EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000176909 (Gene tree)
Gene ID: 284358
Gene Symbol: MAMSTR
Alias: MASTR|FLJ36070
Full Name: MEF2 activating motif and SAP domain containing transcriptional regulator
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 7,057 bases
Position: chr19:48,712,722-48,719,778
Accession: 26689
RBP type: canonical RBP
Summary: MAMSTR (MEF2 Activating Motif And SAP Domain Containing Transcriptional Regulator) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and obsolete transcription factor activity, RNA polymerase II transcription factor binding. An important paralog of this gene is MTDH.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000349192	SAP	PF02037.27	3.2e-08	1	1
ENSP00000324175	SAP	PF02037.27	4.6e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000318083	MAMSTR-201	1837	XM_011526808	ENSP00000324175	415 (aa)	XP_011525110	Q6ZN01
ENST00000356751	MAMSTR-202	1825	XM_011526807	ENSP00000349192	312 (aa)	XP_011525109	Q6ZN01
ENST00000599703	MAMSTR-205	714	-	ENSP00000469544	219 (aa)	-	M0QY28
ENST00000594582	MAMSTR-203	1693	XM_011526809	ENSP00000471590	247 (aa)	XP_011525111	Q6ZN01
ENST00000595591	MAMSTR-204	415	-	ENSP00000469127	11 (aa)	-	M0QXF1

Gene Model

Click here to download ENSG00000176909's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000176909	rs381254	19	48717947	?	Serum alkaline phosphatase levels	29403010	[0.024-0.049] unit decrease novel	0.036126122	EFO_0004533

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000176909's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000176909	MAMSTR	100	92.913	ENSAMEG00000014802	MAMSTR	100	76.180	Ailuropoda_melanoleuca
ENSG00000176909	MAMSTR	99	88.387	ENSANAG00000025139	MAMSTR	78	80.739	Aotus_nancymaae
ENSG00000176909	MAMSTR	100	81.132	ENSBTAG00000011617	MAMSTR	100	78.522	Bos_taurus
ENSG00000176909	MAMSTR	100	91.566	ENSCJAG00000000326	MAMSTR	100	91.566	Callithrix_jacchus
ENSG00000176909	MAMSTR	100	81.875	ENSCAFG00000003914	MAMSTR	100	77.397	Canis_familiaris
ENSG00000176909	MAMSTR	100	78.344	ENSCAFG00020026340	MAMSTR	100	72.600	Canis_lupus_dingo
ENSG00000176909	MAMSTR	100	78.616	ENSCHIG00000017698	MAMSTR	100	76.429	Capra_hircus
ENSG00000176909	MAMSTR	100	87.711	ENSTSYG00000026265	MAMSTR	100	87.470	Carlito_syrichta
ENSG00000176909	MAMSTR	100	70.433	ENSCPOG00000031881	MAMSTR	100	71.154	Cavia_porcellus
ENSG00000176909	MAMSTR	100	93.253	ENSCCAG00000029438	MAMSTR	100	93.253	Cebus_capucinus
ENSG00000176909	MAMSTR	100	96.154	ENSCATG00000031813	MAMSTR	100	96.154	Cercocebus_atys
ENSG00000176909	MAMSTR	100	72.600	ENSCLAG00000005822	MAMSTR	100	71.897	Chinchilla_lanigera
ENSG00000176909	MAMSTR	100	96.635	ENSCSAG00000002823	MAMSTR	100	96.635	Chlorocebus_sabaeus
ENSG00000176909	MAMSTR	100	97.108	ENSCANG00000016741	MAMSTR	100	97.108	Colobus_angolensis_palliatus
ENSG00000176909	MAMSTR	100	72.115	ENSCGRG00001018713	Mamstr	100	72.488	Cricetulus_griseus_chok1gshd
ENSG00000176909	MAMSTR	100	74.473	ENSDNOG00000034507	MAMSTR	100	76.995	Dasypus_novemcinctus
ENSG00000176909	MAMSTR	100	64.789	ENSDORG00000001229	Mamstr	100	64.169	Dipodomys_ordii
ENSG00000176909	MAMSTR	65	96.774	ENSETEG00000017393	-	65	96.774	Echinops_telfairi
ENSG00000176909	MAMSTR	99	76.923	ENSEASG00005004688	MAMSTR	92	77.644	Equus_asinus_asinus
ENSG00000176909	MAMSTR	99	82.637	ENSECAG00000020390	MAMSTR	99	81.490	Equus_caballus
ENSG00000176909	MAMSTR	89	79.928	ENSEEUG00000011877	MAMSTR	99	74.737	Erinaceus_europaeus
ENSG00000176909	MAMSTR	100	81.410	ENSFCAG00000007361	MAMSTR	100	81.731	Felis_catus
ENSG00000176909	MAMSTR	100	99.679	ENSGGOG00000001237	MAMSTR	100	99.679	Gorilla_gorilla
ENSG00000176909	MAMSTR	100	71.971	ENSHGLG00000016428	MAMSTR	100	69.596	Heterocephalus_glaber_female
ENSG00000176909	MAMSTR	100	72.530	ENSHGLG00100005311	MAMSTR	100	70.120	Heterocephalus_glaber_male
ENSG00000176909	MAMSTR	100	87.838	ENSSTOG00000020068	MAMSTR	100	83.894	Ictidomys_tridecemlineatus
ENSG00000176909	MAMSTR	100	73.494	ENSJJAG00000017177	Mamstr	100	69.639	Jaculus_jaculus
ENSG00000176909	MAMSTR	100	81.081	ENSLAFG00000017394	MAMSTR	100	78.571	Loxodonta_africana
ENSG00000176909	MAMSTR	100	96.867	ENSMFAG00000045502	MAMSTR	100	96.867	Macaca_fascicularis
ENSG00000176909	MAMSTR	100	95.904	ENSMNEG00000041978	MAMSTR	100	95.904	Macaca_nemestrina
ENSG00000176909	MAMSTR	100	70.843	ENSMAUG00000013527	Mamstr	100	72.048	Mesocricetus_auratus
ENSG00000176909	MAMSTR	100	86.984	ENSMICG00000013193	MAMSTR	100	86.603	Microcebus_murinus
ENSG00000176909	MAMSTR	99	75.714	ENSMOCG00000020029	Mamstr	99	75.714	Microtus_ochrogaster
ENSG00000176909	MAMSTR	84	46.454	ENSMODG00000002229	-	80	42.586	Monodelphis_domestica
ENSG00000176909	MAMSTR	100	75.000	MGP_CAROLIEiJ_G0029733	-	100	75.467	Mus_caroli
ENSG00000176909	MAMSTR	100	74.299	ENSMUSG00000042918	Mamstr	100	74.533	Mus_musculus
ENSG00000176909	MAMSTR	100	74.941	MGP_PahariEiJ_G0012958	Mamstr	100	74.941	Mus_pahari
ENSG00000176909	MAMSTR	100	73.721	MGP_SPRETEiJ_G0030831	-	100	73.953	Mus_spretus
ENSG00000176909	MAMSTR	100	79.688	ENSMPUG00000003791	MAMSTR	100	76.484	Mustela_putorius_furo
ENSG00000176909	MAMSTR	100	77.541	ENSNGAG00000016579	Mamstr	100	78.014	Nannospalax_galili
ENSG00000176909	MAMSTR	100	63.014	ENSNLEG00000004605	-	100	86.722	Nomascus_leucogenys
ENSG00000176909	MAMSTR	84	53.759	ENSMEUG00000015223	-	88	52.941	Notamacropus_eugenii
ENSG00000176909	MAMSTR	88	67.033	ENSOPRG00000015106	MAMSTR	65	73.260	Ochotona_princeps
ENSG00000176909	MAMSTR	100	65.321	ENSODEG00000017655	MAMSTR	100	63.700	Octodon_degus
ENSG00000176909	MAMSTR	72	93.548	ENSOCUG00000021342	-	100	60.857	Oryctolagus_cuniculus
ENSG00000176909	MAMSTR	100	81.150	ENSOGAG00000003568	MAMSTR	100	78.846	Otolemur_garnettii
ENSG00000176909	MAMSTR	96	83.784	ENSOARG00000012032	MAMSTR	100	77.367	Ovis_aries
ENSG00000176909	MAMSTR	100	82.372	ENSPPRG00000004054	MAMSTR	100	81.731	Panthera_pardus
ENSG00000176909	MAMSTR	100	99.679	ENSPTRG00000011253	MAMSTR	100	99.679	Pan_troglodytes
ENSG00000176909	MAMSTR	100	96.867	ENSPANG00000022678	MAMSTR	100	96.867	Papio_anubis
ENSG00000176909	MAMSTR	100	40.050	ENSPCIG00000001155	-	100	39.400	Phascolarctos_cinereus
ENSG00000176909	MAMSTR	100	98.857	ENSPPYG00000010591	-	100	97.436	Pongo_abelii
ENSG00000176909	MAMSTR	97	79.538	ENSPCAG00000001125	-	100	77.558	Procavia_capensis
ENSG00000176909	MAMSTR	100	88.571	ENSPCOG00000023398	MAMSTR	100	87.857	Propithecus_coquereli
ENSG00000176909	MAMSTR	100	75.962	ENSPVAG00000009535	MAMSTR	100	72.289	Pteropus_vampyrus
ENSG00000176909	MAMSTR	100	74.353	ENSRNOG00000024580	Mamstr	100	74.588	Rattus_norvegicus
ENSG00000176909	MAMSTR	100	97.115	ENSRBIG00000043644	MAMSTR	100	97.115	Rhinopithecus_bieti
ENSG00000176909	MAMSTR	100	97.349	ENSRROG00000033087	MAMSTR	100	97.349	Rhinopithecus_roxellana
ENSG00000176909	MAMSTR	100	89.157	ENSSBOG00000028762	MAMSTR	100	88.675	Saimiri_boliviensis_boliviensis
ENSG00000176909	MAMSTR	100	77.885	ENSSARG00000002931	MAMSTR	100	77.218	Sorex_araneus
ENSG00000176909	MAMSTR	100	83.387	ENSSSCG00000003143	MAMSTR	100	83.254	Sus_scrofa
ENSG00000176909	MAMSTR	55	86.705	ENSTBEG00000012239	-	55	86.705	Tupaia_belangeri
ENSG00000176909	MAMSTR	97	84.768	ENSTTRG00000014557	MAMSTR	100	77.831	Tursiops_truncatus
ENSG00000176909	MAMSTR	100	79.630	ENSUAMG00000010490	MAMSTR	100	76.852	Ursus_americanus
ENSG00000176909	MAMSTR	100	81.410	ENSVVUG00000023147	MAMSTR	100	77.209	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001085	RNA polymerase II transcription factor binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0010831	positive regulation of myotube differentiation	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	48715301	Missense_Mutation	NA	S129C	0.21
BLCA	chr19	48713378	Silent	novel	L379L	0.19
BLCA	chr19	48713719	Missense_Mutation	rs745349713	D321N	0.31
BRCA	chr19	48716786	Intron	novel		0.26
BRCA	chr19	48713738	Silent	rs776354357	L314L	0.05
CESC	chr19	48713497	In_Frame_Ins	novel	S339_P340insRMK	0.34
CESC	chr19	48713498	In_Frame_Ins	novel	S339_P340insNLCSPLTIIT	0.24
CESC	chr19	48713410	Missense_Mutation	novel	P369T	0.31
CESC	chr19	48712996	3'UTR	novel		0.43
COAD	chr19	48715871	Intron	novel		0.33
COAD	chr19	48719029	Translation_Start_Site	novel	M1?	0.36
COAD	chr19	48714848	Frame_Shift_Ins	rs765520198	*H163Tfs9**	0.21
COAD	chr19	48715698	Missense_Mutation	novel	A56V	0.38
COAD	chr19	48715378	Silent	NA	Y103Y	0.4
COAD	chr19	48713495	Frame_Shift_Del	NA	*S341Pfs39**	0.29
COAD	chr19	48715708	Missense_Mutation	novel	S53A	0.12
COAD	chr19	48716786	Intron	novel		0.23
DLBC	chr19	48716860	Intron	novel		0.46
ESCA	chr19	48715323	Missense_Mutation	novel	A122T	0.18
GBM	chr19	48713756	Silent	novel	R308R	0.11
HNSC	chr19	48713314	Missense_Mutation	novel	D401H	0.44
HNSC	chr19	48713967	Missense_Mutation	novel	P268A	0.21
HNSC	chr19	48713893	Missense_Mutation	novel	E292D	0.09
LIHC	chr19	48716786	Intron	novel		0.22
LUSC	chr19	48714553	Missense_Mutation	novel	E179G	0.83	SAP
LUSC	chr19	48713337	Missense_Mutation	novel	S393N	0.23
OV	chr19	48713316	Missense_Mutation	NA	S400F	0.53
PRAD	chr19	48713912	Missense_Mutation	NA	S286L	0.13
READ	chr19	48714905	Missense_Mutation	NA	M143I	0.29
READ	chr19	48713954	Missense_Mutation	NA	P272R	0.58
READ	chr19	48715418	Missense_Mutation	NA	R90M	0.18
SARC	chr19	48713325	Missense_Mutation	novel	A397D	0.07
SKCM	chr19	48713419	Missense_Mutation	NA	P366S	0.39
SKCM	chr19	48713959	Silent	novel	P270P	0.54
SKCM	chr19	48713987	Missense_Mutation	NA	G261E	0.42
SKCM	chr19	48713532	Missense_Mutation	rs770569678	P328L	0.48
STAD	chr19	48713989	Silent	novel	P260P	0.06
STAD	chr19	48714848	Frame_Shift_Ins	rs765520198	*H163Tfs9**	0.26
STAD	chr19	48713339	Frame_Shift_Del	novel	*S393Afs27**	0.37
STAD	chr19	48714848	Frame_Shift_Ins	rs765520198	*H163Tfs9**	0.37
UCEC	chr19	48713320	Missense_Mutation	NA	L399V	0.39
UCEC	chr19	48713457	Missense_Mutation	novel	S353Y	0.17
UCEC	chr19	48715701	Missense_Mutation	NA	T55M	0.2
UCEC	chr19	48719026	Silent	NA	T2T	0.27
UCEC	chr19	48715905	Intron	novel		0.58
UCEC	chr19	48715706	Silent	NA	S53S	0.23
UCEC	chr19	48713265	3'UTR	novel		0.14
UCEC	chr19	48719040	5'UTR	novel		0.18
UCEC	chr19	48718999	Missense_Mutation	novel	Q11H	0.64
UCEC	chr19	48715707	Missense_Mutation	rs759687984	S53L	0.22
UCEC	chr19	48713546	Silent	novel	P323P	0.46
UCEC	chr19	48713046	3'UTR	novel		0.39
UCEC	chr19	48715403	Missense_Mutation	novel	R95K	0.31
UCEC	chr19	48714849	Frame_Shift_Del	rs752869239	*P162Hfs14**	0.38
UCEC	chr19	48715324	Silent	novel	S121S	0.52
UCEC	chr19	48715810	Intron	novel		0.54
UCEC	chr19	48714849	Frame_Shift_Del	rs752869239	*P162Hfs14**	0.37
UCEC	chr19	48715747	Missense_Mutation	novel	I40V	0.07
UCEC	chr19	48713339	Frame_Shift_Del	novel	*S393Afs27**	0.5
UCEC	chr19	48713374	Missense_Mutation	NA	G381R	0.45
UCEC	chr19	48715630	Missense_Mutation	novel	K79E	0.36
UCEC	chr19	48713860	Missense_Mutation	novel	Q303H	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0915	0.027508
KIRP	DEL	0.0486	0.054726
LUAD	DEL	0.2558	1.5526e-05
LUSC	DEL	0.2116	1.1877e-06
OV	DEL	0.4905	2.441e-17
PAAD	DEL	0.087	0.035089
READ	DEL	0.0909	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.2321	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.029	Kaplan-Meier Survival Analysis
MESO	0.0059	Kaplan-Meier Survival Analysis
HNSC	0.02	Kaplan-Meier Survival Analysis
LUSC	0.0034	Kaplan-Meier Survival Analysis
KIRP	0.0075	Kaplan-Meier Survival Analysis
PAAD	0.049	Kaplan-Meier Survival Analysis
PCPG	0.041	Kaplan-Meier Survival Analysis
BLCA	0.0086	Kaplan-Meier Survival Analysis
UCEC	0.016	Kaplan-Meier Survival Analysis
LIHC	0.0002	Kaplan-Meier Survival Analysis
UVM	0.00013	Kaplan-Meier Survival Analysis