EuRBPDB

Description

Ensembl ID: ENSG00000175931 (Gene tree)
Gene ID: 63893
Gene Symbol: UBE2O
Alias: E2-230K
Full Name: ubiquitin conjugating enzyme E2 O
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 63,756 bases
Position: chr17:76,389,451-76,453,206
Accession: 29554
RBP type: non-canonical RBP
Summary: (Ubiquitin Conjugating Enzyme E2 O) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2Z.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590658	UBE2O-206	567	-	ENSP00000467623	189 (aa)	-	K7EQ12
ENST00000587127	UBE2O-204	3569	-	ENSP00000468498	807 (aa)	-	K7ES11
ENST00000586505	UBE2O-203	522	-	-	- (aa)	-	-
ENST00000319380	UBE2O-201	5436	XM_005257567	ENSP00000323687	1292 (aa)	XP_005257624	Q9C0C9
ENST00000586409	UBE2O-202	3579	-	-	- (aa)	-	-
ENST00000587581	UBE2O-205	545	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000175931	DNA, Mitochondrial	9E-6	25240745

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000175931	rs447921	17	76418477	?	Mitochondrial DNA levels	25240745	[NR]		EFO_0006312
ENSG00000175931	rs181558256	17	76398695	?	Mumps	28928442	[0.45-1.11] unit decrease	0.782	EFO_0008404
ENSG00000175931	rs11077815	17	76393809	C	Lymphocyte counts	27863252	[0.017-0.032] unit decrease	0.02463137	EFO_0004587
ENSG00000175931	rs4789294	17	76423095	G	Lymphocyte percentage of white cells	27863252	[0.02-0.037] unit increase	0.02858509	EFO_0007993
ENSG00000175931	rs144887234	17	76414710	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004842	ubiquitin-protein transferase activity	23455153.24703950.	IDA	Function
GO:0005515	protein binding	23455153.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	24703950.	IDA	Component
GO:0005737	cytoplasm	24703950.	IDA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0006513	protein monoubiquitination	23455153.24703950.	IDA	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0030513	positive regulation of BMP signaling pathway	23455153.	IDA	Process
GO:0042147	retrograde transport, endosome to Golgi	23452853.	IMP	Process
GO:0061630	ubiquitin protein ligase activity	21873635.	IBA	Function
GO:0061630	ubiquitin protein ligase activity	23455153.	IDA	Function
GO:0061631	ubiquitin conjugating enzyme activity	21873635.	IBA	Function
GO:0061631	ubiquitin conjugating enzyme activity	23455153.	IDA	Function
GO:0070534	protein K63-linked ubiquitination	23452853.	IMP	Process