EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000177700 (Gene tree)
Gene ID: 5441
Gene Symbol: POLR2L
Alias: RPB10beta|RBP10|RPABC5|RPB7.6|hRPB7.6|hsRPB10b
Full Name: RNA polymerase II subunit L
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 5,190 bases
Position: chr11:837,356-842,545
Accession: 9199
RBP type: canonical RBP
Summary: This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000324124	RNA_pol_N	PF01194.17	8.2e-33	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28381627	Characterization of RBP9 and RBP10, two developmentally regulated RNA-binding proteins in Trypanosoma brucei.	Open Biol	2017 Apr	De Pablos LM	doi: 10.1098/rsob.160159.
28651963	Conversion of procyclic-form Trypanosoma brucei to the bloodstream form by transient expression of RBP10.	Mol Biochem Parasitol	2017 Sep	Mugo E	doi: 10.1016/j.molbiopara.2017.06.009
28800584	Expression of the RNA-binding protein RBP10 promotes the bloodstream-form differentiation state in Trypanosoma brucei.	PLoS Pathog	2017 Aug 11	Mugo E	doi: 10.1371/journal.ppat.1006560
22296558	Expression of the RNA recognition motif protein RBP10 promotes a bloodstream-form transcript pattern in Trypanosoma brucei.	Mol Microbiol	2012 Mar	Wurst M	doi: 10.1111/j.1365-2958.2012.07988.x

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000322028	POLR2L-201	892	-	ENSP00000324124	67 (aa)	-	P62875
ENST00000534030	POLR2L-202	585	-	ENSP00000432807	67 (aa)	-	P62875

Gene Model

Click here to download ENSG00000177700's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa04623	Cytosolic DNA-sensing pathway	KEGG
hsa05016	Huntington disease	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000177700	rs6762	11	838722	C	Mean platelet volume	27863252	[0.016-0.032] unit increase	0.02411371	EFO_0004584
ENSG00000177700	rs35702851	11	841284	C	Pulse pressure	30578418	[0.12-0.24] mmHg decrease	0.1798	EFO_0005763

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000177700's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000177700	POLR2L	100	98.507	ENSAPOG00000011116	polr2l	100	98.507	Acanthochromis_polyacanthus
ENSG00000177700	POLR2L	100	98.507	ENSACIG00000005514	polr2l	100	98.507	Amphilophus_citrinellus
ENSG00000177700	POLR2L	100	98.507	ENSAOCG00000012342	polr2l	100	98.507	Amphiprion_ocellaris
ENSG00000177700	POLR2L	100	98.507	ENSAPEG00000015365	polr2l	100	98.507	Amphiprion_percula
ENSG00000177700	POLR2L	100	98.507	ENSATEG00000007953	polr2l	100	98.507	Anabas_testudineus
ENSG00000177700	POLR2L	100	100.000	ENSACAG00000015509	POLR2L	100	100.000	Anolis_carolinensis
ENSG00000177700	POLR2L	100	100.000	ENSANAG00000022996	POLR2L	100	100.000	Aotus_nancymaae
ENSG00000177700	POLR2L	100	98.507	ENSACLG00000026685	polr2l	100	98.507	Astatotilapia_calliptera
ENSG00000177700	POLR2L	100	98.507	ENSAMXG00000037735	polr2l	100	98.507	Astyanax_mexicanus
ENSG00000177700	POLR2L	100	100.000	ENSBTAG00000031061	POLR2L	100	100.000	Bos_taurus
ENSG00000177700	POLR2L	100	85.075	WBGene00021347	rpb-10	100	85.075	Caenorhabditis_elegans
ENSG00000177700	POLR2L	100	100.000	ENSCJAG00000041101	POLR2L	100	100.000	Callithrix_jacchus
ENSG00000177700	POLR2L	100	100.000	ENSCAFG00020017621	POLR2L	100	100.000	Canis_lupus_dingo
ENSG00000177700	POLR2L	100	100.000	ENSCHIG00000023006	POLR2L	100	100.000	Capra_hircus
ENSG00000177700	POLR2L	100	71.642	ENSTSYG00000027353	-	100	71.642	Carlito_syrichta
ENSG00000177700	POLR2L	100	100.000	ENSCPOG00000033252	POLR2L	100	100.000	Cavia_porcellus
ENSG00000177700	POLR2L	100	100.000	ENSCCAG00000035630	POLR2L	100	100.000	Cebus_capucinus
ENSG00000177700	POLR2L	100	100.000	ENSCATG00000041490	POLR2L	100	100.000	Cercocebus_atys
ENSG00000177700	POLR2L	100	68.493	ENSCATG00000034571	-	100	68.493	Cercocebus_atys
ENSG00000177700	POLR2L	100	100.000	ENSCLAG00000002071	POLR2L	100	100.000	Chinchilla_lanigera
ENSG00000177700	POLR2L	100	100.000	ENSCSAG00000010528	POLR2L	100	100.000	Chlorocebus_sabaeus
ENSG00000177700	POLR2L	100	100.000	ENSCPBG00000007106	POLR2L	100	100.000	Chrysemys_picta_bellii
ENSG00000177700	POLR2L	100	89.552	ENSCSAVG00000006078	-	100	89.552	Ciona_savignyi
ENSG00000177700	POLR2L	100	100.000	ENSCANG00000043116	POLR2L	100	100.000	Colobus_angolensis_palliatus
ENSG00000177700	POLR2L	100	95.522	ENSCGRG00001003398	-	87	95.522	Cricetulus_griseus_chok1gshd
ENSG00000177700	POLR2L	100	100.000	ENSCGRG00001023078	-	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000177700	POLR2L	100	95.522	ENSCGRG00000019284	-	87	95.522	Cricetulus_griseus_crigri
ENSG00000177700	POLR2L	100	100.000	ENSCGRG00000018042	-	100	100.000	Cricetulus_griseus_crigri
ENSG00000177700	POLR2L	100	98.507	ENSCSEG00000001959	polr2l	100	98.507	Cynoglossus_semilaevis
ENSG00000177700	POLR2L	100	98.507	ENSCVAG00000007386	polr2l	100	98.507	Cyprinodon_variegatus
ENSG00000177700	POLR2L	100	98.507	ENSDARG00000058349	polr2l	100	98.507	Danio_rerio
ENSG00000177700	POLR2L	96	76.562	ENSDNOG00000049434	-	100	76.562	Dasypus_novemcinctus
ENSG00000177700	POLR2L	100	92.537	FBgn0039218	Rpb10	100	92.537	Drosophila_melanogaster
ENSG00000177700	POLR2L	100	100.000	ENSETEG00000012556	POLR2L	100	100.000	Echinops_telfairi
ENSG00000177700	POLR2L	100	95.522	ENSEBUG00000010353	-	100	95.522	Eptatretus_burgeri
ENSG00000177700	POLR2L	100	95.522	ENSEBUG00000000392	-	100	95.522	Eptatretus_burgeri
ENSG00000177700	POLR2L	100	100.000	ENSEASG00005007478	POLR2L	100	100.000	Equus_asinus_asinus
ENSG00000177700	POLR2L	100	70.149	ENSEASG00005017228	-	85	70.149	Equus_asinus_asinus
ENSG00000177700	POLR2L	100	70.149	ENSECAG00000001180	POLR2L	85	70.149	Equus_caballus
ENSG00000177700	POLR2L	100	100.000	ENSECAG00000031030	POLR2L	100	100.000	Equus_caballus
ENSG00000177700	POLR2L	100	74.627	ENSEEUG00000015795	-	100	74.627	Erinaceus_europaeus
ENSG00000177700	POLR2L	100	100.000	ENSELUG00000009612	RPAB5	100	100.000	Esox_lucius
ENSG00000177700	POLR2L	100	100.000	ENSFCAG00000043112	POLR2L	100	100.000	Felis_catus
ENSG00000177700	POLR2L	100	100.000	ENSFALG00000012058	POLR2L	100	100.000	Ficedula_albicollis
ENSG00000177700	POLR2L	100	100.000	ENSFDAG00000021533	POLR2L	100	100.000	Fukomys_damarensis
ENSG00000177700	POLR2L	100	98.507	ENSFHEG00000019804	polr2l	100	98.507	Fundulus_heteroclitus
ENSG00000177700	POLR2L	100	100.000	ENSGMOG00000001279	polr2l	100	100.000	Gadus_morhua
ENSG00000177700	POLR2L	100	100.000	ENSGALG00000006841	POLR2L	100	100.000	Gallus_gallus
ENSG00000177700	POLR2L	100	98.507	ENSGAFG00000013789	polr2l	100	98.507	Gambusia_affinis
ENSG00000177700	POLR2L	100	100.000	ENSGAGG00000017751	-	51	100.000	Gopherus_agassizii
ENSG00000177700	POLR2L	100	97.015	ENSGAGG00000006577	POLR2L	100	97.015	Gopherus_agassizii
ENSG00000177700	POLR2L	99	69.697	ENSGGOG00000040273	-	100	69.697	Gorilla_gorilla
ENSG00000177700	POLR2L	100	100.000	ENSGGOG00000010821	POLR2L	100	100.000	Gorilla_gorilla
ENSG00000177700	POLR2L	100	98.507	ENSHBUG00000013767	polr2l	100	98.507	Haplochromis_burtoni
ENSG00000177700	POLR2L	100	100.000	ENSHGLG00000007095	POLR2L	100	100.000	Heterocephalus_glaber_female
ENSG00000177700	POLR2L	100	100.000	ENSHGLG00100010399	POLR2L	100	100.000	Heterocephalus_glaber_male
ENSG00000177700	POLR2L	100	97.015	ENSHCOG00000008730	polr2l	100	97.015	Hippocampus_comes
ENSG00000177700	POLR2L	100	97.015	ENSIPUG00000017431	polr2l	100	97.015	Ictalurus_punctatus
ENSG00000177700	POLR2L	99	71.642	ENSSTOG00000022797	-	81	71.642	Ictidomys_tridecemlineatus
ENSG00000177700	POLR2L	100	86.567	ENSJJAG00000011334	-	100	86.567	Jaculus_jaculus
ENSG00000177700	POLR2L	100	100.000	ENSJJAG00000011194	-	100	100.000	Jaculus_jaculus
ENSG00000177700	POLR2L	100	98.507	ENSKMAG00000003267	polr2l	100	98.507	Kryptolebias_marmoratus
ENSG00000177700	POLR2L	100	97.015	ENSLBEG00000000928	polr2l	100	97.015	Labrus_bergylta
ENSG00000177700	POLR2L	100	97.015	ENSLACG00000017570	POLR2L	100	97.015	Latimeria_chalumnae
ENSG00000177700	POLR2L	100	100.000	ENSMFAG00000001554	POLR2L	100	100.000	Macaca_fascicularis
ENSG00000177700	POLR2L	100	100.000	ENSMNEG00000026729	POLR2L	100	100.000	Macaca_nemestrina
ENSG00000177700	POLR2L	100	69.863	ENSMLEG00000042017	-	100	69.863	Mandrillus_leucophaeus
ENSG00000177700	POLR2L	100	97.015	ENSMAMG00000021937	polr2l	100	97.015	Mastacembelus_armatus
ENSG00000177700	POLR2L	100	98.507	ENSMZEG00005000960	polr2l	100	98.507	Maylandia_zebra
ENSG00000177700	POLR2L	100	100.000	ENSMGAG00000011610	POLR2L	100	100.000	Meleagris_gallopavo
ENSG00000177700	POLR2L	100	100.000	ENSMAUG00000019023	Polr2l	100	100.000	Mesocricetus_auratus
ENSG00000177700	POLR2L	100	100.000	ENSMICG00000047069	POLR2L	100	100.000	Microcebus_murinus
ENSG00000177700	POLR2L	100	100.000	ENSMOCG00000021062	Polr2l	100	100.000	Microtus_ochrogaster
ENSG00000177700	POLR2L	100	98.507	ENSMMOG00000017276	polr2l	100	98.507	Mola_mola
ENSG00000177700	POLR2L	100	97.015	ENSMALG00000018890	polr2l	100	97.015	Monopterus_albus
ENSG00000177700	POLR2L	100	100.000	MGP_CAROLIEiJ_G0030702	Polr2l	100	100.000	Mus_caroli
ENSG00000177700	POLR2L	100	100.000	ENSMUSG00000038489	Polr2l	100	100.000	Mus_musculus
ENSG00000177700	POLR2L	100	100.000	MGP_PahariEiJ_G0013901	Polr2l	100	100.000	Mus_pahari
ENSG00000177700	POLR2L	100	98.507	ENSMLUG00000005362	POLR2L	100	98.507	Myotis_lucifugus
ENSG00000177700	POLR2L	100	86.567	ENSNGAG00000014203	-	100	86.567	Nannospalax_galili
ENSG00000177700	POLR2L	100	100.000	ENSNGAG00000015204	-	100	100.000	Nannospalax_galili
ENSG00000177700	POLR2L	100	98.507	ENSNBRG00000013837	polr2l	100	98.507	Neolamprologus_brichardi
ENSG00000177700	POLR2L	100	100.000	ENSNLEG00000008683	POLR2L	100	100.000	Nomascus_leucogenys
ENSG00000177700	POLR2L	100	100.000	ENSMEUG00000003938	POLR2L	100	100.000	Notamacropus_eugenii
ENSG00000177700	POLR2L	100	97.015	ENSOPRG00000001702	-	100	97.015	Ochotona_princeps
ENSG00000177700	POLR2L	100	98.507	ENSOPRG00000009675	-	100	98.507	Ochotona_princeps
ENSG00000177700	POLR2L	100	100.000	ENSODEG00000016905	-	100	100.000	Octodon_degus
ENSG00000177700	POLR2L	100	88.060	ENSODEG00000014372	-	100	88.060	Octodon_degus
ENSG00000177700	POLR2L	100	98.507	ENSORLG00000027182	polr2l	99	98.507	Oryzias_latipes
ENSG00000177700	POLR2L	100	98.507	ENSORLG00020012637	polr2l	99	98.507	Oryzias_latipes_hni
ENSG00000177700	POLR2L	100	98.507	ENSORLG00015011064	polr2l	99	98.507	Oryzias_latipes_hsok
ENSG00000177700	POLR2L	100	98.507	ENSOMEG00000020485	polr2l	99	98.507	Oryzias_melastigma
ENSG00000177700	POLR2L	100	100.000	ENSOGAG00000024166	POLR2L	100	100.000	Otolemur_garnettii
ENSG00000177700	POLR2L	52	100.000	ENSPTIG00000012764	POLR2L	52	100.000	Panthera_tigris_altaica
ENSG00000177700	POLR2L	100	100.000	ENSPTRG00000052712	POLR2L	100	100.000	Pan_troglodytes
ENSG00000177700	POLR2L	100	100.000	ENSPANG00000032375	POLR2L	100	100.000	Papio_anubis
ENSG00000177700	POLR2L	100	98.507	ENSPKIG00000017973	polr2l	84	98.507	Paramormyrops_kingsleyae
ENSG00000177700	POLR2L	100	100.000	ENSPSIG00000013867	POLR2L	100	100.000	Pelodiscus_sinensis
ENSG00000177700	POLR2L	100	94.030	ENSPMGG00000004854	polr2l	100	94.030	Periophthalmus_magnuspinnatus
ENSG00000177700	POLR2L	100	86.567	ENSPEMG00000014839	-	100	86.567	Peromyscus_maniculatus_bairdii
ENSG00000177700	POLR2L	100	100.000	ENSPCIG00000008250	-	100	100.000	Phascolarctos_cinereus
ENSG00000177700	POLR2L	100	70.149	ENSPCIG00000011752	-	100	70.149	Phascolarctos_cinereus
ENSG00000177700	POLR2L	100	98.507	ENSPFOG00000004650	polr2l	100	98.507	Poecilia_formosa
ENSG00000177700	POLR2L	100	98.507	ENSPLAG00000010698	polr2l	100	98.507	Poecilia_latipinna
ENSG00000177700	POLR2L	100	98.507	ENSPMEG00000015438	polr2l	100	98.507	Poecilia_mexicana
ENSG00000177700	POLR2L	100	98.507	ENSPREG00000022948	polr2l	100	98.507	Poecilia_reticulata
ENSG00000177700	POLR2L	100	94.030	ENSPPYG00000029850	POLR2L	100	94.030	Pongo_abelii
ENSG00000177700	POLR2L	100	100.000	ENSPCAG00000011644	POLR2L	100	100.000	Procavia_capensis
ENSG00000177700	POLR2L	100	100.000	ENSPVAG00000014859	POLR2L	100	100.000	Pteropus_vampyrus
ENSG00000177700	POLR2L	100	98.507	ENSPNYG00000007348	polr2l	100	98.507	Pundamilia_nyererei
ENSG00000177700	POLR2L	100	98.507	ENSPNAG00000015066	polr2l	100	98.507	Pygocentrus_nattereri
ENSG00000177700	POLR2L	100	95.522	ENSRNOG00000023805	AABR07042789.1	100	95.522	Rattus_norvegicus
ENSG00000177700	POLR2L	100	100.000	ENSRBIG00000033751	POLR2L	100	100.000	Rhinopithecus_bieti
ENSG00000177700	POLR2L	100	100.000	ENSRROG00000045437	-	100	100.000	Rhinopithecus_roxellana
ENSG00000177700	POLR2L	100	100.000	ENSRROG00000001154	-	100	100.000	Rhinopithecus_roxellana
ENSG00000177700	POLR2L	100	73.529	YOR210W	RPB10	97	73.529	Saccharomyces_cerevisiae
ENSG00000177700	POLR2L	100	67.164	ENSSBOG00000026975	-	100	67.164	Saimiri_boliviensis_boliviensis
ENSG00000177700	POLR2L	100	95.522	ENSSFOG00015010252	polr2l	100	95.522	Scleropages_formosus
ENSG00000177700	POLR2L	100	98.507	ENSSMAG00000021392	polr2l	100	98.507	Scophthalmus_maximus
ENSG00000177700	POLR2L	100	97.015	ENSSDUG00000008725	polr2l	100	97.015	Seriola_dumerili
ENSG00000177700	POLR2L	100	97.015	ENSSLDG00000024029	polr2l	100	97.015	Seriola_lalandi_dorsalis
ENSG00000177700	POLR2L	100	100.000	ENSSARG00000007627	POLR2L	100	100.000	Sorex_araneus
ENSG00000177700	POLR2L	100	89.552	ENSSPUG00000005252	POLR2L	69	89.552	Sphenodon_punctatus
ENSG00000177700	POLR2L	100	98.507	ENSSPAG00000019322	polr2l	100	98.507	Stegastes_partitus
ENSG00000177700	POLR2L	100	71.642	ENSSSCG00000012839	-	100	71.642	Sus_scrofa
ENSG00000177700	POLR2L	100	100.000	ENSSSCG00000033068	-	100	100.000	Sus_scrofa
ENSG00000177700	POLR2L	100	83.582	ENSSSCG00000000461	-	100	83.582	Sus_scrofa
ENSG00000177700	POLR2L	100	86.567	ENSTGUG00000009757	POLR2L	100	86.567	Taeniopygia_guttata
ENSG00000177700	POLR2L	100	97.015	ENSTRUG00000017292	polr2l	100	97.015	Takifugu_rubripes
ENSG00000177700	POLR2L	100	97.015	ENSTTRG00000012496	POLR2L	100	97.015	Tursiops_truncatus
ENSG00000177700	POLR2L	100	100.000	ENSUAMG00000024755	-	100	100.000	Ursus_americanus
ENSG00000177700	POLR2L	100	65.672	ENSUAMG00000016335	-	63	65.672	Ursus_americanus
ENSG00000177700	POLR2L	100	100.000	ENSVVUG00000000205	POLR2L	100	100.000	Vulpes_vulpes
ENSG00000177700	POLR2L	100	100.000	ENSXETG00000025768	polr2l.1	100	100.000	Xenopus_tropicalis
ENSG00000177700	POLR2L	100	97.015	ENSXETG00000002878	polr2l.2	100	97.015	Xenopus_tropicalis
ENSG00000177700	POLR2L	100	98.507	ENSXMAG00000007260	polr2l	100	98.507	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0001054	RNA polymerase I activity	21873635.	IBA	Function
GO:0001055	RNA polymerase II activity	21873635.	IBA	Function
GO:0001056	RNA polymerase III activity	21873635.	IBA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	9852112.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005665	RNA polymerase II, core complex	21873635.	IBA	Component
GO:0005665	RNA polymerase II, core complex	9852112.	IDA	Component
GO:0005666	RNA polymerase III complex	21873635.	IBA	Component
GO:0005736	RNA polymerase I complex	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006351	transcription, DNA-templated	-	TAS	Process
GO:0006356	regulation of transcription by RNA polymerase I	8786124.	TAS	Process
GO:0006361	transcription initiation from RNA polymerase I promoter	-	TAS	Process
GO:0006362	transcription elongation from RNA polymerase I promoter	-	TAS	Process
GO:0006363	termination of RNA polymerase I transcription	-	TAS	Process
GO:0006366	transcription by RNA polymerase II	9852112.	IDA	Process
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006370	7-methylguanosine mRNA capping	-	TAS	Process
GO:0006383	transcription by RNA polymerase III	-	IEA	Process
GO:0008270	zinc ion binding	21873635.	IBA	Function
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0035019	somatic stem cell population maintenance	-	TAS	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0045815	positive regulation of gene expression, epigenetic	-	TAS	Process
GO:0050434	positive regulation of viral transcription	-	TAS	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process