EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000177613 (Gene tree)
Gene ID: 23283
Gene Symbol: CSTF2T
Alias: DKFZp434C1013|KIAA0689|CstF-64T|tauCstF-64
Full Name: cleavage stimulation factor subunit 2 tau variant
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 4,110 bases
Position: chr10:51,695,486-51,699,595
Accession: 17086
RBP type: canonical RBP
Summary: (Cleavage Stimulation Factor Subunit 2 Tau Variant) is a Protein Coding gene. Diseases associated with CSTF2T include Oligoasthenoteratozoospermia. Among its related pathways are RNA Polymerase II Transcription Termination and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CSTF2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000332444	RRM_1	PF00076.22	1.7e-24	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17029590	Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.	Biochem J	2007 Feb 1	Monarez RR	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000331173	CSTF2T-201	4105	-	ENSP00000332444	616 (aa)	-	Q9H0L4

Gene Model

Click here to download ENSG00000177613's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000177613	rs14168	10	51695802	A	Mammographic density (non-dense area)	25342443			EFO_0006504\|EFO_0005941

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177613's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000177613	CSTF2T	99	69.255	ENSG00000101811	CSTF2	84	88.360

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000177613	CSTF2T	100	91.396	ENSAMEG00000015766	CSTF2T	100	91.396	Ailuropoda_melanoleuca
ENSG00000177613	CSTF2T	54	85.843	ENSANAG00000027508	-	89	85.843	Aotus_nancymaae
ENSG00000177613	CSTF2T	100	88.144	ENSBTAG00000018406	CSTF2T	100	88.612	Bos_taurus
ENSG00000177613	CSTF2T	53	86.103	ENSCJAG00000011554	-	97	86.103	Callithrix_jacchus
ENSG00000177613	CSTF2T	53	80.243	ENSCJAG00000039083	-	93	79.939	Callithrix_jacchus
ENSG00000177613	CSTF2T	91	100.000	ENSCAFG00000015567	CSTF2T	100	68.981	Canis_familiaris
ENSG00000177613	CSTF2T	100	87.382	ENSCHIG00000016590	CSTF2T	100	87.224	Capra_hircus
ENSG00000177613	CSTF2T	100	92.903	ENSTSYG00000007750	CSTF2T	100	93.226	Carlito_syrichta
ENSG00000177613	CSTF2T	100	87.520	ENSCPOG00000004195	CSTF2T	100	87.167	Cavia_porcellus
ENSG00000177613	CSTF2T	54	85.629	ENSCCAG00000020816	-	88	85.629	Cebus_capucinus
ENSG00000177613	CSTF2T	53	86.486	ENSCATG00000041868	-	95	86.486	Cercocebus_atys
ENSG00000177613	CSTF2T	100	88.750	ENSCLAG00000017916	CSTF2T	100	89.062	Chinchilla_lanigera
ENSG00000177613	CSTF2T	100	97.258	ENSCSAG00000018437	CSTF2T	100	97.258	Chlorocebus_sabaeus
ENSG00000177613	CSTF2T	69	96.212	ENSCHOG00000011888	-	68	96.212	Choloepus_hoffmanni
ENSG00000177613	CSTF2T	53	85.758	ENSCANG00000005843	-	92	85.758	Colobus_angolensis_palliatus
ENSG00000177613	CSTF2T	100	85.826	ENSCGRG00001003222	Cstf2t	100	85.202	Cricetulus_griseus_chok1gshd
ENSG00000177613	CSTF2T	100	86.739	ENSCGRG00000008682	Cstf2t	100	86.427	Cricetulus_griseus_crigri
ENSG00000177613	CSTF2T	100	90.438	ENSDNOG00000003283	CSTF2T	100	90.600	Dasypus_novemcinctus
ENSG00000177613	CSTF2T	82	91.304	ENSDORG00000011245	Cstf2t	100	87.893	Dipodomys_ordii
ENSG00000177613	CSTF2T	100	92.432	ENSEASG00005012929	CSTF2T	100	93.076	Equus_asinus_asinus
ENSG00000177613	CSTF2T	100	91.214	ENSECAG00000004701	CSTF2T	100	92.013	Equus_caballus
ENSG00000177613	CSTF2T	90	81.579	ENSELUG00000004079	-	98	57.346	Esox_lucius
ENSG00000177613	CSTF2T	100	93.506	ENSFCAG00000046300	CSTF2T	100	94.481	Felis_catus
ENSG00000177613	CSTF2T	100	84.365	ENSFDAG00000021170	CSTF2T	100	87.307	Fukomys_damarensis
ENSG00000177613	CSTF2T	100	97.403	ENSGGOG00000042388	-	100	97.403	Gorilla_gorilla
ENSG00000177613	CSTF2T	100	97.403	ENSGGOG00000036416	-	100	97.403	Gorilla_gorilla
ENSG00000177613	CSTF2T	82	89.464	ENSHGLG00000015478	CSTF2T	100	87.191	Heterocephalus_glaber_female
ENSG00000177613	CSTF2T	82	89.464	ENSHGLG00100000336	CSTF2T	100	87.211	Heterocephalus_glaber_male
ENSG00000177613	CSTF2T	100	90.605	ENSSTOG00000026303	CSTF2T	100	90.764	Ictidomys_tridecemlineatus
ENSG00000177613	CSTF2T	100	84.253	ENSLAFG00000002058	CSTF2T	100	85.227	Loxodonta_africana
ENSG00000177613	CSTF2T	52	86.196	ENSMFAG00000042009	-	97	86.196	Macaca_fascicularis
ENSG00000177613	CSTF2T	54	85.928	ENSMMUG00000042906	-	99	85.928	Macaca_mulatta
ENSG00000177613	CSTF2T	52	86.196	ENSMNEG00000031410	-	97	86.196	Macaca_nemestrina
ENSG00000177613	CSTF2T	100	88.217	ENSMAUG00000006359	Cstf2t	100	89.650	Mesocricetus_auratus
ENSG00000177613	CSTF2T	100	87.402	ENSMICG00000030551	-	100	89.928	Microcebus_murinus
ENSG00000177613	CSTF2T	100	92.718	ENSMICG00000000867	-	100	93.861	Microcebus_murinus
ENSG00000177613	CSTF2T	100	86.250	ENSMOCG00000020428	Cstf2t	100	86.875	Microtus_ochrogaster
ENSG00000177613	CSTF2T	81	83.111	ENSMALG00000008842	-	97	55.987	Monopterus_albus
ENSG00000177613	CSTF2T	82	89.749	MGP_CAROLIEiJ_G0022872	Cstf2t	100	88.766	Mus_caroli
ENSG00000177613	CSTF2T	82	89.168	ENSMUSG00000053536	Cstf2t	100	87.207	Mus_musculus
ENSG00000177613	CSTF2T	82	88.168	MGP_PahariEiJ_G0014365	Cstf2t	100	85.957	Mus_pahari
ENSG00000177613	CSTF2T	100	83.645	MGP_SPRETEiJ_G0023790	Cstf2t	100	87.676	Mus_spretus
ENSG00000177613	CSTF2T	100	91.613	ENSMPUG00000020141	CSTF2T	100	91.613	Mustela_putorius_furo
ENSG00000177613	CSTF2T	100	86.159	ENSMLUG00000011187	-	100	86.314	Myotis_lucifugus
ENSG00000177613	CSTF2T	100	83.226	ENSMLUG00000027140	-	100	83.226	Myotis_lucifugus
ENSG00000177613	CSTF2T	100	89.172	ENSNGAG00000003304	Cstf2t	100	89.490	Nannospalax_galili
ENSG00000177613	CSTF2T	100	94.042	ENSNLEG00000012025	CSTF2T	100	94.042	Nomascus_leucogenys
ENSG00000177613	CSTF2T	100	84.062	ENSODEG00000012386	CSTF2T	100	83.906	Octodon_degus
ENSG00000177613	CSTF2T	100	83.117	ENSOCUG00000004647	-	100	83.117	Oryctolagus_cuniculus
ENSG00000177613	CSTF2T	100	93.831	ENSOGAG00000014565	CSTF2T	100	93.994	Otolemur_garnettii
ENSG00000177613	CSTF2T	100	88.608	ENSOARG00000019124	-	100	88.924	Ovis_aries
ENSG00000177613	CSTF2T	100	87.520	ENSOARG00000013688	-	100	88.144	Ovis_aries
ENSG00000177613	CSTF2T	53	86.280	ENSPPAG00000032242	-	96	86.280	Pan_paniscus
ENSG00000177613	CSTF2T	100	93.831	ENSPPRG00000018659	CSTF2T	100	94.156	Panthera_pardus
ENSG00000177613	CSTF2T	100	90.584	ENSPTIG00000021145	CSTF2T	100	91.396	Panthera_tigris_altaica
ENSG00000177613	CSTF2T	53	86.280	ENSPTRG00000043097	-	96	86.280	Pan_troglodytes
ENSG00000177613	CSTF2T	52	86.196	ENSPANG00000029734	-	97	86.196	Papio_anubis
ENSG00000177613	CSTF2T	98	52.019	ENSPFOG00000016756	CSTF2T	94	66.379	Poecilia_formosa
ENSG00000177613	CSTF2T	100	96.640	ENSPPYG00000002441	CSTF2T	100	96.640	Pongo_abelii
ENSG00000177613	CSTF2T	100	90.468	ENSPCAG00000000046	CSTF2T	100	91.599	Procavia_capensis
ENSG00000177613	CSTF2T	99	92.683	ENSPCOG00000010982	CSTF2T	99	93.669	Propithecus_coquereli
ENSG00000177613	CSTF2T	100	92.370	ENSPVAG00000006274	CSTF2T	100	92.370	Pteropus_vampyrus
ENSG00000177613	CSTF2T	100	88.013	ENSRNOG00000050289	Cstf2t	100	88.013	Rattus_norvegicus
ENSG00000177613	CSTF2T	100	97.727	ENSRBIG00000029324	CSTF2T	100	97.727	Rhinopithecus_bieti
ENSG00000177613	CSTF2T	100	97.890	ENSRROG00000042507	CSTF2T	100	97.890	Rhinopithecus_roxellana
ENSG00000177613	CSTF2T	100	96.916	ENSSBOG00000022638	CSTF2T	100	96.916	Saimiri_boliviensis_boliviensis
ENSG00000177613	CSTF2T	88	95.276	ENSSARG00000002013	-	87	94.094	Sorex_araneus
ENSG00000177613	CSTF2T	79	90.816	ENSSPAG00000009247	-	96	54.984	Stegastes_partitus
ENSG00000177613	CSTF2T	100	93.831	ENSSSCG00000010430	CSTF2T	100	93.831	Sus_scrofa
ENSG00000177613	CSTF2T	99	52.572	ENSTRUG00000004323	-	97	51.713	Takifugu_rubripes
ENSG00000177613	CSTF2T	100	82.792	ENSTBEG00000014379	CSTF2T	100	82.792	Tupaia_belangeri
ENSG00000177613	CSTF2T	100	92.532	ENSTTRG00000003341	CSTF2T	100	92.857	Tursiops_truncatus
ENSG00000177613	CSTF2T	100	88.612	ENSUMAG00000011141	CSTF2T	100	90.016	Ursus_maritimus
ENSG00000177613	CSTF2T	65	96.020	ENSVVUG00000002575	CSTF2T	96	95.631	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005515	protein binding	16189514.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	21873635.	IBA	Component
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0098789	pre-mRNA cleavage required for polyadenylation	21873635.	IBA	Process