EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000178209 (Gene tree)
Gene ID: 5339
Gene Symbol: PLEC
Alias: PCN|PLTN|EBS1|PLEC1
Full Name: plectin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 61,646 bases
Position: chr8:143,915,147-143,976,792
Accession: 9069
RBP type: canonical RBP
Summary: Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as \hemidesmosomal protein 1\" or \"plectin 1, intermediate filament binding 500kDa\". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000323856	S10_plectin	PF03501.15	7.7e-35	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30872628	Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral Sclerosis.	Sci Rep	2019 Mar 14	Leoni E	doi: 10.1038/s41598-019-40632-4.
24895129	The role of Mg(II) in DNA cleavage site recognition in group II intron ribozymes: solution structure and metal ion binding sites of the RNA-DNA complex.	J Biol Chem	2014 Jul 25	Skilandat M	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000398774	PLEC-207	14646	XM_005250984	ENSP00000381756	4515 (aa)	XP_005251041	Q15149
ENST00000528131	PLEC-214	564	-	ENSP00000436702	174 (aa)	-	E9PIA2
ENST00000345136	PLEC-202	14803	XM_005250980	ENSP00000344848	4547 (aa)	XP_005251037	Q15149
ENST00000436759	PLEC-208	14787	XM_006716588	ENSP00000388180	4574 (aa)	XP_006716651	Q15149
ENST00000356346	PLEC-205	14683	XM_005250981	ENSP00000348702	4533 (aa)	XP_005251038	Q15149
ENST00000526416	PLEC-209	583	-	ENSP00000433557	190 (aa)	-	E9PKG0
ENST00000357649	PLEC-206	14689	XM_005250978	ENSP00000350277	4551 (aa)	XP_005251035	Q15149
ENST00000527816	PLEC-212	583	-	ENSP00000434490	83 (aa)	-	E9PQ28
ENST00000528025	PLEC-213	2115	-	ENSP00000437303	703 (aa)	-	E9PMV1
ENST00000532346	PLEC-215	316	-	-	- (aa)	-	-
ENST00000354958	PLEC-204	14751	XM_005250982	ENSP00000347044	4525 (aa)	XP_005251039	Q15149
ENST00000527303	PLEC-211	11406	-	ENSP00000433982	3447 (aa)	-	H0YDN1
ENST00000322810	PLEC-201	15249	XM_005250976	ENSP00000323856	4684 (aa)	XP_005251033	Q15149
ENST00000527096	PLEC-210	13713	-	ENSP00000434583	4570 (aa)	-	Q15149
ENST00000354589	PLEC-203	14736	XM_005250979	ENSP00000346602	4547 (aa)	XP_005251036	Q15149

Gene Model

Click here to download ENSG00000178209's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000178209	Bronchodilator Agents	4E-6	26634245
ENSG00000178209	Forced Expiratory Volume	4E-6	26634245
ENSG00000178209	Fibrinogen	6E-10	26561523
ENSG00000178209	Cholesterol	9E-10	20686565
ENSG00000178209	Bronchodilator Agents	4E-6	26634245
ENSG00000178209	Forced Expiratory Volume	4E-6	26634245
ENSG00000178209	Fibrinogen	1E-9	23969696
ENSG00000178209	Bronchodilator Agents	3E-6	26634245
ENSG00000178209	Forced Expiratory Volume	3E-6	26634245
ENSG00000178209	Bronchodilator Agents	3E-6	26634245
ENSG00000178209	Forced Expiratory Volume	3E-6	26634245
ENSG00000178209	Bronchodilator Agents	5E-6	26634245
ENSG00000178209	Forced Expiratory Volume	5E-6	26634245
ENSG00000178209	Bronchodilator Agents	5E-6	26634245
ENSG00000178209	Forced Expiratory Volume	5E-6	26634245
ENSG00000178209	Platelet Count	5E-10	22139419
ENSG00000178209	Cholesterol, LDL	7E-12	24097068
ENSG00000178209	Bronchodilator Agents	1E-6	26634245
ENSG00000178209	Forced Expiratory Volume	1E-6	26634245
ENSG00000178209	Cholesterol, LDL	4E-13	20686565
ENSG00000178209	Body Height	1E-9	25282103
ENSG00000178209	Bronchodilator Agents	3E-6	26634245
ENSG00000178209	Forced Expiratory Volume	3E-6	26634245
ENSG00000178209	Fibrinogen	2E-9	28107422
ENSG00000178209	Cholesterol	6E-9	24097068
ENSG00000178209	Bronchodilator Agents	5E-6	26634245
ENSG00000178209	Forced Expiratory Volume	5E-6	26634245
ENSG00000178209	Bronchodilator Agents	4E-6	26634245
ENSG00000178209	Forced Expiratory Volume	4E-6	26634245
ENSG00000178209	Bronchodilator Agents	4E-6	26634245
ENSG00000178209	Forced Expiratory Volume	4E-6	26634245
ENSG00000178209	Bronchodilator Agents	4E-6	26634245
ENSG00000178209	Forced Expiratory Volume	4E-6	26634245
ENSG00000178209	Bronchodilator Agents	5E-6	26634245
ENSG00000178209	Forced Expiratory Volume	5E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000178209	rs7464572	8	143946999	C	Fibrinogen	23969696	[0.005-0.009] unit decrease	0.007	EFO_0004623
ENSG00000178209	rs11136341	8	143969375	G	LDL cholesterol	24097068	[NR] unit increase	0.045	EFO_0004611
ENSG00000178209	rs11780978	8	143960684	A	Fibrinogen levels	26561523	NR unit increase	0.0059	EFO_0004623
ENSG00000178209	rs6995402	8	143931393	C	Platelet count	22139419	[1.58-3.03] 10^9/l increase	2.304	EFO_0004309
ENSG00000178209	rs7003580	8	143933366	C	Anti-saccade response	29064472			EFO_0006874
ENSG00000178209	rs11780978	8	143960684	A	Osteoarthritis of the hip (hospital diagnosed)	29559693	[1.0834-1.1708]	1.1263	EFO_1000786
ENSG00000178209	rs7833924	8	143921861	G	Platelet count	27863252	[0.037-0.051] unit increase	0.04389853	EFO_0004309
ENSG00000178209	rs11136335	8	143929609	G	Mosquito bite size	28199695	[0.015-0.036] unit decrease	0.0259095	EFO_0008378
ENSG00000178209	rs56117011	8	143925474	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.045	EFO_0004314\|GO_0097366
ENSG00000178209	rs35916068	8	143925516	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.045	EFO_0004314\|GO_0097366
ENSG00000178209	rs11778026	8	143922240	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.045	EFO_0004314\|GO_0097366
ENSG00000178209	rs7155	8	143915294	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.043	EFO_0004314\|GO_0097366
ENSG00000178209	rs7002002	8	143923759	A	Post bronchodilator FEV1	26634245	NR unit increase	0.044	EFO_0004314\|GO_0097366
ENSG00000178209	rs7016416	8	143923488	T	Post bronchodilator FEV1	26634245	NR unit increase	0.044	EFO_0004314\|GO_0097366
ENSG00000178209	rs1140522	8	143924001	T	Post bronchodilator FEV1	26634245	NR unit increase	0.044	EFO_0004314\|GO_0097366
ENSG00000178209	rs6984820	8	143919156	T	Post bronchodilator FEV1	26634245	NR unit increase	0.044	EFO_0004314\|GO_0097366
ENSG00000178209	rs6558407	8	143921326	T	Post bronchodilator FEV1	26634245	NR unit increase	0.045	EFO_0004314\|GO_0097366
ENSG00000178209	rs11777402	8	143921568	A	Post bronchodilator FEV1	26634245	NR unit increase	0.045	EFO_0004314\|GO_0097366
ENSG00000178209	rs11786903	8	143922430	A	Post bronchodilator FEV1	26634245	NR unit increase	0.045	EFO_0004314\|GO_0097366
ENSG00000178209	rs55646585	8	143925453	T	Post bronchodilator FEV1	26634245	NR unit increase	0.045	EFO_0004314\|GO_0097366
ENSG00000178209	rs1065837	8	143916167	A	Post bronchodilator FEV1	26634245	NR unit increase	0.047	EFO_0004314\|GO_0097366
ENSG00000178209	rs11136341	8	143969375	G	LDL cholesterol	20686565	[0.99-1.81] mg/dL increase	1.4	EFO_0004611
ENSG00000178209	rs7464572	8	143946999	?	Fibrinogen levels	28107422	unit increase	0.0066	EFO_0004623
ENSG00000178209	rs11783655	8	143963405	A	Height	25282103	[0.012-0.024] unit decrease	0.018	EFO_0004339
ENSG00000178209	rs7832643	8	143948489	T	LDL cholesterol levels	28334899	[0.026-0.041] unit increase (EA Beta value)	0.0339	EFO_0004611
ENSG00000178209	rs7832643	8	143948489	T	Total cholesterol levels	28334899	[0.022-0.036] unit increase (EA Beta values)	0.0289	EFO_0004574
ENSG00000178209	rs11783655	8	143963405	T	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.027	EFO_0004611
ENSG00000178209	rs11136341	8	143969375	A	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.03	EFO_0004611
ENSG00000178209	rs11136341	8	143969375	A	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.03	EFO_0004611
ENSG00000178209	rs11136341	8	143969375	A	Total cholesterol levels	29507422	unit decrease	0.027	EFO_0004574
ENSG00000178209	rs11136341	8	143969375	A	Total cholesterol levels	29507422	unit decrease	0.026	EFO_0004574
ENSG00000178209	rs11780978	8	143960684	A	Osteoarthritis (hip)	30374069	[NR]	1.05646	EFO_1000786
ENSG00000178209	rs73715570	8	143951130	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000178209	rs7819099	8	143918694	?	Red blood cell count	30595370			EFO_0004305
ENSG00000178209	rs11136336	8	143933019	?	Fat-free mass	30593698	[0.075-0.164] unit decrease	0.11946	EFO_0004995
ENSG00000178209	rs11136336	8	143933019	?	Fat-free mass	30593698	[0.073-0.169] unit decrease	0.12116	EFO_0004995
ENSG00000178209	rs117961539	8	143915298	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178209's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000178209	PLEC	100	100.000	ENSAMEG00000006191	PLEC	100	90.669	Ailuropoda_melanoleuca
ENSG00000178209	PLEC	100	100.000	ENSANAG00000032431	PLEC	100	96.714	Aotus_nancymaae
ENSG00000178209	PLEC	100	100.000	ENSBTAG00000011922	PLEC	100	92.493	Bos_taurus
ENSG00000178209	PLEC	100	100.000	ENSCJAG00000021472	PLEC	100	96.991	Callithrix_jacchus
ENSG00000178209	PLEC	100	100.000	ENSCAFG00000001433	PLEC	100	92.501	Canis_familiaris
ENSG00000178209	PLEC	88	92.675	ENSCHIG00000022260	PLEC	99	92.675	Capra_hircus
ENSG00000178209	PLEC	100	100.000	ENSTSYG00000033419	PLEC	100	94.903	Carlito_syrichta
ENSG00000178209	PLEC	100	100.000	ENSCAPG00000013570	PLEC	100	90.947	Cavia_aperea
ENSG00000178209	PLEC	100	100.000	ENSCPOG00000007957	PLEC	100	93.389	Cavia_porcellus
ENSG00000178209	PLEC	100	100.000	ENSCCAG00000031237	PLEC	100	97.204	Cebus_capucinus
ENSG00000178209	PLEC	100	100.000	ENSCATG00000009349	PLEC	100	98.527	Cercocebus_atys
ENSG00000178209	PLEC	100	100.000	ENSCLAG00000012830	PLEC	100	93.730	Chinchilla_lanigera
ENSG00000178209	PLEC	100	98.795	ENSCPBG00000021974	PLEC	99	72.814	Chrysemys_picta_bellii
ENSG00000178209	PLEC	100	100.000	ENSCGRG00001019864	Plec	100	93.546	Cricetulus_griseus_chok1gshd
ENSG00000178209	PLEC	100	100.000	ENSCGRG00000002714	Plec	100	92.903	Cricetulus_griseus_crigri
ENSG00000178209	PLEC	100	100.000	ENSDNOG00000031742	PLEC	99	89.268	Dasypus_novemcinctus
ENSG00000178209	PLEC	84	94.253	ENSETEG00000015535	-	62	91.826	Echinops_telfairi
ENSG00000178209	PLEC	78	100.000	ENSEEUG00000004554	-	67	97.095	Erinaceus_europaeus
ENSG00000178209	PLEC	100	100.000	ENSFCAG00000042897	PLEC	100	92.856	Felis_catus
ENSG00000178209	PLEC	100	100.000	ENSFDAG00000011856	PLEC	100	93.261	Fukomys_damarensis
ENSG00000178209	PLEC	100	100.000	ENSGGOG00000012217	PLEC	100	97.213	Gorilla_gorilla
ENSG00000178209	PLEC	100	100.000	ENSHGLG00000012646	PLEC	100	93.154	Heterocephalus_glaber_female
ENSG00000178209	PLEC	100	100.000	ENSHGLG00100011759	PLEC	100	82.572	Heterocephalus_glaber_male
ENSG00000178209	PLEC	100	100.000	ENSSTOG00000023061	PLEC	100	92.603	Ictidomys_tridecemlineatus
ENSG00000178209	PLEC	100	100.000	ENSJJAG00000012390	Plec	100	93.372	Jaculus_jaculus
ENSG00000178209	PLEC	100	100.000	ENSMFAG00000032066	PLEC	100	98.527	Macaca_fascicularis
ENSG00000178209	PLEC	100	100.000	ENSMMUG00000000388	PLEC	100	95.014	Macaca_mulatta
ENSG00000178209	PLEC	100	100.000	ENSMNEG00000011406	PLEC	100	98.484	Macaca_nemestrina
ENSG00000178209	PLEC	100	100.000	ENSMLEG00000033296	PLEC	100	97.916	Mandrillus_leucophaeus
ENSG00000178209	PLEC	100	100.000	ENSMAUG00000001116	Plec	100	93.525	Mesocricetus_auratus
ENSG00000178209	PLEC	100	100.000	ENSMICG00000016160	PLEC	100	94.307	Microcebus_murinus
ENSG00000178209	PLEC	100	100.000	ENSMOCG00000000674	Plec	100	93.582	Microtus_ochrogaster
ENSG00000178209	PLEC	100	100.000	MGP_CAROLIEiJ_G0019913	Plec	100	93.561	Mus_caroli
ENSG00000178209	PLEC	100	100.000	ENSMUSG00000022565	Plec	100	93.518	Mus_musculus
ENSG00000178209	PLEC	100	100.000	MGP_PahariEiJ_G0019923	Plec	100	93.412	Mus_pahari
ENSG00000178209	PLEC	100	100.000	MGP_SPRETEiJ_G0020816	Plec	100	93.539	Mus_spretus
ENSG00000178209	PLEC	100	100.000	ENSMPUG00000007329	PLEC	100	90.808	Mustela_putorius_furo
ENSG00000178209	PLEC	100	100.000	ENSNGAG00000008931	Plec	100	93.710	Nannospalax_galili
ENSG00000178209	PLEC	100	100.000	ENSMEUG00000004499	-	70	92.743	Notamacropus_eugenii
ENSG00000178209	PLEC	100	98.795	ENSOPRG00000015206	PLEC	69	92.237	Ochotona_princeps
ENSG00000178209	PLEC	100	100.000	ENSODEG00000014671	PLEC	100	93.375	Octodon_degus
ENSG00000178209	PLEC	100	100.000	ENSOCUG00000023075	-	100	92.241	Oryctolagus_cuniculus
ENSG00000178209	PLEC	100	100.000	ENSOARG00000015846	-	100	80.114	Ovis_aries
ENSG00000178209	PLEC	100	100.000	ENSPPAG00000042112	PLEC	100	91.084	Pan_paniscus
ENSG00000178209	PLEC	100	100.000	ENSPTRG00000020672	PLEC	100	99.210	Pan_troglodytes
ENSG00000178209	PLEC	100	100.000	ENSPANG00000023403	-	100	98.228	Papio_anubis
ENSG00000178209	PLEC	100	100.000	ENSPEMG00000011922	Plec	100	93.826	Peromyscus_maniculatus_bairdii
ENSG00000178209	PLEC	100	100.000	ENSPCIG00000014981	PLEC	100	82.485	Phascolarctos_cinereus
ENSG00000178209	PLEC	100	100.000	ENSPCOG00000023279	PLEC	100	94.476	Propithecus_coquereli
ENSG00000178209	PLEC	100	100.000	ENSPVAG00000009376	PLEC	91	93.131	Pteropus_vampyrus
ENSG00000178209	PLEC	100	100.000	ENSRNOG00000023781	Plec	100	93.605	Rattus_norvegicus
ENSG00000178209	PLEC	100	100.000	ENSRBIG00000041068	PLEC	75	95.337	Rhinopithecus_bieti
ENSG00000178209	PLEC	100	100.000	ENSRROG00000015881	PLEC	100	98.249	Rhinopithecus_roxellana
ENSG00000178209	PLEC	100	100.000	ENSSBOG00000025259	PLEC	100	94.556	Saimiri_boliviensis_boliviensis
ENSG00000178209	PLEC	99	98.780	ENSSHAG00000009020	PLEC	99	78.770	Sarcophilus_harrisii
ENSG00000178209	PLEC	100	95.181	ENSTTRG00000010427	PLEC	95	91.172	Tursiops_truncatus
ENSG00000178209	PLEC	100	100.000	ENSVVUG00000010214	PLEC	100	92.288	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003779	actin binding	-	IEA	Function
GO:0005198	structural molecule activity	21873635.	IBA	Function
GO:0005200	structural constituent of cytoskeleton	21873635.	IBA	Function
GO:0005515	protein binding	12482924.18827015.19242489.19932097.22240165.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005882	intermediate filament	21873635.	IBA	Component
GO:0005886	plasma membrane	8633055.	NAS	Component
GO:0005903	brush border	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	21873635.	IBA	Component
GO:0005925	focal adhesion	-	IDA	Component
GO:0008307	structural constituent of muscle	21873635.	IBA	Function
GO:0016020	membrane	21873635.	IBA	Component
GO:0016528	sarcoplasm	21223964.	ISS	Component
GO:0030056	hemidesmosome	21873635.	IBA	Component
GO:0030056	hemidesmosome	12482924.	IDA	Component
GO:0030506	ankyrin binding	21873635.	IBA	Function
GO:0030506	ankyrin binding	21223964.	IPI	Function
GO:0031581	hemidesmosome assembly	21873635.	IBA	Process
GO:0031581	hemidesmosome assembly	12482924.	IDA	Process
GO:0031581	hemidesmosome assembly	-	TAS	Process
GO:0042060	wound healing	21873635.	IBA	Process
GO:0042383	sarcolemma	21873635.	IBA	Component
GO:0042383	sarcolemma	21109228.	IDA	Component
GO:0043034	costamere	21223964.	TAS	Component
GO:0045104	intermediate filament cytoskeleton organization	21873635.	IBA	Process
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048471	perinuclear region of cytoplasm	21873635.	IBA	Component
GO:0070062	extracellular exosome	19199708.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18084872	An early evaluation of malignant tendency with plectin expression in human colorectal adenoma and adenocarcinoma.	J Med	2004	Lee KY	-
24218614	Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer.	Proc Natl Acad Sci U S A	2013 Nov 26	Shin SJ	doi: 10.1073/pnas.1309720110
27566071	Cell Pleomorphism and Cytoskeleton Disorganization in Human Liver Cancer.	In Vivo	2016 09-10	Cheng CC	-
19709076	BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization.	Cancer Sci	2009 Nov	Niwa T	doi: 10.1111/j.1349-7006.2009.01282.x

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr8	143924201	Nonsense_Mutation	novel	K2047*	0.33
ACC	chr8	143916899	Missense_Mutation	novel	G4445R	0.47
ACC	chr8	143917086	Silent	rs782762199	S4382S	0.35
ACC	chr8	143920799	Nonsense_Mutation	novel	R3145*	0.53
BLCA	chr8	143922331	Missense_Mutation	novel	S2634F	0.29
BLCA	chr8	143919660	Silent	rs782378294	L3524L	0.74
BLCA	chr8	143934929	Missense_Mutation	novel	E413K	0.14
BLCA	chr8	143938673	Silent	novel	Q181Q	0.18
BLCA	chr8	143943899	Intron	rs782271543		0.28
BLCA	chr8	143918441	Missense_Mutation	novel	E3931K	0.56
BLCA	chr8	143925710	Missense_Mutation	novel	A1544T	0.4
BLCA	chr8	143919800	Missense_Mutation	novel	L3478V	0.31
BLCA	chr8	143939428	Intron	novel		0.33
BLCA	chr8	143933238	Silent	novel	L596L	0.36
BLCA	chr8	143916699	Silent	novel	L4511L	0.3
BLCA	chr8	143920763	Missense_Mutation	NA	L3157F	0.23
BLCA	chr8	143921697	Missense_Mutation	NA	E2845D	0.36
BLCA	chr8	143922555	Missense_Mutation	NA	E2595D	0.34
BLCA	chr8	143923127	Nonsense_Mutation	NA	E2405*	0.36
BLCA	chr8	143918718	Missense_Mutation	NA	R3838S	0.21
BLCA	chr8	143929221	Missense_Mutation	rs199523622	E1185K	0.23
BLCA	chr8	143929497	Missense_Mutation	novel	E1137K	0.35
BLCA	chr8	143916707	Frame_Shift_Del	novel	*Q4509Rfs3**	0.13
BLCA	chr8	143919330	Missense_Mutation	novel	E3634D	0.19
BLCA	chr8	143918346	Missense_Mutation	NA	Q3962H	0.38
BLCA	chr8	143918821	Missense_Mutation	rs369798520	R3804L	0.14
BLCA	chr8	143919750	Silent	rs782511815	L3494L	0.32
BLCA	chr8	143917536	Silent	rs200145450	T4232T	0.14
BLCA	chr8	143918894	Missense_Mutation	novel	V3780L	0.1
BLCA	chr8	143918199	Silent	novel	L4011L	0.43
BLCA	chr8	143935967	Missense_Mutation	novel	K298N	0.6
BLCA	chr8	143935237	Missense_Mutation	novel	E364Q	0.1
BLCA	chr8	143944661	Intron	novel		0.28
BLCA	chr8	143929232	Missense_Mutation	novel	S1181F	0.33
BLCA	chr8	143917755	Silent	NA	L4159L	0.18
BLCA	chr8	143923586	Missense_Mutation	rs782713908	E2252K	0.51
BLCA	chr8	143917417	Missense_Mutation	NA	S4272Y	0.31
BLCA	chr8	143927889	Missense_Mutation	NA	L1259V	0.5
BLCA	chr8	143925515	Missense_Mutation	NA	E1609K	0.16
BLCA	chr8	143921017	Missense_Mutation	NA	A3072E	0.29
BLCA	chr8	143924159	Missense_Mutation	NA	E2061K	0.09
BLCA	chr8	143943785	Intron	rs535379967		0.13
BLCA	chr8	143929811	Missense_Mutation	NA	E1057Q	0.28
BLCA	chr8	143930214	Nonsense_Mutation	NA	E985*	0.26
BLCA	chr8	143923209	Silent	novel	L2377L	0.5
BLCA	chr8	143916855	Silent	rs201042249	I4459I	0.43
BLCA	chr8	143917111	Missense_Mutation	rs782530213	S4374L	0.3
BLCA	chr8	143918933	Missense_Mutation	NA	E3767Q	0.17
BLCA	chr8	143920154	Nonsense_Mutation	NA	E3360*	0.15
BLCA	chr8	143920526	Missense_Mutation	novel	E3236Q	0.08
BLCA	chr8	143943899	Intron	rs782271543		0.33
BLCA	chr8	143921499	Silent	novel	V2911V	0.19
BLCA	chr8	143918676	Silent	novel	L3852L	0.07
BLCA	chr8	143925574	Nonsense_Mutation	novel	E1589delinsALPI*	0.15
BLCA	chr8	143924153	Missense_Mutation	rs782016873	E2063K	0.38
BLCA	chr8	143925803	Missense_Mutation	novel	A1513S	0.14
BLCA	chr8	143938680	Missense_Mutation	rs781949709	R179H	0.4
BLCA	chr8	143920461	Silent	novel	L3257L	0.27
BLCA	chr8	143925341	In_Frame_Del	novel	V1658_R1666del	0.63
BLCA	chr8	143917138	Missense_Mutation	NA	S4365F	0.13
BLCA	chr8	143925336	In_Frame_Del	novel	A1660_K1668del	0.42
BLCA	chr8	143917598	Missense_Mutation	novel	E4212Q	0.11
BLCA	chr8	143919239	Missense_Mutation	novel	E3665K	0.15
BLCA	chr8	143922360	Missense_Mutation	novel	E2624D	0.27
BLCA	chr8	143924133	Silent	rs375568532	A2069A	0.25
BRCA	chr8	143921646	Silent	NA	T2862T	0.11
BRCA	chr8	143921697	Missense_Mutation	NA	E2845D	0.14
BRCA	chr8	143921480	Missense_Mutation	novel	Y2918H	0.15
BRCA	chr8	143935313	Splice_Region	novel	K338K	0.09
BRCA	chr8	143943841	Intron	novel		0.1
BRCA	chr8	143919255	Silent	rs200741156	T3659T	0.39
BRCA	chr8	143935017	Missense_Mutation	NA	R410S	0.41
BRCA	chr8	143950535	Missense_Mutation	rs782166303	R58W	0.4	S10_plectin
BRCA	chr8	143953880	5'Flank	novel		0.67
BRCA	chr8	143932444	Missense_Mutation	NA	S782G	0.2
BRCA	chr8	143939499	Intron	novel		0.19
BRCA	chr8	143927022	Silent	NA	A1437A	0.22
BRCA	chr8	143950485	Silent	novel	L74L	0.26
BRCA	chr8	143932481	Silent	NA	L769L	0.48
BRCA	chr8	143920097	Missense_Mutation	NA	P3379A	0.18
BRCA	chr8	143926992	Missense_Mutation	NA	E1447D	0.16
BRCA	chr8	143923068	Silent	NA	A2424A	0.3
BRCA	chr8	143916917	Silent	novel	L4439L	0.17
BRCA	chr8	143933259	Silent	NA	L589L	0.15
BRCA	chr8	143921137	Missense_Mutation	NA	V3032A	0.19
BRCA	chr8	143917364	Missense_Mutation	NA	S4290P	0.4
BRCA	chr8	143931577	Missense_Mutation	NA	S891C	0.7
BRCA	chr8	143919271	Missense_Mutation	rs368982802	T3654M	0.43
BRCA	chr8	143933194	Splice_Region	novel		0.19
BRCA	chr8	143932843	Nonsense_Mutation	novel	Q700*	0.5
BRCA	chr8	143918949	Missense_Mutation	rs782341937	E3761D	0.18
CESC	chr8	143924244	Silent	NA	L2032L	0.23
CESC	chr8	143932803	Missense_Mutation	rs199826059	R713Q	0.42
CESC	chr8	143922396	Splice_Site	NA	X2613_splice	0.2
CESC	chr8	143923326	Missense_Mutation	NA	Q2338H	0.23
CESC	chr8	143923523	Missense_Mutation	NA	E2273Q	0.25
CESC	chr8	143925521	Missense_Mutation	rs782341251	G1607R	0.39
CESC	chr8	143919012	Silent	NA	Q3740Q	0.35
CESC	chr8	143921195	Missense_Mutation	rs782517831	E3013K	0.07
CESC	chr8	143917406	Missense_Mutation	NA	R4276C	0.36
CESC	chr8	143918528	Missense_Mutation	NA	E3902K	0.39
CESC	chr8	143918967	Missense_Mutation	NA	M3755I	0.33
CESC	chr8	143918533	Missense_Mutation	rs377598440	S3900L	0.32
CESC	chr8	143950241	Missense_Mutation	NA	P156S	0.5
CESC	chr8	143933003	Missense_Mutation	NA	Q646H	0.39
CESC	chr8	143918669	Missense_Mutation	rs201007788	E3855K	0.36
CESC	chr8	143927859	Missense_Mutation	NA	L1269V	0.29
CESC	chr8	143924318	Missense_Mutation	rs782008499	E2008K	0.21
CESC	chr8	143930152	Silent	NA	A1005A	0.22
CESC	chr8	143939543	Intron	novel		0.44
CESC	chr8	143950398	Silent	rs781796596	P103P	0.35
CESC	chr8	143950418	Missense_Mutation	NA	L97V	0.34	S10_plectin
CESC	chr8	143950675	Frame_Shift_Ins	novel	*Q11Pfs15**	0.13	S10_plectin
CESC	chr8	143918659	Missense_Mutation	rs781986718	R3858H	0.18
CESC	chr8	143915265	3'UTR	novel		0.5
CESC	chr8	143917193	Missense_Mutation	rs199941693	A4347T	0.32
CESC	chr8	143921429	Missense_Mutation	rs782431119	V2935I	0.08
CESC	chr8	143922272	Missense_Mutation	novel	E2654K	0.61
CESC	chr8	143927581	Silent	rs782335843	T1332T	0.35
CESC	chr8	143933249	Missense_Mutation	rs782655007	V593M	0.37
CESC	chr8	143950606	Missense_Mutation	novel	R34L	0.08	S10_plectin
CESC	chr8	143920045	Missense_Mutation	NA	S3396C	0.29
CESC	chr8	143920833	Silent	NA	L3133L	0.83
CESC	chr8	143922633	Silent	NA	Q2569Q	0.26
CESC	chr8	143918937	Silent	novel	K3765K	0.22
CESC	chr8	143924352	Missense_Mutation	novel	K1996N	0.32
CESC	chr8	143929694	Missense_Mutation	rs201071539	G1096S	0.25
CESC	chr8	143935083	Silent	NA	I388I	0.21
CESC	chr8	143920428	Silent	NA	L3268L	0.18
CESC	chr8	143922599	Missense_Mutation	novel	D2581H	0.17
CESC	chr8	143923209	Silent	novel	L2377L	0.26
CESC	chr8	143924261	Missense_Mutation	novel	D2027N	0.2
CESC	chr8	143915961	3'UTR	novel		0.21
CESC	chr8	143920028	Missense_Mutation	NA	E3402Q	0.19
CESC	chr8	143922329	Nonsense_Mutation	NA	E2635*	0.26
CESC	chr8	143923286	Missense_Mutation	NA	E2352Q	0.15
CESC	chr8	143921949	Missense_Mutation	NA	K2761N	0.56
CESC	chr8	143931961	Silent	novel	L855L	0.17
CESC	chr8	143938164	Missense_Mutation	novel	S221L	0.45
CESC	chr8	143950643	Missense_Mutation	rs782673771	E22K	0.24	S10_plectin
CESC	chr8	143921345	Missense_Mutation	rs371422018	V2963M	0.46
CESC	chr8	143923287	Silent	rs559736151	A2351A	0.33
CHOL	chr8	143917505	Nonsense_Mutation	NA	E4243*	0.23
CHOL	chr8	143953868	5'Flank	novel		0.46
COAD	chr8	143921803	Missense_Mutation	rs368335274	A2810V	0.12
COAD	chr8	143921737	Missense_Mutation	novel	R2832L	0.14
COAD	chr8	143932431	Missense_Mutation	NA	T786I	0.16
COAD	chr8	143934841	Missense_Mutation	NA	R442H	0.37
COAD	chr8	143937190	Missense_Mutation	novel	A243D	0.29
COAD	chr8	143920066	Missense_Mutation	rs781828296	T3389M	0.26
COAD	chr8	143930474	Missense_Mutation	NA	K926N	0.32
COAD	chr8	143933305	Frame_Shift_Ins	NA	*E574Gfs11**	0.22
COAD	chr8	143919105	Silent	rs34365303	I3709I	0.46
COAD	chr8	143921267	Missense_Mutation	novel	G2989C	0.08
COAD	chr8	143918688	Missense_Mutation	novel	K3848N	0.13
COAD	chr8	143920544	Nonsense_Mutation	NA	E3230*	0.39
COAD	chr8	143932989	Missense_Mutation	rs781887816	R651H	0.25
COAD	chr8	143935071	Silent	NA	V392V	0.4
COAD	chr8	143935883	Silent	rs782104325	D326D	0.24
COAD	chr8	143926820	Missense_Mutation	novel	F1473L	0.32
COAD	chr8	143953796	5'Flank	novel		0.37
COAD	chr8	143921510	Missense_Mutation	novel	E2908K	0.12
COAD	chr8	143919695	Missense_Mutation	rs782455932	R3513C	0.46
COAD	chr8	143932810	Missense_Mutation	rs782724039	R711W	0.23
COAD	chr8	143916877	Missense_Mutation	novel	Q4452R	0.37
COAD	chr8	143920925	Nonsense_Mutation	novel	Q3103*	0.1
COAD	chr8	143922149	Missense_Mutation	NA	R2695W	0.67
COAD	chr8	143919043	Missense_Mutation	rs782707803	S3730L	0.19
COAD	chr8	143919104	Missense_Mutation	NA	D3710N	0.48
COAD	chr8	143918179	Missense_Mutation	rs199504789	R4018H	0.43
COAD	chr8	143932795	Missense_Mutation	novel	E716K	0.32
COAD	chr8	143919178	Missense_Mutation	rs782153391	K3685R	0.36
COAD	chr8	143919877	Missense_Mutation	NA	S3452N	0.28
COAD	chr8	143922960	Silent	rs531846605	T2460T	0.29
COAD	chr8	143917411	Missense_Mutation	rs781988786	R4274H	0.28
COAD	chr8	143919395	Missense_Mutation	rs782148173	D3613N	0.11
COAD	chr8	143922791	Missense_Mutation	rs531930290	A2517T	0.36
COAD	chr8	143921685	Silent	NA	V2849V	0.3
COAD	chr8	143922584	Missense_Mutation	rs571406033	R2586W	0.49
COAD	chr8	143932985	Silent	rs199968254	P652P	0.46
COAD	chr8	143921005	Missense_Mutation	rs375208309	R3076Q	0.37
COAD	chr8	143919404	Missense_Mutation	rs201765507	G3610S	0.3
COAD	chr8	143920030	Missense_Mutation	rs200413602	A3401V	0.28
COAD	chr8	143927731	Silent	rs556372016	T1282T	0.19
COAD	chr8	143953737	5'Flank	NA		0.33
COAD	chr8	143918897	Missense_Mutation	novel	Y3779H	0.13
COAD	chr8	143937031	Missense_Mutation	novel	G265D	0.07
COAD	chr8	143921346	Silent	rs374602421	P2962P	0.2
COAD	chr8	143918717	Nonsense_Mutation	NA	Q3839*	0.19
COAD	chr8	143945234	Intron	rs782675850		0.31
COAD	chr8	143923256	Nonsense_Mutation	novel	Q2362*	0.09
COAD	chr8	143916581	Missense_Mutation	rs200447944	R4551C	0.31
COAD	chr8	143920994	Missense_Mutation	rs760837198	R3080W	0.18
COAD	chr8	143925461	Nonsense_Mutation	novel	R1627*	0.16
COAD	chr8	143931644	Missense_Mutation	rs782679986	R869W	0.16
COAD	chr8	143932225	Missense_Mutation	rs372672134	R800W	0.09
COAD	chr8	143950592	Frame_Shift_Del	rs782253915	*H39Mfs69**	0.16	S10_plectin
COAD	chr8	143924119	Missense_Mutation	rs782698507	A2074V	0.39
COAD	chr8	143935074	Silent	rs781860563	Y391Y	0.27
COAD	chr8	143925802	Missense_Mutation	novel	A1513V	0.73
COAD	chr8	143920793	Missense_Mutation	rs782145186	V3147I	0.5
COAD	chr8	143922181	Missense_Mutation	novel	R2684Q	0.42
COAD	chr8	143932458	Missense_Mutation	NA	V777E	0.29
COAD	chr8	143934441	Missense_Mutation	NA	A486V	0.41
COAD	chr8	143938159	Frame_Shift_Del	novel	*D223Tfs30**	0.47
COAD	chr8	143950258	Missense_Mutation	NA	P150H	0.27
COAD	chr8	143920794	Silent	rs782802729	D3146D	0.38
COAD	chr8	143918394	Silent	rs782372017	I3946I	0.38
COAD	chr8	143916325	In_Frame_Del	novel	T4628_R4639del	0.29
COAD	chr8	143924107	Missense_Mutation	novel	K2078T	0.19
COAD	chr8	143922661	Missense_Mutation	novel	A2560V	0.26
COAD	chr8	143932707	Silent	NA	Q718Q	0.32
COAD	chr8	143921006	Missense_Mutation	rs782575301	R3076W	0.25
COAD	chr8	143927967	Missense_Mutation	rs533410461	R1233C	0.16
COAD	chr8	143921312	Missense_Mutation	rs199661077	E2974K	0.27
COAD	chr8	143930534	Splice_Region	rs781821809	D906D	0.21
COAD	chr8	143935115	Missense_Mutation	NA	V378M	0.14
COAD	chr8	143918985	Silent	NA	R3749R	0.22
COAD	chr8	143950845	5'UTR	novel		0.43
COAD	chr8	143919105	Silent	rs34365303	I3709I	0.26
COAD	chr8	143922255	Silent	rs372843420	D2659D	0.21
COAD	chr8	143923095	Missense_Mutation	NA	E2415D	0.27
COAD	chr8	143923435	Missense_Mutation	rs377663841	A2302V	0.24
COAD	chr8	143933299	Missense_Mutation	novel	E576G	0.06
DLBC	chr8	143923650	Silent	rs539190005	A2230A	0.23
DLBC	chr8	143920024	Missense_Mutation	rs782277164	Q3403R	0.19
DLBC	chr8	143935887	Missense_Mutation	novel	R325K	0.18
ESCA	chr8	143934325	Missense_Mutation	novel	F525L	0.3
ESCA	chr8	143915220	3'UTR	novel		0.29
ESCA	chr8	143920590	Silent	rs782504063	T3214T	0.29
ESCA	chr8	143922377	Missense_Mutation	novel	E2619Q	0.28
ESCA	chr8	143922555	Missense_Mutation	NA	E2595D	0.32
ESCA	chr8	143922624	Silent	novel	E2572E	0.19
ESCA	chr8	143920956	Silent	novel	I3092I	0.11
ESCA	chr8	143922854	Missense_Mutation	novel	E2496K	0.14
ESCA	chr8	143930496	Missense_Mutation	novel	S919L	0.18
ESCA	chr8	143918862	Silent	rs373814127	F3790F	0.1
ESCA	chr8	143917142	Missense_Mutation	rs782010335	L4364F	0.22
ESCA	chr8	143920108	Missense_Mutation	rs782085661	P3375L	0.1
ESCA	chr8	143930451	Missense_Mutation	novel	R934H	0.11
ESCA	chr8	143915327	3'UTR	novel		0.79
ESCA	chr8	143920018	Missense_Mutation	novel	Q3405R	0.39
ESCA	chr8	143920232	Nonsense_Mutation	novel	Q3334*	0.23
ESCA	chr8	143915606	3'UTR	rs530662366		0.2
ESCA	chr8	143938642	Missense_Mutation	novel	H192N	0.1
GBM	chr8	143918167	Missense_Mutation	NA	F4022S	0.26
GBM	chr8	143917977	Silent	rs782025071	S4085S	0.35
GBM	chr8	143917220	Missense_Mutation	rs782591407	R4338C	0.44
GBM	chr8	143919396	Silent	rs782809989	I3612I	0.46
GBM	chr8	143919551	Missense_Mutation	rs371846683	E3561K	0.26
GBM	chr8	143920928	Nonsense_Mutation	novel	E3102*	0.15
GBM	chr8	143921005	Missense_Mutation	rs375208309	R3076Q	0.51
GBM	chr8	143924151	Missense_Mutation	novel	E2063D	0.53
GBM	chr8	143931973	Silent	rs782027096	I851I	0.56
GBM	chr8	143935942	Nonsense_Mutation	novel	R307*	0.51
GBM	chr8	143927287	Nonsense_Mutation	NA	Q1406*	0.14
GBM	chr8	143927288	Silent	rs782001764	C1405C	0.14
GBM	chr8	143916372	Silent	rs782187551	S4620S	0.82
GBM	chr8	143919749	Missense_Mutation	rs533543775	A3495T	0.66
GBM	chr8	143950638	Silent	novel	G23G	0.69
GBM	chr8	143919663	Silent	rs373820763	A3523A	0.5
GBM	chr8	143918561	Missense_Mutation	novel	G3891R	0.43
GBM	chr8	143920348	Missense_Mutation	novel	C3295Y	0.41
GBM	chr8	143922690	Silent	novel	I2550I	0.45
GBM	chr8	143923036	Missense_Mutation	novel	E2435G	0.1
GBM	chr8	143929971	Missense_Mutation	rs199833127	D1039N	0.5
GBM	chr8	143933998	Splice_Region	novel	S558S	0.35
GBM	chr8	143920817	Nonsense_Mutation	rs137853161	R3139*	0.46
GBM	chr8	143917830	Silent	NA	G4134G	0.34
GBM	chr8	143931989	Frame_Shift_Del	novel	*Q846Afs38**	0.17
GBM	chr8	143916590	Missense_Mutation	NA	A4548T	0.09
HNSC	chr8	143924002	Missense_Mutation	rs781911978	A2113V	0.53
HNSC	chr8	143918525	Missense_Mutation	novel	R3903W	0.29
HNSC	chr8	143921966	Missense_Mutation	novel	Q2756K	0.37
HNSC	chr8	143918610	Silent	novel	V3874V	0.36
HNSC	chr8	143917359	Silent	novel	V4291V	0.08
HNSC	chr8	143921201	Missense_Mutation	novel	D3011N	0.38
HNSC	chr8	143917581	Silent	novel	L4217L	0.23
HNSC	chr8	143923934	Missense_Mutation	novel	E2136Q	0.15
HNSC	chr8	143932954	Nonsense_Mutation	novel	Q663*	0.2
HNSC	chr8	143917269	Silent	novel	S4321S	0.07
HNSC	chr8	143934717	Missense_Mutation	novel	Q457R	0.16
HNSC	chr8	143922148	Missense_Mutation	rs782713454	R2695Q	0.27
HNSC	chr8	143927572	Silent	novel	R1335R	0.11
HNSC	chr8	143927673	Nonsense_Mutation	novel	Q1302*	0.3
HNSC	chr8	143932523	Frame_Shift_Ins	novel	*L755Ffs10**	0.41
HNSC	chr8	143932975	Missense_Mutation	novel	D656N	0.26
HNSC	chr8	143950364	Frame_Shift_Del	NA	*H115Tfs138**	0.6
HNSC	chr8	143950638	Silent	novel	G23G	0.33
HNSC	chr8	143924124	Silent	novel	E2072E	0.34
HNSC	chr8	143942485	Intron	novel		0.62
HNSC	chr8	143938684	Missense_Mutation	novel	D178N	0.21
HNSC	chr8	143919318	Silent	novel	V3638V	0.16
HNSC	chr8	143926844	Silent	rs535828050	T1465T	0.09
HNSC	chr8	143922377	Missense_Mutation	novel	E2619K	0.15
HNSC	chr8	143923887	Silent	novel	L2151L	0.1
HNSC	chr8	143919624	Silent	NA	V3536V	0.24
HNSC	chr8	143917522	Missense_Mutation	novel	T4237I	0.38
HNSC	chr8	143927513	Missense_Mutation	novel	P1355L	0.5
HNSC	chr8	143919694	Missense_Mutation	rs781908703	R3513H	0.31
HNSC	chr8	143918067	Silent	rs781980270	I4055I	0.22
HNSC	chr8	143927990	Frame_Shift_Ins	novel	*L1225Qfs66**	0.08
HNSC	chr8	143922227	Missense_Mutation	novel	E2669Q	0.2
HNSC	chr8	143918036	Silent	novel	L4066L	0.41
HNSC	chr8	143920305	Silent	rs782474875	S3309S	0.25
HNSC	chr8	143919587	Missense_Mutation	novel	A3549T	0.25
HNSC	chr8	143922782	Missense_Mutation	novel	E2520K	0.26
HNSC	chr8	143920191	Silent	novel	L3347L	0.09
HNSC	chr8	143934410	Frame_Shift_Ins	novel	*G497Wfs30**	0.35
HNSC	chr8	143927028	Silent	novel	S1435S	0.36
HNSC	chr8	143921505	Silent	rs782420340	R2909R	0.25
HNSC	chr8	143924915	Missense_Mutation	rs782791575	E1809K	0.23
HNSC	chr8	143923289	Missense_Mutation	novel	A2351T	0.3
HNSC	chr8	143918625	Silent	novel	F3869F	0.25
HNSC	chr8	143920914	Silent	novel	K3106K	0.24
HNSC	chr8	143923541	Missense_Mutation	novel	Q2267E	0.13
HNSC	chr8	143938202	Silent	novel	R208R	0.07
HNSC	chr8	143953787	5'Flank	novel		0.11
HNSC	chr8	143921241	Silent	novel	E2997E	0.19
HNSC	chr8	143922227	Missense_Mutation	novel	E2669K	0.56
HNSC	chr8	143938664	Silent	rs782244901	T184T	0.16
HNSC	chr8	143922141	Silent	novel	H2697H	0.7
HNSC	chr8	143916452	Missense_Mutation	novel	E4594K	0.19
HNSC	chr8	143919137	Missense_Mutation	novel	E3699K	0.19
HNSC	chr8	143919824	Missense_Mutation	novel	D3470N	0.22
HNSC	chr8	143920118	Missense_Mutation	novel	E3372Q	0.18
HNSC	chr8	143920209	Silent	novel	L3341L	0.13
HNSC	chr8	143920544	Missense_Mutation	novel	E3230K	0.23
HNSC	chr8	143920928	Missense_Mutation	rs782058888	E3102K	0.28
HNSC	chr8	143921670	Silent	novel	Q2854Q	0.38
HNSC	chr8	143923187	Missense_Mutation	novel	E2385K	0.16
HNSC	chr8	143923586	Missense_Mutation	rs782713908	E2252K	0.23
HNSC	chr8	143923970	Missense_Mutation	novel	E2124K	0.21
HNSC	chr8	143924361	Silent	novel	L1993L	0.44
HNSC	chr8	143934696	Missense_Mutation	novel	M464K	0.31
HNSC	chr8	143916580	Missense_Mutation	rs373265918	R4551H	0.08
HNSC	chr8	143917274	Missense_Mutation	novel	I4320F	0.17
HNSC	chr8	143918298	Frame_Shift_Del	novel	*L3974Rfs26**	0.47
HNSC	chr8	143927030	Missense_Mutation	novel	S1435T	0.17
HNSC	chr8	143919102	Silent	rs782356658	D3710D	0.38
HNSC	chr8	143920787	Missense_Mutation	novel	E3149Q	0.37
HNSC	chr8	143917889	Missense_Mutation	rs369738267	D4115N	0.33
HNSC	chr8	143917415	Missense_Mutation	rs749212061	V4273M	0.21
HNSC	chr8	143930141	Splice_Region	novel		0.56
HNSC	chr8	143937062	Missense_Mutation	novel	V255L	0.42
HNSC	chr8	143929724	Missense_Mutation	rs372173655	E1086K	0.33
HNSC	chr8	143919895	Missense_Mutation	novel	R3446L	0.13
HNSC	chr8	143927470	Missense_Mutation	novel	Q1369H	0.16
HNSC	chr8	143917090	Missense_Mutation	rs370769102	R4381H	0.29
HNSC	chr8	143923617	Silent	rs782048792	A2241A	0.5
HNSC	chr8	143919083	In_Frame_Del	novel	G3713_H3717delinsD	0.12
HNSC	chr8	143927650	Silent	novel	V1309V	0.5
HNSC	chr8	143919836	Missense_Mutation	novel	E3466Q	0.19
HNSC	chr8	143927526	Missense_Mutation	novel	E1351K	0.18
HNSC	chr8	143921352	Silent	rs782214798	R2960R	0.11
HNSC	chr8	143918861	Missense_Mutation	novel	E3791Q	0.11
KICH	chr8	143921379	Silent	rs186703073	G2951G	0.25
KIRC	chr8	143917847	Missense_Mutation	rs782528455	R4129C	0.33
KIRC	chr8	143921700	Silent	NA	N2844N	0.31
KIRC	chr8	143921647	Missense_Mutation	rs371900885	T2862M	0.1
KIRC	chr8	143953806	5'Flank	novel		0.36
KIRC	chr8	143933201	Missense_Mutation	rs559590378	R609C	0.42
KIRC	chr8	143918275	Missense_Mutation	NA	P3986Q	0.77
KIRC	chr8	143917301	Nonsense_Mutation	novel	Q4311*	0.28
KIRC	chr8	143917302	Silent	novel	E4310E	0.28
KIRC	chr8	143925717	Silent	NA	R1541R	0.54
KIRP	chr8	143916687	Missense_Mutation	novel	W4515C	0.52
KIRP	chr8	143923540	Missense_Mutation	NA	Q2267L	0.25
KIRP	chr8	143921124	Silent	novel	S3036S	0.52
KIRP	chr8	143923464	Silent	novel	A2292A	0.44
KIRP	chr8	143925107	Missense_Mutation	novel	E1745K	0.22
KIRP	chr8	143924289	Silent	rs782152422	L2017L	0.44
KIRP	chr8	143923437	Silent	rs575031901	D2301D	0.09
LGG	chr8	143918830	Missense_Mutation	rs782426059	N3801S	0.1
LGG	chr8	143921802	Silent	rs374178650	A2810A	0.53
LGG	chr8	143917228	Missense_Mutation	rs782499153	R4335H	0.33
LGG	chr8	143925253	Missense_Mutation	rs371895113	R1696Q	0.22
LGG	chr8	143933044	Missense_Mutation	rs201553684	V633M	0.5
LGG	chr8	143919577	Missense_Mutation	rs201343829	A3552V	0.33
LGG	chr8	143920646	Missense_Mutation	novel	E3196K	0.29
LGG	chr8	143925437	Missense_Mutation	rs782021381	R1635C	0.38
LGG	chr8	143927658	Missense_Mutation	rs782194062	R1307W	0.33
LGG	chr8	143930205	Missense_Mutation	rs200647397	V988M	0.5
LGG	chr8	143937238	Missense_Mutation	rs782376931	R227Q	0.29
LGG	chr8	143942488	Intron	novel		0.56
LGG	chr8	143921564	Missense_Mutation	NA	A2890T	0.43
LIHC	chr8	143927722	Silent	rs782313733	A1285A	0.19
LIHC	chr8	143930207	Missense_Mutation	novel	A987D	0.09
LIHC	chr8	143919511	Missense_Mutation	novel	R3574K	0.17
LIHC	chr8	143927559	Missense_Mutation	novel	E1340K	0.34
LIHC	chr8	143922543	Silent	NA	L2599L	0.47
LIHC	chr8	143919997	Missense_Mutation	rs782481395	R3412H	0.09
LIHC	chr8	143924163	Missense_Mutation	novel	Q2059H	0.14
LIHC	chr8	143917193	Missense_Mutation	rs199941693	A4347T	0.09
LIHC	chr8	143917430	Missense_Mutation	NA	S4268A	0.14
LIHC	chr8	143916315	In_Frame_Del	novel	T4628_R4639del	0.27
LIHC	chr8	143929200	Missense_Mutation	novel	E1192Q	0.29
LUAD	chr8	143920740	Silent	novel	A3164A	0.5
LUAD	chr8	143917365	Missense_Mutation	NA	M4289I	0.44
LUAD	chr8	143923513	Missense_Mutation	novel	R2276L	0.1
LUAD	chr8	143924021	Missense_Mutation	novel	A2107P	0.45
LUAD	chr8	143938201	Missense_Mutation	novel	D209Y	0.73
LUAD	chr8	143918669	Nonsense_Mutation	NA	E3855*	0.23
LUAD	chr8	143921823	Frame_Shift_Del	novel	*Q2793Rfs37**	0.26
LUAD	chr8	143916371	Missense_Mutation	novel	G4621C	0.07
LUAD	chr8	143920050	Silent	NA	I3394I	0.24
LUAD	chr8	143924171	Missense_Mutation	rs781860739	R2057W	0.29
LUAD	chr8	143939493	Intron	novel		0.5
LUAD	chr8	143929709	Missense_Mutation	novel	A1091S	0.22
LUAD	chr8	143917541	Missense_Mutation	novel	N4231D	0.37
LUAD	chr8	143932806	Missense_Mutation	NA	A712V	0.3
LUAD	chr8	143923262	Missense_Mutation	rs200620255	R2360C	0.12
LUAD	chr8	143938655	Missense_Mutation	novel	K187N	0.08
LUAD	chr8	143932524	Missense_Mutation	novel	L755S	0.16
LUAD	chr8	143916849	Silent	NA	P4461P	0.11
LUAD	chr8	143916854	Missense_Mutation	rs782787833	D4460N	0.16
LUAD	chr8	143931975	Missense_Mutation	rs189137260	I851V	0.28
LUAD	chr8	143920789	Missense_Mutation	NA	A3148G	0.24
LUAD	chr8	143916667	Missense_Mutation	novel	Q4522L	0.29
LUAD	chr8	143919409	Missense_Mutation	novel	T3608R	0.54
LUAD	chr8	143919977	Missense_Mutation	novel	E3419Q	0.06
LUAD	chr8	143923902	Missense_Mutation	NA	E2146D	0.26
LUAD	chr8	143935055	Missense_Mutation	rs782693579	A398T	0.2
LUAD	chr8	143916922	Missense_Mutation	rs371875530	R4437Q	0.07
LUAD	chr8	143918985	Silent	novel	R3749R	0.13
LUAD	chr8	143918800	Missense_Mutation	rs782720846	R3811H	0.13
LUAD	chr8	143929730	Nonsense_Mutation	NA	G1084*	0.56
LUAD	chr8	143916835	Missense_Mutation	NA	R4466L	0.43
LUAD	chr8	143919180	Missense_Mutation	NA	E3684D	0.14
LUAD	chr8	143916983	Missense_Mutation	NA	V4417M	0.22
LUAD	chr8	143923184	Missense_Mutation	novel	A2386P	0.29
LUAD	chr8	143924445	Silent	novel	R1965R	0.54
LUAD	chr8	143917298	Missense_Mutation	novel	E4312Q	0.48
LUAD	chr8	143917835	Missense_Mutation	NA	V4133L	0.26
LUAD	chr8	143918003	Missense_Mutation	novel	V4077L	0.5
LUAD	chr8	143919518	Missense_Mutation	rs375044211	G3572S	0.29
LUAD	chr8	143921756	Missense_Mutation	rs373228579	R2826C	0.13
LUAD	chr8	143918513	Missense_Mutation	NA	G3907S	0.6
LUAD	chr8	143922609	Missense_Mutation	novel	Q2577H	0.35
LUAD	chr8	143917800	Silent	rs555118583	A4144A	0.26
LUAD	chr8	143918589	Silent	NA	V3881V	0.73
LUAD	chr8	143922727	Missense_Mutation	NA	E2538V	0.72
LUAD	chr8	143918967	Missense_Mutation	NA	M3755I	0.15
LUAD	chr8	143916567	Silent	rs782213390	D4555D	0.22
LUAD	chr8	143920589	Missense_Mutation	novel	V3215L	0.28
LUAD	chr8	143916373	Missense_Mutation	novel	S4620F	0.41
LUAD	chr8	143932021	Silent	rs373347166	A835A	0.42
LUAD	chr8	143920658	Missense_Mutation	novel	V3192L	0.25
LUAD	chr8	143923071	Silent	rs200335976	A2423A	0.2
LUAD	chr8	143935967	In_Frame_Del	novel	T296_K298del	0.32
LUAD	chr8	143922601	Missense_Mutation	novel	H2580R	0.15
LUAD	chr8	143936990	Missense_Mutation	NA	L279V	0.19
LUAD	chr8	143920172	Missense_Mutation	novel	A3354P	0.09
LUAD	chr8	143937024	Silent	rs782187697	P267P	0.21
LUAD	chr8	143919422	Missense_Mutation	NA	A3604S	0.13
LUAD	chr8	143919407	Missense_Mutation	NA	G3609C	0.26
LUAD	chr8	143923138	Missense_Mutation	novel	R2401L	0.17
LUAD	chr8	143923288	Missense_Mutation	rs781956194	A2351V	0.32
LUAD	chr8	143923406	Missense_Mutation	rs375723079	E2312K	0.09
LUAD	chr8	143926870	Missense_Mutation	rs372256096	R1457C	0.06
LUAD	chr8	143935901	Silent	NA	F320F	0.32
LUAD	chr8	143917962	Missense_Mutation	NA	M4090I	0.19
LUAD	chr8	143918798	Missense_Mutation	NA	E3812K	0.15
LUAD	chr8	143918316	Silent	NA	D3972D	0.1
LUAD	chr8	143923486	Missense_Mutation	rs199821611	R2285Q	0.5
LUAD	chr8	143920995	Silent	novel	L3079L	0.37
LUAD	chr8	143919518	Missense_Mutation	NA	G3572R	0.22
LUAD	chr8	143929509	Silent	rs782253745	L1133L	0.13
LUAD	chr8	143919750	Silent	rs782511815	L3494L	0.29
LUAD	chr8	143918560	Missense_Mutation	novel	G3891V	0.44
LUAD	chr8	143916539	Missense_Mutation	NA	V4565L	0.67
LUAD	chr8	143934710	Silent	novel	L459L	0.43
LUSC	chr8	143921310	Missense_Mutation	rs369984112	E2974D	0.31
LUSC	chr8	143922039	Silent	novel	L2731L	0.55
LUSC	chr8	143917154	Missense_Mutation	novel	R4360C	0.57
LUSC	chr8	143917903	Missense_Mutation	novel	T4110N	0.29
LUSC	chr8	143929193	Missense_Mutation	rs782710264	S1194L	0.17
LUSC	chr8	143922573	Silent	rs199958797	I2589I	0.17
LUSC	chr8	143921267	Missense_Mutation	novel	G2989C	0.22
LUSC	chr8	143925349	Missense_Mutation	rs782569624	A1664G	0.54
LUSC	chr8	143929775	Missense_Mutation	NA	H1069Y	0.13
LUSC	chr8	143916838	Missense_Mutation	novel	E4465G	0.12
LUSC	chr8	143917136	Missense_Mutation	novel	I4366V	0.32
LUSC	chr8	143923578	Silent	NA	L2254L	0.37
LUSC	chr8	143932205	Silent	NA	E806E	0.08
LUSC	chr8	143932468	Nonsense_Mutation	NA	E774*	0.27
LUSC	chr8	143916672	Silent	rs199719299	A4520A	0.08
LUSC	chr8	143918900	Missense_Mutation	novel	D3778Y	0.27
LUSC	chr8	143919483	Silent	rs62642461	S3583S	0.3
LUSC	chr8	143920612	Missense_Mutation	novel	P3207L	0.1
LUSC	chr8	143924881	Missense_Mutation	novel	A1820V	0.15
LUSC	chr8	143921019	Silent	novel	T3071T	0.06
LUSC	chr8	143916837	Missense_Mutation	novel	E4465D	0.13
LUSC	chr8	143916839	Missense_Mutation	novel	E4465K	0.13
LUSC	chr8	143917029	Missense_Mutation	novel	R4401S	0.15
LUSC	chr8	143916693	Silent	novel	K4513K	0.44
LUSC	chr8	143920141	Frame_Shift_Ins	novel	*E3364Gfs30**	0.05
LUSC	chr8	143925687	Silent	novel	Q1551Q	0.33
LUSC	chr8	143919360	Silent	NA	V3624V	0.31
LUSC	chr8	143920667	Missense_Mutation	NA	D3189Y	0.14
LUSC	chr8	143922673	Missense_Mutation	rs554586153	R2556L	0.21
LUSC	chr8	143919294	Silent	NA	T3646T	0.1
LUSC	chr8	143924156	Nonsense_Mutation	NA	E2062*	0.6
LUSC	chr8	143924298	Silent	novel	R2014R	0.42
LUSC	chr8	143927971	Silent	novel	V1231V	0.09
LUSC	chr8	143924134	Missense_Mutation	rs201624086	A2069V	0.15
LUSC	chr8	143920262	Missense_Mutation	novel	G3324R	0.21
LUSC	chr8	143922782	Missense_Mutation	novel	E2520Q	0.13
LUSC	chr8	143921019	Silent	novel	T3071T	0.8
LUSC	chr8	143919087	Silent	NA	G3715G	0.35
LUSC	chr8	143918955	In_Frame_Ins	novel	I3758_I3759insMISIII	0.17
LUSC	chr8	143950364	Frame_Shift_Del	NA	*H115Tfs138**	0.11
LUSC	chr8	143927550	Missense_Mutation	novel	G1343C	0.48
LUSC	chr8	143953796	5'Flank	novel		0.56
LUSC	chr8	143933344	Missense_Mutation	rs199965040	R561Q	0.12
LUSC	chr8	143927266	Missense_Mutation	novel	I1413F	0.15
LUSC	chr8	143924273	Missense_Mutation	novel	Q2023K	0.24
LUSC	chr8	143919448	Missense_Mutation	NA	R3595L	0.31
LUSC	chr8	143919270	Silent	novel	T3654T	0.47
LUSC	chr8	143921190	Silent	novel	T3014T	0.38
LUSC	chr8	143917020	Silent	NA	L4404L	0.21
LUSC	chr8	143932982	Missense_Mutation	novel	E653D	0.42
LUSC	chr8	143922319	Missense_Mutation	rs782359358	S2638I	0.29
LUSC	chr8	143924409	Silent	novel	A1977A	0.14
LUSC	chr8	143918753	Missense_Mutation	novel	G3827C	0.38
LUSC	chr8	143918754	Silent	novel	T3826T	0.37
LUSC	chr8	143919821	In_Frame_Del	novel	L3468_G3471delinsR	0.37
LUSC	chr8	143950379	Missense_Mutation	rs782783624	A110T	0.44
LUSC	chr8	143923171	Missense_Mutation	rs782329522	A2390V	0.31
LUSC	chr8	143923172	Missense_Mutation	novel	A2390S	0.3
LUSC	chr8	143920943	Missense_Mutation	NA	I3097L	0.1
LUSC	chr8	143917345	Missense_Mutation	novel	R4296P	0.15
LUSC	chr8	143917850	Missense_Mutation	novel	V4128L	0.14
LUSC	chr8	143918597	Frame_Shift_Del	novel	*Q3864Dfs4**	0.08
LUSC	chr8	143921997	Silent	novel	A2745A	0.22
LUSC	chr8	143925771	Silent	novel	A1523A	0.39
LUSC	chr8	143916726	Missense_Mutation	novel	K4502N	0.25
LUSC	chr8	143935069	Missense_Mutation	rs782798891	S393L	0.36
LUSC	chr8	143918565	Silent	novel	L3889L	0.42
LUSC	chr8	143932130	Missense_Mutation	novel	E831D	0.1
LUSC	chr8	143932400	Splice_Region	rs536284705	S796S	0.14
LUSC	chr8	143926829	Silent	novel	Y1470Y	0.37
LUSC	chr8	143919938	Missense_Mutation	novel	V3432L	0.66
LUSC	chr8	143920847	Missense_Mutation	novel	I3129V	0.58
LUSC	chr8	143920857	Missense_Mutation	novel	E3125D	0.26
LUSC	chr8	143922559	Missense_Mutation	novel	R2594L	0.44
LUSC	chr8	143920981	Missense_Mutation	rs782130064	T3084M	0.19
LUSC	chr8	143927928	Missense_Mutation	rs782316766	E1246K	0.47
LUSC	chr8	143916691	Missense_Mutation	NA	G4514A	0.28
LUSC	chr8	143918691	Silent	NA	L3847L	0.09
LUSC	chr8	143924019	Silent	rs370973974	A2107A	0.23
LUSC	chr8	143918987	Missense_Mutation	novel	R3749G	0.27
LUSC	chr8	143919521	Missense_Mutation	rs782257743	T3571S	0.28
LUSC	chr8	143919540	Silent	NA	L3564L	0.17
LUSC	chr8	143921324	Missense_Mutation	rs782099953	G2970S	0.08
OV	chr8	143916630	Silent	novel	L4534L	0.1
OV	chr8	143917577	Missense_Mutation	rs201221940	D4219N	0.06
OV	chr8	143917524	Silent	NA	L4236L	0.51
OV	chr8	143920948	Missense_Mutation	novel	I3095S	0.28
OV	chr8	143919916	Missense_Mutation	NA	R3439M	0.23
OV	chr8	143921471	Missense_Mutation	NA	Q2921E	0.2
OV	chr8	143938675	Missense_Mutation	novel	Q181K	0.21
OV	chr8	143918366	Missense_Mutation	NA	P3956S	0.5
OV	chr8	143919313	Missense_Mutation	novel	A3640G	0.42
OV	chr8	143916731	In_Frame_Del	novel	K4491_R4500del	0.39
PAAD	chr8	143917804	Missense_Mutation	rs200521669	S4143L	0.03
PAAD	chr8	143917941	Silent	novel	P4097P	0.12
PAAD	chr8	143920817	Nonsense_Mutation	rs137853161	R3139*	0.06
PAAD	chr8	143919929	Missense_Mutation	novel	L3435M	0.19
PAAD	chr8	143917041	Silent	rs782590185	P4397P	0.09
PAAD	chr8	143917377	Silent	rs143548638	T4285T	0.18
PAAD	chr8	143917431	Silent	rs200575172	T4267T	0.06
PAAD	chr8	143917537	Missense_Mutation	novel	T4232M	0.18
PAAD	chr8	143918830	Missense_Mutation	rs782426059	N3801S	0.12
PAAD	chr8	143920795	Missense_Mutation	novel	D3146G	0.18
PAAD	chr8	143921405	Missense_Mutation	novel	L2943M	0.18
PAAD	chr8	143921693	Silent	novel	L2847L	0.17
PAAD	chr8	143921760	Silent	rs542710594	D2824D	0.18
PAAD	chr8	143922653	Nonsense_Mutation	novel	E2563*	0.18
PAAD	chr8	143923172	Missense_Mutation	rs62641756	A2390T	0.22
PAAD	chr8	143923229	Missense_Mutation	rs782319175	R2371C	0.19
PAAD	chr8	143923530	Silent	rs375489890	A2270A	0.18
PAAD	chr8	143927510	Frame_Shift_Del	novel	*L1356Wfs69**	0.18
PAAD	chr8	143930158	Missense_Mutation	novel	Q1003H	0.25
PAAD	chr8	143932923	Missense_Mutation	novel	Q673P	0.18
PAAD	chr8	143933343	Silent	novel	R561R	0.17
PAAD	chr8	143934355	Missense_Mutation	novel	L515M	0.18
PAAD	chr8	143922302	Missense_Mutation	rs782503698	R2644C	0.1
PAAD	chr8	143917915	Missense_Mutation	rs782096389	A4106V	0.15
PAAD	chr8	143953742	5'Flank	novel		0.1
PRAD	chr8	143921116	Missense_Mutation	rs782819280	R3039Q	0.59
PRAD	chr8	143932505	Silent	rs782547448	A761A	0.19
PRAD	chr8	143917927	Frame_Shift_Ins	novel	*E4102Vfs20**	0.3
PRAD	chr8	143917928	Nonsense_Mutation	novel	E4102*	0.28
PRAD	chr8	143921755	Missense_Mutation	rs782161008	R2826H	0.16
PRAD	chr8	143942471	Intron	novel		0.22
PRAD	chr8	143919670	Missense_Mutation	rs782088523	T3521M	0.28
PRAD	chr8	143927538	Missense_Mutation	rs782365536	R1347C	0.24
PRAD	chr8	143924826	Silent	rs542255749	A1838A	0.31
PRAD	chr8	143929546	Missense_Mutation	NA	Q1120H	0.16
PRAD	chr8	143920845	Silent	NA	I3129I	0.07
PRAD	chr8	143916734	Missense_Mutation	rs782348944	R4500C	0.29
PRAD	chr8	143937239	Missense_Mutation	rs782648152	R227W	0.43
READ	chr8	143917090	Missense_Mutation	rs370769102	R4381H	0.27
READ	chr8	143917074	Silent	rs782377686	S4386S	0.47
READ	chr8	143919220	Missense_Mutation	NA	P3671H	0.09
READ	chr8	143916551	Frame_Shift_Del	NA	*K4561Afs3**	0.44
READ	chr8	143922856	Missense_Mutation	rs782367691	A2495V	0.18
READ	chr8	143924501	Missense_Mutation	NA	A1947P	0.34
READ	chr8	143919302	Missense_Mutation	rs200293573	D3644N	0.48
READ	chr8	143916879	Silent	rs375246252	A4451A	0.17
SARC	chr8	143918717	Frame_Shift_Del	novel	*G3831Dfs44**	0.34
SARC	chr8	143921265	Silent	novel	G2989G	0.23
SARC	chr8	143917160	Nonsense_Mutation	novel	Q4358*	0.18
SARC	chr8	143917161	Silent	novel	D4357D	0.18
SARC	chr8	143922324	Missense_Mutation	novel	K2636N	0.37
SARC	chr8	143917947	Silent	novel	I4095I	0.19
SARC	chr8	143919573	Silent	rs200805625	G3553G	0.27
SARC	chr8	143921551	Missense_Mutation	novel	G2894A	0.37
SARC	chr8	143923090	Missense_Mutation	NA	A2417V	0.22
SKCM	chr8	143922006	Silent	NA	H2742H	0.5
SKCM	chr8	143921775	Silent	rs375590561	L2819L	0.36
SKCM	chr8	143917194	Silent	rs372573622	I4346I	0.16
SKCM	chr8	143916756	Silent	novel	A4492A	0.37
SKCM	chr8	143924367	Silent	rs782000075	I1991I	0.45
SKCM	chr8	143924415	Missense_Mutation	NA	K1975N	0.32
SKCM	chr8	143932031	Missense_Mutation	novel	S832F	0.48
SKCM	chr8	143953818	5'Flank	novel		0.22
SKCM	chr8	143917584	Silent	novel	I4216I	0.18
SKCM	chr8	143929515	Missense_Mutation	NA	L1131V	0.63
SKCM	chr8	143929760	Silent	rs782546743	L1074L	0.67
SKCM	chr8	143923157	Missense_Mutation	NA	D2395H	0.17
SKCM	chr8	143917683	Silent	novel	Q4183Q	0.23
SKCM	chr8	143923812	Silent	NA	A2176A	0.28
SKCM	chr8	143924222	Missense_Mutation	novel	D2040N	0.36
SKCM	chr8	143925765	Silent	novel	R1525R	0.35
SKCM	chr8	143930425	Missense_Mutation	rs372400636	R943C	0.5
SKCM	chr8	143930426	Silent	novel	G942G	0.5
SKCM	chr8	143920477	Missense_Mutation	NA	S3252F	0.18
SKCM	chr8	143921511	Silent	rs782338339	A2907A	0.25
SKCM	chr8	143921727	Silent	rs782694404	I2835I	0.21
SKCM	chr8	143927560	Silent	rs781841776	L1339L	0.19
SKCM	chr8	143932451	Silent	NA	F779F	0.25
SKCM	chr8	143918670	Silent	rs781815870	A3854A	0.63
SKCM	chr8	143920445	Missense_Mutation	NA	P3263S	0.47
SKCM	chr8	143932464	Missense_Mutation	NA	E775V	0.53
SKCM	chr8	143918030	Missense_Mutation	NA	G4068S	0.47
SKCM	chr8	143917118	In_Frame_Del	novel	T4363_D4371del	0.27
SKCM	chr8	143920067	Missense_Mutation	NA	T3389A	0.06
SKCM	chr8	143920746	Silent	NA	V3162V	0.39
SKCM	chr8	143923902	Silent	NA	E2146E	0.63
SKCM	chr8	143924435	Missense_Mutation	novel	E1969K	0.62
SKCM	chr8	143924436	Silent	rs201218437	A1968A	0.62
SKCM	chr8	143921642	Missense_Mutation	NA	L2864I	0.2
SKCM	chr8	143922711	Silent	NA	F2543F	0.35
SKCM	chr8	143927461	Silent	novel	A1372A	0.22
SKCM	chr8	143921136	Silent	NA	V3032V	0.39
SKCM	chr8	143934727	Silent	novel	L454L	0.63
SKCM	chr8	143934728	Splice_Region	novel	I453I	0.64
SKCM	chr8	143930197	Silent	novel	S990S	0.27
SKCM	chr8	143930198	Missense_Mutation	novel	S990F	0.27
SKCM	chr8	143945234	Intron	rs782675850		0.4
SKCM	chr8	143943862	Intron	novel		0.7
SKCM	chr8	143917203	Silent	novel	D4343D	0.19
SKCM	chr8	143917428	Silent	novel	S4268S	0.4
SKCM	chr8	143921506	Missense_Mutation	rs201916690	R2909H	0.15
SKCM	chr8	143917658	Missense_Mutation	NA	P4192S	0.44
SKCM	chr8	143922250	Missense_Mutation	NA	V2661G	0.43
SKCM	chr8	143917125	Silent	rs368964907	F4369F	0.39
SKCM	chr8	143922933	Silent	NA	L2469L	0.59
SKCM	chr8	143932653	Silent	NA	L736L	0.41
SKCM	chr8	143916701	Silent	novel	L4511L	0.3
SKCM	chr8	143916702	Silent	novel	A4510A	0.29
SKCM	chr8	143919619	Missense_Mutation	NA	P3538L	0.17
SKCM	chr8	143920598	Missense_Mutation	rs376638828	R3212W	0.16
SKCM	chr8	143925507	Silent	novel	E1611E	0.16
SKCM	chr8	143918004	Silent	rs782492397	F4076F	0.19
SKCM	chr8	143920881	Silent	NA	L3117L	0.44
SKCM	chr8	143917066	Missense_Mutation	rs782259278	S4389F	0.35
SKCM	chr8	143932418	Silent	NA	A790A	0.37
SKCM	chr8	143924409	Silent	rs374790646	A1977A	0.27
SKCM	chr8	143920477	Missense_Mutation	NA	S3252F	0.22
SKCM	chr8	143916817	Missense_Mutation	novel	A4472V	0.53
SKCM	chr8	143923804	Missense_Mutation	NA	A2179V	0.29
SKCM	chr8	143919308	Missense_Mutation	novel	P3642S	0.37
SKCM	chr8	143927026	Missense_Mutation	rs201955391	P1436L	0.72
SKCM	chr8	143918605	Missense_Mutation	novel	G3876E	0.53
SKCM	chr8	143918754	Silent	rs781847790	T3826T	0.31
SKCM	chr8	143917125	Silent	rs368964907	F4369F	0.16
SKCM	chr8	143917417	Missense_Mutation	NA	S4272F	0.09
SKCM	chr8	143931581	Missense_Mutation	NA	R890C	0.19
SKCM	chr8	143938681	Missense_Mutation	NA	R179C	0.11
SKCM	chr8	143919483	Silent	rs62642461	S3583S	0.19
SKCM	chr8	143919326	Missense_Mutation	NA	N3636D	0.28
SKCM	chr8	143921636	Silent	rs376462203	L2866L	0.28
SKCM	chr8	143921637	Silent	novel	I2865I	0.28
SKCM	chr8	143921482	Missense_Mutation	rs782080849	P2917L	0.5
SKCM	chr8	143934731	Splice_Site	novel	X453_splice	0.38
SKCM	chr8	143916337	Missense_Mutation	novel	T4632I	0.24
SKCM	chr8	143919432	Silent	NA	R3600R	0.36
SKCM	chr8	143924367	Silent	rs782000075	I1991I	0.47
SKCM	chr8	143924366	Missense_Mutation	rs566759064	A1992T	0.1
SKCM	chr8	143929216	Silent	NA	K1186K	0.17
SKCM	chr8	143916789	Silent	NA	I4481I	0.26
SKCM	chr8	143920164	Silent	rs782394973	A3356A	0.49
SKCM	chr8	143918363	Silent	NA	L3957L	0.44
SKCM	chr8	143934383	In_Frame_Del	NA	K505del	0.17
SKCM	chr8	143920633	Missense_Mutation	novel	G3200D	0.69
SKCM	chr8	143950640	Missense_Mutation	rs545313769	G23S	0.16	S10_plectin
SKCM	chr8	143927070	Silent	NA	L1421L	0.41
SKCM	chr8	143920475	Silent	NA	L3253L	0.4
SKCM	chr8	143927287	Nonsense_Mutation	NA	Q1406*	0.3
SKCM	chr8	143916973	Missense_Mutation	NA	I4420T	0.11
SKCM	chr8	143933323	Missense_Mutation	NA	V568A	0.17
SKCM	chr8	143934651	Missense_Mutation	NA	I479T	0.11
SKCM	chr8	143919219	Silent	rs782052487	P3671P	0.37
SKCM	chr8	143919220	Missense_Mutation	novel	P3671L	0.37
SKCM	chr8	143921277	Silent	NA	D2985D	0.18
SKCM	chr8	143918749	Missense_Mutation	novel	S3828F	0.33
SKCM	chr8	143920130	Missense_Mutation	rs781821437	R3368C	0.5
SKCM	chr8	143921499	Silent	novel	V2911V	0.35
SKCM	chr8	143917224	Silent	rs368889216	S4336S	0.45
SKCM	chr8	143920092	Silent	NA	V3380V	0.39
SKCM	chr8	143920343	Nonsense_Mutation	NA	R3297*	0.71
STAD	chr8	143917009	Missense_Mutation	NA	S4408L	0.26
STAD	chr8	143921020	Missense_Mutation	rs368122904	T3071M	0.17
STAD	chr8	143921230	Missense_Mutation	NA	Y3001C	0.24
STAD	chr8	143934424	Missense_Mutation	rs200260527	L492F	0.3
STAD	chr8	143916345	Silent	novel	G4629G	0.19
STAD	chr8	143927060	Missense_Mutation	novel	T1425P	0.14
STAD	chr8	143924313	Silent	rs371589575	D2009D	0.25
STAD	chr8	143932876	Missense_Mutation	novel	E689K	0.28
STAD	chr8	143917637	Missense_Mutation	NA	P4199T	0.13
STAD	chr8	143923485	Silent	NA	R2285R	0.16
STAD	chr8	143927481	Missense_Mutation	rs781861123	R1366W	0.26
STAD	chr8	143917570	Missense_Mutation	rs376783002	S4221L	0.33
STAD	chr8	143924319	Silent	rs782258533	A2007A	0.32
STAD	chr8	143920367	Missense_Mutation	rs781854050	V3289M	0.43
STAD	chr8	143933203	Missense_Mutation	novel	Y608C	0.24
STAD	chr8	143917377	Silent	NA	T4285T	0.16
STAD	chr8	143919223	Missense_Mutation	NA	D3670G	0.11
STAD	chr8	143918961	Missense_Mutation	NA	I3757M	0.1
STAD	chr8	143919164	Missense_Mutation	NA	E3690Q	0.06
STAD	chr8	143935212	Missense_Mutation	novel	L372P	0.11
STAD	chr8	143920669	Missense_Mutation	NA	S3188F	0.2
STAD	chr8	143922029	In_Frame_Del	novel	R2718_Q2734del	0.23
STAD	chr8	143929788	Silent	novel	H1064H	0.43
STAD	chr8	143925527	Missense_Mutation	NA	R1605C	0.15
STAD	chr8	143916843	Silent	novel	T4463T	0.08
STAD	chr8	143918109	Silent	rs782243173	D4041D	0.24
STAD	chr8	143916663	Silent	NA	R4523R	0.39
STAD	chr8	143929518	Missense_Mutation	rs373993300	R1130W	0.25
STAD	chr8	143919146	Missense_Mutation	rs782559387	T3696A	0.11
STAD	chr8	143921086	Missense_Mutation	novel	A3049V	0.14
STAD	chr8	143919231	Silent	rs373564804	C3667C	0.11
STAD	chr8	143923288	Missense_Mutation	rs781956194	A2351V	0.52
STAD	chr8	143921845	Missense_Mutation	rs781927659	Q2796R	0.28
STAD	chr8	143922779	Missense_Mutation	novel	R2521C	0.14
STAD	chr8	143929257	Silent	novel	L1173L	0.14
STAD	chr8	143918972	Missense_Mutation	rs781877026	R3754C	0.22
STAD	chr8	143918885	Missense_Mutation	rs202175941	R3783C	0.2
STAD	chr8	143920635	Silent	NA	A3199A	0.27
STAD	chr8	143925254	Nonsense_Mutation	rs782185897	R1696*	0.32
STAD	chr8	143919383	Missense_Mutation	novel	S3617G	0.34
STAD	chr8	143922856	Missense_Mutation	rs782367691	A2495V	0.36
STAD	chr8	143925416	Missense_Mutation	novel	D1642N	0.5
STAD	chr8	143919744	Silent	rs781808958	G3496G	0.3
STAD	chr8	143922721	Missense_Mutation	NA	A2540V	0.24
STAD	chr8	143927941	Silent	NA	V1241V	0.36
STAD	chr8	143930281	Silent	NA	G962G	0.36
STAD	chr8	143926866	Missense_Mutation	rs782146862	T1458M	0.37
STAD	chr8	143935301	Silent	rs199868457	I342I	0.24
STAD	chr8	143923850	Nonsense_Mutation	rs368550010	R2164*	0.75
STAD	chr8	143916507	Silent	NA	P4575P	0.16
STAD	chr8	143925786	Missense_Mutation	NA	Q1518H	0.22
STAD	chr8	143924274	Silent	rs782216683	A2022A	0.48
STAD	chr8	143916475	Missense_Mutation	rs782720210	A4586V	0.16
STAD	chr8	143917484	Frame_Shift_Del	NA	*Q4250Rfs9**	0.09
STAD	chr8	143916540	Silent	rs782135892	D4564D	0.3
STAD	chr8	143918180	Missense_Mutation	rs577333649	R4018C	0.29
STAD	chr8	143918547	Silent	rs530897932	H3895H	0.36
STAD	chr8	143919967	Missense_Mutation	novel	I3422T	0.24
STAD	chr8	143921726	Missense_Mutation	rs782264628	A2836T	0.24
STAD	chr8	143923128	Missense_Mutation	novel	Q2404H	0.25
STAD	chr8	143923864	Missense_Mutation	rs782332277	R2159Q	0.25
STAD	chr8	143917945	Missense_Mutation	rs782457644	R4096H	0.12
STAD	chr8	143923086	Silent	rs782156855	A2418A	0.35
STAD	chr8	143916973	Missense_Mutation	NA	I4420T	0.08
STAD	chr8	143917177	Missense_Mutation	NA	D4352G	0.15
STAD	chr8	143922079	Missense_Mutation	rs560763455	R2718Q	0.18
STAD	chr8	143926813	Nonsense_Mutation	NA	E1476*	0.08
STAD	chr8	143922778	Missense_Mutation	rs201594706	R2521H	0.39
STAD	chr8	143916557	Missense_Mutation	rs782099999	A4559T	0.23
STAD	chr8	143917090	Missense_Mutation	rs370769102	R4381H	0.31
STAD	chr8	143929187	Missense_Mutation	rs529986115	A1196E	0.31
STAD	chr8	143937163	Splice_Site	NA	X251_splice	0.22
STAD	chr8	143916923	Missense_Mutation	rs782022985	R4437W	0.14
STAD	chr8	143917040	Missense_Mutation	rs200924154	A4398T	0.1
STAD	chr8	143918109	Silent	rs782243173	D4041D	0.22
STAD	chr8	143920985	Missense_Mutation	rs546852080	R3083C	0.22
STAD	chr8	143923227	Silent	rs782604351	R2371R	0.18
STAD	chr8	143918184	Silent	rs781888669	D4016D	0.33
STAD	chr8	143921191	Missense_Mutation	rs201565643	T3014M	0.12
STAD	chr8	143918987	Silent	novel	R3749R	0.08
STAD	chr8	143933250	Silent	rs782361163	D592D	0.21
STAD	chr8	143943863	Intron	novel		0.08
STAD	chr8	143919782	Missense_Mutation	rs782748769	V3484M	0.17
STAD	chr8	143924312	Missense_Mutation	rs367715409	E2010K	0.11
STAD	chr8	143918575	Missense_Mutation	rs781826150	R3886Q	0.34
STAD	chr8	143924075	Missense_Mutation	rs782177660	R2089C	0.5
STAD	chr8	143921739	Silent	rs782116380	G2831G	0.08
STAD	chr8	143923912	Missense_Mutation	rs376537341	A2143V	0.19
STAD	chr8	143926785	Missense_Mutation	novel	E1485V	0.12
STAD	chr8	143922085	Missense_Mutation	rs782531536	Q2716R	0.21
STAD	chr8	143924171	Missense_Mutation	rs781860739	R2057W	0.22
STAD	chr8	143920007	Missense_Mutation	rs375101631	R3409C	0.05
STAD	chr8	143917321	Missense_Mutation	rs782411778	T4304M	0.13
STAD	chr8	143921405	Silent	rs782364084	L2943L	0.07
STAD	chr8	143921998	Missense_Mutation	rs370351676	A2745V	0.22
STAD	chr8	143922960	Silent	rs531846605	T2460T	0.19
STAD	chr8	143919523	Missense_Mutation	NA	V3570A	0.21
STAD	chr8	143919618	Silent	rs201096903	P3538P	0.29
STAD	chr8	143919503	Missense_Mutation	NA	Y3577H	0.16
STAD	chr8	143923261	Missense_Mutation	rs565225660	R2360H	0.18
STAD	chr8	143923963	Missense_Mutation	rs782084501	R2126H	0.62
STAD	chr8	143917914	Silent	rs202099348	A4106A	0.12
STAD	chr8	143916579	Silent	rs200589588	R4551R	0.23
STAD	chr8	143921031	Silent	rs375108349	S3067S	0.16
STAD	chr8	143924134	Missense_Mutation	rs201624086	A2069V	0.38
STAD	chr8	143916621	Silent	rs782219243	P4537P	0.38
STAD	chr8	143916781	Missense_Mutation	NA	D4484G	0.42
STAD	chr8	143923908	Silent	rs200338935	A2144A	0.48
STAD	chr8	143925527	Missense_Mutation	NA	R1605C	0.19
STAD	chr8	143916815	Missense_Mutation	rs201163149	V4473I	0.15
STAD	chr8	143932165	Silent	NA	L820L	0.18
STAD	chr8	143921079	Silent	rs201211875	F3051F	0.2
STAD	chr8	143923405	Missense_Mutation	NA	E2312G	0.22
STAD	chr8	143919376	Missense_Mutation	rs548876454	R3619H	0.13
STAD	chr8	143916887	Silent	novel	L4449L	0.34
STAD	chr8	143927578	Silent	rs377059744	D1333D	0.22
STAD	chr8	143923382	In_Frame_Del	novel	R2316_A2319del	0.26
STAD	chr8	143916682	Missense_Mutation	NA	Y4517C	0.09
STAD	chr8	143919270	Silent	rs116901140	T3654T	0.23
STAD	chr8	143919643	Missense_Mutation	rs370079447	A3530V	0.24
STAD	chr8	143921031	Silent	rs375108349	S3067S	0.16
STAD	chr8	143921300	Missense_Mutation	rs539060494	R2978C	0.14
STAD	chr8	143921366	Missense_Mutation	rs782271365	V2956M	0.37
STAD	chr8	143924081	Missense_Mutation	rs566539439	R2087C	0.16
STAD	chr8	143916606	Silent	rs782693539	R4542R	0.31
STAD	chr8	143917864	Missense_Mutation	rs369056956	T4123M	0.48
STAD	chr8	143919374	Missense_Mutation	rs782236056	V3620M	0.35
STAD	chr8	143919953	Missense_Mutation	NA	T3427A	0.19
STAD	chr8	143931644	Missense_Mutation	rs782679986	R869W	0.25
STAD	chr8	143919613	Missense_Mutation	rs369621159	R3540Q	0.23
STAD	chr8	143927965	Silent	rs370987177	R1233R	0.24
STAD	chr8	143916818	Missense_Mutation	NA	A4472T	0.1
STAD	chr8	143921184	Frame_Shift_Del	novel	*C3017Afs43**	0.21
STAD	chr8	143934383	Missense_Mutation	NA	K505N	0.12
STAD	chr8	143924208	Missense_Mutation	NA	E2044D	0.18
STAD	chr8	143919774	Silent	rs202133975	T3486T	0.12
STAD	chr8	143920130	Missense_Mutation	rs781821437	R3368C	0.15
STAD	chr8	143919078	Silent	rs375573910	G3718G	0.18
STAD	chr8	143927639	Missense_Mutation	rs782533009	R1313H	0.3
TGCT	chr8	143917287	Missense_Mutation	novel	W4315C	0.1
THCA	chr8	143933064	Missense_Mutation	novel	N626I	0.55
THCA	chr8	143934923	Frame_Shift_Del	novel	*Q415Sfs45**	0.43
THCA	chr8	143950241	Missense_Mutation	NA	P156S	0.23
THCA	chr8	143920816	Missense_Mutation	rs782565838	R3139Q	0.44
THYM	chr8	143921316	Silent	rs782326556	F2972F	0.16
UCEC	chr8	143917151	Missense_Mutation	rs781292412	A4361T	0.5
UCEC	chr8	143924216	Missense_Mutation	NA	E2042K	0.67
UCEC	chr8	143950372	Missense_Mutation	rs782063023	R112H	0.41
UCEC	chr8	143916710	Missense_Mutation	rs200361523	A4508T	0.38
UCEC	chr8	143917040	Missense_Mutation	rs200924154	A4398T	0.32
UCEC	chr8	143919568	Missense_Mutation	novel	V3555A	0.25
UCEC	chr8	143923201	Missense_Mutation	novel	L2380P	0.46
UCEC	chr8	143936986	Missense_Mutation	novel	H280R	0.34
UCEC	chr8	143921351	Missense_Mutation	rs201160327	V2961M	0.43
UCEC	chr8	143923410	Silent	rs782289515	F2310F	0.64
UCEC	chr8	143924206	Missense_Mutation	rs369142466	R2045Q	0.76
UCEC	chr8	143918884	Missense_Mutation	NA	R3783L	0.05
UCEC	chr8	143921647	Missense_Mutation	NA	T2862K	0.33
UCEC	chr8	143922975	Silent	rs781896656	A2455A	0.16
UCEC	chr8	143933062	Missense_Mutation	novel	L627I	0.25
UCEC	chr8	143935856	Silent	rs782193446	H335H	0.37
UCEC	chr8	143932928	Missense_Mutation	NA	E671D	0.58
UCEC	chr8	143933267	Missense_Mutation	NA	R587W	0.43
UCEC	chr8	143922758	Nonsense_Mutation	novel	E2528*	0.5
UCEC	chr8	143917853	Missense_Mutation	novel	A4127T	0.41
UCEC	chr8	143919277	Missense_Mutation	novel	P3652H	0.42
UCEC	chr8	143919591	Silent	rs377293976	H3547H	0.36
UCEC	chr8	143920380	Silent	novel	S3284S	0.46
UCEC	chr8	143926804	Missense_Mutation	rs369706837	R1479W	0.35
UCEC	chr8	143950537	Missense_Mutation	rs376219705	A57V	0.49	S10_plectin
UCEC	chr8	143932458	Missense_Mutation	NA	V777E	0.32
UCEC	chr8	143920030	Missense_Mutation	rs200413602	A3401V	0.41
UCEC	chr8	143921298	Silent	novel	R2978R	0.73
UCEC	chr8	143918750	Missense_Mutation	novel	S3828P	0.44
UCEC	chr8	143933267	Missense_Mutation	NA	R587W	0.29
UCEC	chr8	143939372	Intron	rs782648372		0.27
UCEC	chr8	143915599	3'UTR	novel		0.38
UCEC	chr8	143919184	Missense_Mutation	rs533151885	A3683V	0.39
UCEC	chr8	143921166	Silent	novel	T3022T	0.35
UCEC	chr8	143921353	Missense_Mutation	rs376887979	R2960H	0.49
UCEC	chr8	143922767	Missense_Mutation	rs561405725	R2525C	0.47
UCEC	chr8	143927002	Missense_Mutation	rs199796047	S1444L	0.45
UCEC	chr8	143917395	Silent	novel	V4279V	0.21
UCEC	chr8	143920353	Silent	rs372844056	V3293V	0.23
UCEC	chr8	143917148	Missense_Mutation	rs782770333	G4362S	0.23
UCEC	chr8	143918121	Silent	rs782549072	S4037S	0.39
UCEC	chr8	143927749	Silent	rs782562298	A1276A	0.58
UCEC	chr8	143932450	Missense_Mutation	NA	D780N	0.3
UCEC	chr8	143918542	Missense_Mutation	NA	R3897H	0.41
UCEC	chr8	143916735	Silent	NA	P4499P	0.2
UCEC	chr8	143922699	Silent	rs201578404	A2547A	0.47
UCEC	chr8	143916712	Missense_Mutation	novel	A4507D	0.32
UCEC	chr8	143917206	Silent	rs202116866	I4342I	0.25
UCEC	chr8	143920066	Missense_Mutation	rs781828296	T3389M	0.33
UCEC	chr8	143921316	Silent	rs782326556	F2972F	0.27
UCEC	chr8	143927481	Missense_Mutation	rs781861123	R1366W	0.29
UCEC	chr8	143934900	Silent	novel	R422R	0.18
UCEC	chr8	143932989	Missense_Mutation	rs781887816	R651H	0.33
UCEC	chr8	143950412	Missense_Mutation	rs781991899	R99C	0.4	S10_plectin
UCEC	chr8	143917793	Missense_Mutation	rs782509992	A4147T	0.35
UCEC	chr8	143921124	Silent	rs200383203	S3036S	0.32
UCEC	chr8	143921213	Missense_Mutation	rs782503783	R3007C	0.18
UCEC	chr8	143918087	Missense_Mutation	rs782136681	R4049W	0.26
UCEC	chr8	143919998	Missense_Mutation	rs782733657	R3412C	0.22
UCEC	chr8	143918951	Missense_Mutation	rs554393133	E3761K	0.65
UCEC	chr8	143920416	Silent	rs28540185	D3272D	0.37
UCEC	chr8	143934367	Missense_Mutation	novel	H511Y	0.38
UCEC	chr8	143917391	Missense_Mutation	rs541897170	V4281M	0.18
UCEC	chr8	143917502	Missense_Mutation	rs781972499	R4244C	0.58
UCEC	chr8	143921190	Silent	rs530936382	T3014T	0.55
UCEC	chr8	143926800	Missense_Mutation	rs371776565	R1480H	0.27
UCEC	chr8	143921244	Silent	rs200012425	H2996H	0.22
UCEC	chr8	143922978	Missense_Mutation	novel	Q2454H	0.33
UCEC	chr8	143927959	Silent	rs576249509	T1235T	0.31
UCEC	chr8	143930013	Missense_Mutation	rs377225173	V1025M	0.29
UCEC	chr8	143915196	3'UTR	novel		0.36
UCEC	chr8	143918891	Missense_Mutation	rs781932676	R3781C	0.35
UCEC	chr8	143920742	Missense_Mutation	rs768113059	A3164T	0.62
UCEC	chr8	143922778	Missense_Mutation	rs201594706	R2521H	0.42
UCEC	chr8	143929945	Silent	novel	S1047S	0.39
UCEC	chr8	143933297	Missense_Mutation	rs782622390	R577W	0.35
UCEC	chr8	143934364	Missense_Mutation	rs199866423	V512M	0.35
UCEC	chr8	143950470	Silent	rs782255533	I79I	0.32
UCEC	chr8	143939523	Intron	novel		0.13
UCEC	chr8	143931563	Missense_Mutation	rs781846297	R896W	0.26
UCEC	chr8	143921279	Missense_Mutation	rs781793289	D2985N	0.51
UCEC	chr8	143919499	Missense_Mutation	rs782569204	S3578L	0.29
UCEC	chr8	143932963	Missense_Mutation	NA	R660C	0.43
UCEC	chr8	143917537	Missense_Mutation	novel	T4232M	0.43
UCEC	chr8	143917996	Missense_Mutation	novel	A4079V	0.38
UCEC	chr8	143918871	Missense_Mutation	rs782756562	E3787D	0.53
UCEC	chr8	143922301	Missense_Mutation	rs782232833	R2644H	0.33
UCEC	chr8	143916720	Missense_Mutation	novel	K4504N	0.34
UCEC	chr8	143918975	Nonsense_Mutation	novel	E3753*	0.22
UCEC	chr8	143919264	Missense_Mutation	novel	E3656D	0.09
UCEC	chr8	143929187	Missense_Mutation	rs529986115	A1196V	0.65
UCEC	chr8	143932810	Missense_Mutation	rs782724039	R711W	0.44
UCEC	chr8	143937228	Frame_Shift_Del	novel	*R231Gfs22**	0.37
UCEC	chr8	143916862	Frame_Shift_Del	novel	*G4457Afs55**	0.54
UCEC	chr8	143919947	Missense_Mutation	rs782650325	V3429M	0.21
UCEC	chr8	143932918	Missense_Mutation	rs782678779	R675C	0.53
UCEC	chr8	143917125	Silent	rs368964907	F4369F	0.3
UCEC	chr8	143918401	Missense_Mutation	NA	G3944D	0.52
UCEC	chr8	143922626	Missense_Mutation	NA	E2572K	0.43
UCEC	chr8	143919413	Missense_Mutation	rs377602333	A3607T	0.18
UCEC	chr8	143943810	Intron	novel		0.55
UCEC	chr8	143918403	Silent	rs559510708	T3943T	0.26
UCEC	chr8	143919990	Silent	rs531993412	G3414G	0.3
UCEC	chr8	143922753	Missense_Mutation	novel	M2529I	0.28
UCEC	chr8	143922976	Missense_Mutation	rs377223579	A2455V	0.14
UCEC	chr8	143924176	Missense_Mutation	novel	R2055M	0.3
UCEC	chr8	143933043	Missense_Mutation	novel	V633A	0.34
UCEC	chr8	143916806	Missense_Mutation	novel	G4476C	0.07
UCEC	chr8	143917449	Missense_Mutation	NA	K4261N	0.31
UCEC	chr8	143917459	Missense_Mutation	novel	L4258R	0.32
UCEC	chr8	143950361	Missense_Mutation	novel	V116M	0.44
UCEC	chr8	143953748	5'Flank	novel		0.11
UCEC	chr8	143917889	Missense_Mutation	rs369738267	D4115N	0.46
UCEC	chr8	143920343	Nonsense_Mutation	NA	R3297*	0.38
UCEC	chr8	143923035	Silent	novel	E2435E	0.4
UCEC	chr8	143933255	Missense_Mutation	novel	N591D	0.07
UCEC	chr8	143916981	Silent	novel	V4417V	0.4
UCEC	chr8	143931569	Missense_Mutation	rs782595372	V894I	0.53
UCEC	chr8	143920291	Missense_Mutation	novel	D3314G	0.21
UCEC	chr8	143922561	Missense_Mutation	novel	E2593D	0.33
UCEC	chr8	143922867	Silent	rs375587611	A2491A	0.25
UCEC	chr8	143923261	Missense_Mutation	rs565225660	R2360H	0.26
UCEC	chr8	143924223	Silent	rs782767089	S2039S	0.35
UCEC	chr8	143932831	Nonsense_Mutation	novel	E704*	0.38
UCEC	chr8	143917224	Silent	rs368889216	S4336S	0.19
UCEC	chr8	143916101	3'UTR	novel		0.5
UCEC	chr8	143922302	Missense_Mutation	rs782503698	R2644C	0.15
UCEC	chr8	143918327	Missense_Mutation	novel	D3969H	0.52
UCEC	chr8	143923046	Nonsense_Mutation	novel	Q2432*	0.09
UCEC	chr8	143944682	Intron	novel		0.38
UCEC	chr8	143919414	Silent	rs369578286	I3606I	0.15
UCEC	chr8	143920598	Missense_Mutation	rs376638828	R3212W	0.47
UCEC	chr8	143918821	Missense_Mutation	rs369798520	R3804Q	0.22
UCEC	chr8	143917562	Missense_Mutation	novel	T4224A	0.39
UCEC	chr8	143918298	Silent	rs782625697	S3978S	0.48
UCEC	chr8	143919824	Missense_Mutation	novel	D3470N	0.38
UCEC	chr8	143922276	Missense_Mutation	novel	K2652N	0.28
UCEC	chr8	143927639	Missense_Mutation	rs782533009	R1313H	0.27
UCEC	chr8	143934411	Frame_Shift_Del	novel	*P496Lfs40**	0.39
UCEC	chr8	143945230	Intron	novel		0.37
UCEC	chr8	143937038	Missense_Mutation	rs782389278	A263T	0.06
UCEC	chr8	143926991	Missense_Mutation	NA	S1448C	0.1
UCEC	chr8	143919889	Missense_Mutation	novel	P3448H	0.48
UCEC	chr8	143922895	Missense_Mutation	rs541098488	R2482Q	0.42
UCEC	chr8	143933286	Silent	rs551804972	D580D	0.34
UCEC	chr8	143934830	Frame_Shift_Ins	novel	*S446Lfs7**	0.25
UCEC	chr8	143950346	Missense_Mutation	novel	G121S	0.41
UCEC	chr8	143922301	Missense_Mutation	rs782232833	R2644H	0.55
UCEC	chr8	143922937	Missense_Mutation	NA	L2468P	0.5
UCEC	chr8	143932796	Silent	rs782141897	D715D	0.45
UCEC	chr8	143921738	Missense_Mutation	rs782025300	R2832C	0.25
UCEC	chr8	143923227	Silent	rs782604351	R2371R	0.44
UCEC	chr8	143920400	Missense_Mutation	novel	G3278S	0.12
UCEC	chr8	143919408	Silent	rs782728053	T3608T	0.53
UCEC	chr8	143920007	Missense_Mutation	rs375101631	R3409C	0.39
UCEC	chr8	143920095	Silent	rs536395359	P3379P	0.24
UCEC	chr8	143921737	Missense_Mutation	rs782339067	R2832H	0.53
UCEC	chr8	143915169	3'UTR	novel		0.16
UCEC	chr8	143921577	Silent	novel	L2885L	0.16
UCEC	chr8	143922239	Missense_Mutation	novel	Q2665K	0.46
UCEC	chr8	143929970	Missense_Mutation	novel	D1039V	0.38
UCEC	chr8	143934808	Splice_Site	novel	X452_splice	0.54
UCEC	chr8	143919899	Missense_Mutation	novel	L3445I	0.3
UCEC	chr8	143918547	Silent	rs530897932	H3895H	0.3
UCEC	chr8	143931588	Silent	NA	S887S	0.22
UCEC	chr8	143915355	3'UTR	novel		0.38
UCEC	chr8	143917081	Missense_Mutation	novel	S4384F	0.6
UCEC	chr8	143917205	Missense_Mutation	rs782492632	D4343N	0.26
UCEC	chr8	143918448	Silent	rs782573219	I3928I	0.17
UCEC	chr8	143918922	Silent	novel	R3770R	0.44
UCEC	chr8	143919519	Silent	rs199879193	T3571T	0.33
UCEC	chr8	143921382	Silent	rs201932982	G2950G	0.36
UCEC	chr8	143922847	Missense_Mutation	rs369522291	T2498M	0.43
UCEC	chr8	143920519	Missense_Mutation	novel	A3238V	0.4
UCEC	chr8	143921634	Silent	novel	L2866L	0.47
UCEC	chr8	143922779	Missense_Mutation	novel	R2521C	0.34
UCEC	chr8	143924370	Missense_Mutation	novel	E1990D	1
UCEC	chr8	143929117	Silent	novel	A1219A	0.29
UCEC	chr8	143929955	Missense_Mutation	rs374310349	R1044H	0.41
UCEC	chr8	143932984	Missense_Mutation	rs530596364	E653K	0.36
UCS	chr8	143923793	Missense_Mutation	rs782634097	R2183W	0.24
UCS	chr8	143932193	Missense_Mutation	novel	K810N	0.59
UCS	chr8	143925589	Missense_Mutation	rs375600751	R1584Q	0.93
UCS	chr8	143920245	Nonsense_Mutation	novel	Y3329*	0.32
UVM	chr8	143916620	Missense_Mutation	rs782439392	D4538N	0.55

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.25	0.018626
KIRC	AMP	0.1193	0.15559
LGG	DEL	0.0468	0.014004
SARC	AMP	0.2607	0.18425
SKCM	AMP	0.455	2.8957e-05
TGCT	AMP	0.56	0.13696
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0052	Kaplan-Meier Survival Analysis
MESO	0.0044	Kaplan-Meier Survival Analysis
HNSC	0.011	Kaplan-Meier Survival Analysis
LUSC	0.0093	Kaplan-Meier Survival Analysis
TGCT	0.04	Kaplan-Meier Survival Analysis
COAD	0.005	Kaplan-Meier Survival Analysis
PAAD	0.0061	Kaplan-Meier Survival Analysis
PCPG	0.02	Kaplan-Meier Survival Analysis
CESC	0.00051	Kaplan-Meier Survival Analysis
LAML	0.0013	Kaplan-Meier Survival Analysis
GBM	0.0026	Kaplan-Meier Survival Analysis
LIHC	0.0024	Kaplan-Meier Survival Analysis
LUAD	0.0004	Kaplan-Meier Survival Analysis
OV	0.011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742