EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000178685 (Gene tree)
Gene ID: 84875
Gene Symbol: PARP10
Alias: FLJ14464
Full Name: poly(ADP-ribose) polymerase family member 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 35,621 bases
Position: chr8:143,977,152-144,012,772
Accession: 25895
RBP type: canonical RBP
Summary: Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000431620	PARP	PF00644.20	1.2e-26	1	1
ENSP00000325618	PARP	PF00644.20	1.2e-26	1	1
ENSP00000434776	PARP	PF00644.20	1.3e-26	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000313059	PARP10-202	1090	-	ENSP00000314320	339 (aa)	-	F8W8G7
ENST00000531537	PARP10-218	578	-	ENSP00000432204	144 (aa)	-	E9PIA6
ENST00000528914	PARP10-213	589	-	ENSP00000434005	135 (aa)	-	E9PSE7
ENST00000529311	PARP10-215	529	-	ENSP00000434411	106 (aa)	-	E9PQQ6
ENST00000526007	PARP10-207	2179	-	-	- (aa)	-	-
ENST00000525486	PARP10-204	564	-	ENSP00000435793	146 (aa)	-	E9PIK9
ENST00000529842	PARP10-216	696	-	ENSP00000436697	144 (aa)	-	E9PIA6
ENST00000528580	PARP10-211	488	-	-	- (aa)	-	-
ENST00000525773	PARP10-205	3404	-	ENSP00000434776	1037 (aa)	-	E9PNI7
ENST00000532311	PARP10-220	481	-	ENSP00000435161	83 (aa)	-	E9PLE8
ENST00000528963	PARP10-214	581	-	-	- (aa)	-	-
ENST00000313028	PARP10-201	3497	-	ENSP00000325618	1025 (aa)	-	Q53GL7
ENST00000532660	PARP10-221	545	-	-	- (aa)	-	-
ENST00000527262	PARP10-209	3027	-	ENSP00000432733	764 (aa)	-	E9PPE7
ENST00000533665	PARP10-222	935	-	-	- (aa)	-	-
ENST00000528625	PARP10-212	685	-	ENSP00000431818	172 (aa)	-	E9PJI2
ENST00000524918	PARP10-203	3469	XM_011517336	ENSP00000431620	1016 (aa)	XP_011515638	E9PK67
ENST00000525879	PARP10-206	939	-	ENSP00000436301	178 (aa)	-	E9PPV8
ENST00000528136	PARP10-210	899	-	ENSP00000431250	128 (aa)	-	E9PM86
ENST00000526985	PARP10-208	571	-	-	- (aa)	-	-
ENST00000530478	PARP10-217	588	-	ENSP00000436333	88 (aa)	-	E9PPU2
ENST00000531707	PARP10-219	500	-	ENSP00000433990	81 (aa)	-	E9PSG8
ENST00000534737	PARP10-223	550	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000178685's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000178685	rs11784833	8	143989244	C	LDL cholesterol	25961943	[0.028-0.056] s.d. increase	0.042	EFO_0004611
ENSG00000178685	rs6985603	8	144012260	?	Tonsillectomy	28928442	[0.023-0.056] unit increase	0.0398	EFO_0007924
ENSG00000178685	rs56261297	8	143992685	?	Mean corpuscular volume	29403010	[0.022-0.045] unit increase novel	0.03373	EFO_0004526
ENSG00000178685	rs6420181	8	144007080	?	Mean corpuscular hemoglobin	29403010	[0.023-0.045] unit increase novel	0.0336	EFO_0004527
ENSG00000178685	rs11136252	8	144010325	?	Fibrinogen levels	28107422	unit increase	0.0056	EFO_0004623
ENSG00000178685	rs11784833	8	143989244	C	Red cell distribution width	28957414	[0.015-0.031] unit decrease	0.0231467	EFO_0005192
ENSG00000178685	rs11784833	8	143989244	T	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.025	EFO_0004611
ENSG00000178685	rs11784833	8	143989244	T	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.027	EFO_0004611
ENSG00000178685	rs11784833	8	143989244	T	Total cholesterol levels	29507422	unit decrease	0.022	EFO_0004574
ENSG00000178685	rs11784833	8	143989244	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178685's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000178685	PARP10	86	54.167	ENSAPOG00000016910	si:ch1073-296d18.1	65	46.067	Acanthochromis_polyacanthus
ENSG00000178685	PARP10	55	33.333	ENSAOCG00000007023	-	70	32.865	Amphiprion_ocellaris
ENSG00000178685	PARP10	99	94.776	ENSANAG00000037218	PARP10	99	84.195	Aotus_nancymaae
ENSG00000178685	PARP10	97	80.851	ENSBTAG00000009677	PARP10	99	65.982	Bos_taurus
ENSG00000178685	PARP10	99	94.488	ENSCJAG00000034531	PARP10	100	85.274	Callithrix_jacchus
ENSG00000178685	PARP10	100	80.822	ENSCHIG00000008072	PARP10	100	66.569	Capra_hircus
ENSG00000178685	PARP10	94	88.148	ENSTSYG00000005439	PARP10	99	75.588	Carlito_syrichta
ENSG00000178685	PARP10	98	80.303	ENSCAPG00000014295	PARP10	99	73.810	Cavia_aperea
ENSG00000178685	PARP10	98	80.303	ENSCPOG00000014235	PARP10	100	66.371	Cavia_porcellus
ENSG00000178685	PARP10	100	91.573	ENSCCAG00000024610	PARP10	100	84.957	Cebus_capucinus
ENSG00000178685	PARP10	100	97.917	ENSCATG00000025822	PARP10	100	92.683	Cercocebus_atys
ENSG00000178685	PARP10	97	83.495	ENSCLAG00000013744	PARP10	100	67.777	Chinchilla_lanigera
ENSG00000178685	PARP10	98	97.727	ENSCSAG00000008843	PARP10	100	92.857	Chlorocebus_sabaeus
ENSG00000178685	PARP10	72	56.284	ENSCPBG00000004075	PARP10	85	56.284	Chrysemys_picta_bellii
ENSG00000178685	PARP10	100	97.222	ENSCANG00000043564	PARP10	97	90.723	Colobus_angolensis_palliatus
ENSG00000178685	PARP10	97	76.471	ENSCGRG00001012953	Parp10	100	64.356	Cricetulus_griseus_chok1gshd
ENSG00000178685	PARP10	97	76.471	ENSCGRG00000003088	Parp10	100	64.356	Cricetulus_griseus_crigri
ENSG00000178685	PARP10	73	53.297	ENSDARG00000087145	si:ch1073-296d18.1	68	53.297	Danio_rerio
ENSG00000178685	PARP10	90	78.788	ENSDNOG00000046110	PARP10	99	64.050	Dasypus_novemcinctus
ENSG00000178685	PARP10	99	75.238	ENSETEG00000014689	-	56	72.000	Echinops_telfairi
ENSG00000178685	PARP10	89	84.043	ENSEASG00005009729	PARP10	99	71.775	Equus_asinus_asinus
ENSG00000178685	PARP10	97	75.573	ENSEEUG00000005507	PARP10	91	73.826	Erinaceus_europaeus
ENSG00000178685	PARP10	100	50.000	ENSELUG00000001455	si:ch1073-296d18.1	70	52.660	Esox_lucius
ENSG00000178685	PARP10	98	84.091	ENSFDAG00000015949	PARP10	100	66.272	Fukomys_damarensis
ENSG00000178685	PARP10	90	44.211	ENSGMOG00000000853	si:ch1073-296d18.1	80	33.043	Gadus_morhua
ENSG00000178685	PARP10	94	50.633	ENSGACG00000008798	si:ch1073-296d18.1	84	33.506	Gasterosteus_aculeatus
ENSG00000178685	PARP10	100	99.438	ENSGGOG00000001802	PARP10	100	98.049	Gorilla_gorilla
ENSG00000178685	PARP10	99	82.090	ENSHGLG00000010423	PARP10	96	66.978	Heterocephalus_glaber_female
ENSG00000178685	PARP10	84	51.913	ENSIPUG00000011187	parp10	74	51.913	Ictalurus_punctatus
ENSG00000178685	PARP10	97	84.706	ENSJJAG00000017801	Parp10	99	64.243	Jaculus_jaculus
ENSG00000178685	PARP10	55	33.275	ENSLBEG00000003798	si:ch1073-296d18.1	90	33.042	Labrus_bergylta
ENSG00000178685	PARP10	99	52.874	ENSLACG00000008645	PARP10	94	38.435	Latimeria_chalumnae
ENSG00000178685	PARP10	85	52.174	ENSLOCG00000008505	si:ch1073-296d18.1	80	35.017	Lepisosteus_oculatus
ENSG00000178685	PARP10	96	63.546	ENSLAFG00000004191	PARP10	98	63.817	Loxodonta_africana
ENSG00000178685	PARP10	99	98.851	ENSMFAG00000044942	PARP10	100	92.759	Macaca_fascicularis
ENSG00000178685	PARP10	99	98.851	ENSMMUG00000000449	PARP10	100	92.671	Macaca_mulatta
ENSG00000178685	PARP10	99	98.851	ENSMNEG00000034827	PARP10	100	92.857	Macaca_nemestrina
ENSG00000178685	PARP10	100	97.222	ENSMLEG00000024662	PARP10	100	92.421	Mandrillus_leucophaeus
ENSG00000178685	PARP10	99	88.060	ENSMICG00000016227	PARP10	100	76.774	Microcebus_murinus
ENSG00000178685	PARP10	97	77.647	ENSMOCG00000000179	Parp10	100	64.229	Microtus_ochrogaster
ENSG00000178685	PARP10	98	66.667	ENSMODG00000010393	-	86	63.600	Monodelphis_domestica
ENSG00000178685	PARP10	97	78.824	MGP_CAROLIEiJ_G0019914	Parp10	100	78.182	Mus_caroli
ENSG00000178685	PARP10	97	78.824	ENSMUSG00000063268	Parp10	99	78.182	Mus_musculus
ENSG00000178685	PARP10	97	80.000	MGP_PahariEiJ_G0019924	Parp10	100	77.273	Mus_pahari
ENSG00000178685	PARP10	97	78.824	MGP_SPRETEiJ_G0020817	Parp10	100	77.273	Mus_spretus
ENSG00000178685	PARP10	79	66.991	ENSMLUG00000002730	PARP10	100	67.275	Myotis_lucifugus
ENSG00000178685	PARP10	98	83.688	ENSNGAG00000023968	Parp10	100	67.682	Nannospalax_galili
ENSG00000178685	PARP10	99	98.305	ENSNLEG00000002423	PARP10	100	94.118	Nomascus_leucogenys
ENSG00000178685	PARP10	95	66.197	ENSMEUG00000001906	-	92	66.452	Notamacropus_eugenii
ENSG00000178685	PARP10	98	71.970	ENSOPRG00000015616	-	66	71.739	Ochotona_princeps
ENSG00000178685	PARP10	98	75.887	ENSODEG00000014276	PARP10	100	64.706	Octodon_degus
ENSG00000178685	PARP10	86	50.000	ENSONIG00000007669	si:ch1073-296d18.1	74	39.835	Oreochromis_niloticus
ENSG00000178685	PARP10	92	55.446	ENSOANG00000013123	-	94	52.529	Ornithorhynchus_anatinus
ENSG00000178685	PARP10	99	80.303	ENSOGAG00000033747	PARP10	99	73.608	Otolemur_garnettii
ENSG00000178685	PARP10	99	80.000	ENSOARG00000015581	PARP10	99	65.962	Ovis_aries
ENSG00000178685	PARP10	100	99.438	ENSPPAG00000041157	PARP10	100	98.168	Pan_paniscus
ENSG00000178685	PARP10	100	99.438	ENSPTRG00000043606	PARP10	100	98.049	Pan_troglodytes
ENSG00000178685	PARP10	99	98.851	ENSPANG00000023348	PARP10	100	92.768	Papio_anubis
ENSG00000178685	PARP10	92	44.330	ENSPFOG00000013067	si:ch1073-296d18.1	100	30.324	Poecilia_formosa
ENSG00000178685	PARP10	55	33.108	ENSPLAG00000022710	-	78	32.487	Poecilia_latipinna
ENSG00000178685	PARP10	55	32.982	ENSPMEG00000019504	-	77	32.632	Poecilia_mexicana
ENSG00000178685	PARP10	100	100.000	ENSPPYG00000018955	PARP10	100	91.033	Pongo_abelii
ENSG00000178685	PARP10	95	82.143	ENSPCAG00000001115	PARP10	90	78.231	Procavia_capensis
ENSG00000178685	PARP10	100	88.194	ENSPCOG00000028616	PARP10	100	77.171	Propithecus_coquereli
ENSG00000178685	PARP10	91	83.333	ENSPVAG00000006369	PARP10	99	68.457	Pteropus_vampyrus
ENSG00000178685	PARP10	99	44.286	ENSPNAG00000024484	si:ch1073-296d18.1	65	51.075	Pygocentrus_nattereri
ENSG00000178685	PARP10	98	73.759	ENSRNOG00000004361	Parp10	100	64.138	Rattus_norvegicus
ENSG00000178685	PARP10	99	96.528	ENSRBIG00000040506	PARP10	100	92.478	Rhinopithecus_bieti
ENSG00000178685	PARP10	98	97.163	ENSRROG00000039086	PARP10	100	90.944	Rhinopithecus_roxellana
ENSG00000178685	PARP10	98	93.939	ENSSBOG00000008301	PARP10	100	82.583	Saimiri_boliviensis_boliviensis
ENSG00000178685	PARP10	98	63.121	ENSSHAG00000002568	-	87	60.956	Sarcophilus_harrisii
ENSG00000178685	PARP10	55	33.275	ENSSLDG00000003545	-	79	33.392	Seriola_lalandi_dorsalis
ENSG00000178685	PARP10	99	48.611	ENSTNIG00000014023	si:ch1073-296d18.1	85	33.846	Tetraodon_nigroviridis
ENSG00000178685	PARP10	100	78.409	ENSTTRG00000006314	PARP10	99	68.462	Tursiops_truncatus
ENSG00000178685	PARP10	55	33.000	ENSXCOG00000003615	-	78	32.877	Xiphophorus_couchianus
ENSG00000178685	PARP10	55	33.275	ENSXMAG00000025112	-	77	33.275	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003950	NAD+ ADP-ribosyltransferase activity	23473667.23575687.	IMP	Function
GO:0005515	protein binding	15674325.22176891.23473667.23481255.24695737.	IPI	Function
GO:0005634	nucleus	15674325.22176891.23473667.	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	15674325.22176891.23473667.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006471	protein ADP-ribosylation	23575687.	IMP	Process
GO:0010629	negative regulation of gene expression	23575687.	IMP	Process
GO:0010847	regulation of chromatin assembly	15674325.	IDA	Process
GO:0019985	translesion synthesis	24695737.	IDA	Process
GO:0032088	negative regulation of NF-kappaB transcription factor activity	23575687.	IMP	Process
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	-	TAS	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045071	negative regulation of viral genome replication	22176891.	IMP	Process
GO:0048147	negative regulation of fibroblast proliferation	15674325.	IDA	Process
GO:0070212	protein poly-ADP-ribosylation	15674325.	IDA	Process
GO:0070212	protein poly-ADP-ribosylation	23473667.	IMP	Process
GO:0070213	protein auto-ADP-ribosylation	18851833.25043379.	IDA	Process
GO:0070213	protein auto-ADP-ribosylation	23575687.	IMP	Process
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	23575687.	IMP	Function
GO:1900045	negative regulation of protein K63-linked ubiquitination	23575687.	IMP	Process
GO:1990404	protein ADP-ribosylase activity	18851833.25043379.	IDA	Function
GO:1990404	protein ADP-ribosylase activity	24695737.	IMP	Function