EuRBPDB

Description

Ensembl ID: ENSG00000178252 (Gene tree)
Gene ID: 11180
Gene Symbol: WDR6
Alias: N
Full Name: WD repeat domain 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 8,892 bases
Position: chr3:49,007,062-49,015,953
Accession: 12758
RBP type: non-canonical RBP
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000438660	WDR6-206	852	-	ENSP00000387692	271 (aa)	-	C9K020
ENST00000452875	WDR6-208	3916	-	ENSP00000414157	68 (aa)	-	F8WE36
ENST00000429900	WDR6-205	563	-	ENSP00000477418	31 (aa)	-	V9GZ48
ENST00000489427	WDR6-215	564	-	ENSP00000477087	125 (aa)	-	V9GYU1
ENST00000448293	WDR6-207	3377	-	ENSP00000413432	1070 (aa)	-	E9PDU5
ENST00000615452	WDR6-222	1949	-	ENSP00000482289	289 (aa)	-	Q6PKC6
ENST00000415265	WDR6-202	1883	-	ENSP00000412195	569 (aa)	-	E9PBK6
ENST00000462064	WDR6-210	589	-	-	- (aa)	-	-
ENST00000419837	WDR6-203	538	-	ENSP00000390740	99 (aa)	-	C9JFP6
ENST00000473238	WDR6-213	568	-	-	- (aa)	-	-
ENST00000608424	WDR6-220	4070	-	ENSP00000477389	1121 (aa)	-	Q9NNW5
ENST00000472878	WDR6-212	556	-	-	- (aa)	-	-
ENST00000491365	WDR6-217	491	-	ENSP00000477463	35 (aa)	-	V9GZ65
ENST00000395474	WDR6-201	4401	-	ENSP00000378857	1151 (aa)	-	A0A087X295
ENST00000461687	WDR6-209	555	-	-	- (aa)	-	-
ENST00000498023	WDR6-219	626	-	-	- (aa)	-	-
ENST00000627177	WDR6-223	207	-	ENSP00000487056	68 (aa)	-	F8WE36
ENST00000471162	WDR6-211	3565	-	-	- (aa)	-	-
ENST00000610967	WDR6-221	4259	-	ENSP00000484799	1151 (aa)	-	A0A087X295
ENST00000488572	WDR6-214	610	-	-	- (aa)	-	-
ENST00000420783	WDR6-204	3656	-	ENSP00000395993	61 (aa)	-	E5RFX3
ENST00000492780	WDR6-218	537	-	-	- (aa)	-	-
ENST00000489684	WDR6-216	1155	-	-	- (aa)	-	-

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	17216128.25416956.	IPI	Function
GO:0005737	cytoplasm	17216128.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0007050	cell cycle arrest	17216128.	IDA	Process
GO:0008180	COP9 signalosome	18850735.	IDA	Component
GO:0008285	negative regulation of cell proliferation	17216128.	IDA	Process
GO:0010507	negative regulation of autophagy	22354037.	IMP	Process