EuRBPDB

Description

Ensembl ID: ENSG00000176915 (Gene tree)
Gene ID: 23141
Gene Symbol: ANKLE2
Alias: LEMD7|Lem4|KIAA0692
Full Name: ankyrin repeat and LEM domain containing 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 36,386 bases
Position: chr12:132,725,503-132,761,888
Accession: 29101
RBP type: non-canonical RBP
Summary: This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000542374	ANKLE2-209	515	-	-	- (aa)	-	-
ENST00000538766	ANKLE2-206	1557	-	ENSP00000445760	258 (aa)	-	F5H1D4
ENST00000545623	ANKLE2-211	1288	-	-	- (aa)	-	-
ENST00000542282	ANKLE2-208	3302	-	ENSP00000437807	293 (aa)	-	Q86XL3
ENST00000439231	ANKLE2-202	1725	-	-	- (aa)	-	-
ENST00000505031	ANKLE2-203	2861	-	-	- (aa)	-	-
ENST00000546061	ANKLE2-212	562	-	-	- (aa)	-	-
ENST00000535036	ANKLE2-204	741	-	ENSP00000437585	118 (aa)	-	F5H6J0
ENST00000538591	ANKLE2-205	886	-	-	- (aa)	-	-
ENST00000357997	ANKLE2-201	4646	XM_005266159	ENSP00000350686	938 (aa)	XP_005266216	Q86XL3
ENST00000542657	ANKLE2-210	2446	-	ENSP00000438551	293 (aa)	-	Q86XL3
ENST00000539605	ANKLE2-207	10890	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000176915	rs117646359	12	132740542	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000176915	rs7138235	12	132736651	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	22770216.	IPI	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0007084	mitotic nuclear envelope reassembly	21873635.	IBA	Process
GO:0007084	mitotic nuclear envelope reassembly	22770216.	IMP	Process
GO:0007084	mitotic nuclear envelope reassembly	-	TAS	Process
GO:0007417	central nervous system development	25259927.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019888	protein phosphatase regulator activity	22770216.	TAS	Function
GO:0030176	integral component of endoplasmic reticulum membrane	22770216.	IDA	Component
GO:0035307	positive regulation of protein dephosphorylation	21873635.	IBA	Process
GO:0035307	positive regulation of protein dephosphorylation	22770216.	IDA	Process
GO:0042326	negative regulation of phosphorylation	21873635.	IBA	Process
GO:0042326	negative regulation of phosphorylation	22770216.	IDA	Process
GO:0043066	negative regulation of apoptotic process	25259927.	IDA	Process
GO:0043666	regulation of phosphoprotein phosphatase activity	-	IEA	Process
GO:0050790	regulation of catalytic activity	22770216.	TAS	Process
GO:0051301	cell division	-	IEA	Process
GO:0051721	protein phosphatase 2A binding	21873635.	IBA	Function
GO:0051721	protein phosphatase 2A binding	22770216.	IDA	Function