EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000176624 (Gene tree)
Gene ID: 51320
Gene Symbol: MEX3C
Alias: FLJ38871|RNF194|RKHD2
Full Name: mex-3 RNA binding family member C
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 43,755 bases
Position: chr18:51,174,550-51,218,304
Accession: 28040
RBP type: canonical RBP
Summary: This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000482566	KH_1	PF00013.29	5.4e-26	1	2
ENSP00000482566	KH_1	PF00013.29	5.4e-26	2	2
ENSP00000385610	KH_1	PF00013.29	1.2e-25	1	2
ENSP00000385610	KH_1	PF00013.29	1.2e-25	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31118679	MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway.	Onco Targets Ther	2019 May 1	Chao H	doi: 10.2147/OTT.S199667
30631154	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	Cell Res	2019 Apr	Hu Q	doi: 10.1038/s41422-018-0134-3
22927639	Mex3c mutation reduces adiposity and increases energy expenditure.	Mol Cell Biol	2012 Nov	Jiao Y	doi: 10.1128/MCB.00452-12
22863774	The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.	EMBO J	2012 Aug 29	Cano F	doi: 10.1038/emboj.2012.218
23140835	A novel post-transcriptional role for ubiquitin in the differential regulation of MHC class I allotypes.	Mol Immunol	2013 Sep	Cano F	doi: 10.1016/j.molimm.2012.10.015
24741071	Mex3c mutation reduces adiposity partially through increasing physical activity.	J Endocrinol	2014 Jun	Han C	doi: 10.1530/JOE-14-0071
24706898	Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.	Proc Natl Acad Sci U S A	2014 Apr 15	Kuniyoshi K	doi: 10.1073/pnas.1401674111
26471122	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	Nat Commun	2015 Oct 16	Cano F	doi: 10.1038/ncomms9670.
27053362	Oocyte-Specific Expression of Mouse MEX3C652AA in the Ovary and Its Potential Role in Regulating Maternal Fos mRNA.	Biol Reprod	2016 May	Li X	doi: 10.1095/biolreprod.115.136630
28808060	The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity.	J Biol Chem	2017 Sep 29	Yang L	doi: 10.1074/jbc.M117.797746
28982131	MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting.	PLoS One	2017 Oct 5	Lu P	doi: 10.1371/journal.pone.0185992
30095198	Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase.	Protein Sci	2018 Sep	Moududee SA	doi: 10.1002/pro.3473.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000616921	MEX3C-204	3269	-	ENSP00000482566	489 (aa)	-	M9T4I7
ENST00000592416	MEX3C-203	3850	-	ENSP00000468078	115 (aa)	-	K7ER23
ENST00000406189	MEX3C-201	3781	-	ENSP00000385610	659 (aa)	-	Q5U5Q3
ENST00000591040	MEX3C-202	799	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000176624's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000176624	Myocardial Infarction	7.2337844E-004	-
ENSG00000176624	Erythrocyte Indices	6.5230000E-005	-
ENSG00000176624	Cytokines	9E-9	22610502
ENSG00000176624	Vaccine Potency	9E-9	22610502

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000176624	rs8096445	18	51186670	A	Immune response to smallpox vaccine (IL-6)	22610502			EFO_0004645\|EFO_0004873
ENSG00000176624	rs8088085	18	51182178	A	Atrial fibrillation	30061737	[1.02-1.05]	1.04	EFO_0000275
ENSG00000176624	rs16952939	18	51217272	A	Educational attainment (MTAG)	30038396	[0.0057-0.0107] unit decrease	0.0082	EFO_0004784
ENSG00000176624	rs57976196	18	51212275	A	Highest math class taken (MTAG)	30038396	[0.0065-0.0131] unit decrease	0.0098	EFO_0004875
ENSG00000176624	rs8088085	18	51182178	A	Atrial fibrillation	29892015	[1.02-1.05]	1.03	EFO_0000275
ENSG00000176624	rs1941961	18	51217780	A	Educational attainment (years of education)	30038396	[0.0058-0.0112] unit increase	0.0085	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000176624's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000176624	MEX3C	89	59.216	ENSG00000183496	MEX3B	90	59.216
ENSG00000176624	MEX3C	90	49.663	ENSG00000254726	MEX3A	77	50.562
ENSG00000176624	MEX3C	89	52.546	ENSG00000181588	MEX3D	97	52.479

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000176624	MEX3C	91	100.000	ENSAMEG00000002897	MEX3C	99	100.000	Ailuropoda_melanoleuca
ENSG00000176624	MEX3C	85	79.167	ENSAPLG00000003916	MEX3C	100	78.240	Anas_platyrhynchos
ENSG00000176624	MEX3C	85	93.888	ENSACAG00000010265	MEX3C	98	93.888	Anolis_carolinensis
ENSG00000176624	MEX3C	99	99.586	ENSANAG00000031189	MEX3C	99	94.793	Aotus_nancymaae
ENSG00000176624	MEX3C	99	98.969	ENSBTAG00000014886	MEX3C	100	95.808	Bos_taurus
ENSG00000176624	MEX3C	98	99.583	ENSCJAG00000001902	MEX3C	98	99.792	Callithrix_jacchus
ENSG00000176624	MEX3C	98	95.178	ENSCAFG00000000162	MEX3C	99	99.511	Canis_familiaris
ENSG00000176624	MEX3C	98	97.904	ENSCAFG00020021673	MEX3C	92	83.414	Canis_lupus_dingo
ENSG00000176624	MEX3C	99	98.763	ENSCHIG00000017962	MEX3C	100	96.096	Capra_hircus
ENSG00000176624	MEX3C	85	99.462	ENSCAPG00000007002	MEX3C	100	99.462	Cavia_aperea
ENSG00000176624	MEX3C	98	98.958	ENSCPOG00000009646	MEX3C	100	95.307	Cavia_porcellus
ENSG00000176624	MEX3C	99	99.379	ENSCCAG00000034228	MEX3C	100	97.888	Cebus_capucinus
ENSG00000176624	MEX3C	99	99.586	ENSCATG00000031557	MEX3C	95	99.064	Cercocebus_atys
ENSG00000176624	MEX3C	99	98.758	ENSCLAG00000006969	MEX3C	100	97.853	Chinchilla_lanigera
ENSG00000176624	MEX3C	100	99.241	ENSCSAG00000018097	MEX3C	100	99.241	Chlorocebus_sabaeus
ENSG00000176624	MEX3C	98	99.375	ENSCHOG00000004915	MEX3C	100	98.188	Choloepus_hoffmanni
ENSG00000176624	MEX3C	95	94.658	ENSCPBG00000025611	MEX3C	100	94.872	Chrysemys_picta_bellii
ENSG00000176624	MEX3C	99	98.971	ENSCANG00000033743	MEX3C	100	98.953	Colobus_angolensis_palliatus
ENSG00000176624	MEX3C	98	98.958	ENSCGRG00001014162	Mex3c	96	95.680	Cricetulus_griseus_chok1gshd
ENSG00000176624	MEX3C	85	99.731	ENSCGRG00000018775	Mex3c	100	99.731	Cricetulus_griseus_crigri
ENSG00000176624	MEX3C	98	99.376	ENSDNOG00000006544	MEX3C	100	96.364	Dasypus_novemcinctus
ENSG00000176624	MEX3C	85	100.000	ENSDORG00000025473	Mex3c	100	100.000	Dipodomys_ordii
ENSG00000176624	MEX3C	85	97.543	ENSETEG00000003647	MEX3C	100	97.543	Echinops_telfairi
ENSG00000176624	MEX3C	100	98.027	ENSECAG00000021727	MEX3C	100	98.027	Equus_caballus
ENSG00000176624	MEX3C	85	99.754	ENSEEUG00000010864	MEX3C	100	99.754	Erinaceus_europaeus
ENSG00000176624	MEX3C	90	63.383	ENSELUG00000020179	MEX3C	76	64.454	Esox_lucius
ENSG00000176624	MEX3C	99	99.380	ENSFCAG00000027546	MEX3C	100	97.130	Felis_catus
ENSG00000176624	MEX3C	90	99.546	ENSFDAG00000021094	MEX3C	100	100.000	Fukomys_damarensis
ENSG00000176624	MEX3C	95	94.433	ENSGAGG00000019588	MEX3C	100	94.647	Gopherus_agassizii
ENSG00000176624	MEX3C	90	100.000	ENSGGOG00000014875	-	100	100.000	Gorilla_gorilla
ENSG00000176624	MEX3C	99	98.965	ENSHGLG00000004567	MEX3C	96	95.820	Heterocephalus_glaber_female
ENSG00000176624	MEX3C	85	99.462	ENSHGLG00100015059	MEX3C	100	99.462	Heterocephalus_glaber_male
ENSG00000176624	MEX3C	98	99.375	ENSSTOG00000022325	MEX3C	100	98.208	Ictidomys_tridecemlineatus
ENSG00000176624	MEX3C	99	97.955	ENSJJAG00000005241	Mex3c	100	99.140	Jaculus_jaculus
ENSG00000176624	MEX3C	85	78.883	ENSLACG00000007331	MEX3C	100	78.883	Latimeria_chalumnae
ENSG00000176624	MEX3C	97	67.821	ENSLOCG00000012879	MEX3C	74	71.205	Lepisosteus_oculatus
ENSG00000176624	MEX3C	99	98.758	ENSLAFG00000027818	MEX3C	100	97.529	Loxodonta_africana
ENSG00000176624	MEX3C	99	99.586	ENSMFAG00000042267	MEX3C	100	99.798	Macaca_fascicularis
ENSG00000176624	MEX3C	99	99.586	ENSMMUG00000023652	MEX3C	100	100.000	Macaca_mulatta
ENSG00000176624	MEX3C	99	99.586	ENSMNEG00000037450	MEX3C	99	99.426	Macaca_nemestrina
ENSG00000176624	MEX3C	87	100.000	ENSMLEG00000040189	MEX3C	81	100.000	Mandrillus_leucophaeus
ENSG00000176624	MEX3C	98	99.375	ENSMAUG00000016546	Mex3c	100	98.633	Mesocricetus_auratus
ENSG00000176624	MEX3C	99	99.586	ENSMICG00000005815	MEX3C	99	98.444	Microcebus_murinus
ENSG00000176624	MEX3C	98	98.958	ENSMOCG00000012424	Mex3c	100	98.765	Microtus_ochrogaster
ENSG00000176624	MEX3C	99	97.119	ENSMODG00000011001	MEX3C	94	90.205	Monodelphis_domestica
ENSG00000176624	MEX3C	99	98.152	MGP_CAROLIEiJ_G0022391	Mex3c	95	94.880	Mus_caroli
ENSG00000176624	MEX3C	100	97.546	ENSMUSG00000037253	Mex3c	95	94.108	Mus_musculus
ENSG00000176624	MEX3C	100	97.342	MGP_PahariEiJ_G0019119	Mex3c	96	90.446	Mus_pahari
ENSG00000176624	MEX3C	100	97.546	MGP_SPRETEiJ_G0023303	Mex3c	96	94.108	Mus_spretus
ENSG00000176624	MEX3C	95	99.785	ENSMPUG00000008769	MEX3C	100	99.785	Mustela_putorius_furo
ENSG00000176624	MEX3C	91	93.191	ENSMLUG00000012585	MEX3C	90	93.191	Myotis_lucifugus
ENSG00000176624	MEX3C	99	98.566	ENSNGAG00000002190	Mex3c	100	98.225	Nannospalax_galili
ENSG00000176624	MEX3C	99	96.480	ENSNLEG00000029756	-	99	96.502	Nomascus_leucogenys
ENSG00000176624	MEX3C	80	97.368	ENSMEUG00000015929	MEX3C	63	97.368	Notamacropus_eugenii
ENSG00000176624	MEX3C	99	98.548	ENSODEG00000018398	MEX3C	100	98.922	Octodon_degus
ENSG00000176624	MEX3C	85	97.304	ENSOANG00000008116	MEX3C	100	97.304	Ornithorhynchus_anatinus
ENSG00000176624	MEX3C	100	95.714	ENSOCUG00000012549	-	100	99.356	Oryctolagus_cuniculus
ENSG00000176624	MEX3C	87	91.726	ENSOCUG00000014295	-	100	91.726	Oryctolagus_cuniculus
ENSG00000176624	MEX3C	95	99.138	ENSOGAG00000030858	MEX3C	100	99.138	Otolemur_garnettii
ENSG00000176624	MEX3C	92	98.891	ENSOARG00000004676	MEX3C	99	98.891	Ovis_aries
ENSG00000176624	MEX3C	89	100.000	ENSPPAG00000038467	-	96	99.770	Pan_paniscus
ENSG00000176624	MEX3C	99	99.380	ENSPPRG00000012151	MEX3C	100	97.130	Panthera_pardus
ENSG00000176624	MEX3C	99	86.804	ENSPTIG00000004865	MEX3C	86	100.000	Panthera_tigris_altaica
ENSG00000176624	MEX3C	99	99.586	ENSPTRG00000010029	MEX3C	100	99.687	Pan_troglodytes
ENSG00000176624	MEX3C	99	99.586	ENSPANG00000006226	MEX3C	99	99.426	Papio_anubis
ENSG00000176624	MEX3C	91	59.236	ENSPKIG00000016813	MEX3C	76	61.803	Paramormyrops_kingsleyae
ENSG00000176624	MEX3C	85	94.258	ENSPSIG00000014521	MEX3C	97	93.810	Pelodiscus_sinensis
ENSG00000176624	MEX3C	99	98.560	ENSPEMG00000022227	-	100	98.235	Peromyscus_maniculatus_bairdii
ENSG00000176624	MEX3C	85	99.731	ENSPEMG00000014770	-	100	99.731	Peromyscus_maniculatus_bairdii
ENSG00000176624	MEX3C	50	100.000	ENSPPYG00000029457	-	94	100.000	Pongo_abelii
ENSG00000176624	MEX3C	99	96.715	ENSPCAG00000009258	MEX3C	95	91.866	Procavia_capensis
ENSG00000176624	MEX3C	99	99.586	ENSPCOG00000027054	MEX3C	100	97.876	Propithecus_coquereli
ENSG00000176624	MEX3C	99	98.560	ENSPVAG00000015135	MEX3C	100	96.364	Pteropus_vampyrus
ENSG00000176624	MEX3C	95	99.569	ENSRNOG00000015777	Mex3c	100	99.569	Rattus_norvegicus
ENSG00000176624	MEX3C	99	99.586	ENSRBIG00000034716	MEX3C	99	99.430	Rhinopithecus_bieti
ENSG00000176624	MEX3C	99	99.586	ENSRROG00000035366	MEX3C	100	99.798	Rhinopithecus_roxellana
ENSG00000176624	MEX3C	99	99.586	ENSSBOG00000024094	MEX3C	100	99.456	Saimiri_boliviensis_boliviensis
ENSG00000176624	MEX3C	85	96.806	ENSSHAG00000009408	-	85	98.010	Sarcophilus_harrisii
ENSG00000176624	MEX3C	92	59.023	ENSSFOG00015020715	MEX3C	90	61.028	Scleropages_formosus
ENSG00000176624	MEX3C	85	99.509	ENSSARG00000006940	MEX3C	100	99.509	Sorex_araneus
ENSG00000176624	MEX3C	95	92.751	ENSSPUG00000017527	MEX3C	100	92.751	Sphenodon_punctatus
ENSG00000176624	MEX3C	99	98.965	ENSSSCG00000034427	MEX3C	100	97.117	Sus_scrofa
ENSG00000176624	MEX3C	85	99.020	ENSTBEG00000014438	MEX3C	100	99.020	Tupaia_belangeri
ENSG00000176624	MEX3C	99	97.947	ENSTTRG00000004570	MEX3C	82	97.778	Tursiops_truncatus
ENSG00000176624	MEX3C	99	99.174	ENSUAMG00000014181	MEX3C	100	99.194	Ursus_americanus
ENSG00000176624	MEX3C	83	99.755	ENSUMAG00000003137	MEX3C	95	99.755	Ursus_maritimus
ENSG00000176624	MEX3C	85	94.103	ENSVPAG00000003137	MEX3C	100	94.103	Vicugna_pacos
ENSG00000176624	MEX3C	94	95.329	ENSVVUG00000014636	MEX3C	100	95.329	Vulpes_vulpes
ENSG00000176624	MEX3C	94	77.489	ENSXETG00000022367	mex3c	87	79.773	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003415	chondrocyte hypertrophy	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	22863774.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0016740	transferase activity	-	IEA	Function
GO:0045598	regulation of fat cell differentiation	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0097009	energy homeostasis	-	IEA	Process