EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000178607 (Gene tree)
Gene ID: 2081
Gene Symbol: ERN1
Alias: IRE1|IRE1P
Full Name: endoplasmic reticulum to nucleus signaling 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 91,678 bases
Position: chr17:64,039,142-64,130,819
Accession: 3449
RBP type: canonical RBP
Summary: This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000401445	Ribonuc_2-5A	PF06479.12	3.3e-40	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26802109	The Nrf2 Activator Vinylsulfone Reduces High Glucose-Induced Neural Tube Defects by Suppressing Cellular Stress and Apoptosis.	Reprod Sci	2016 Aug	Dong D	doi: 10.1177/1933719115625846
30973085	Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.	Neurol Res	2019 Jul	Mostafa DG	doi: 10.1080/01616412.2019.1596206
16205645	Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells.	Oncogene	2006 Jan 26	Zu K	-
16825573	Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.	Science	2006 Jul 7	Hollien J	-
19651891	Regulated Ire1-dependent decay of messenger RNAs in mammalian cells.	J Cell Biol	2009 Aug 10	Hollien J	doi: 10.1083/jcb.200903014
22321539	Activation of the unfolded protein response by Listeria monocytogenes.	Cell Microbiol	2012 Jun	Pillich H	doi: 10.1111/j.1462-5822.2012.01769.x
22064246	Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis.	Int J Biochem Cell Biol	2012 Jan	Zhang R	doi: 10.1016/j.biocel.2011.10.019
25451798	Di-O-demethylcurcumin protects SK-N-SH cells against mitochondrial and endoplasmic reticulum-mediated apoptotic cell death induced by Aβ25-35.	Neurochem Int	2015 Jan	Pinkaew D	doi: 10.1016/j.neuint.2014.10.008
25337580	Dictyopteris undulata Extract Induces Apoptosis via Induction of Endoplasmic Reticulum Stress in Human Colon Cancer Cells.	J Cancer Prev	2014 Jun	Kang KA	doi: 10.15430/JCP.2014.19.2.118.
24177270	Tick-borne encephalitis virus triggers inositol-requiring enzyme 1 (IRE1) and transcription factor 6 (ATF6) pathways of unfolded protein response.	Virus Res	2013 Dec 26	Yu C	doi: 10.1016/j.virusres.2013.10.012
30556250	Long noncoding RNA MEG3 inhibits breast cancer growth via upregulating endoplasmic reticulum stress and activating NF-kB and p53.	J Cell Biochem	2019 Apr	Zhang Y	doi: 10.1002/jcb.27982
30606992	Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells.	Biol Pharm Bull	2019	Park E	doi: 10.1248/bpb.b18-00603.
16461360	pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.	J Cell Biol	2006 Feb 13	Yoshida H	-
23314846	ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.	Diabetologia	2013 Apr	Han J	doi: 10.1007/s00125-012-2809-5
28360534	Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid.	J Pain Res	2017 Mar 20	Zhou F	doi: 10.2147/JPR.S125805
27844183	Evaluation and Treatment of Endoplasmic Reticulum (ER) Stress in Right Ventricular Dysfunction during Monocrotaline-Induced Rat Pulmonary Arterial Hypertension.	Cardiovasc Drugs Ther	2016 Dec	Wang JJ	-
24055755	Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish.	Aquat Toxicol	2013 Oct 15	Komoike Y	doi: 10.1016/j.aquatox.2013.08.017
27809414	Salidroside protects against homocysteine-induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress.	Cardiovasc Ther	2017 Feb	Zhu L	doi: 10.1111/1755-5922.12234.
26083833	COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.	Mol Endocrinol	2015 Aug	Fang J	doi: 10.1210/me.2015-1012
29559889	Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance.	Front Mol Neurosci	2018 Mar 6	Liu D	doi: 10.3389/fnmol.2018.00072
30612943	Carbon monoxide releasing molecule-3 alleviates neuron death after spinal cord injury via inflammasome regulation.	EBioMedicine	2019 Feb	Zheng G	doi: 10.1016/j.ebiom.2018.12.059

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000433197	ERN1-201	7876	XM_017024347	ENSP00000401445	977 (aa)	XP_016879836	O75460
ENST00000584041	ERN1-207	566	-	-	- (aa)	-	-
ENST00000577567	ERN1-202	398	-	-	- (aa)	-	-
ENST00000583077	ERN1-205	503	-	-	- (aa)	-	-
ENST00000583028	ERN1-204	523	-	-	- (aa)	-	-
ENST00000583896	ERN1-206	571	-	-	- (aa)	-	-
ENST00000606895	ERN1-208	2068	-	ENSP00000475519	70 (aa)	-	O75460
ENST00000579249	ERN1-203	548	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000178607's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04140	Autophagy - animal	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04210	Apoptosis	KEGG
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	KEGG
hsa05010	Alzheimer disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000178607	Stroke	6.6206780E-004	19369658

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000178607	rs199650082	17	64044166	T	Liver injury in anti-retroviral drug treated HIV	28388302	[7.1-46.9]	18.2	EFO_0006904\|EFO_0000764\|EFO_0004228

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178607's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000178607	ERN1	87	63.387	ENSG00000134398	ERN2	94	65.517

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000178607	ERN1	98	93.659	ENSAMEG00000002855	ERN1	97	94.503	Ailuropoda_melanoleuca
ENSG00000178607	ERN1	97	83.139	ENSAPLG00000007775	ERN1	99	83.033	Anas_platyrhynchos
ENSG00000178607	ERN1	98	79.522	ENSACAG00000016707	ERN1	96	79.725	Anolis_carolinensis
ENSG00000178607	ERN1	100	97.551	ENSANAG00000019640	ERN1	100	97.551	Aotus_nancymaae
ENSG00000178607	ERN1	99	94.289	ENSBTAG00000016799	ERN1	98	94.363	Bos_taurus
ENSG00000178607	ERN1	100	97.658	ENSCJAG00000019415	ERN1	100	97.658	Callithrix_jacchus
ENSG00000178607	ERN1	99	94.851	ENSCAFG00000011784	ERN1	98	96.089	Canis_familiaris
ENSG00000178607	ERN1	98	95.525	ENSCAFG00020026580	ERN1	96	96.089	Canis_lupus_dingo
ENSG00000178607	ERN1	98	94.050	ENSCHIG00000025852	ERN1	100	93.946	Capra_hircus
ENSG00000178607	ERN1	98	88.100	ENSTSYG00000029092	ERN1	99	88.360	Carlito_syrichta
ENSG00000178607	ERN1	100	88.127	ENSCAPG00000011651	ERN1	98	89.677	Cavia_aperea
ENSG00000178607	ERN1	100	93.552	ENSCPOG00000000570	ERN1	100	93.756	Cavia_porcellus
ENSG00000178607	ERN1	94	96.518	ENSCCAG00000034845	ERN1	100	98.647	Cebus_capucinus
ENSG00000178607	ERN1	100	98.874	ENSCATG00000040819	ERN1	100	98.874	Cercocebus_atys
ENSG00000178607	ERN1	87	96.540	ENSCLAG00000006912	ERN1	98	96.540	Chinchilla_lanigera
ENSG00000178607	ERN1	100	98.671	ENSCSAG00000003990	ERN1	100	98.671	Chlorocebus_sabaeus
ENSG00000178607	ERN1	97	80.882	ENSCPBG00000009183	ERN1	95	81.529	Chrysemys_picta_bellii
ENSG00000178607	ERN1	95	45.825	ENSCSAVG00000010472	-	74	60.247	Ciona_savignyi
ENSG00000178607	ERN1	100	98.876	ENSCANG00000032329	ERN1	100	98.876	Colobus_angolensis_palliatus
ENSG00000178607	ERN1	98	93.750	ENSCGRG00001003211	Ern1	98	93.737	Cricetulus_griseus_chok1gshd
ENSG00000178607	ERN1	99	93.182	ENSCGRG00000010036	Ern1	98	93.946	Cricetulus_griseus_crigri
ENSG00000178607	ERN1	100	92.638	ENSDNOG00000009467	ERN1	98	93.952	Dasypus_novemcinctus
ENSG00000178607	ERN1	97	85.593	ENSETEG00000004162	ERN1	94	85.503	Echinops_telfairi
ENSG00000178607	ERN1	59	65.574	ENSEBUG00000003040	ERN1	78	65.574	Eptatretus_burgeri
ENSG00000178607	ERN1	100	93.252	ENSEASG00005014413	ERN1	99	94.572	Equus_asinus_asinus
ENSG00000178607	ERN1	100	95.599	ENSECAG00000011262	ERN1	98	96.142	Equus_caballus
ENSG00000178607	ERN1	86	94.836	ENSEEUG00000006091	ERN1	81	94.836	Erinaceus_europaeus
ENSG00000178607	ERN1	98	95.516	ENSFCAG00000003507	ERN1	98	95.620	Felis_catus
ENSG00000178607	ERN1	97	82.893	ENSFALG00000002305	ERN1	96	83.121	Ficedula_albicollis
ENSG00000178607	ERN1	98	93.848	ENSFDAG00000013825	ERN1	100	93.848	Fukomys_damarensis
ENSG00000178607	ERN1	99	81.470	ENSGALG00000003476	ERN1	96	82.784	Gallus_gallus
ENSG00000178607	ERN1	83	79.554	ENSGAGG00000006329	-	97	80.301	Gopherus_agassizii
ENSG00000178607	ERN1	100	99.591	ENSGGOG00000006532	ERN1	100	99.591	Gorilla_gorilla
ENSG00000178607	ERN1	100	94.063	ENSHGLG00000010207	ERN1	97	94.397	Heterocephalus_glaber_female
ENSG00000178607	ERN1	98	94.161	ENSHGLG00100019030	ERN1	99	94.397	Heterocephalus_glaber_male
ENSG00000178607	ERN1	99	95.223	ENSSTOG00000009067	ERN1	100	94.990	Ictidomys_tridecemlineatus
ENSG00000178607	ERN1	98	75.364	ENSLACG00000016078	ERN1	98	76.110	Latimeria_chalumnae
ENSG00000178607	ERN1	97	76.280	ENSLOCG00000013703	ERN1	96	76.514	Lepisosteus_oculatus
ENSG00000178607	ERN1	98	95.193	ENSLAFG00000008504	ERN1	100	95.298	Loxodonta_africana
ENSG00000178607	ERN1	100	98.875	ENSMFAG00000040147	ERN1	100	98.875	Macaca_fascicularis
ENSG00000178607	ERN1	100	98.875	ENSMMUG00000015185	ERN1	100	98.875	Macaca_mulatta
ENSG00000178607	ERN1	100	98.671	ENSMNEG00000044337	ERN1	100	98.671	Macaca_nemestrina
ENSG00000178607	ERN1	98	98.957	ENSMLEG00000033739	ERN1	100	98.957	Mandrillus_leucophaeus
ENSG00000178607	ERN1	99	81.677	ENSMGAG00000007831	ERN1	97	82.715	Meleagris_gallopavo
ENSG00000178607	ERN1	99	95.643	ENSMICG00000010050	ERN1	97	95.772	Microcebus_murinus
ENSG00000178607	ERN1	98	93.021	ENSMOCG00000003999	Ern1	98	92.902	Microtus_ochrogaster
ENSG00000178607	ERN1	98	80.873	ENSMODG00000009349	ERN1	98	80.977	Monodelphis_domestica
ENSG00000178607	ERN1	99	93.146	MGP_CAROLIEiJ_G0017324	Ern1	97	93.333	Mus_caroli
ENSG00000178607	ERN1	98	93.215	ENSMUSG00000020715	Ern1	97	93.333	Mus_musculus
ENSG00000178607	ERN1	98	92.902	MGP_PahariEiJ_G0018454	Ern1	98	92.797	Mus_pahari
ENSG00000178607	ERN1	98	93.215	MGP_SPRETEiJ_G0018168	Ern1	98	93.111	Mus_spretus
ENSG00000178607	ERN1	99	94.872	ENSMPUG00000014770	ERN1	99	94.917	Mustela_putorius_furo
ENSG00000178607	ERN1	99	93.724	ENSMLUG00000016729	ERN1	97	94.921	Myotis_lucifugus
ENSG00000178607	ERN1	98	94.283	ENSNGAG00000019135	Ern1	98	94.265	Nannospalax_galili
ENSG00000178607	ERN1	100	99.284	ENSNLEG00000015074	ERN1	100	99.284	Nomascus_leucogenys
ENSG00000178607	ERN1	91	83.696	ENSMEUG00000008103	ERN1	89	83.696	Notamacropus_eugenii
ENSG00000178607	ERN1	98	91.684	ENSOPRG00000008129	ERN1	99	92.179	Ochotona_princeps
ENSG00000178607	ERN1	99	92.593	ENSODEG00000007755	ERN1	99	93.229	Octodon_degus
ENSG00000178607	ERN1	92	86.792	ENSOANG00000008033	ERN1	99	86.942	Ornithorhynchus_anatinus
ENSG00000178607	ERN1	98	94.075	ENSOCUG00000012090	ERN1	100	93.667	Oryctolagus_cuniculus
ENSG00000178607	ERN1	92	94.966	ENSOGAG00000003863	ERN1	99	94.855	Otolemur_garnettii
ENSG00000178607	ERN1	99	92.850	ENSOARG00000014398	ERN1	98	93.118	Ovis_aries
ENSG00000178607	ERN1	100	99.693	ENSPPAG00000031054	ERN1	100	99.693	Pan_paniscus
ENSG00000178607	ERN1	98	95.308	ENSPPRG00000009424	ERN1	98	95.203	Panthera_pardus
ENSG00000178607	ERN1	98	95.412	ENSPTIG00000000179	ERN1	98	95.516	Panthera_tigris_altaica
ENSG00000178607	ERN1	100	99.795	ENSPTRG00000009535	ERN1	100	99.795	Pan_troglodytes
ENSG00000178607	ERN1	100	99.079	ENSPANG00000020738	ERN1	100	99.079	Papio_anubis
ENSG00000178607	ERN1	98	79.791	ENSPSIG00000017320	ERN1	98	80.403	Pelodiscus_sinensis
ENSG00000178607	ERN1	98	93.841	ENSPEMG00000002339	Ern1	98	93.528	Peromyscus_maniculatus_bairdii
ENSG00000178607	ERN1	98	85.297	ENSPCIG00000005771	ERN1	98	85.297	Phascolarctos_cinereus
ENSG00000178607	ERN1	99	97.234	ENSPPYG00000008539	ERN1	100	99.419	Pongo_abelii
ENSG00000178607	ERN1	93	75.000	ENSPCAG00000016275	ERN1	100	74.728	Procavia_capensis
ENSG00000178607	ERN1	99	91.607	ENSPCOG00000023564	ERN1	99	91.607	Propithecus_coquereli
ENSG00000178607	ERN1	99	91.478	ENSPVAG00000000484	ERN1	97	92.169	Pteropus_vampyrus
ENSG00000178607	ERN1	99	93.250	ENSRNOG00000012864	Ern1	99	93.319	Rattus_norvegicus
ENSG00000178607	ERN1	100	98.773	ENSRBIG00000033096	ERN1	100	98.773	Rhinopithecus_bieti
ENSG00000178607	ERN1	99	97.846	ENSRROG00000017577	ERN1	100	98.837	Rhinopithecus_roxellana
ENSG00000178607	ERN1	99	95.282	ENSSBOG00000035494	ERN1	100	98.721	Saimiri_boliviensis_boliviensis
ENSG00000178607	ERN1	95	84.324	ENSSHAG00000014118	ERN1	100	84.324	Sarcophilus_harrisii
ENSG00000178607	ERN1	98	72.456	ENSSFOG00015005661	ern1	95	73.545	Scleropages_formosus
ENSG00000178607	ERN1	99	78.283	ENSSPUG00000004797	ERN1	99	78.728	Sphenodon_punctatus
ENSG00000178607	ERN1	98	93.946	ENSSSCG00000017279	ERN1	98	93.841	Sus_scrofa
ENSG00000178607	ERN1	97	82.770	ENSTGUG00000004752	-	99	83.085	Taeniopygia_guttata
ENSG00000178607	ERN1	98	88.889	ENSTTRG00000007006	ERN1	99	89.167	Tursiops_truncatus
ENSG00000178607	ERN1	97	93.559	ENSUAMG00000007437	ERN1	97	93.579	Ursus_americanus
ENSG00000178607	ERN1	97	94.837	ENSUMAG00000017551	ERN1	97	93.895	Ursus_maritimus
ENSG00000178607	ERN1	97	95.886	ENSVVUG00000006214	ERN1	95	96.089	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	9637683.	IDA	Function
GO:0001935	endothelial cell proliferation	23529610.	IDA	Process
GO:0004521	endoribonuclease activity	21873635.	IBA	Function
GO:0004521	endoribonuclease activity	9637683.11779465.19328063.21317875.	IDA	Function
GO:0004672	protein kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	9637683.21317875.	IDA	Function
GO:0005161	platelet-derived growth factor receptor binding	26315405.	IPI	Function
GO:0005515	protein binding	11278723.15234121.16645094.18369366.19135427.19328063.20103773.23529610.25241761.25742138.27238082.	IPI	Function
GO:0005524	ATP binding	9637683.	IDA	Function
GO:0005637	nuclear inner membrane	-	IEA	Component
GO:0005737	cytoplasm	19622636.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005783	endoplasmic reticulum	23529610.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0006379	mRNA cleavage	-	ISS	Process
GO:0006402	mRNA catabolic process	22013210.	TAS	Process
GO:0006468	protein phosphorylation	9637683.	IDA	Process
GO:0007050	cell cycle arrest	-	ISS	Process
GO:0007257	activation of JUN kinase activity	10650002.	IDA	Process
GO:0016241	regulation of macroautophagy	22013210.	TAS	Process
GO:0019899	enzyme binding	23103912.	IPI	Function
GO:0030176	integral component of endoplasmic reticulum membrane	9637683.	IDA	Component
GO:0030544	Hsp70 protein binding	20625543.	IPI	Function
GO:0030968	endoplasmic reticulum unfolded protein response	21873635.	IBA	Process
GO:0033120	positive regulation of RNA splicing	11779464.19622636.	IDA	Process
GO:0034620	cellular response to unfolded protein	19328063.	IDA	Process
GO:0034620	cellular response to unfolded protein	20625543.	IMP	Process
GO:0034976	response to endoplasmic reticulum stress	10650002.	IDA	Process
GO:0035924	cellular response to vascular endothelial growth factor stimulus	23529610.	IDA	Process
GO:0036289	peptidyl-serine autophosphorylation	20103773.	IDA	Process
GO:0036498	IRE1-mediated unfolded protein response	21873635.	IBA	Process
GO:0036498	IRE1-mediated unfolded protein response	9637683.11779465.19328063.29198525.	IDA	Process
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0042802	identical protein binding	12637535.21317875.	IPI	Function
GO:0042803	protein homodimerization activity	21317875.29198525.	IDA	Function
GO:0042803	protein homodimerization activity	-	ISS	Function
GO:0043531	ADP binding	21317875.	IDA	Function
GO:0046777	protein autophosphorylation	9637683.19328063.	IDA	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051879	Hsp90 protein binding	12446770.	IDA	Function
GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	11779464.19328063.19622636.21317875.	IDA	Process
GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	20625543.21317875.	IMP	Process
GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	22013210.	TAS	Process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	21873635.	IBA	Process
GO:0071333	cellular response to glucose stimulus	20103773.	IDA	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process
GO:0098787	mRNA cleavage involved in mRNA processing	21317875.	IDA	Process
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	16645094.	IMP	Process
GO:1901142	insulin metabolic process	20103773.	IDA	Process
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	26315405.	IMP	Process
GO:1990332	Ire1 complex	19328063.	NAS	Component
GO:1990579	peptidyl-serine trans-autophosphorylation	21317875.	IMP	Process
GO:1990597	AIP1-IRE1 complex	-	IEA	Component
GO:1990604	IRE1-TRAF2-ASK1 complex	21873635.	IBA	Component
GO:1990604	IRE1-TRAF2-ASK1 complex	23000344.	IDA	Component
GO:1990630	IRE1-RACK1-PP2A complex	20103773.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27829216	ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.	Oncotarget	2016 Dec 13	Strietz J	doi: 10.18632/oncotarget.13086.
29311133	Dual IRE1 RNase functions dictate glioblastoma development.	EMBO Mol Med	2018 Mar	Lhomond S	doi: 10.15252/emmm.201707929.
17638880	IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo.	Cancer Res	2007 Jul 15	Drogat B	-
26742428	Activation of IRE1α-XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma.	Biochem Biophys Res Commun	2016 Jan 29	Jin C	doi: 10.1016/j.bbrc.2015.12.119
23363253	Insulin receptor, IRS1, IRS2, INSIG1, INSIG2, RRAD, and BAIAP2 gene expressions in glioma U87 cells with ERN1 loss of function: effect of hypoxia and glutamine or glucose deprivation.	Endocr Regul	2013 Jan	Minchenko DO	-
25816608	Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.	Ukr Biochem J	2014 Nov-Dec	Minchenko OH	-
28618969	Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer.	Tumour Biol	2017 Jun	Ranjan A	doi: 10.1177/1010428317705517.
28167662	Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.	Blood	2017 Apr 27	Bujisic B	doi: 10.1182/blood-2016-09-741348
29235329	Expression of IGFBP6, IGFBP7, NOV, CYR61, WISP1 and WISP2 genes in U87 glioma cells in glutamine deprivation condition.	Ukr Biochem J	2016 May-Jun	Minchenko OH	doi: 10.15407/ubj88.03.066.
29537195	Expression of proliferation related transcription factor genes in U87 glioma cells with IRE1 knockdown: upon glucose and glutamine deprivation.	Fiziol Zh	2016	Tsymbal DO	-
29263275	Deficiency of the IRE1α-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1.	J Virol	2018 Feb 26	Li K	doi: 10.1128/JVI.01331-17
25870107	Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress.	Mol Cell Biol	2015 Jun	Bright MD	doi: 10.1128/MCB.00013-15
26134873	RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling.	Oncol Rep	2015 Sep	Zhu H	doi: 10.3892/or.2015.4083
26517687	A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1.	Oncotarget	2015 Dec 1	Ming J	doi: 10.18632/oncotarget.5827.
24565834	Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells.	Biochem Biophys Res Commun	2014 Mar 7	Shimodaira Y	doi: 10.1016/j.bbrc.2014.02.054
24970676	Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells.	Int J Mol Med	2014 Sep	Cheng X	doi: 10.3892/ijmm.2014.1822
28358375	Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response.	Cell Death Dis	2017 Mar 30	Taguchi Y	doi: 10.1038/cddis.2017.147.
28128204	A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability.	Nat Commun	2017 Jan 27	Liu J	doi: 10.1038/ncomms14186.
30111846	Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.	Nat Commun	2018 Aug 15	Logue SE	doi: 10.1038/s41467-018-05763-8.
30305738	IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.	Nature	2018 Oct	Song M	doi: 10.1038/s41586-018-0597-x

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	64063998	Frame_Shift_Del	novel	*N357Gfs3**	0.16
BLCA	chr17	64054393	Missense_Mutation	novel	E604K	0.56
BLCA	chr17	64043856	3'UTR	novel		0.44
BRCA	chr17	64045372	Silent	novel	V880V	0.07
BRCA	chr17	64052925	Missense_Mutation	NA	G703D	0.26
BRCA	chr17	64066782	Missense_Mutation	NA	N244S	0.09
BRCA	chr17	64060562	Silent	rs752482120	A371A	0.32
BRCA	chr17	64053304	Missense_Mutation	rs372670758	S674L	0.18
BRCA	chr17	64052891	Silent	NA	L714L	0.47
BRCA	chr17	64052782	Missense_Mutation	novel	P751T	0.08
BRCA	chr17	64047919	Missense_Mutation	rs780870849	A823V	0.23
CESC	chr17	64047970	Missense_Mutation	rs775768349	R806H	0.15
CESC	chr17	64043909	3'UTR	novel		0.45
CESC	chr17	64072066	Silent	NA	L131L	0.31
CESC	chr17	64075226	Missense_Mutation	NA	E102K	0.31
CESC	chr17	64044886	Missense_Mutation	novel	D899Y	0.43	Ribonuc_2-5A
CESC	chr17	64045406	Missense_Mutation	novel	V869A	0.5	Ribonuc_2-5A
CESC	chr17	64052936	Silent	novel	P699P	0.39
CESC	chr17	64044106	Missense_Mutation	rs200145771	H939R	0.43	Ribonuc_2-5A
CESC	chr17	64044867	Missense_Mutation	NA	R905T	0.43	Ribonuc_2-5A
CHOL	chr17	64065272	Silent	novel	V286V	0.38
COAD	chr17	64047978	Silent	NA	V803V	0.32
COAD	chr17	64065216	Missense_Mutation	NA	A305V	0.31
COAD	chr17	64047929	Missense_Mutation	NA	R820C	0.33
COAD	chr17	64052960	Silent	NA	P691P	0.21
COAD	chr17	64066868	Silent	rs367596145	D215D	0.36
COAD	chr17	64079698	Silent	NA	L82L	0.33
COAD	chr17	64047940	Missense_Mutation	novel	D816V	0.05
COAD	chr17	64064047	Silent	NA	F342F	0.43
COAD	chr17	64079676	Missense_Mutation	novel	N90D	0.05
COAD	chr17	64052818	Missense_Mutation	novel	A739T	0.05
COAD	chr17	64072063	Silent	rs374999844	T132T	0.28
COAD	chr17	64043997	Silent	rs368375095	D975D	0.26
COAD	chr17	64055926	In_Frame_Ins	NA	Q473dup	0.33
COAD	chr17	64054314	Missense_Mutation	NA	C630Y	0.19
COAD	chr17	64044083	Missense_Mutation	novel	A947P	0.31	Ribonuc_2-5A
DLBC	chr17	64057803	Missense_Mutation	novel	L466P	0.08
DLBC	chr17	64060490	Silent	novel	S395S	0.16
ESCA	chr17	64054286	Nonsense_Mutation	novel	Y639*	0.13
GBM	chr17	64047911	Missense_Mutation	rs758266847	V826M	0.12
GBM	chr17	64060537	Missense_Mutation	NA	P380S	0.37
GBM	chr17	64054323	Missense_Mutation	novel	R627L	0.04
GBM	chr17	64066706	Silent	rs183713088	P269P	0.32
HNSC	chr17	64045474	Silent	rs751720267	S846S	0.19
HNSC	chr17	64066924	Missense_Mutation	novel	H197D	0.08
HNSC	chr17	64044079	Missense_Mutation	novel	M948T	0.28	Ribonuc_2-5A
HNSC	chr17	64049149	Silent	novel	S769S	0.48
HNSC	chr17	64043989	Silent	novel	*978*	0.19
KIRC	chr17	64045467	Frame_Shift_Del	novel	I849*	0.28	Ribonuc_2-5A
KIRC	chr17	64064074	Silent	novel	V333V	0.12
KIRP	chr17	64044188	Missense_Mutation	rs185854736	R912W	0.35	Ribonuc_2-5A
LGG	chr17	64054306	Missense_Mutation	novel	K633Q	0.24
LGG	chr17	64066706	Silent	rs183713088	P269P	0.88
LGG	chr17	64045444	Silent	novel	G856G	0.24
LGG	chr17	64047929	Missense_Mutation	NA	R820C	0.36
LGG	chr17	64066927	Missense_Mutation	novel	S196T	0.32
LGG	chr17	64057837	Missense_Mutation	novel	I455F	0.09
LIHC	chr17	64057964	Missense_Mutation	novel	E412D	0.4
LIHC	chr17	64055863	Missense_Mutation	novel	Q495L	0.07
LIHC	chr17	64047946	Missense_Mutation	novel	A814E	0.07
LIHC	chr17	64130112	5'UTR	novel		0.86
LUAD	chr17	64049109	Missense_Mutation	NA	A783T	0.25
LUAD	chr17	64057819	Missense_Mutation	novel	I461F	0.1
LUAD	chr17	64047858	Missense_Mutation	novel	Q843H	0.25	Ribonuc_2-5A
LUAD	chr17	64045416	Missense_Mutation	novel	G866W	0.6	Ribonuc_2-5A
LUAD	chr17	64068216	Missense_Mutation	NA	S185L	0.12
LUAD	chr17	64054358	Silent	novel	L615L	0.48
LUAD	chr17	64054280	Silent	NA	A641A	0.56
LUAD	chr17	64066784	Silent	NA	I243I	0.1
LUAD	chr17	64052853	Missense_Mutation	novel	R727L	0.09
LUAD	chr17	64057985	Silent	novel	N405N	0.15
LUAD	chr17	64098185	Silent	rs374385951	T37T	0.19
LUAD	chr17	64057805	Silent	rs375031481	P465P	0.1
LUAD	chr17	64054313	Nonsense_Mutation	novel	C630*	0.17
LUSC	chr17	64053269	Splice_Region	novel		0.15
LUSC	chr17	64068281	Silent	novel	I163I	0.13
LUSC	chr17	64098225	Missense_Mutation	NA	S24N	0.27
LUSC	chr17	64044062	Missense_Mutation	NA	E954K	0.19	Ribonuc_2-5A
LUSC	chr17	64060513	Missense_Mutation	NA	E388K	0.27
LUSC	chr17	64057905	Missense_Mutation	novel	R432L	0.33
LUSC	chr17	64055729	Missense_Mutation	rs772826129	G540S	0.08
LUSC	chr17	64066918	Missense_Mutation	novel	V199M	0.34
LUSC	chr17	64066811	Silent	novel	R234R	0.57
OV	chr17	64052891	Silent	novel	L714L	0.09
OV	chr17	64064119	In_Frame_Ins	novel	G318_P319insAVFLASV	0.4
OV	chr17	64043962	3'UTR	novel		0.48
OV	chr17	64098147	Missense_Mutation	NA	G50A	0.13
OV	chr17	64066813	Missense_Mutation	novel	R234G	0.09
OV	chr17	64045409	Missense_Mutation	NA	A868D	0.45	Ribonuc_2-5A
OV	chr17	64057895	Silent	novel	A435A	0.17
PAAD	chr17	64047980	Missense_Mutation	novel	V803I	0.18
PAAD	chr17	64052782	Missense_Mutation	novel	P751S	0.18
PAAD	chr17	64057986	Missense_Mutation	rs780208953	N405S	0.29
PRAD	chr17	64053316	Frame_Shift_Del	novel	*Q670Rfs20**	0.27
PRAD	chr17	64047929	Missense_Mutation	NA	R820C	0.31
PRAD	chr17	64053348	Silent	rs774733130	A659A	0.26
PRAD	chr17	64063991	Missense_Mutation	novel	L361P	0.39
READ	chr17	64052800	Missense_Mutation	rs750705699	E745K	0.38
SKCM	chr17	64044053	Missense_Mutation	NA	F957I	0.25	Ribonuc_2-5A
SKCM	chr17	64049182	Missense_Mutation	novel	F758L	0.34
SKCM	chr17	64064030	Missense_Mutation	novel	S348N	0.34
SKCM	chr17	64047896	Missense_Mutation	novel	F831I	0.1
SKCM	chr17	64060537	Missense_Mutation	NA	P380S	0.34
SKCM	chr17	64047899	Missense_Mutation	NA	P830S	0.24
SKCM	chr17	64066707	Missense_Mutation	rs777538073	P269L	0.32
SKCM	chr17	64053326	Missense_Mutation	NA	T667A	0.27
SKCM	chr17	64053283	Missense_Mutation	NA	S681F	0.2
SKCM	chr17	64055760	Silent	rs754109329	S529S	0.35
SKCM	chr17	64079722	Silent	novel	L74L	0.43
SKCM	chr17	64057950	Missense_Mutation	NA	T417I	0.31
SKCM	chr17	64052918	Silent	NA	I705I	0.7
SKCM	chr17	64044144	Silent	rs8077780	P926P	0.14
SKCM	chr17	64054792	Missense_Mutation	NA	S570F	0.12
SKCM	chr17	64044081	Silent	NA	A947A	0.29
SKCM	chr17	64044140	Missense_Mutation	NA	D928N	0.91	Ribonuc_2-5A
SKCM	chr17	64054794	Silent	NA	I569I	0.44
SKCM	chr17	64054792	Missense_Mutation	NA	S570F	0.44
SKCM	chr17	64052786	Silent	rs765646119	E749E	0.14
SKCM	chr17	64072020	Missense_Mutation	NA	L147F	0.58
SKCM	chr17	64043973	3'UTR	novel		0.22
SKCM	chr17	64044026	Missense_Mutation	NA	P966S	0.11
SKCM	chr17	64054792	Missense_Mutation	NA	S570F	0.45
SKCM	chr17	64047894	Silent	rs61745997	F831F	0.2
SKCM	chr17	64054792	Missense_Mutation	NA	S570F	1
SKCM	chr17	64072094	Missense_Mutation	NA	Q122R	0.2
SKCM	chr17	64057883	Silent	novel	S439S	0.47
SKCM	chr17	64044109	Missense_Mutation	NA	P938L	0.22	Ribonuc_2-5A
SKCM	chr17	64060501	Missense_Mutation	NA	P392S	0.34
SKCM	chr17	64054299	Missense_Mutation	NA	R635Q	0.34
SKCM	chr17	64066766	Silent	rs746472253	T249T	0.31
STAD	chr17	64045473	Missense_Mutation	rs766760061	D847N	0.21	Ribonuc_2-5A
STAD	chr17	64066745	Missense_Mutation	NA	M256I	0.18
STAD	chr17	64060563	Missense_Mutation	rs376936066	A371V	0.36
STAD	chr17	64072036	Silent	rs763718430	S141S	0.67
STAD	chr17	64066839	Missense_Mutation	NA	P225H	0.31
STAD	chr17	64047963	Missense_Mutation	NA	L808F	0.27
STAD	chr17	64057986	Missense_Mutation	rs780208953	N405S	0.36
STAD	chr17	64072097	Frame_Shift_Del	novel	*K121Sfs11**	0.21
STAD	chr17	64045464	Nonsense_Mutation	novel	E850*	0.07	Ribonuc_2-5A
STAD	chr17	64064086	Silent	NA	K329K	0.23
STAD	chr17	64043960	3'UTR	rs763697732		0.31
STAD	chr17	64066847	Silent	rs757259673	Y222Y	0.21
STAD	chr17	64054371	Missense_Mutation	novel	R611H	0.25
STAD	chr17	64066847	Silent	rs757259673	Y222Y	0.38
STAD	chr17	64054378	Missense_Mutation	NA	A609T	0.25
UCEC	chr17	64052902	Missense_Mutation	rs761547515	D711N	0.53
UCEC	chr17	64066743	Missense_Mutation	NA	S257F	0.53
UCEC	chr17	64055688	Missense_Mutation	novel	E553D	0.43
UCEC	chr17	64054354	Nonsense_Mutation	novel	R617*	0.48
UCEC	chr17	64044165	Silent	novel	R919R	0.07
UCEC	chr17	64044086	Missense_Mutation	rs200358341	R946W	0.44	Ribonuc_2-5A
UCEC	chr17	64052973	Missense_Mutation	novel	R687K	0.36
UCEC	chr17	64044135	Missense_Mutation	novel	F929L	0.44	Ribonuc_2-5A
UCEC	chr17	64098185	Silent	rs374385951	T37T	0.49
UCEC	chr17	64068193	Missense_Mutation	NA	Y193H	0.55
UCEC	chr17	64055678	Nonsense_Mutation	NA	G557*	0.5
UCEC	chr17	64055806	Missense_Mutation	NA	S514Y	0.43
UCEC	chr17	64052853	Missense_Mutation	rs769854043	R727H	0.71
UCEC	chr17	64064125	Silent	novel	L316L	0.33
UCEC	chr17	64064007	Missense_Mutation	novel	R356G	0.37
UCEC	chr17	64068222	Missense_Mutation	novel	A183V	0.28
UCEC	chr17	64044117	Silent	novel	S935S	0.5
UCEC	chr17	64047948	Silent	novel	I813I	0.24
UCEC	chr17	64072086	Missense_Mutation	novel	W125G	0.48
UCEC	chr17	64075175	Missense_Mutation	novel	G119S	0.18
UCEC	chr17	64066699	Frame_Shift_Ins	novel	*K272Qfs51**	0.36
UCEC	chr17	64066706	Silent	rs183713088	P269P	0.49
UCEC	chr17	64055824	Missense_Mutation	NA	G508D	0.38
UCEC	chr17	64055740	Missense_Mutation	rs567044945	S536L	0.41
UCEC	chr17	64054362	Missense_Mutation	novel	Q614R	0.3
UCEC	chr17	64066789	Missense_Mutation	rs773561085	H242Y	0.49
UCEC	chr17	64044057	Silent	novel	R955R	0.16
UCEC	chr17	64044921	Missense_Mutation	rs758628467	R887H	0.23	Ribonuc_2-5A
UCEC	chr17	64047946	Missense_Mutation	rs563941838	A814V	0.37
UCEC	chr17	64054420	Missense_Mutation	rs201570900	D595N	0.35
UCEC	chr17	64068259	Nonsense_Mutation	novel	R171*	0.4
UCEC	chr17	64068251	Silent	NA	L173L	0.42
UCEC	chr17	64044115	Missense_Mutation	rs756172050	R936H	0.3	Ribonuc_2-5A
UCEC	chr17	64043885	3'UTR	novel		0.35
UCEC	chr17	64044135	Silent	novel	F929F	0.32
UCEC	chr17	64060553	Missense_Mutation	novel	K374N	0.34
UCEC	chr17	64044135	Silent	novel	F929F	0.49
UCEC	chr17	64044121	Missense_Mutation	novel	T934I	0.36	Ribonuc_2-5A
UCEC	chr17	64044135	Silent	novel	F929F	0.08
UCEC	chr17	64045389	Missense_Mutation	rs776930056	R875W	0.34	Ribonuc_2-5A
UCEC	chr17	64043994	Silent	novel	A976A	0.42
UCEC	chr17	64055796	Silent	novel	Y517Y	0.35
UCEC	chr17	64044913	Missense_Mutation	novel	R890G	0.41	Ribonuc_2-5A
UCEC	chr17	64055874	Silent	novel	Q491Q	0.38
UCEC	chr17	64064086	Missense_Mutation	novel	K329N	0.27
UCEC	chr17	64054739	Missense_Mutation	rs773459403	R588W	0.32
UCEC	chr17	64045438	Silent	NA	I858I	0.34
UCEC	chr17	64045452	Missense_Mutation	novel	L854M	0.17	Ribonuc_2-5A
UCEC	chr17	64047980	Missense_Mutation	novel	V803I	0.25
UCEC	chr17	64066670	Splice_Site	novel	X281_splice	0.38
UCEC	chr17	64098124	Nonsense_Mutation	novel	E58*	0.26
UCEC	chr17	64052926	Missense_Mutation	rs750842031	G703S	0.26
UCEC	chr17	64055846	Missense_Mutation	novel	P501S	0.34
UCEC	chr17	64043996	Missense_Mutation	rs142212892	A976T	0.33
UCEC	chr17	64057942	Missense_Mutation	NA	R420W	0.35
UCEC	chr17	64066814	Silent	novel	Q233Q	0.51
UCEC	chr17	64044115	Missense_Mutation	rs756172050	R936H	0.42	Ribonuc_2-5A

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3971	0.00012456
DLBC	DEL	0.0625	0.18166
KIRP	AMP	0.6667	0.14801
LGG	AMP	0.0585	1.52e-05
READ	AMP	0.1818	0.15915
SARC	AMP	0.214	0.032181
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0051	Kaplan-Meier Survival Analysis
ACC	0.0003	Kaplan-Meier Survival Analysis
HNSC	0.05	Kaplan-Meier Survival Analysis
SKCM	0.015	Kaplan-Meier Survival Analysis
LUSC	0.007	Kaplan-Meier Survival Analysis
KIRP	0.0013	Kaplan-Meier Survival Analysis
BLCA	0.039	Kaplan-Meier Survival Analysis
CESC	0.015	Kaplan-Meier Survival Analysis
KICH	0.0057	Kaplan-Meier Survival Analysis
UCEC	0.0096	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0069	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742