EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000177469 (Gene tree)
Gene ID: 284119
Gene Symbol: CAVIN1
Alias: cavin-1|CGL4|PTRF
Full Name: caveolae associated protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 21,069 bases
Position: chr17:42,402,449-42,423,517
Accession: 9688
RBP type: non-canonical RBP
Summary: This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000357037	CAVIN1-201	3828	-	ENSP00000349541	390 (aa)	-	Q6NZI2

Gene Model

Click here to download ENSG00000177469's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000177469	Platelet Function Tests	7.8616571E-006	-
ENSG00000177469	Psoriasis	6E-7	25903422
ENSG00000177469	Crohn Disease	3E-8	21102463

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000177469	rs11871801	17	42418754	A	Crohn's disease	21102463	[1.10-1.21]	1.15	EFO_0000384
ENSG00000177469	rs963986	17	42409561	C	Psoriasis	23143594		1.15	EFO_0000676
ENSG00000177469	rs8068844	17	42419266	?	Eczema	30595370			HP_0000964

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177469's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000177469	CAVIN1	81	41.945	ENSMUSG00000045954	Cavin2	73	38.375	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	17026959.19525939.24013648.24567387.	IPI	Function
GO:0005634	nucleus	15242332.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	17026959.	IDA	Component
GO:0005739	mitochondrion	15242332.	IDA	Component
GO:0005783	endoplasmic reticulum	-	IEA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005901	caveola	21873635.	IBA	Component
GO:0005901	caveola	17026959.19525939.24013648.	IDA	Component
GO:0006361	transcription initiation from RNA polymerase I promoter	9582279.	IDA	Process
GO:0006363	termination of RNA polymerase I transcription	9582279.	IDA	Process
GO:0006363	termination of RNA polymerase I transcription	-	TAS	Process
GO:0009303	rRNA transcription	-	ISS	Process
GO:0009306	protein secretion	-	IEA	Process
GO:0032991	protein-containing complex	24013648.	IDA	Component
GO:0042134	rRNA primary transcript binding	9582279.	IDA	Function
GO:0042802	identical protein binding	24013648.	IPI	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045121	membrane raft	25204797.	IDA	Component
GO:2000147	positive regulation of cell motility	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23770857	Cavin-1 is essential for the tumor-promoting effect of caveolin-1 and enhances its prognostic potency in pancreatic cancer.	Oncogene	2014 May 22	Liu L	doi: 10.1038/onc.2013.223
21913217	Down-regulation of the cavin family proteins in breast cancer.	J Cell Biochem	2012 Jan	Bai L	doi: 10.1002/jcb.23358.
27894957	DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.	Cancer Lett	2017 Feb 1	Huertas-Mart??nez J	doi: 10.1016/j.canlet.2016.11.020
27203393	PTRF suppresses the progression of colorectal cancers.	Oncotarget	2017 Jul 25	Wang F	doi: 10.18632/oncotarget.9424.
27634346	MicroRNA187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF.	Oncol Rep	2016 Nov	Peng J	doi: 10.3892/or.2016.5083
25942420	Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration.	PLoS One	2015 May 5	Meng F	doi: 10.1371/journal.pone.0126056
23404184	Caveolin-1 and polymerase I and transcript release factor: new players in insulin-like growth factor-I receptor signaling.	J Endocrinol Invest	2013 Mar	Hamoudane M	doi: 10.3275/8848
23214712	PTRF/cavin-1 is essential for multidrug resistance in cancer cells.	J Proteome Res	2013 Feb 1	Yi JS	doi: 10.1021/pr300651m
22461895	PTRF/cavin-1 and MIF proteins are identified as non-small cell lung cancer biomarkers by label-free proteomics.	PLoS One	2012	G??mez-Pozo A	doi: 10.1371/journal.pone.0033752
23938946	Caveola-forming proteins caveolin-1 and PTRF in prostate cancer.	Nat Rev Urol	2013 Sep	Nassar ZD	doi: 10.1038/nrurol.2013.168
23934189	PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer.	Oncogene	2014 Jul 3	Moon H	doi: 10.1038/onc.2013.315
28393200	MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer.	Oncol Rep	2017 May	Cai Y	doi: 10.3892/or.2017.5548

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	42422920	Missense_Mutation	novel	K60E	0.93
BLCA	chr17	42423070	Missense_Mutation	rs560641597	E10Q	0.27
BLCA	chr17	42405060	Missense_Mutation	NA	R267Q	0.64
BLCA	chr17	42422792	Silent	novel	T102T	0.53
BLCA	chr17	42404815	Missense_Mutation	novel	D349N	0.13
BLCA	chr17	42404776	Missense_Mutation	novel	R362W	0.57
BLCA	chr17	42404872	Missense_Mutation	NA	E330K	0.22
BLCA	chr17	42404874	Missense_Mutation	NA	R329H	0.25
BLCA	chr17	42404921	Silent	rs780026361	T313T	0.28
BRCA	chr17	42405063	Missense_Mutation	NA	T266M	0.13
BRCA	chr17	42404800	Missense_Mutation	NA	E354Q	0.4
BRCA	chr17	42404885	Silent	NA	V325V	0.29
BRCA	chr17	42405196	Nonsense_Mutation	NA	K222*	0.37
BRCA	chr17	42422994	Missense_Mutation	NA	P35L	0.48
CESC	chr17	42405022	Missense_Mutation	novel	R280C	0.37
CESC	chr17	42403480	3'UTR	novel		0.21
CESC	chr17	42404918	Silent	NA	A314A	0.49
CESC	chr17	42404919	Missense_Mutation	novel	A314V	0.17
COAD	chr17	42404985	Missense_Mutation	NA	T292M	0.13
COAD	chr17	42405330	Missense_Mutation	NA	A177V	0.22
COAD	chr17	42405096	Missense_Mutation	NA	T255M	0.23
COAD	chr17	42405298	Missense_Mutation	NA	E188K	0.37
COAD	chr17	42405208	Missense_Mutation	NA	A218T	0.37
COAD	chr17	42405335	Silent	novel	S175S	0.31
COAD	chr17	42404786	Silent	NA	A358A	0.15
COAD	chr17	42405274	Missense_Mutation	novel	A196T	0.38
COAD	chr17	42404678	3'UTR	novel		0.47
COAD	chr17	42422986	Frame_Shift_Del	NA	*A38Pfs6**	0.21
COAD	chr17	42422917	Missense_Mutation	NA	I61F	0.34
COAD	chr17	42405094	Missense_Mutation	NA	R256C	0.25
COAD	chr17	42405354	Missense_Mutation	NA	S169N	0.33
ESCA	chr17	42405020	Silent	novel	R280R	0.22
ESCA	chr17	42422655	Missense_Mutation	novel	R148H	0.42
ESCA	chr17	42405251	Silent	novel	S203S	0.38
GBM	chr17	42404838	Missense_Mutation	novel	M341K	0.42
HNSC	chr17	42405176	Silent	novel	R228R	0.18
HNSC	chr17	42405346	Silent	novel	L172L	0.11
HNSC	chr17	42404762	Silent	novel	S366S	0.25
KIRP	chr17	42405341	Missense_Mutation	NA	K173N	0.2
LAML	chr17	42422640	Missense_Mutation	novel	V153G	1
LGG	chr17	42405022	Missense_Mutation	novel	R280C	0.33
LIHC	chr17	42422743	Missense_Mutation	rs758025496	V119I	0.28
LIHC	chr17	42422838	Missense_Mutation	NA	Q87L	0.27
LIHC	chr17	42404887	Missense_Mutation	NA	V325I	0.35
LIHC	chr17	42422991	Nonsense_Mutation	novel	S36*	0.43
LIHC	chr17	42404967	Missense_Mutation	rs144331065	R298H	0.11
LUAD	chr17	42404888	Silent	novel	H324H	0.16
LUAD	chr17	42404872	Missense_Mutation	NA	E330K	0.04
LUAD	chr17	42405180	Missense_Mutation	NA	R227L	0.22
LUSC	chr17	42422748	Missense_Mutation	NA	V117D	0.33
LUSC	chr17	42404954	Silent	NA	T302T	0.18
LUSC	chr17	42404775	Missense_Mutation	novel	R362P	0.32
LUSC	chr17	42404900	Silent	rs746135739	P320P	0.1
OV	chr17	42422868	Missense_Mutation	NA	E77V	0.67
PAAD	chr17	42405335	Silent	novel	S175S	0.33
PAAD	chr17	42405061	Missense_Mutation	NA	R267W	0.18
PAAD	chr17	42405248	Silent	NA	D204D	0.2
PRAD	chr17	42405254	Silent	novel	S202S	0.07
PRAD	chr17	42405021	Missense_Mutation	novel	R280H	0.41
READ	chr17	42404873	Silent	rs754999996	R329R	0.27
READ	chr17	42405001	Missense_Mutation	NA	R287C	0.35
SARC	chr17	42404879	Missense_Mutation	novel	K327N	0.46
SKCM	chr17	42422728	Missense_Mutation	NA	V124M	0.5
SKCM	chr17	42404786	Silent	NA	A358A	0.33
SKCM	chr17	42405317	Silent	novel	K181K	0.28
SKCM	chr17	42405255	Missense_Mutation	NA	S202L	0.44
SKCM	chr17	42422853	Missense_Mutation	novel	M82K	0.45
SKCM	chr17	42405286	Missense_Mutation	novel	P192S	0.46
SKCM	chr17	42404679	3'UTR	novel		0.5
SKCM	chr17	42405255	Missense_Mutation	NA	S202L	0.48
SKCM	chr17	42405286	Missense_Mutation	NA	P192T	0.39
SKCM	chr17	42405255	Missense_Mutation	NA	S202L	0.76
STAD	chr17	42405251	Silent	novel	S203S	0.19
STAD	chr17	42423013	Missense_Mutation	NA	A29T	0.29
STAD	chr17	42404875	Missense_Mutation	rs752558303	R329C	0.35
STAD	chr17	42404819	Silent	NA	D347D	0.24
STAD	chr17	42405187	Missense_Mutation	NA	G225S	0.18
STAD	chr17	42405154	Missense_Mutation	novel	F236L	0.09
STAD	chr17	42423009	Missense_Mutation	NA	Q30R	0.16
STAD	chr17	42405212	Silent	novel	S216S	0.38
STAD	chr17	42405063	Missense_Mutation	NA	T266M	0.3
STAD	chr17	42405202	Missense_Mutation	NA	R220C	0.26
STAD	chr17	42405210	Missense_Mutation	novel	R217H	0.12
STAD	chr17	42404934	Missense_Mutation	novel	A309V	0.18
UCEC	chr17	42405192	Missense_Mutation	NA	R223H	0.31
UCEC	chr17	42404646	3'UTR	novel		0.39
UCEC	chr17	42422669	Silent	novel	A143A	0.11
UCEC	chr17	42405283	Missense_Mutation	novel	E193K	0.08
UCEC	chr17	42405293	Silent	novel	G189G	0.38
UCEC	chr17	42422791	Missense_Mutation	novel	T103A	0.18
UCEC	chr17	42405094	Missense_Mutation	NA	R256C	0.38
UCEC	chr17	42403540	3'UTR	novel		0.37
UCEC	chr17	42405114	Missense_Mutation	novel	R249H	0.48
UCEC	chr17	42403628	3'UTR	novel		0.36
UCEC	chr17	42422845	Missense_Mutation	rs61729284	A85S	0.21
UCEC	chr17	42404979	Missense_Mutation	NA	R294Q	0.31
UCEC	chr17	42405084	Missense_Mutation	novel	T259I	0.28
UCEC	chr17	42403628	3'UTR	novel		0.15
UCEC	chr17	42422796	Missense_Mutation	novel	A101V	0.41
UCEC	chr17	42404985	Missense_Mutation	NA	T292M	0.38
UCEC	chr17	42404932	Missense_Mutation	NA	R310C	0.47
UCEC	chr17	42422919	Missense_Mutation	NA	K60T	0.43
UCEC	chr17	42405093	Missense_Mutation	rs775121102	R256H	0.23
UCEC	chr17	42405209	Silent	novel	R217R	0.45
UCEC	chr17	42405347	Silent	NA	S171S	0.24
UCEC	chr17	42422923	Missense_Mutation	novel	D59N	0.36
UCEC	chr17	42405299	Silent	novel	G187G	0.42
UCS	chr17	42404776	Missense_Mutation	novel	R362W	0.07
UCS	chr17	42405044	Silent	novel	K272K	0.49

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2667	0.0017784
BRCA	DEL	0.2954	4.8302e-10
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
UCEC	DEL	0.2004	5.8317e-06
UCS	DEL	0.4286	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
STAD	0.012	Kaplan-Meier Survival Analysis
SARC	0.0028	Kaplan-Meier Survival Analysis
MESO	0.0034	Kaplan-Meier Survival Analysis
HNSC	0.013	Kaplan-Meier Survival Analysis
LUSC	0.019	Kaplan-Meier Survival Analysis
ESCA	0.03	Kaplan-Meier Survival Analysis
COAD	0.023	Kaplan-Meier Survival Analysis
BLCA	0.0014	Kaplan-Meier Survival Analysis
READ	0.026	Kaplan-Meier Survival Analysis
GBM	0.00013	Kaplan-Meier Survival Analysis
THCA	0.0045	Kaplan-Meier Survival Analysis
OV	0.0065	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742