EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000176102 (Gene tree)
Gene ID
1479
Gene Symbol
CSTF3
Alias
CstF-77
Full Name
cleavage stimulation factor subunit 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
85,184 bases
Position
chr11:33,077,188-33,162,371
Accession
2485
RBP type
canonical RBP
Summary
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000315791SufPF05843.141e-8311
ENSP00000431355SufPF05843.141.3e-8311
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
11113135The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice.J Biol Chem2001 Mar 16Dass B-
10606651The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene.Nucleic Acids Res2000 Jan 15Hatton LS-
19887456The hinge domain of the cleavage stimulation factor protein CstF-64 is essential for CstF-77 interaction, nuclear localization, and polyadenylation.J Biol Chem2010 Jan 1Hockert JAdoi: 10.1074/jbc.M109.061705
17380053Identification of DDX1 as a JC virus transcriptional control region-binding protein.Microbiol Immunol2007Sunden Y-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000526480CSTF3-207479--- (aa)--
ENST00000524556CSTF3-204558-ENSP0000043475352 (aa)-E9PNK2
ENST00000524827CSTF3-2062911-ENSP00000431355749 (aa)-E9PLP8
ENST00000438862CSTF3-2031132-ENSP00000388711103 (aa)-Q12996
ENST00000524775CSTF3-205434-ENSP0000043190361 (aa)-E9PJ06
ENST00000323959CSTF3-2012797-ENSP00000315791717 (aa)-Q12996
ENST00000528865CSTF3-208592-ENSP0000043513891 (aa)-H0YE74
ENST00000431742CSTF3-202715-ENSP0000039306444 (aa)-Q12996
Gene Model
Click here to download ENSG00000176102's gene model file
Pathways
Pathway IDPathway NameSource
hsa03015mRNA surveillance pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000176102Depressive Disorder8E-727622933
ENSG00000176102Citalopram8E-727622933
ENSG00000176102Mood Disorders8E-727622933
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000176102rs1426415021133109861?Non-response to citalopram or escitalopram and depression27622933[2.155-9.671]4.565EFO_0003761|EFO_0007871|EFO_0006329|EFO_0004247
ENSG00000176102rs618893061133083157GMosquito bite size28199695[0.022-0.055] unit decrease0.038376EFO_0008378
ENSG00000176102rs729049321133114521?Heel bone mineral density30048462[0.028-0.052] unit increase0.0400648EFO_0009270
ENSG00000176102rs729049321133114521?Heel bone mineral density30595370EFO_0009270
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000176102's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000176102CSTF310091.365ENSAPOG00000014054cstf310091.365Acanthochromis_polyacanthus
ENSG00000176102CSTF39999.859ENSAMEG00000007187CSTF39899.859Ailuropoda_melanoleuca
ENSG00000176102CSTF38786.080ENSACIG00000005539cstf310086.080Amphilophus_citrinellus
ENSG00000176102CSTF310091.086ENSAOCG00000010930cstf310091.086Amphiprion_ocellaris
ENSG00000176102CSTF310091.086ENSAPEG00000007903cstf310091.086Amphiprion_percula
ENSG00000176102CSTF310091.226ENSATEG00000000190cstf310091.226Anabas_testudineus
ENSG00000176102CSTF39998.023ENSAPLG00000007217CSTF310098.023Anas_platyrhynchos
ENSG00000176102CSTF310095.682ENSACAG00000002823CSTF310095.682Anolis_carolinensis
ENSG00000176102CSTF3100100.000ENSANAG00000020699CSTF3100100.000Aotus_nancymaae
ENSG00000176102CSTF39891.773ENSACLG00000007820cstf310091.086Astatotilapia_calliptera
ENSG00000176102CSTF310090.669ENSAMXG00000014198cstf310090.947Astyanax_mexicanus
ENSG00000176102CSTF3100100.000ENSBTAG00000008617CSTF3100100.000Bos_taurus
ENSG00000176102CSTF39749.313WBGene00006307suf-19949.313Caenorhabditis_elegans
ENSG00000176102CSTF3100100.000ENSCJAG00000005533CSTF3100100.000Callithrix_jacchus
ENSG00000176102CSTF310099.861ENSCAFG00000007264CSTF310099.861Canis_familiaris
ENSG00000176102CSTF399100.000ENSCAFG00020002715CSTF399100.000Canis_lupus_dingo
ENSG00000176102CSTF399100.000ENSCHIG00000016418CSTF3100100.000Capra_hircus
ENSG00000176102CSTF39999.577ENSTSYG00000000451CSTF310099.577Carlito_syrichta
ENSG00000176102CSTF39998.889ENSCAPG00000010958CSTF39896.591Cavia_aperea
ENSG00000176102CSTF310099.582ENSCPOG00000005545CSTF310099.582Cavia_porcellus
ENSG00000176102CSTF3100100.000ENSCCAG00000024790CSTF3100100.000Cebus_capucinus
ENSG00000176102CSTF3100100.000ENSCATG00000007080CSTF3100100.000Cercocebus_atys
ENSG00000176102CSTF3100100.000ENSCLAG00000016179CSTF3100100.000Chinchilla_lanigera
ENSG00000176102CSTF39998.889ENSCHOG00000002497CSTF379100.000Choloepus_hoffmanni
ENSG00000176102CSTF310097.354ENSCPBG00000006753CSTF310097.354Chrysemys_picta_bellii
ENSG00000176102CSTF39962.098ENSCING00000006401-9862.098Ciona_intestinalis
ENSG00000176102CSTF39861.785ENSCSAVG00000004851-10061.785Ciona_savignyi
ENSG00000176102CSTF3100100.000ENSCANG00000035468CSTF3100100.000Colobus_angolensis_palliatus
ENSG00000176102CSTF310099.303ENSCGRG00001014773Cstf310099.303Cricetulus_griseus_chok1gshd
ENSG00000176102CSTF310099.303ENSCGRG00000004142Cstf310099.303Cricetulus_griseus_crigri
ENSG00000176102CSTF310091.074ENSCSEG00000014283cstf310091.074Cynoglossus_semilaevis
ENSG00000176102CSTF310090.251ENSCVAG00000019739cstf310090.251Cyprinodon_variegatus
ENSG00000176102CSTF310090.934ENSDARG00000018904cstf310090.934Danio_rerio
ENSG00000176102CSTF39999.020ENSDNOG00000007366CSTF39999.020Dasypus_novemcinctus
ENSG00000176102CSTF39998.889ENSDORG00000005898Cstf39992.102Dipodomys_ordii
ENSG00000176102CSTF39857.025FBgn0003559su(f)9857.025Drosophila_melanogaster
ENSG00000176102CSTF39998.889ENSETEG00000017097CSTF39094.237Echinops_telfairi
ENSG00000176102CSTF38474.050ENSEBUG00000015459cstf39674.050Eptatretus_burgeri
ENSG00000176102CSTF399100.000ENSEASG00005019884CSTF310099.857Equus_asinus_asinus
ENSG00000176102CSTF399100.000ENSECAG00000023338CSTF310099.857Equus_caballus
ENSG00000176102CSTF310098.361ENSEEUG00000015167CSTF310094.142Erinaceus_europaeus
ENSG00000176102CSTF310089.679ENSELUG00000023393cstf310089.679Esox_lucius
ENSG00000176102CSTF310099.721ENSFCAG00000030711CSTF310099.721Felis_catus
ENSG00000176102CSTF39398.649ENSFALG00000010764CSTF310096.928Ficedula_albicollis
ENSG00000176102CSTF3100100.000ENSFDAG00000012082CSTF310099.861Fukomys_damarensis
ENSG00000176102CSTF310090.390ENSFHEG00000020623cstf310090.390Fundulus_heteroclitus
ENSG00000176102CSTF310089.430ENSGMOG00000012275cstf310089.430Gadus_morhua
ENSG00000176102CSTF310098.050ENSGALG00000011685CSTF310098.050Gallus_gallus
ENSG00000176102CSTF310090.669ENSGAFG00000002181cstf310090.669Gambusia_affinis
ENSG00000176102CSTF310090.529ENSGACG00000015997cstf310090.529Gasterosteus_aculeatus
ENSG00000176102CSTF310097.214ENSGAGG00000006200CSTF310097.214Gopherus_agassizii
ENSG00000176102CSTF399100.000ENSGGOG00000026591CSTF39994.076Gorilla_gorilla
ENSG00000176102CSTF39891.773ENSHBUG00000016656cstf310091.086Haplochromis_burtoni
ENSG00000176102CSTF3100100.000ENSHGLG00000017834CSTF310099.721Heterocephalus_glaber_female
ENSG00000176102CSTF3100100.000ENSHGLG00100018042CSTF310099.721Heterocephalus_glaber_male
ENSG00000176102CSTF39889.377ENSHCOG00000015218cstf310088.858Hippocampus_comes
ENSG00000176102CSTF310090.237ENSIPUG00000013170CSTF310090.237Ictalurus_punctatus
ENSG00000176102CSTF3100100.000ENSSTOG00000013306CSTF3100100.000Ictidomys_tridecemlineatus
ENSG00000176102CSTF399100.000ENSJJAG00000018430Cstf39987.448Jaculus_jaculus
ENSG00000176102CSTF310089.833ENSKMAG00000010916cstf310089.833Kryptolebias_marmoratus
ENSG00000176102CSTF310090.111ENSLBEG00000002306cstf310090.111Labrus_bergylta
ENSG00000176102CSTF310093.863ENSLACG00000017296CSTF310093.863Latimeria_chalumnae
ENSG00000176102CSTF310093.305ENSLOCG00000004415cstf310093.305Lepisosteus_oculatus
ENSG00000176102CSTF310099.582ENSLAFG00000008712CSTF310099.582Loxodonta_africana
ENSG00000176102CSTF3100100.000ENSMFAG00000029516CSTF3100100.000Macaca_fascicularis
ENSG00000176102CSTF3100100.000ENSMMUG00000002542CSTF3100100.000Macaca_mulatta
ENSG00000176102CSTF3100100.000ENSMNEG00000021807CSTF3100100.000Macaca_nemestrina
ENSG00000176102CSTF3100100.000ENSMLEG00000039594CSTF3100100.000Mandrillus_leucophaeus
ENSG00000176102CSTF310091.086ENSMAMG00000020423cstf310091.086Mastacembelus_armatus
ENSG00000176102CSTF39891.773ENSMZEG00005012082cstf310091.086Maylandia_zebra
ENSG00000176102CSTF310098.189ENSMGAG00000001383CSTF310098.189Meleagris_gallopavo
ENSG00000176102CSTF310099.163ENSMAUG00000002487Cstf310099.163Mesocricetus_auratus
ENSG00000176102CSTF3100100.000ENSMICG00000004784CSTF310099.721Microcebus_murinus
ENSG00000176102CSTF310099.303ENSMOCG00000017583Cstf310099.303Microtus_ochrogaster
ENSG00000176102CSTF39991.127ENSMMOG00000016026cstf39888.482Mola_mola
ENSG00000176102CSTF310084.100ENSMODG00000025205-10084.100Monodelphis_domestica
ENSG00000176102CSTF310098.745ENSMODG00000009745-10098.745Monodelphis_domestica
ENSG00000176102CSTF310090.808ENSMALG00000012050cstf310090.808Monopterus_albus
ENSG00000176102CSTF310099.303MGP_CAROLIEiJ_G0024026Cstf310099.303Mus_caroli
ENSG00000176102CSTF310099.303ENSMUSG00000027176Cstf310099.303Mus_musculus
ENSG00000176102CSTF310099.303MGP_PahariEiJ_G0025464Cstf310099.303Mus_pahari
ENSG00000176102CSTF310099.303MGP_SPRETEiJ_G0024939Cstf310099.303Mus_spretus
ENSG00000176102CSTF310099.721ENSMPUG00000011457CSTF310099.721Mustela_putorius_furo
ENSG00000176102CSTF39999.437ENSMLUG00000003073-9999.718Myotis_lucifugus
ENSG00000176102CSTF310096.095ENSMLUG00000026022-10096.095Myotis_lucifugus
ENSG00000176102CSTF310099.303ENSNGAG00000010677Cstf310099.303Nannospalax_galili
ENSG00000176102CSTF38791.040ENSNBRG00000007345cstf310091.040Neolamprologus_brichardi
ENSG00000176102CSTF3100100.000ENSNLEG00000017901CSTF3100100.000Nomascus_leucogenys
ENSG00000176102CSTF37395.029ENSMEUG00000005640-10095.029Notamacropus_eugenii
ENSG00000176102CSTF310096.721ENSOPRG00000000199-66100.000Ochotona_princeps
ENSG00000176102CSTF310099.721ENSODEG00000016737-10099.721Octodon_degus
ENSG00000176102CSTF39897.674ENSODEG00000006311-9787.107Octodon_degus
ENSG00000176102CSTF39891.773ENSONIG00000005563cstf310091.086Oreochromis_niloticus
ENSG00000176102CSTF39990.000ENSOANG00000015140CSTF310097.077Ornithorhynchus_anatinus
ENSG00000176102CSTF310099.582ENSOCUG00000015417CSTF310099.582Oryctolagus_cuniculus
ENSG00000176102CSTF310090.934ENSORLG00000009762cstf310090.934Oryzias_latipes
ENSG00000176102CSTF310090.934ENSORLG00020005540cstf310090.934Oryzias_latipes_hni
ENSG00000176102CSTF310090.795ENSORLG00015003551cstf310090.795Oryzias_latipes_hsok
ENSG00000176102CSTF310090.098ENSOMEG00000003848cstf310090.098Oryzias_melastigma
ENSG00000176102CSTF310099.306ENSOGAG00000010229CSTF310099.306Otolemur_garnettii
ENSG00000176102CSTF399100.000ENSOARG00000017271CSTF39999.844Ovis_aries
ENSG00000176102CSTF39996.333ENSPPAG00000027358CSTF39996.333Pan_paniscus
ENSG00000176102CSTF310099.721ENSPPRG00000016852CSTF310099.721Panthera_pardus
ENSG00000176102CSTF310099.721ENSPTIG00000008716CSTF310099.721Panthera_tigris_altaica
ENSG00000176102CSTF3100100.000ENSPTRG00000003485CSTF3100100.000Pan_troglodytes
ENSG00000176102CSTF3100100.000ENSPANG00000013722CSTF3100100.000Papio_anubis
ENSG00000176102CSTF310092.469ENSPKIG00000023648cstf310092.469Paramormyrops_kingsleyae
ENSG00000176102CSTF310096.936ENSPSIG00000009173CSTF310096.936Pelodiscus_sinensis
ENSG00000176102CSTF310086.885ENSPMGG00000000164cstf39895.733Periophthalmus_magnuspinnatus
ENSG00000176102CSTF310099.163ENSPEMG00000011481Cstf310099.163Peromyscus_maniculatus_bairdii
ENSG00000176102CSTF39980.337ENSPMAG00000007282cstf39980.337Petromyzon_marinus
ENSG00000176102CSTF39996.051ENSPCIG00000026406-10098.240Phascolarctos_cinereus
ENSG00000176102CSTF310081.198ENSPCIG00000030419-9081.894Phascolarctos_cinereus
ENSG00000176102CSTF310090.808ENSPFOG00000017239cstf310090.808Poecilia_formosa
ENSG00000176102CSTF310090.808ENSPLAG00000009456cstf310090.808Poecilia_latipinna
ENSG00000176102CSTF310090.808ENSPMEG00000010320cstf310090.808Poecilia_mexicana
ENSG00000176102CSTF310090.808ENSPREG00000013549cstf310090.808Poecilia_reticulata
ENSG00000176102CSTF3100100.000ENSPPYG00000003375CSTF3100100.000Pongo_abelii
ENSG00000176102CSTF39897.674ENSPCAG00000008025-71100.000Procavia_capensis
ENSG00000176102CSTF3100100.000ENSPCOG00000014417CSTF310094.561Propithecus_coquereli
ENSG00000176102CSTF3100100.000ENSPVAG00000002350CSTF310094.561Pteropus_vampyrus
ENSG00000176102CSTF39891.773ENSPNYG00000018259cstf310091.086Pundamilia_nyererei
ENSG00000176102CSTF310092.050ENSPNAG00000020182cstf310092.050Pygocentrus_nattereri
ENSG00000176102CSTF39998.889ENSRNOG00000012089Cstf310099.200Rattus_norvegicus
ENSG00000176102CSTF399100.000ENSRBIG00000044258CSTF3100100.000Rhinopithecus_bieti
ENSG00000176102CSTF3100100.000ENSRROG00000043450CSTF3100100.000Rhinopithecus_roxellana
ENSG00000176102CSTF3100100.000ENSSBOG00000024764CSTF3100100.000Saimiri_boliviensis_boliviensis
ENSG00000176102CSTF310097.908ENSSHAG00000018128-10097.908Sarcophilus_harrisii
ENSG00000176102CSTF310085.495ENSSHAG00000003135-9985.495Sarcophilus_harrisii
ENSG00000176102CSTF310092.190ENSSFOG00015022133cstf310092.190Scleropages_formosus
ENSG00000176102CSTF310090.251ENSSMAG00000002197cstf310090.251Scophthalmus_maximus
ENSG00000176102CSTF310091.086ENSSDUG00000020426cstf310091.086Seriola_dumerili
ENSG00000176102CSTF310091.226ENSSLDG00000025649cstf310091.226Seriola_lalandi_dorsalis
ENSG00000176102CSTF310099.582ENSSARG00000000391CSTF310099.582Sorex_araneus
ENSG00000176102CSTF39697.106ENSSPUG00000010546CSTF310097.106Sphenodon_punctatus
ENSG00000176102CSTF310091.226ENSSPAG00000004958cstf310091.226Stegastes_partitus
ENSG00000176102CSTF399100.000ENSSSCG00000040954CSTF310099.302Sus_scrofa
ENSG00000176102CSTF39997.740ENSTGUG00000005010CSTF310097.740Taeniopygia_guttata
ENSG00000176102CSTF310089.833ENSTRUG00000004959cstf310089.833Takifugu_rubripes
ENSG00000176102CSTF39990.704ENSTNIG00000013811cstf39990.704Tetraodon_nigroviridis
ENSG00000176102CSTF39096.417ENSTBEG00000001544CSTF39096.417Tupaia_belangeri
ENSG00000176102CSTF3100100.000ENSTTRG00000016366CSTF310096.932Tursiops_truncatus
ENSG00000176102CSTF39999.718ENSUMAG00000018971CSTF310099.680Ursus_maritimus
ENSG00000176102CSTF3100100.000ENSVPAG00000007800CSTF310099.861Vicugna_pacos
ENSG00000176102CSTF399100.000ENSVVUG00000014938CSTF3100100.000Vulpes_vulpes
ENSG00000176102CSTF38879.375ENSXETG00000021399cstf310080.583Xenopus_tropicalis
ENSG00000176102CSTF38796.226ENSXETG00000017946-9943.685Xenopus_tropicalis
ENSG00000176102CSTF38790.400ENSXCOG00000011741cstf310090.400Xiphophorus_couchianus
ENSG00000176102CSTF310090.808ENSXMAG00000009545cstf310090.808Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000398mRNA splicing, via spliceosome-TASProcess
GO:0003723RNA binding22681889.HDAFunction
GO:0003729mRNA binding21873635.IBAFunction
GO:0005515protein binding7590244.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0006369termination of RNA polymerase II transcription-TASProcess
GO:0006378mRNA polyadenylation7984242.TASProcess
GO:0006379mRNA cleavage7984242.TASProcess
GO:0031123RNA 3'-end processing21873635.IBAProcess
GO:0031124mRNA 3'-end processing-TASProcess

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