EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000178695 (Gene tree)
Gene ID: 115207
Gene Symbol: KCTD12
Alias: KIAA1778|PFET1|C13orf2
Full Name: potassium channel tetramerization domain containing 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 6,240 bases
Position: chr13:76,880,166-76,886,405
Accession: 14678
RBP type: non-canonical RBP
Summary: (Potassium Channel Tetramerization Domain Containing 12) is a Protein Coding gene. Diseases associated with KCTD12 include Gastrointestinal Stromal Tumor. Among its related pathways are Sweet Taste Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. An important paralog of this gene is KCTD8.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000377474	KCTD12-201	6225	-	ENSP00000366694	325 (aa)	-	Q96CX2

Gene Model

Click here to download ENSG00000178695's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000178695	Platelet Function Tests	5.4200000E-006	-
ENSG00000178695	Anticonvulsants	2E-7	25944848
ENSG00000178695	Bipolar Disorder	2E-7	25944848
ENSG00000178695	Depressive Disorder	2E-7	25944848
ENSG00000178695	Psychotropic Drugs	2E-7	25944848
ENSG00000178695	Schizophrenia	2E-7	25944848

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178695's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0030054	cell junction	-	IEA	Component
GO:0042734	presynaptic membrane	-	IEA	Component
GO:0042802	identical protein binding	27152988.	IPI	Function
GO:0045211	postsynaptic membrane	-	IEA	Component
GO:0051260	protein homooligomerization	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23290008	Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor.	Hum Pathol	2013 Jul	Hasegawa T	doi: 10.1016/j.humpath.2012.10.013
26847701	KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.	Sci Rep	2016 Feb 5	Li L	doi: 10.1038/srep20460.
28869606	KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.	Oncogene	2017 Nov 2	Zhong Y	doi: 10.1038/onc.2017.287

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr13	76885489	Silent	novel	I220I	0.43
BLCA	chr13	76885423	Silent	NA	T242T	0.82
BRCA	chr13	76886017	In_Frame_Del	novel	G41_V44del	0.57
BRCA	chr13	76881528	3'UTR	novel		0.08
BRCA	chr13	76885211	Missense_Mutation	novel	I313T	0.14
CESC	chr13	76880772	3'UTR	novel		0.21
CESC	chr13	76885879	Silent	rs751329210	R90R	0.27
CESC	chr13	76880216	3'UTR	novel		0.1
CESC	chr13	76880856	3'UTR	novel		0.53
COAD	chr13	76885445	Missense_Mutation	novel	R235P	0.22
COAD	chr13	76885338	Missense_Mutation	novel	Y271H	0.35
COAD	chr13	76885244	Missense_Mutation	NA	F302Y	0.13
COAD	chr13	76885497	Missense_Mutation	novel	Y218H	0.24
COAD	chr13	76885472	Missense_Mutation	NA	A226V	0.13
COAD	chr13	76886108	Frame_Shift_Del	novel	*G14Afs25**	0.13
ESCA	chr13	76880815	3'UTR	novel		0.52
ESCA	chr13	76880816	3'UTR	novel		0.33
GBM	chr13	76885294	Silent	NA	S285S	0.19
GBM	chr13	76885315	Silent	rs567595130	E278E	0.61
HNSC	chr13	76885359	Missense_Mutation	novel	E264K	0.34
HNSC	chr13	76885957	Silent	novel	F64F	0.28
KIRP	chr13	76885356	Missense_Mutation	novel	R265G	0.28
LUAD	chr13	76885891	Silent	rs561972031	G86G	0.34
LUSC	chr13	76885230	Missense_Mutation	novel	D307Y	0.38
LUSC	chr13	76885921	Missense_Mutation	NA	S76R	0.26
MESO	chr13	76885293	Nonsense_Mutation	novel	E286*	0.5
OV	chr13	76885225	Missense_Mutation	NA	Q308H	0.56
OV	chr13	76885294	Silent	NA	S285S	0.43
PAAD	chr13	76885265	Missense_Mutation	novel	S295N	0.2
PAAD	chr13	76885912	Silent	novel	R79R	0.19
READ	chr13	76885311	Missense_Mutation	novel	A280T	0.43
SARC	chr13	76880316	3'UTR	novel		0.27
SARC	chr13	76883785	3'UTR	novel		0.33
SKCM	chr13	76885294	Silent	NA	S285S	0.8
SKCM	chr13	76885246	Silent	NA	A301A	0.35
STAD	chr13	76885210	Missense_Mutation	NA	I313M	0.06
UCEC	chr13	76883790	3'UTR	novel		0.4
UCEC	chr13	76881503	3'UTR	novel		0.55
UCEC	chr13	76880609	3'UTR	novel		0.17
UCEC	chr13	76881288	3'UTR	novel		0.3
UCEC	chr13	76880197	3'UTR	novel		0.51
UCEC	chr13	76885378	Silent	novel	R257R	0.2
UCEC	chr13	76880539	3'UTR	novel		0.36
UCEC	chr13	76883459	3'UTR	novel		0.33
UCEC	chr13	76886077	Silent	novel	S24S	0.8
UCEC	chr13	76880789	3'UTR	novel		0.11
UCEC	chr13	76883689	3'UTR	novel		0.7
UCEC	chr13	76885115	3'UTR	novel		0.35
UCEC	chr13	76880265	3'UTR	novel		0.23
UCEC	chr13	76883524	3'UTR	novel		0.31
UCEC	chr13	76880615	3'UTR	novel		0.19
UCEC	chr13	76880810	3'UTR	novel		0.16
UCEC	chr13	76883763	3'UTR	novel		0.22
UCEC	chr13	76883860	3'UTR	rs142071448		0.59
UCEC	chr13	76880226	3'UTR	novel		0.31
UCEC	chr13	76885115	3'UTR	novel		0.17
UCEC	chr13	76881622	3'UTR	novel		0.71
UCEC	chr13	76883464	3'UTR	rs529854695		0.26
UCEC	chr13	76880192	3'UTR	novel		0.32
UCEC	chr13	76885119	3'UTR	novel		0.27
UCEC	chr13	76885057	3'UTR	novel		0.5
UCEC	chr13	76880866	3'UTR	novel		0.33
UCEC	chr13	76883492	3'UTR	novel		0.36
UCEC	chr13	76880815	3'UTR	novel		0.31
UCEC	chr13	76885463	Missense_Mutation	novel	K229R	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4167	0.076931
PRAD	DEL	0.2785	1.7107e-36

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.016	Kaplan-Meier Survival Analysis
ACC	0.014	Kaplan-Meier Survival Analysis
SKCM	0.011	Kaplan-Meier Survival Analysis
KIRP	0.046	Kaplan-Meier Survival Analysis
PAAD	0.012	Kaplan-Meier Survival Analysis
LAML	0.0022	Kaplan-Meier Survival Analysis
UCEC	0.0031	Kaplan-Meier Survival Analysis
LGG	0.0015	Kaplan-Meier Survival Analysis
LUAD	0.00022	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742