EuRBPDB

Description

Ensembl ID: ENSG00000176393 (Gene tree)
Gene ID: 6051
Gene Symbol: RNPEP
Alias: APB
Full Name: arginyl aminopeptidase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 23,776 bases
Position: chr1:201,982,372-202,006,147
Accession: 10078
RBP type: non-canonical RBP
Summary: (Arginyl Aminopeptidase) is a Protein Coding gene. Diseases associated with RNPEP include Nerve Compression Syndrome and Focal Hand Dystonia. Gene Ontology (GO) annotations related to this gene include binding and aminopeptidase activity. An important paralog of this gene is RNPEPL1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000295640	RNPEP-201	2427	-	ENSP00000295640	650 (aa)	-	Q9H4A4
ENST00000479531	RNPEP-208	667	-	-	- (aa)	-	-
ENST00000487116	RNPEP-211	851	-	ENSP00000478325	171 (aa)	-	A0A087WU27
ENST00000492849	RNPEP-213	958	-	-	- (aa)	-	-
ENST00000447312	RNPEP-203	1166	-	ENSP00000389602	344 (aa)	-	C9JMZ3
ENST00000478617	RNPEP-207	1069	-	-	- (aa)	-	-
ENST00000449524	RNPEP-204	505	-	ENSP00000407614	168 (aa)	-	H7C2T3
ENST00000479726	RNPEP-209	822	-	-	- (aa)	-	-
ENST00000464707	RNPEP-205	450	-	-	- (aa)	-	-
ENST00000367286	RNPEP-202	2282	XM_005245421	ENSP00000356255	611 (aa)	XP_005245478	A6NKB8
ENST00000481780	RNPEP-210	847	-	-	- (aa)	-	-
ENST00000620670	RNPEP-214	683	-	-	- (aa)	-	-
ENST00000492587	RNPEP-212	780	-	ENSP00000478884	151 (aa)	-	A0A087WUS4
ENST00000471105	RNPEP-206	2093	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000176393	Butyrylcholinesterase	9E-16	21862451
ENSG00000176393	Bronchodilator Agents	1E-6	26634245
ENSG00000176393	Lung Volume Measurements	1E-6	26634245
ENSG00000176393	Pulmonary Disease, Chronic Obstructive	1E-6	26634245
ENSG00000176393	Bronchodilator Agents	2E-6	26634245
ENSG00000176393	Forced Expiratory Volume	2E-6	26634245
ENSG00000176393	Pulmonary Disease, Chronic Obstructive	2E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000176393	rs144177292	1	201994931	T	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.178	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000176393	rs144177292	1	201994931	T	Post bronchodilator FEV1 in COPD	26634245	NR unit increase	0.721	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000176393	rs4950806	1	201983446	T	Butyrylcholinesterase levels	21862451	[0.10-0.18] SD decrease	0.14	EFO_0004571
ENSG00000176393	rs59698324	1	201996727	C	Blood protein levels	30072576	[0.32-0.42] unit increase	0.371	EFO_0007937

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000176393	RNPEP	95	94.172	ENSMUSG00000041926	Rnpep	100	88.615	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004177	aminopeptidase activity	9405297.	ISS	Function
GO:0004177	aminopeptidase activity	12119107.	NAS	Function
GO:0004301	epoxide hydrolase activity	12119107.	NAS	Function
GO:0005576	extracellular region	27068509.	HDA	Component
GO:0005576	extracellular region	21873635.	IBA	Component
GO:0005576	extracellular region	9405297.	ISS	Component
GO:0005576	extracellular region	10467730.	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	9405297.	ISS	Component
GO:0005886	plasma membrane	10467730.	TAS	Component
GO:0006508	proteolysis	12119107.	IC	Process
GO:0008235	metalloexopeptidase activity	12119107.	NAS	Function
GO:0008270	zinc ion binding	12119107.	NAS	Function
GO:0030141	secretory granule	21873635.	IBA	Component
GO:0045776	negative regulation of blood pressure	21873635.	IBA	Process
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component