EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000178199 (Gene tree)
Gene ID: 340152
Gene Symbol: ZC3H12D
Alias: dJ281H8.1|MCPIP4|C6orf95
Full Name: zinc finger CCCH-type containing 12D
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 38,267 bases
Position: chr6:149,446,795-149,485,061
Accession: 21175
RBP type: canonical RBP
Summary: (Zinc Finger CCCH-Type Containing 12D) is a Protein Coding gene. Diseases associated with ZC3H12D include Follicular Lymphoma and Lymphoma. Gene Ontology (GO) annotations related to this gene include endonuclease activity. An important paralog of this gene is ZC3H12A.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000386616	RNase_Zc3h12a	PF11977.8	1.8e-64	1	1
ENSP00000395209	RNase_Zc3h12a	PF11977.8	3.8e-34	1	1
ENSP00000387062	RNase_Zc3h12a	PF11977.8	8.4e-20	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409948	ZC3H12D-202	753	-	ENSP00000387062	167 (aa)	-	B7ZBA4
ENST00000409806	ZC3H12D-201	5791	-	ENSP00000386616	527 (aa)	-	A2A288
ENST00000498662	ZC3H12D-205	1335	-	-	- (aa)	-	-
ENST00000458251	ZC3H12D-203	810	-	ENSP00000395209	106 (aa)	-	H0Y4Y6
ENST00000462655	ZC3H12D-204	803	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000178199's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000178199	rs394563	6	149475878	?	Dupuytren's disease	28886342	[1.16-1.26]	1.2077295	EFO_0004229
ENSG00000178199	rs431978	6	149471864	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178199's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000178199	ZC3H12D	97	72.816	ENSG00000163874	ZC3H12A	84	56.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000178199	ZC3H12D	98	95.192	ENSAMEG00000018283	-	100	88.213	Ailuropoda_melanoleuca
ENSG00000178199	ZC3H12D	98	83.654	ENSAPLG00000008379	ZC3H12D	98	69.182	Anas_platyrhynchos
ENSG00000178199	ZC3H12D	97	82.524	ENSACAG00000006984	ZC3H12D	90	66.667	Anolis_carolinensis
ENSG00000178199	ZC3H12D	98	99.038	ENSANAG00000020234	ZC3H12D	100	90.926	Aotus_nancymaae
ENSG00000178199	ZC3H12D	98	94.231	ENSBTAG00000007388	ZC3H12D	99	69.017	Bos_taurus
ENSG00000178199	ZC3H12D	98	99.038	ENSCJAG00000019606	ZC3H12D	100	94.012	Callithrix_jacchus
ENSG00000178199	ZC3H12D	98	95.192	ENSCAFG00000000375	ZC3H12D	99	59.735	Canis_familiaris
ENSG00000178199	ZC3H12D	89	82.432	ENSCAFG00020013539	-	77	86.463	Canis_lupus_dingo
ENSG00000178199	ZC3H12D	98	95.192	ENSCHIG00000025964	ZC3H12D	99	68.324	Capra_hircus
ENSG00000178199	ZC3H12D	89	81.879	ENSTSYG00000034158	-	100	75.904	Carlito_syrichta
ENSG00000178199	ZC3H12D	89	80.263	ENSCAPG00000014473	ZC3H12D	91	61.996	Cavia_aperea
ENSG00000178199	ZC3H12D	98	95.192	ENSCPOG00000014608	ZC3H12D	92	67.728	Cavia_porcellus
ENSG00000178199	ZC3H12D	98	99.038	ENSCCAG00000013595	ZC3H12D	100	90.170	Cebus_capucinus
ENSG00000178199	ZC3H12D	98	100.000	ENSCATG00000038224	ZC3H12D	100	95.210	Cercocebus_atys
ENSG00000178199	ZC3H12D	98	94.231	ENSCLAG00000002831	ZC3H12D	92	68.511	Chinchilla_lanigera
ENSG00000178199	ZC3H12D	98	100.000	ENSCSAG00000017217	ZC3H12D	99	92.830	Chlorocebus_sabaeus
ENSG00000178199	ZC3H12D	98	100.000	ENSCANG00000028774	ZC3H12D	100	95.210	Colobus_angolensis_palliatus
ENSG00000178199	ZC3H12D	98	90.385	ENSCGRG00001019159	Zc3h12d	100	62.094	Cricetulus_griseus_chok1gshd
ENSG00000178199	ZC3H12D	98	90.385	ENSCGRG00000006178	Zc3h12d	100	62.094	Cricetulus_griseus_crigri
ENSG00000178199	ZC3H12D	97	89.320	ENSDORG00000027483	-	99	81.672	Dipodomys_ordii
ENSG00000178199	ZC3H12D	71	77.333	ENSETEG00000016119	-	95	62.679	Echinops_telfairi
ENSG00000178199	ZC3H12D	98	95.192	ENSEASG00005008940	ZC3H12D	79	84.716	Equus_asinus_asinus
ENSG00000178199	ZC3H12D	98	95.192	ENSECAG00000017135	ZC3H12D	98	70.201	Equus_caballus
ENSG00000178199	ZC3H12D	89	77.027	ENSEEUG00000000087	-	84	77.027	Erinaceus_europaeus
ENSG00000178199	ZC3H12D	98	96.154	ENSFCAG00000011290	ZC3H12D	96	77.922	Felis_catus
ENSG00000178199	ZC3H12D	98	84.615	ENSFALG00000013127	ZC3H12D	99	70.927	Ficedula_albicollis
ENSG00000178199	ZC3H12D	98	95.192	ENSFDAG00000000874	ZC3H12D	82	77.273	Fukomys_damarensis
ENSG00000178199	ZC3H12D	98	82.692	ENSGALG00000038782	ZC3H12D	52	66.364	Gallus_gallus
ENSG00000178199	ZC3H12D	100	98.802	ENSGGOG00000005511	ZC3H12D	100	98.802	Gorilla_gorilla
ENSG00000178199	ZC3H12D	90	78.431	ENSHGLG00000008570	-	96	78.431	Heterocephalus_glaber_female
ENSG00000178199	ZC3H12D	90	78.431	ENSHGLG00100008141	-	96	78.431	Heterocephalus_glaber_male
ENSG00000178199	ZC3H12D	98	92.308	ENSSTOG00000013975	ZC3H12D	100	73.208	Ictidomys_tridecemlineatus
ENSG00000178199	ZC3H12D	97	75.728	ENSLACG00000016816	ZC3H12D	93	63.514	Latimeria_chalumnae
ENSG00000178199	ZC3H12D	98	93.269	ENSLAFG00000021535	-	100	80.685	Loxodonta_africana
ENSG00000178199	ZC3H12D	98	100.000	ENSMFAG00000034693	ZC3H12D	100	95.210	Macaca_fascicularis
ENSG00000178199	ZC3H12D	100	91.617	ENSMMUG00000014999	-	100	91.617	Macaca_mulatta
ENSG00000178199	ZC3H12D	98	100.000	ENSMNEG00000004043	ZC3H12D	100	95.210	Macaca_nemestrina
ENSG00000178199	ZC3H12D	100	95.210	ENSMLEG00000027838	-	100	95.210	Mandrillus_leucophaeus
ENSG00000178199	ZC3H12D	98	82.692	ENSMGAG00000012594	ZC3H12D	96	69.381	Meleagris_gallopavo
ENSG00000178199	ZC3H12D	98	98.077	ENSMICG00000044838	ZC3H12D	100	80.566	Microcebus_murinus
ENSG00000178199	ZC3H12D	98	92.308	ENSMOCG00000015590	Zc3h12d	100	62.795	Microtus_ochrogaster
ENSG00000178199	ZC3H12D	98	92.308	ENSMODG00000016829	-	95	75.828	Monodelphis_domestica
ENSG00000178199	ZC3H12D	98	91.346	MGP_CAROLIEiJ_G0015104	Zc3h12d	100	64.168	Mus_caroli
ENSG00000178199	ZC3H12D	98	91.346	ENSMUSG00000039981	Zc3h12d	100	63.803	Mus_musculus
ENSG00000178199	ZC3H12D	98	91.346	MGP_PahariEiJ_G0023723	Zc3h12d	100	64.534	Mus_pahari
ENSG00000178199	ZC3H12D	98	91.346	MGP_SPRETEiJ_G0015911	Zc3h12d	100	63.620	Mus_spretus
ENSG00000178199	ZC3H12D	98	95.192	ENSMPUG00000018072	-	99	85.556	Mustela_putorius_furo
ENSG00000178199	ZC3H12D	98	95.192	ENSMLUG00000029238	ZC3H12D	100	87.013	Myotis_lucifugus
ENSG00000178199	ZC3H12D	97	91.262	ENSNGAG00000010502	Zc3h12d	93	62.607	Nannospalax_galili
ENSG00000178199	ZC3H12D	100	97.605	ENSNLEG00000015313	-	100	97.605	Nomascus_leucogenys
ENSG00000178199	ZC3H12D	98	90.385	ENSMEUG00000004686	-	99	77.660	Notamacropus_eugenii
ENSG00000178199	ZC3H12D	98	96.154	ENSOPRG00000014034	ZC3H12D	100	68.880	Ochotona_princeps
ENSG00000178199	ZC3H12D	98	94.231	ENSODEG00000002553	ZC3H12D	91	66.383	Octodon_degus
ENSG00000178199	ZC3H12D	94	88.000	ENSOANG00000020837	-	100	79.141	Ornithorhynchus_anatinus
ENSG00000178199	ZC3H12D	99	97.143	ENSOCUG00000007690	-	85	88.213	Oryctolagus_cuniculus
ENSG00000178199	ZC3H12D	98	99.038	ENSOGAG00000031025	ZC3H12D	99	76.437	Otolemur_garnettii
ENSG00000178199	ZC3H12D	98	95.192	ENSOARG00000002626	ZC3H12D	99	64.741	Ovis_aries
ENSG00000178199	ZC3H12D	100	98.802	ENSPPAG00000041304	ZC3H12D	100	98.802	Pan_paniscus
ENSG00000178199	ZC3H12D	98	96.154	ENSPPRG00000004536	ZC3H12D	96	77.922	Panthera_pardus
ENSG00000178199	ZC3H12D	96	76.398	ENSPTIG00000014208	-	98	76.398	Panthera_tigris_altaica
ENSG00000178199	ZC3H12D	100	98.102	ENSPTRG00000050357	ZC3H12D	100	98.102	Pan_troglodytes
ENSG00000178199	ZC3H12D	98	100.000	ENSPANG00000034987	ZC3H12D	100	95.210	Papio_anubis
ENSG00000178199	ZC3H12D	98	82.692	ENSPSIG00000016475	ZC3H12D	97	69.231	Pelodiscus_sinensis
ENSG00000178199	ZC3H12D	98	89.423	ENSPEMG00000010962	Zc3h12d	100	62.250	Peromyscus_maniculatus_bairdii
ENSG00000178199	ZC3H12D	98	100.000	ENSPPYG00000017087	ZC3H12D	100	95.066	Pongo_abelii
ENSG00000178199	ZC3H12D	98	93.269	ENSPCAG00000002991	ZC3H12D	100	60.113	Procavia_capensis
ENSG00000178199	ZC3H12D	98	99.038	ENSPCOG00000017645	ZC3H12D	100	80.907	Propithecus_coquereli
ENSG00000178199	ZC3H12D	98	91.346	ENSRNOG00000016041	Zc3h12d	100	64.935	Rattus_norvegicus
ENSG00000178199	ZC3H12D	98	99.038	ENSRBIG00000012478	ZC3H12D	100	95.210	Rhinopithecus_bieti
ENSG00000178199	ZC3H12D	98	99.038	ENSRROG00000038053	ZC3H12D	100	95.210	Rhinopithecus_roxellana
ENSG00000178199	ZC3H12D	98	99.038	ENSSBOG00000023337	ZC3H12D	100	94.012	Saimiri_boliviensis_boliviensis
ENSG00000178199	ZC3H12D	98	90.385	ENSSHAG00000017000	ZC3H12D	99	53.818	Sarcophilus_harrisii
ENSG00000178199	ZC3H12D	87	46.497	ENSSFOG00015020795	-	95	46.667	Scleropages_formosus
ENSG00000178199	ZC3H12D	89	58.228	ENSSPUG00000005643	-	96	58.228	Sphenodon_punctatus
ENSG00000178199	ZC3H12D	98	94.231	ENSSSCG00000004109	ZC3H12D	98	68.609	Sus_scrofa
ENSG00000178199	ZC3H12D	98	83.654	ENSTGUG00000010664	ZC3H12D	99	70.701	Taeniopygia_guttata
ENSG00000178199	ZC3H12D	98	95.192	ENSTBEG00000000892	-	100	83.987	Tupaia_belangeri
ENSG00000178199	ZC3H12D	90	84.000	ENSUMAG00000002782	-	68	78.992	Ursus_maritimus
ENSG00000178199	ZC3H12D	84	82.979	ENSVVUG00000005116	-	99	77.215	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000932	P-body	24415781.26134560.	IDA	Component
GO:0004519	endonuclease activity	-	IEA	Function
GO:0005515	protein binding	26134560.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0036464	cytoplasmic ribonucleoprotein granule	-	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0061158	3'-UTR-mediated mRNA destabilization	-	ISS	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	149474430	Silent	novel	Q38Q	0.1
BLCA	chr6	149456721	Missense_Mutation	novel	E209K	0.2
BLCA	chr6	149474517	Silent	novel	F9F	0.37
BRCA	chr6	149474310	Silent	NA	L78L	0.17
CESC	chr6	149461937	Silent	novel	G113G	0.51
CESC	chr6	149474517	Silent	novel	F9F	0.39
CESC	chr6	149474517	Missense_Mutation	novel	F9L	0.44
CESC	chr6	149456804	Missense_Mutation	NA	R181H	0.47
COAD	chr6	149456763	Missense_Mutation	NA	V195I	0.39
COAD	chr6	149461927	Missense_Mutation	novel	A117T	0.36	RNase_Zc3h12a
COAD	chr6	149456848	Silent	NA	P166P	0.72
COAD	chr6	149451018	Frame_Shift_Ins	novel	*H417Sfs82**	0.2
COAD	chr6	149456809	Silent	NA	D179D	0.42
ESCA	chr6	149450696	Missense_Mutation	novel	L524Q	0.1
GBM	chr6	149474438	Missense_Mutation	novel	V36M	0.35
GBM	chr6	149474475	Silent	NA	V23V	0.46
KIRC	chr6	149452621	Missense_Mutation	NA	P261H	0.5
KIRC	chr6	149456723	Missense_Mutation	novel	P208H	0.36
LIHC	chr6	149474602	5'UTR	novel		0.46
LIHC	chr6	149450832	Missense_Mutation	NA	A479T	0.3
LIHC	chr6	149456721	Nonsense_Mutation	NA	E209*	0.21
LUSC	chr6	149451016	Missense_Mutation	novel	H417Q	0.86
PRAD	chr6	149452668	Missense_Mutation	NA	F245L	0.29
READ	chr6	149474267	Missense_Mutation	NA	V93L	0.38	RNase_Zc3h12a
READ	chr6	149452697	Missense_Mutation	NA	G236C	0.3
READ	chr6	149461909	Missense_Mutation	NA	D123Y	0.36	RNase_Zc3h12a
SARC	chr6	149450604	3'UTR	novel		0.29
SKCM	chr6	149474522	Missense_Mutation	NA	E8K	0.45
SKCM	chr6	149474426	Missense_Mutation	NA	L40F	0.52
SKCM	chr6	149452659	Silent	NA	R248R	0.39
SKCM	chr6	149474477	Missense_Mutation	novel	V23M	0.58
SKCM	chr6	149456707	Silent	NA	F213F	0.2
SKCM	chr6	149474292	Silent	novel	T84T	0.56
SKCM	chr6	149456698	Silent	NA	Q216Q	0.3
SKCM	chr6	149461966	Missense_Mutation	NA	G104R	0.76	RNase_Zc3h12a
SKCM	chr6	149461951	Missense_Mutation	NA	F109V	0.18	RNase_Zc3h12a
SKCM	chr6	149474495	Missense_Mutation	NA	R17W	0.35
STAD	chr6	149456743	Silent	NA	R201R	0.16
STAD	chr6	149452702	Missense_Mutation	NA	P234H	0.33
STAD	chr6	149456884	Silent	novel	A154A	0.11
STAD	chr6	149474453	Missense_Mutation	rs761352055	A31T	0.37
STAD	chr6	149456855	Missense_Mutation	NA	Y164C	0.15
STAD	chr6	149456671	Silent	rs767946272	N225N	0.2
STAD	chr6	149456809	Silent	NA	D179D	0.12
STAD	chr6	149456848	Silent	NA	P166P	0.26
UCEC	chr6	149474267	Missense_Mutation	NA	V93M	0.4	RNase_Zc3h12a
UCEC	chr6	149474538	Silent	NA	E2E	0.42
UCEC	chr6	149456730	Missense_Mutation	NA	E206K	0.29
UCEC	chr6	149474453	Missense_Mutation	rs761352055	A31T	0.31
UCEC	chr6	149474453	Missense_Mutation	rs761352055	A31T	0.1
UCEC	chr6	149450701	Silent	novel	A522A	0.45
UCEC	chr6	149474490	Missense_Mutation	novel	E18D	0.44
UCEC	chr6	149461885	Missense_Mutation	NA	V131I	0.24	RNase_Zc3h12a
UCEC	chr6	149452653	Silent	rs376266753	P250P	0.27
UCEC	chr6	149456731	Silent	novel	S205S	0.33
UCEC	chr6	149456731	Silent	novel	S205S	0.21
UCEC	chr6	149474329	Missense_Mutation	rs202172414	R72H	0.14
UCEC	chr6	149456821	Silent	novel	L175L	0.09
UCEC	chr6	149456811	Missense_Mutation	novel	D179N	0.47
UCEC	chr6	149456808	Missense_Mutation	novel	D180N	0.41
UCEC	chr6	149456721	Missense_Mutation	novel	E209K	0.33
UCEC	chr6	149461941	Missense_Mutation	rs776664471	R112Q	0.43	RNase_Zc3h12a
UCEC	chr6	149474391	Silent	novel	E51E	0.2
UCEC	chr6	149456722	Silent	NA	P208P	0.49
UCEC	chr6	149456731	Silent	novel	S205S	0.56
UCEC	chr6	149450474	3'UTR	novel		0.67
UCEC	chr6	149461894	Missense_Mutation	novel	Y128H	0.31	RNase_Zc3h12a
UCEC	chr6	149461931	Missense_Mutation	novel	K115N	0.41	RNase_Zc3h12a
UCEC	chr6	149474363	Missense_Mutation	novel	R61W	0.4
UCEC	chr6	149474276	Nonsense_Mutation	novel	R90*	0.31	RNase_Zc3h12a
UCEC	chr6	149450621	3'UTR	novel		0.26
UCEC	chr6	149450746	Silent	novel	L507L	0.25
UCEC	chr6	149474244	Silent	rs368280369	A100A	0.5
UCEC	chr6	149456844	Missense_Mutation	NA	R168C	0.38
UCEC	chr6	149461853	Silent	novel	P141P	0.08

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3505	0.00027473
KIRC	DEL	0.2443	7.439e-11
KIRP	DEL	0.1042	0.054498
LGG	DEL	0.1442	0.0022414
MESO	DEL	0.4368	0.0023534
PAAD	DEL	0.375	0.11274
SKCM	DEL	0.5531	1.5442e-06
THYM	DEL	0.1463	0.10691
UVM	DEL	0.2875	0.0054289

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0015	Kaplan-Meier Survival Analysis
STAD	0.02	Kaplan-Meier Survival Analysis
SARC	0.0075	Kaplan-Meier Survival Analysis
MESO	0.045	Kaplan-Meier Survival Analysis
HNSC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
PAAD	0.041	Kaplan-Meier Survival Analysis
BLCA	0.038	Kaplan-Meier Survival Analysis
CESC	0.0009	Kaplan-Meier Survival Analysis
READ	0.0009	Kaplan-Meier Survival Analysis
LAML	0.018	Kaplan-Meier Survival Analysis
UCEC	0.039	Kaplan-Meier Survival Analysis
LIHC	0.026	Kaplan-Meier Survival Analysis
LGG	0.00089	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00046	Kaplan-Meier Survival Analysis