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs11715661	3	128102003	T	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs34709844	3	128100026	A	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs6787614	3	128098635	A	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs35437840	3	128106463	T	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs34545799	3	128118665	T	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs36069551	3	128095234	A	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs55684215	3	128093949	A	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs13091198	3	128093194	T	Post bronchodilator FEV1	26634245	NR unit increase	0.057	EFO_0004314\|GO_0097366
ENSG00000175792	rs11707462	3	128119787	C	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs56050323	3	128128455	A	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs34172752	3	128122901	A	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs35531186	3	128122217	T	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs34562493	3	128098179	T	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs11709377	3	128096827	A	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000175792	rs34174370	3	128130901	T	Post bronchodilator FEV1	26634245	NR unit increase	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs11714619	3	128131233	A	Post bronchodilator FEV1	26634245	NR unit increase	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs73192978	3	128149432	A	Post bronchodilator FEV1	26634245	NR unit increase	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs73192979	3	128149478	T	Post bronchodilator FEV1	26634245	NR unit increase	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs35347185	3	128135684	T	Post bronchodilator FEV1	26634245	NR unit increase	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs13095660	3	128129313	T	Post bronchodilator FEV1	26634245	NR unit increase	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs6788497	3	128129545	T	Post bronchodilator FEV1	26634245	NR unit increase	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs13059975	3	128130841	T	Post bronchodilator FEV1	26634245	NR unit increase	0.061	EFO_0004314\|GO_0097366
ENSG00000175792	rs6783253	3	128132718	A	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs6800225	3	128143335	T	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs34817706	3	128142215	A	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs6797834	3	128137557	T	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs11714052	3	128095614	A	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs35515217	3	128094968	T	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000175792	rs66987356	3	128122255	A	Post bronchodilator FEV1	26634245	NR unit increase	0.063	EFO_0004314\|GO_0097366
ENSG00000175792	rs35421223	3	128111036	A	Post bronchodilator FEV1	26634245	NR unit increase	0.063	EFO_0004314\|GO_0097366
ENSG00000175792	rs11709060	3	128075405	?	Cardiovascular disease	30595370			EFO_0000319

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000175792's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000175792	RUVBL1	100	54.198	FBgn0040075	rept	91	45.254	Drosophila_melanogaster
ENSG00000175792	RUVBL1	100	51.908	ENSG00000183207	RUVBL2	92	57.000	Homo_sapiens
ENSG00000175792	RUVBL1	100	99.781	ENSMUSG00000030079	Ruvbl1	100	100.000	Mus_musculus
ENSG00000175792	RUVBL1	100	51.908	ENSMUSG00000003868	Ruvbl2	95	51.969	Mus_musculus
ENSG00000175792	RUVBL1	99	77.070	YDR190C	RVB1	94	70.737	Saccharomyces_cerevisiae
ENSG00000175792	RUVBL1	100	54.198	YPL235W	RVB2	91	42.697	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000492	box C/D snoRNP assembly	21873635.	IBA	Process
GO:0000812	Swr1 complex	21873635.	IBA	Component
GO:0000812	Swr1 complex	24463511.	IDA	Component
GO:0001094	TFIID-class transcription factor complex binding	-	IEA	Function
GO:0003678	DNA helicase activity	9843967.	IDA	Function
GO:0003713	transcription coactivator activity	11080158.	IDA	Function
GO:0004003	ATP-dependent DNA helicase activity	21873635.	IBA	Function
GO:0005515	protein binding	10966108.11080158.15647280.16230350.17636026.17761535.18026119.18087039.18358808.19179534.19299493.20371770.20864032.23824326.25416956.26711270.27705803.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	9843967.18026119.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005815	microtubule organizing center	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0006338	chromatin remodeling	21873635.	IBA	Process
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007283	spermatogenesis	9588198.	TAS	Process
GO:0016020	membrane	-	IEA	Component
GO:0016363	nuclear matrix	-	IEA	Component
GO:0016573	histone acetylation	21873635.	IBA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016887	ATPase activity	10966108.	IDA	Function
GO:0017025	TBP-class protein binding	11080158.	IDA	Function
GO:0031011	Ino80 complex	21873635.	IBA	Component
GO:0031011	Ino80 complex	18026119.21303910.	IDA	Component
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0035267	NuA4 histone acetyltransferase complex	21873635.	IBA	Component
GO:0035267	NuA4 histone acetyltransferase complex	10966108.14966270.	IDA	Component
GO:0040008	regulation of growth	-	IEA	Process
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	-	IEA	Function
GO:0043531	ADP binding	-	IEA	Function
GO:0043967	histone H4 acetylation	14966270.	IDA	Process
GO:0043968	histone H2A acetylation	14966270.	IDA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051117	ATPase binding	-	IEA	Function
GO:0051301	cell division	-	IEA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071339	MLL1 complex	15960975.	IDA	Component
GO:0090263	positive regulation of canonical Wnt signaling pathway	11080158.	IDA	Process
GO:0097255	R2TP complex	21873635.	IBA	Component
GO:0097255	R2TP complex	26711270.	IDA	Component
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process
GO:1904837	beta-catenin-TCF complex assembly	-	TAS	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process
GO:1990904	ribonucleoprotein complex	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22895545	Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma.	Oncol Rep	2012 Nov	Lauscher JC	doi: 10.3892/or.2012.1968
18087039	SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells.	Proc Natl Acad Sci U S A	2007 Dec 26	Kim JH	-
14675489	Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a.	Mol Cancer	2003 Dec 15	Carlson ML	-
28341484	RUVBL1-ITFG1 interaction is required for collective invasion in breast cancer.	Biochim Biophys Acta Gen Subj	2017 Jul	Fan W	doi: 10.1016/j.bbagen.2017.03.016
29545175	RUVBL1, a novel C-RAF-binding protein, activates the RAF/MEK/ERK pathway to promote lung cancer tumorigenesis.	Biochem Biophys Res Commun	2018 Apr 15	Guo H	doi: 10.1016/j.bbrc.2018.03.084

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	128081225	3'UTR	novel		0.46
ACC	chr3	128123653	Silent	novel	L24L	0.12
BLCA	chr3	128123615	Missense_Mutation	NA	S37L	0.58
BLCA	chr3	128082529	Nonsense_Mutation	novel	E389*	0.08
BLCA	chr3	128123713	Missense_Mutation	NA	E4D	0.21
BLCA	chr3	128097490	Nonsense_Mutation	NA	R276*	0.52
BLCA	chr3	128112941	Missense_Mutation	NA	S103L	0.3
BLCA	chr3	128123715	Missense_Mutation	NA	E4Q	0.13
BLCA	chr3	128123791	5'UTR	novel		0.25
BLCA	chr3	128081386	Missense_Mutation	rs766547190	P412L	0.06
BRCA	chr3	128087802	Silent	rs772966421	T341T	0.06
BRCA	chr3	128100655	Missense_Mutation	novel	K231N	0.07
BRCA	chr3	128097388	Missense_Mutation	NA	E310K	0.16
BRCA	chr3	128097490	Nonsense_Mutation	NA	R276*	0.14
BRCA	chr3	128100714	Nonsense_Mutation	NA	E212*	0.29
BRCA	chr3	128081349	Silent	NA	S424S	0.37
CESC	chr3	128098922	Missense_Mutation	rs758610032	M259I	0.32
CESC	chr3	128097412	Missense_Mutation	NA	D302N	0.14
COAD	chr3	128104816	Missense_Mutation	novel	V157E	0.09
COAD	chr3	128100605	Missense_Mutation	NA	A248V	0.38
COAD	chr3	128081246	3'UTR	novel		0.08
COAD	chr3	128112900	Missense_Mutation	NA	R117C	0.34
COAD	chr3	128112900	Missense_Mutation	NA	R117C	0.24
COAD	chr3	128101611	Missense_Mutation	novel	R184Q	0.28
COAD	chr3	128104854	Missense_Mutation	novel	E144D	0.14
COAD	chr3	128104796	Missense_Mutation	novel	A164T	0.22
COAD	chr3	128087768	Missense_Mutation	novel	D353N	0.16
COAD	chr3	128081330	Missense_Mutation	NA	E431K	0.2
GBM	chr3	128087728	Missense_Mutation	NA	Y366C	0.48
GBM	chr3	128081330	Missense_Mutation	NA	E431K	0.24
HNSC	chr3	128123607	Missense_Mutation	novel	V40L	0.16
HNSC	chr3	128123812	5'UTR	novel		0.42
HNSC	chr3	128081224	3'UTR	novel		0.19
KIRP	chr3	128112941	Missense_Mutation	NA	S103L	0.36
KIRP	chr3	128123738	5'UTR	novel		0.47
LAML	chr3	128081349	Silent	NA	S424S	0.18
LGG	chr3	128112900	Missense_Mutation	NA	R117C	0.41
LIHC	chr3	128112919	Silent	NA	E110E	0.17
LUAD	chr3	128087787	Silent	novel	S346S	0.41
LUAD	chr3	128101555	Splice_Site	novel	X198_splice	0.22
LUAD	chr3	128104810	Missense_Mutation	NA	I159R	0.3
LUAD	chr3	128097337	Missense_Mutation	NA	V327I	0.23
LUAD	chr3	128123584	Missense_Mutation	NA	E47D	0.16
LUAD	chr3	128123611	Silent	NA	G38G	0.13
LUAD	chr3	128097372	Missense_Mutation	novel	L315R	0.39
LUAD	chr3	128097392	Silent	novel	D308D	0.6
LUAD	chr3	128101610	Silent	novel	R184R	0.3
LUAD	chr3	128123653	Silent	NA	L24L	0.3
LUSC	chr3	128098931	Silent	novel	I256I	0.39
LUSC	chr3	128112956	Missense_Mutation	novel	G98E	0.28
LUSC	chr3	128098942	Nonsense_Mutation	novel	G253*	0.24
LUSC	chr3	128101630	Missense_Mutation	novel	E178Q	0.04
LUSC	chr3	128112941	Nonsense_Mutation	novel	S103*	0.06
LUSC	chr3	128104918	Missense_Mutation	NA	R123L	0.3
LUSC	chr3	128104894	Missense_Mutation	novel	Y131F	0.1
LUSC	chr3	128081342	Nonsense_Mutation	novel	K427*	0.23
OV	chr3	128081159	3'UTR	novel		0.23
OV	chr3	128087794	Frame_Shift_Del	novel	*I344Hfs9**	0.15
OV	chr3	128123762	5'UTR	novel		0.11
OV	chr3	128123764	5'UTR	novel		0.05
PRAD	chr3	128097454	Missense_Mutation	rs748047032	D288N	0.38
READ	chr3	128081184	3'UTR	rs569769466		0.33
READ	chr3	128081330	Missense_Mutation	NA	E431K	0.33
READ	chr3	128082572	Splice_Region	novel	I374I	0.41
READ	chr3	128104901	Missense_Mutation	rs772341250	E129K	0.13
SKCM	chr3	128097431	Silent	NA	V295V	0.23
SKCM	chr3	128123621	Missense_Mutation	rs561000621	A35V	0.36
SKCM	chr3	128104850	Missense_Mutation	NA	P146S	0.11
SKCM	chr3	128098889	Silent	NA	E270E	0.4
STAD	chr3	128082552	Missense_Mutation	novel	T381M	0.41
STAD	chr3	128097364	Missense_Mutation	NA	A318T	0.45
STAD	chr3	128104850	Missense_Mutation	NA	P146S	0.38
STAD	chr3	128123679	Missense_Mutation	rs200468252	A16T	0.5
STAD	chr3	128112894	Missense_Mutation	NA	A119T	0.05
STAD	chr3	128087741	Missense_Mutation	rs546455182	R362W	0.24
STAD	chr3	128097408	Missense_Mutation	NA	E303G	0.18
STAD	chr3	128112908	Missense_Mutation	novel	E114G	0.12
STAD	chr3	128097367	Missense_Mutation	NA	R317C	0.1
STAD	chr3	128097456	Missense_Mutation	NA	I287T	0.19
STAD	chr3	128100661	Silent	rs778413732	H229H	0.22
STAD	chr3	128082562	Missense_Mutation	NA	R378C	0.12
THYM	chr3	128098941	Frame_Shift_Del	novel	*G253Dfs7**	0.3
UCEC	chr3	128100651	Nonsense_Mutation	NA	E233*	0.17
UCEC	chr3	128081223	3'UTR	novel		0.52
UCEC	chr3	128104917	Silent	novel	R123R	0.08
UCEC	chr3	128113014	Silent	novel	L79L	0.13
UCEC	chr3	128087718	Missense_Mutation	NA	Q369H	0.37
UCEC	chr3	128100650	Frame_Shift_Del	novel	*E233Nfs9**	0.33
UCEC	chr3	128100604	Silent	NA	A248A	0.07
UCEC	chr3	128100651	Nonsense_Mutation	NA	E233*	0.29
UCEC	chr3	128081319	Silent	novel	S434S	0.3
UCEC	chr3	128081101	3'UTR	novel		0.27
UCEC	chr3	128082562	Missense_Mutation	NA	R378C	0.41
UCEC	chr3	128097346	Missense_Mutation	novel	A324T	0.34
UCEC	chr3	128097493	Missense_Mutation	novel	L275F	0.47
UCEC	chr3	128097370	Missense_Mutation	novel	H316Y	0.1
UCEC	chr3	128097450	Missense_Mutation	novel	Q289R	0.25
UCEC	chr3	128104919	Nonsense_Mutation	novel	R123*	0.43
UCEC	chr3	128100655	Silent	novel	K231K	0.56
UCEC	chr3	128097349	Missense_Mutation	rs774903268	I323V	0.26
UCEC	chr3	128082552	Missense_Mutation	novel	T381M	0.35
UCEC	chr3	128081175	3'UTR	novel		0.56
UCEC	chr3	128082562	Missense_Mutation	NA	R378C	0.29
UCEC	chr3	128098946	Splice_Site	novel	X252_splice	0.42
UCEC	chr3	128097482	Missense_Mutation	novel	E278D	0.24
UCEC	chr3	128123652	Missense_Mutation	novel	G25R	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
GBM	DEL	0.0797	0.00094652
KIRC	DEL	0.1837	0.11092
LGG	DEL	0.0604	0.04374

Survival Analysis

Cancer	P-value	Q-value
THYM	0.044	Kaplan-Meier Survival Analysis
SARC	0.0072	Kaplan-Meier Survival Analysis
MESO	0.00024	Kaplan-Meier Survival Analysis
ACC	0.015	Kaplan-Meier Survival Analysis
HNSC	0.027	Kaplan-Meier Survival Analysis
COAD	0.015	Kaplan-Meier Survival Analysis
READ	0.007	Kaplan-Meier Survival Analysis
KICH	0.029	Kaplan-Meier Survival Analysis
UCEC	0.012	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
DLBC	0.0064	Kaplan-Meier Survival Analysis
LGG	0.011	Kaplan-Meier Survival Analysis
LUAD	0.0087	Kaplan-Meier Survival Analysis
UVM	0.0002	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Cell lines and drugs in GSE70138 or GSE92742