EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000177679 (Gene tree)
Gene ID: 222183
Gene Symbol: SRRM3
Alias: FLJ37078
Full Name: serine/arginine repetitive matrix 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 120,618 bases
Position: chr7:76,166,675-76,287,292
Accession: 26729
RBP type: canonical RBP
Summary: (Serine/Arginine Repetitive Matrix 3) is a Protein Coding gene. Diseases associated with SRRM3 include Breast Cancer.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000480851	cwf21	PF08312.12	2.7e-14	1	1
ENSP00000480851	SRRM_C	PF15230.6	1.8e-23	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000612155	SRRM3-205	2150	-	-	- (aa)	-	-
ENST00000479294	SRRM3-203	549	-	-	- (aa)	-	-
ENST00000464752	SRRM3-201	2797	-	ENSP00000483698	109 (aa)	-	A0A087X0W5
ENST00000611745	SRRM3-204	3612	-	ENSP00000480851	653 (aa)	-	A0A087WXA3
ENST00000479284	SRRM3-202	589	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000177679's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000177679	rs11770797	7	76226193	?	Blood protein levels	28240269			EFO_0008242
ENSG00000177679	rs4728638	7	76272712	T	Educational attainment (MTAG)	30038396	[0.0083-0.0157] unit increase	0.012	EFO_0004784
ENSG00000177679	rs3960554	7	76216279	G	Eotaxin levels	27989323	[0.047-0.113] SD units decrease	0.0798	EFO_0008122
ENSG00000177679	rs60717745	7	76216765	C	Educational attainment (years of education)	30038396	[0.0081-0.0155] unit decrease	0.0118	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177679's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000177679	SRRM3	87	51.178	ENSACAG00000000452	SRRM3	51	64.605	Anolis_carolinensis
ENSG00000177679	SRRM3	73	98.750	ENSANAG00000031983	SRRM3	59	85.326	Aotus_nancymaae
ENSG00000177679	SRRM3	61	90.909	ENSBTAG00000007879	-	98	84.639	Bos_taurus
ENSG00000177679	SRRM3	100	96.172	ENSCJAG00000016307	SRRM3	100	96.172	Callithrix_jacchus
ENSG00000177679	SRRM3	95	79.936	ENSCAFG00000013537	SRRM3	73	92.388	Canis_familiaris
ENSG00000177679	SRRM3	81	76.136	ENSCAFG00020013073	SRRM3	88	77.108	Canis_lupus_dingo
ENSG00000177679	SRRM3	100	96.784	ENSCCAG00000033359	SRRM3	100	96.784	Cebus_capucinus
ENSG00000177679	SRRM3	89	85.204	ENSCLAG00000007682	SRRM3	100	91.129	Chinchilla_lanigera
ENSG00000177679	SRRM3	73	98.750	ENSCSAG00000018140	SRRM3	97	96.546	Chlorocebus_sabaeus
ENSG00000177679	SRRM3	89	87.671	ENSCGRG00001011385	Srrm3	51	90.361	Cricetulus_griseus_chok1gshd
ENSG00000177679	SRRM3	100	73.893	ENSDNOG00000046922	SRRM3	56	69.780	Dasypus_novemcinctus
ENSG00000177679	SRRM3	72	93.750	ENSEASG00005016840	-	88	93.093	Equus_asinus_asinus
ENSG00000177679	SRRM3	75	91.463	ENSECAG00000022142	-	88	92.771	Equus_caballus
ENSG00000177679	SRRM3	63	94.203	ENSFCAG00000044112	SRRM3	55	89.227	Felis_catus
ENSG00000177679	SRRM3	95	53.282	ENSFDAG00000016913	SRRM3	99	97.500	Fukomys_damarensis
ENSG00000177679	SRRM3	70	91.262	ENSGGOG00000036497	-	82	90.244	Gorilla_gorilla
ENSG00000177679	SRRM3	83	91.346	ENSSTOG00000014181	SRRM3	100	91.129	Ictidomys_tridecemlineatus
ENSG00000177679	SRRM3	99	81.860	ENSJJAG00000023441	Srrm3	60	78.237	Jaculus_jaculus
ENSG00000177679	SRRM3	58	57.513	ENSMGAG00000003690	SRRM3	75	64.014	Meleagris_gallopavo
ENSG00000177679	SRRM3	89	83.390	ENSMAUG00000017613	Srrm3	100	89.516	Mesocricetus_auratus
ENSG00000177679	SRRM3	88	92.857	ENSMICG00000010668	SRRM3	56	93.072	Microcebus_murinus
ENSG00000177679	SRRM3	96	88.198	ENSMOCG00000002565	Srrm3	51	89.458	Microtus_ochrogaster
ENSG00000177679	SRRM3	61	92.424	MGP_CAROLIEiJ_G0027845	-	97	90.361	Mus_caroli
ENSG00000177679	SRRM3	96	88.836	ENSMUSG00000039860	Srrm3	100	90.323	Mus_musculus
ENSG00000177679	SRRM3	95	88.350	MGP_PahariEiJ_G0024425	Srrm3	100	89.516	Mus_pahari
ENSG00000177679	SRRM3	96	88.836	MGP_SPRETEiJ_G0028844	Srrm3	100	91.129	Mus_spretus
ENSG00000177679	SRRM3	100	72.129	ENSNLEG00000008423	-	54	80.422	Nomascus_leucogenys
ENSG00000177679	SRRM3	89	89.384	ENSODEG00000015988	SRRM3	56	89.227	Octodon_degus
ENSG00000177679	SRRM3	61	87.879	ENSOGAG00000030805	SRRM3	55	91.667	Otolemur_garnettii
ENSG00000177679	SRRM3	100	98.928	ENSPTRG00000019317	SRRM3	100	98.928	Pan_troglodytes
ENSG00000177679	SRRM3	70	79.339	ENSPCAG00000013700	SRRM3	76	79.339	Procavia_capensis
ENSG00000177679	SRRM3	100	91.118	ENSPCOG00000028464	SRRM3	55	91.160	Propithecus_coquereli
ENSG00000177679	SRRM3	58	78.796	ENSPVAG00000003400	SRRM3	55	92.606	Pteropus_vampyrus
ENSG00000177679	SRRM3	96	88.995	ENSRNOG00000001439	Srrm3	51	89.759	Rattus_norvegicus
ENSG00000177679	SRRM3	79	96.951	ENSRROG00000034980	SRRM3	94	96.951	Rhinopithecus_roxellana
ENSG00000177679	SRRM3	85	45.161	ENSSPUG00000006285	SRRM3	65	78.182	Sphenodon_punctatus
ENSG00000177679	SRRM3	61	85.124	ENSTTRG00000014836	-	67	85.124	Tursiops_truncatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003729	mRNA binding	21873635.	IBA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr7	76264805	Missense_Mutation	novel	E239Q	0.58
BLCA	chr7	76261415	Splice_Site	novel	X213_splice	0.93
BRCA	chr7	76283594	Intron	novel		0.2
CESC	chr7	76285681	Silent	rs548789462	S600S	0.37
CESC	chr7	76285867	3'UTR	novel		0.11
CESC	chr7	76267317	Missense_Mutation	novel	S297N	0.3
COAD	chr7	76285768	Silent	novel	S629S	0.45
COAD	chr7	76285888	3'UTR	novel		0.17
COAD	chr7	76248193	Missense_Mutation	rs370360717	S80L	0.35
COAD	chr7	76285867	3'UTR	novel		0.26
COAD	chr7	76235041	5'UTR	novel		0.1
COAD	chr7	76285867	3'UTR	novel		0.13
COAD	chr7	76285867	3'UTR	novel		0.5
COAD	chr7	76286163	3'UTR	novel		0.26
COAD	chr7	76285930	3'UTR	novel		0.27
COAD	chr7	76261405	Missense_Mutation	rs782810649	R210H	0.31
COAD	chr7	76261405	Missense_Mutation	rs782810649	R210H	0.23
COAD	chr7	76285733	Missense_Mutation	rs570515153	G618R	0.1
ESCA	chr7	76265387	Missense_Mutation	rs527778424	R250Q	0.17
ESCA	chr7	76287174	3'UTR	novel		0.18
ESCA	chr7	76285888	3'UTR	novel		0.12
ESCA	chr7	76285814	Missense_Mutation	rs782419324	R645W	0.38
ESCA	chr7	76287200	3'UTR	rs555014493		0.16
ESCA	chr7	76285749	Missense_Mutation	rs782818176	R623H	0.08
HNSC	chr7	76283053	Missense_Mutation	novel	K562R	0.22	cwf21
HNSC	chr7	76259987	Silent	novel	V139V	0.47
HNSC	chr7	76264776	Missense_Mutation	novel	S229Y	0.14
HNSC	chr7	76267280	Missense_Mutation	novel	E285K	0.22
HNSC	chr7	76264810	Missense_Mutation	novel	K240N	0.18
HNSC	chr7	76264790	In_Frame_Del	novel	N237_K240del	0.18
KIRP	chr7	76285992	3'UTR	novel		0.29
LGG	chr7	76264794	Missense_Mutation	novel	E235V	0.44
LIHC	chr7	76267351	Nonsense_Mutation	novel	W308*	0.43
LIHC	chr7	76235241	Missense_Mutation	novel	R59S	0.53
LIHC	chr7	76261572	Missense_Mutation	novel	R222I	0.38
LUAD	chr7	76265447	Missense_Mutation	novel	S270I	0.23
LUAD	chr7	76265381	Missense_Mutation	rs545251939	P248L	0.12
LUAD	chr7	76248215	Frame_Shift_Ins	novel	*G89Wfs8**	0.21
LUAD	chr7	76265380	Missense_Mutation	novel	P248T	0.17
LUAD	chr7	76264777	Silent	novel	S229S	0.22
LUSC	chr7	76268892	Intron	novel		0.67
LUSC	chr7	76248208	Missense_Mutation	rs781833246	R85Q	0.5
LUSC	chr7	76260002	Frame_Shift_Del	novel	*A145Pfs62**	0.57
LUSC	chr7	76265385	Silent	novel	G249G	0.31
MESO	chr7	76285974	3'UTR	rs200253789		0.3
OV	chr7	76248218	Silent	novel	V88V	0.12
READ	chr7	76285770	Missense_Mutation	rs190294181	R630Q	0.1
READ	chr7	76264805	Nonsense_Mutation	novel	E239*	0.38
SARC	chr7	76259917	Missense_Mutation	novel	T116I	0.2
SARC	chr7	76267300	Silent	novel	S291S	0.21
SKCM	chr7	76264788	Missense_Mutation	novel	R233K	0.21
SKCM	chr7	76265453	Missense_Mutation	novel	S272F	0.25
SKCM	chr7	76248201	Missense_Mutation	rs782801115	E83K	0.25
SKCM	chr7	76248193	Nonsense_Mutation	novel	S80*	0.47
SKCM	chr7	76283063	Silent	novel	R565R	0.96
STAD	chr7	76267363	Silent	novel	Q312Q	0.38
STAD	chr7	76259909	Silent	novel	V113V	0.22
STAD	chr7	76267312	Silent	novel	S295S	0.4
STAD	chr7	76283056	Missense_Mutation	novel	R563Q	0.31	cwf21
STAD	chr7	76267259	Splice_Region	novel	L278L	0.19
UCEC	chr7	76286958	3'UTR	novel		0.44
UCEC	chr7	76259947	Missense_Mutation	novel	G126D	0.45
UCEC	chr7	76285849	3'UTR	NA		0.32
UCEC	chr7	76286127	3'UTR	novel		0.44
UCEC	chr7	76287108	3'UTR	novel		0.07
UCEC	chr7	76287111	3'UTR	novel		0.44
UCEC	chr7	76287199	3'UTR	novel		0.52
UCEC	chr7	76285895	3'UTR	rs528111865		0.44
UCEC	chr7	76264762	Splice_Region	novel		0.19
UCEC	chr7	76261410	Missense_Mutation	novel	D212Y	0.42
UCEC	chr7	76285905	3'UTR	novel		0.48
UCEC	chr7	76285779	Missense_Mutation	novel	S633N	0.38
UCEC	chr7	76285793	Missense_Mutation	novel	P638S	0.4
UCEC	chr7	76285891	3'UTR	novel		0.39
UCEC	chr7	76285748	Missense_Mutation	rs782033133	R623C	0.4
UCEC	chr7	76286917	3'UTR	novel		0.38
UCEC	chr7	76285743	Missense_Mutation	novel	S621I	0.22
UCEC	chr7	76286017	3'UTR	rs530861916		0.48
UCEC	chr7	76285964	3'UTR	novel		0.24
UCEC	chr7	76261554	Missense_Mutation	novel	S216Y	0.35
UCEC	chr7	76287209	3'UTR	novel		0.11
UCEC	chr7	76283582	Intron	novel		0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.2708	0.13215
TGCT	AMP	0.6933	0.035574
THCA	DEL	0.002	0.27619

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00018	Kaplan-Meier Survival Analysis
PAAD	0.0047	Kaplan-Meier Survival Analysis
BLCA	0.039	Kaplan-Meier Survival Analysis
READ	0.031	Kaplan-Meier Survival Analysis
LAML	0.039	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
OV	0.039	Kaplan-Meier Survival Analysis