EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000178896 (Gene tree)
Gene ID: 54512
Gene Symbol: EXOSC4
Alias: hRrp41p|FLJ20591|Rrp41p|RRP41|RRP41A|Ski6p|SKI6|p12A
Full Name: exosome component 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 16,562 bases
Position: chr8:144,064,087-144,080,648
Accession: 18189
RBP type: canonical RBP
Summary: (Exosome Component 4) is a Protein Coding gene. Among its related pathways are PERK regulates gene expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include 3'-5'-exoribonuclease activity and exoribonuclease activity. An important paralog of this gene is EXOSC6.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000315476	RNase_PH	PF01138.21	4.1e-33	1	1
ENSP00000436539	RNase_PH	PF01138.21	1.3e-18	1	1
ENSP00000432661	RNase_PH	PF01138.21	3.8e-12	1	1
ENSP00000315476	RNase_PH_C	PF03725.15	1.8e-07	1	1
ENSP00000436539	RNase_PH_C	PF03725.15	2e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28355211	Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex.	PLoS Genet	2017 Mar 29	Delan-Forino C	doi: 10.1371/journal.pgen.1006699
12947419	An exosome-like complex in Sulfolobus solfataricus.	EMBO Rep	2003 Sep	Evguenieva-Hackenberg E	-
22503705	Heterogeneous complexes of the RNA exosome in Sulfolobus solfataricus.	Biochimie	2012 Jul	Witharana C	doi: 10.1016/j.biochi.2012.03.026
20488184	The evolutionarily conserved subunits Rrp4 and Csl4 confer different substrate specificities to the archaeal exosome.	FEBS Lett	2010 Jul 2	Roppelt V	doi: 10.1016/j.febslet.2010.05.014
24789718	Structure and function of the archaeal exosome.	Wiley Interdiscip Rev RNA	2014 Sep-Oct	Evguenieva-Hackenberg E	doi: 10.1002/wrna.1234

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000316052	EXOSC4-201	887	-	ENSP00000315476	245 (aa)	-	Q9NPD3
ENST00000527954	EXOSC4-203	1065	XM_011517134	ENSP00000436539	261 (aa)	XP_011515436	E9PI41
ENST00000525936	EXOSC4-202	606	-	ENSP00000432661	156 (aa)	-	E9PPI9

Gene Model

Click here to download ENSG00000178896's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178896's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000178896	EXOSC4	69	33.918	ENSG00000077348	EXOSC5	80	32.512
ENSG00000178896	EXOSC4	72	34.392	ENSG00000223496	EXOSC6	70	34.555

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000178896	EXOSC4	100	74.694	ENSAPOG00000000255	exosc4	100	74.694	Acanthochromis_polyacanthus
ENSG00000178896	EXOSC4	96	32.389	ENSAPOG00000022329	exosc6	88	32.389	Acanthochromis_polyacanthus
ENSG00000178896	EXOSC4	76	33.333	ENSAMEG00000011623	EXOSC5	88	32.127	Ailuropoda_melanoleuca
ENSG00000178896	EXOSC4	100	97.959	ENSAMEG00000006093	EXOSC4	100	97.959	Ailuropoda_melanoleuca
ENSG00000178896	EXOSC4	96	31.301	ENSACIG00000016636	exosc6	88	31.301	Amphilophus_citrinellus
ENSG00000178896	EXOSC4	100	74.694	ENSACIG00000017924	exosc4	100	74.694	Amphilophus_citrinellus
ENSG00000178896	EXOSC4	51	30.827	ENSACIG00000024067	exosc5	61	30.827	Amphilophus_citrinellus
ENSG00000178896	EXOSC4	100	75.102	ENSAOCG00000005105	exosc4	100	75.102	Amphiprion_ocellaris
ENSG00000178896	EXOSC4	96	31.984	ENSAOCG00000006951	exosc6	88	31.984	Amphiprion_ocellaris
ENSG00000178896	EXOSC4	96	31.984	ENSAPEG00000022951	exosc6	88	31.984	Amphiprion_percula
ENSG00000178896	EXOSC4	100	75.102	ENSAPEG00000003972	exosc4	100	75.102	Amphiprion_percula
ENSG00000178896	EXOSC4	96	30.328	ENSATEG00000014148	exosc6	88	31.148	Anabas_testudineus
ENSG00000178896	EXOSC4	68	31.737	ENSATEG00000008886	exosc5	77	31.737	Anabas_testudineus
ENSG00000178896	EXOSC4	100	75.510	ENSATEG00000007766	exosc4	100	75.510	Anabas_testudineus
ENSG00000178896	EXOSC4	77	73.158	ENSACAG00000004017	EXOSC4	99	73.158	Anolis_carolinensis
ENSG00000178896	EXOSC4	72	31.667	ENSACAG00000003784	EXOSC5	75	31.667	Anolis_carolinensis
ENSG00000178896	EXOSC4	72	32.275	ENSANAG00000009362	EXOSC6	68	32.984	Aotus_nancymaae
ENSG00000178896	EXOSC4	100	100.000	ENSANAG00000026123	EXOSC4	100	100.000	Aotus_nancymaae
ENSG00000178896	EXOSC4	96	33.468	ENSACLG00000022304	exosc6	88	33.468	Astatotilapia_calliptera
ENSG00000178896	EXOSC4	100	74.694	ENSACLG00000020071	exosc4	100	74.694	Astatotilapia_calliptera
ENSG00000178896	EXOSC4	91	33.047	ENSAMXG00000026269	exosc6	84	33.047	Astyanax_mexicanus
ENSG00000178896	EXOSC4	98	75.104	ENSAMXG00000030867	exosc4	98	75.104	Astyanax_mexicanus
ENSG00000178896	EXOSC4	74	34.021	ENSBTAG00000053923	EXOSC6	69	34.392	Bos_taurus
ENSG00000178896	EXOSC4	100	97.551	ENSBTAG00000014607	EXOSC4	100	97.551	Bos_taurus
ENSG00000178896	EXOSC4	89	30.769	ENSBTAG00000016034	EXOSC5	87	30.769	Bos_taurus
ENSG00000178896	EXOSC4	99	43.388	WBGene00007201	exos-4.1	100	43.388	Caenorhabditis_elegans
ENSG00000178896	EXOSC4	72	34.392	ENSCJAG00000014559	EXOSC6	70	34.555	Callithrix_jacchus
ENSG00000178896	EXOSC4	69	33.918	ENSCJAG00000020152	EXOSC5	80	32.512	Callithrix_jacchus
ENSG00000178896	EXOSC4	100	98.776	ENSCJAG00000021458	EXOSC4	100	98.776	Callithrix_jacchus
ENSG00000178896	EXOSC4	69	33.918	ENSCAFG00000032654	EXOSC5	80	32.512	Canis_familiaris
ENSG00000178896	EXOSC4	100	97.959	ENSCAFG00000001521	EXOSC4	100	97.959	Canis_familiaris
ENSG00000178896	EXOSC4	100	97.959	ENSCAFG00020018820	EXOSC4	100	97.959	Canis_lupus_dingo
ENSG00000178896	EXOSC4	69	33.918	ENSCAFG00020014770	EXOSC5	80	32.512	Canis_lupus_dingo
ENSG00000178896	EXOSC4	73	34.555	ENSCAFG00020020974	EXOSC6	70	34.555	Canis_lupus_dingo
ENSG00000178896	EXOSC4	83	30.918	ENSCHIG00000026498	EXOSC5	83	30.918	Capra_hircus
ENSG00000178896	EXOSC4	100	97.143	ENSCHIG00000021121	EXOSC4	100	97.143	Capra_hircus
ENSG00000178896	EXOSC4	78	33.498	ENSCHIG00000007389	EXOSC6	75	33.659	Capra_hircus
ENSG00000178896	EXOSC4	100	98.776	ENSTSYG00000029697	EXOSC4	100	98.776	Carlito_syrichta
ENSG00000178896	EXOSC4	69	33.333	ENSTSYG00000014183	EXOSC5	80	32.020	Carlito_syrichta
ENSG00000178896	EXOSC4	77	98.404	ENSCAPG00000017958	EXOSC4	86	98.404	Cavia_aperea
ENSG00000178896	EXOSC4	83	30.918	ENSCPOG00000035731	EXOSC5	81	30.918	Cavia_porcellus
ENSG00000178896	EXOSC4	73	30.366	ENSCPOG00000002371	-	67	30.366	Cavia_porcellus
ENSG00000178896	EXOSC4	73	32.597	ENSCPOG00000037814	-	68	33.516	Cavia_porcellus
ENSG00000178896	EXOSC4	100	98.776	ENSCPOG00000022671	EXOSC4	100	98.776	Cavia_porcellus
ENSG00000178896	EXOSC4	78	98.953	ENSCCAG00000025515	EXOSC4	92	98.953	Cebus_capucinus
ENSG00000178896	EXOSC4	82	31.527	ENSCCAG00000013179	EXOSC5	80	31.527	Cebus_capucinus
ENSG00000178896	EXOSC4	69	33.918	ENSCATG00000044084	EXOSC5	80	32.512	Cercocebus_atys
ENSG00000178896	EXOSC4	100	100.000	ENSCATG00000029965	EXOSC4	100	100.000	Cercocebus_atys
ENSG00000178896	EXOSC4	100	98.367	ENSCLAG00000014676	EXOSC4	100	98.367	Chinchilla_lanigera
ENSG00000178896	EXOSC4	100	100.000	ENSCSAG00000008802	EXOSC4	100	100.000	Chlorocebus_sabaeus
ENSG00000178896	EXOSC4	69	33.918	ENSCSAG00000003522	EXOSC5	73	32.020	Chlorocebus_sabaeus
ENSG00000178896	EXOSC4	88	30.137	ENSCHOG00000000047	EXOSC5	86	30.137	Choloepus_hoffmanni
ENSG00000178896	EXOSC4	100	80.816	ENSCPBG00000018860	EXOSC4	100	80.816	Chrysemys_picta_bellii
ENSG00000178896	EXOSC4	93	53.509	ENSCING00000009562	-	92	53.509	Ciona_intestinalis
ENSG00000178896	EXOSC4	54	31.343	ENSCSAVG00000009006	-	51	31.343	Ciona_savignyi
ENSG00000178896	EXOSC4	98	54.772	ENSCSAVG00000008006	-	98	54.772	Ciona_savignyi
ENSG00000178896	EXOSC4	93	30.962	ENSCSAVG00000002563	-	87	30.962	Ciona_savignyi
ENSG00000178896	EXOSC4	69	33.918	ENSCANG00000039325	EXOSC5	82	31.553	Colobus_angolensis_palliatus
ENSG00000178896	EXOSC4	100	100.000	ENSCANG00000035733	EXOSC4	100	100.000	Colobus_angolensis_palliatus
ENSG00000178896	EXOSC4	69	33.918	ENSCGRG00001017207	Exosc5	81	32.195	Cricetulus_griseus_chok1gshd
ENSG00000178896	EXOSC4	100	97.143	ENSCGRG00001020452	Exosc4	100	97.143	Cricetulus_griseus_chok1gshd
ENSG00000178896	EXOSC4	73	35.079	ENSCGRG00001000899	Exosc6	70	35.079	Cricetulus_griseus_chok1gshd
ENSG00000178896	EXOSC4	100	97.143	ENSCGRG00000016505	Exosc4	100	97.143	Cricetulus_griseus_crigri
ENSG00000178896	EXOSC4	53	35.115	ENSCGRG00000003031	Exosc5	61	35.115	Cricetulus_griseus_crigri
ENSG00000178896	EXOSC4	100	73.878	ENSCSEG00000010906	exosc4	100	73.878	Cynoglossus_semilaevis
ENSG00000178896	EXOSC4	98	75.519	ENSCVAG00000006625	exosc4	98	75.519	Cyprinodon_variegatus
ENSG00000178896	EXOSC4	98	75.833	ENSDARG00000103432	exosc4	99	75.833	Danio_rerio
ENSG00000178896	EXOSC4	91	31.304	ENSDARG00000036060	exosc6	84	31.304	Danio_rerio
ENSG00000178896	EXOSC4	100	97.143	ENSDNOG00000009800	EXOSC4	100	97.143	Dasypus_novemcinctus
ENSG00000178896	EXOSC4	73	35.079	ENSDNOG00000032035	EXOSC6	70	35.079	Dasypus_novemcinctus
ENSG00000178896	EXOSC4	69	33.918	ENSDNOG00000017137	EXOSC5	82	32.512	Dasypus_novemcinctus
ENSG00000178896	EXOSC4	100	96.735	ENSDORG00000008461	Exosc4	100	96.735	Dipodomys_ordii
ENSG00000178896	EXOSC4	69	33.333	ENSDORG00000003611	Exosc5	83	32.020	Dipodomys_ordii
ENSG00000178896	EXOSC4	96	53.361	FBgn0032487	Ski6	95	53.361	Drosophila_melanogaster
ENSG00000178896	EXOSC4	74	32.812	ENSETEG00000009358	EXOSC5	89	31.696	Echinops_telfairi
ENSG00000178896	EXOSC4	98	68.750	ENSEBUG00000014277	exosc4	99	68.750	Eptatretus_burgeri
ENSG00000178896	EXOSC4	58	35.417	ENSEBUG00000000312	exosc5	58	35.417	Eptatretus_burgeri
ENSG00000178896	EXOSC4	100	98.367	ENSEASG00005010166	EXOSC4	100	98.367	Equus_asinus_asinus
ENSG00000178896	EXOSC4	72	34.392	ENSEASG00005013410	EXOSC6	70	34.555	Equus_asinus_asinus
ENSG00000178896	EXOSC4	69	33.918	ENSEASG00005006327	EXOSC5	72	32.512	Equus_asinus_asinus
ENSG00000178896	EXOSC4	100	98.367	ENSECAG00000013658	EXOSC4	100	98.367	Equus_caballus
ENSG00000178896	EXOSC4	72	34.392	ENSECAG00000039860	EXOSC6	70	34.555	Equus_caballus
ENSG00000178896	EXOSC4	69	33.918	ENSECAG00000024210	EXOSC5	80	32.512	Equus_caballus
ENSG00000178896	EXOSC4	62	31.126	ENSEEUG00000007299	EXOSC5	57	31.126	Erinaceus_europaeus
ENSG00000178896	EXOSC4	92	33.333	ENSELUG00000015515	exosc6	84	33.333	Esox_lucius
ENSG00000178896	EXOSC4	72	32.961	ENSELUG00000021719	exosc5	74	32.961	Esox_lucius
ENSG00000178896	EXOSC4	100	75.102	ENSELUG00000021011	exosc4	100	75.102	Esox_lucius
ENSG00000178896	EXOSC4	100	98.367	ENSFCAG00000034465	EXOSC4	100	98.367	Felis_catus
ENSG00000178896	EXOSC4	69	33.333	ENSFCAG00000033818	EXOSC5	80	32.020	Felis_catus
ENSG00000178896	EXOSC4	73	34.031	ENSFCAG00000046021	EXOSC6	70	34.031	Felis_catus
ENSG00000178896	EXOSC4	80	30.303	ENSFALG00000012886	EXOSC5	97	30.303	Ficedula_albicollis
ENSG00000178896	EXOSC4	90	31.250	ENSFDAG00000001207	EXOSC5	90	31.250	Fukomys_damarensis
ENSG00000178896	EXOSC4	100	98.367	ENSFDAG00000006708	EXOSC4	100	98.367	Fukomys_damarensis
ENSG00000178896	EXOSC4	96	31.174	ENSFHEG00000017490	exosc6	88	31.174	Fundulus_heteroclitus
ENSG00000178896	EXOSC4	98	75.519	ENSFHEG00000013533	exosc4	98	75.519	Fundulus_heteroclitus
ENSG00000178896	EXOSC4	100	74.286	ENSGMOG00000002113	exosc4	98	74.286	Gadus_morhua
ENSG00000178896	EXOSC4	69	32.749	ENSGMOG00000015865	exosc5	73	32.749	Gadus_morhua
ENSG00000178896	EXOSC4	96	31.967	ENSGMOG00000008151	exosc6	88	31.967	Gadus_morhua
ENSG00000178896	EXOSC4	79	35.468	ENSGAFG00000015179	exosc6	78	35.266	Gambusia_affinis
ENSG00000178896	EXOSC4	99	75.207	ENSGAFG00000021407	exosc4	99	75.207	Gambusia_affinis
ENSG00000178896	EXOSC4	100	73.061	ENSGACG00000017838	exosc4	97	73.061	Gasterosteus_aculeatus
ENSG00000178896	EXOSC4	96	32.520	ENSGACG00000002690	exosc6	88	32.520	Gasterosteus_aculeatus
ENSG00000178896	EXOSC4	100	100.000	ENSGGOG00000040193	-	100	100.000	Gorilla_gorilla
ENSG00000178896	EXOSC4	69	33.918	ENSGGOG00000008428	EXOSC5	80	32.512	Gorilla_gorilla
ENSG00000178896	EXOSC4	100	100.000	ENSGGOG00000044212	-	100	100.000	Gorilla_gorilla
ENSG00000178896	EXOSC4	96	33.468	ENSHBUG00000011123	exosc6	88	33.468	Haplochromis_burtoni
ENSG00000178896	EXOSC4	100	74.694	ENSHBUG00000006605	exosc4	100	74.694	Haplochromis_burtoni
ENSG00000178896	EXOSC4	100	98.776	ENSHGLG00000016299	EXOSC4	100	98.776	Heterocephalus_glaber_female
ENSG00000178896	EXOSC4	73	35.602	ENSHGLG00000021313	EXOSC6	70	35.602	Heterocephalus_glaber_female
ENSG00000178896	EXOSC4	100	98.776	ENSHGLG00100018786	EXOSC4	100	98.776	Heterocephalus_glaber_male
ENSG00000178896	EXOSC4	100	73.061	ENSHCOG00000018875	exosc4	95	73.061	Hippocampus_comes
ENSG00000178896	EXOSC4	96	30.204	ENSHCOG00000012112	exosc6	88	30.204	Hippocampus_comes
ENSG00000178896	EXOSC4	98	73.444	ENSIPUG00000011922	Exosc4	98	73.444	Ictalurus_punctatus
ENSG00000178896	EXOSC4	56	37.410	ENSIPUG00000011820	Exosc5	58	37.410	Ictalurus_punctatus
ENSG00000178896	EXOSC4	90	31.250	ENSIPUG00000004761	exosc6	83	30.973	Ictalurus_punctatus
ENSG00000178896	EXOSC4	76	32.804	ENSSTOG00000019738	EXOSC5	88	31.674	Ictidomys_tridecemlineatus
ENSG00000178896	EXOSC4	73	34.555	ENSSTOG00000006849	EXOSC6	70	34.555	Ictidomys_tridecemlineatus
ENSG00000178896	EXOSC4	100	95.935	ENSSTOG00000002632	EXOSC4	100	95.935	Ictidomys_tridecemlineatus
ENSG00000178896	EXOSC4	69	33.333	ENSJJAG00000013914	Exosc5	87	32.692	Jaculus_jaculus
ENSG00000178896	EXOSC4	100	98.367	ENSJJAG00000009655	Exosc4	100	98.367	Jaculus_jaculus
ENSG00000178896	EXOSC4	96	31.148	ENSKMAG00000009821	exosc6	88	31.148	Kryptolebias_marmoratus
ENSG00000178896	EXOSC4	99	75.620	ENSKMAG00000015373	exosc4	99	75.620	Kryptolebias_marmoratus
ENSG00000178896	EXOSC4	94	32.083	ENSLBEG00000018680	exosc6	75	32.083	Labrus_bergylta
ENSG00000178896	EXOSC4	100	73.469	ENSLBEG00000012754	exosc4	100	73.469	Labrus_bergylta
ENSG00000178896	EXOSC4	56	88.636	ENSLACG00000009217	EXOSC4	98	89.764	Latimeria_chalumnae
ENSG00000178896	EXOSC4	99	74.793	ENSLOCG00000008878	exosc4	98	74.793	Lepisosteus_oculatus
ENSG00000178896	EXOSC4	92	32.766	ENSLOCG00000017597	exosc6	85	33.898	Lepisosteus_oculatus
ENSG00000178896	EXOSC4	69	33.333	ENSLAFG00000013753	EXOSC5	83	30.435	Loxodonta_africana
ENSG00000178896	EXOSC4	100	98.367	ENSLAFG00000030187	EXOSC4	100	98.367	Loxodonta_africana
ENSG00000178896	EXOSC4	69	33.918	ENSMFAG00000045851	EXOSC5	73	32.512	Macaca_fascicularis
ENSG00000178896	EXOSC4	100	100.000	ENSMFAG00000000161	EXOSC4	100	100.000	Macaca_fascicularis
ENSG00000178896	EXOSC4	72	34.392	ENSMFAG00000035562	EXOSC6	70	34.555	Macaca_fascicularis
ENSG00000178896	EXOSC4	100	100.000	ENSMMUG00000007160	EXOSC4	100	100.000	Macaca_mulatta
ENSG00000178896	EXOSC4	69	33.918	ENSMMUG00000014345	EXOSC5	80	32.512	Macaca_mulatta
ENSG00000178896	EXOSC4	72	34.392	ENSMMUG00000048384	EXOSC6	70	34.555	Macaca_mulatta
ENSG00000178896	EXOSC4	69	33.918	ENSMNEG00000044403	EXOSC5	73	32.512	Macaca_nemestrina
ENSG00000178896	EXOSC4	100	100.000	ENSMNEG00000033938	EXOSC4	100	100.000	Macaca_nemestrina
ENSG00000178896	EXOSC4	69	33.918	ENSMLEG00000042915	EXOSC5	80	32.512	Mandrillus_leucophaeus
ENSG00000178896	EXOSC4	100	100.000	ENSMLEG00000041197	EXOSC4	100	100.000	Mandrillus_leucophaeus
ENSG00000178896	EXOSC4	94	31.950	ENSMAMG00000016983	exosc6	84	35.047	Mastacembelus_armatus
ENSG00000178896	EXOSC4	100	74.694	ENSMAMG00000014749	exosc4	100	74.694	Mastacembelus_armatus
ENSG00000178896	EXOSC4	96	33.468	ENSMZEG00005010720	exosc6	88	33.468	Maylandia_zebra
ENSG00000178896	EXOSC4	100	74.694	ENSMZEG00005025086	exosc4	100	74.694	Maylandia_zebra
ENSG00000178896	EXOSC4	73	35.602	ENSMAUG00000008040	Exosc6	70	35.602	Mesocricetus_auratus
ENSG00000178896	EXOSC4	62	33.974	ENSMAUG00000010419	Exosc5	77	34.392	Mesocricetus_auratus
ENSG00000178896	EXOSC4	100	96.735	ENSMAUG00000007911	Exosc4	100	96.735	Mesocricetus_auratus
ENSG00000178896	EXOSC4	83	30.583	ENSMICG00000002016	EXOSC5	82	30.583	Microcebus_murinus
ENSG00000178896	EXOSC4	78	33.659	ENSMICG00000027202	EXOSC6	75	33.659	Microcebus_murinus
ENSG00000178896	EXOSC4	73	35.602	ENSMOCG00000003020	Exosc6	70	35.602	Microtus_ochrogaster
ENSG00000178896	EXOSC4	69	33.918	ENSMOCG00000002379	Exosc5	80	34.314	Microtus_ochrogaster
ENSG00000178896	EXOSC4	100	97.551	ENSMOCG00000020295	Exosc4	100	97.551	Microtus_ochrogaster
ENSG00000178896	EXOSC4	99	74.380	ENSMMOG00000016779	exosc4	99	74.380	Mola_mola
ENSG00000178896	EXOSC4	87	95.305	ENSMODG00000010435	EXOSC4	99	95.305	Monodelphis_domestica
ENSG00000178896	EXOSC4	69	31.579	ENSMODG00000008642	EXOSC5	67	31.579	Monodelphis_domestica
ENSG00000178896	EXOSC4	94	32.231	ENSMALG00000007871	exosc6	82	32.231	Monopterus_albus
ENSG00000178896	EXOSC4	100	74.286	ENSMALG00000020564	exosc4	100	74.286	Monopterus_albus
ENSG00000178896	EXOSC4	83	31.250	MGP_CAROLIEiJ_G0029376	Exosc5	88	31.674	Mus_caroli
ENSG00000178896	EXOSC4	100	95.918	MGP_CAROLIEiJ_G0019919	Exosc4	100	95.918	Mus_caroli
ENSG00000178896	EXOSC4	83	31.731	ENSMUSG00000061286	Exosc5	88	32.127	Mus_musculus
ENSG00000178896	EXOSC4	73	35.897	ENSMUSG00000109941	Exosc6	70	35.897	Mus_musculus
ENSG00000178896	EXOSC4	100	95.918	ENSMUSG00000034259	Exosc4	100	95.918	Mus_musculus
ENSG00000178896	EXOSC4	83	31.250	MGP_PahariEiJ_G0021229	Exosc5	88	31.674	Mus_pahari
ENSG00000178896	EXOSC4	100	96.735	MGP_PahariEiJ_G0019929	Exosc4	100	96.735	Mus_pahari
ENSG00000178896	EXOSC4	83	31.250	MGP_SPRETEiJ_G0030472	Exosc5	88	31.674	Mus_spretus
ENSG00000178896	EXOSC4	100	95.918	MGP_SPRETEiJ_G0020822	Exosc4	100	95.918	Mus_spretus
ENSG00000178896	EXOSC4	69	34.503	ENSMPUG00000017649	EXOSC5	80	33.005	Mustela_putorius_furo
ENSG00000178896	EXOSC4	77	96.825	ENSMPUG00000007260	EXOSC4	95	96.825	Mustela_putorius_furo
ENSG00000178896	EXOSC4	69	33.918	ENSMLUG00000013104	EXOSC5	80	32.512	Myotis_lucifugus
ENSG00000178896	EXOSC4	100	97.143	ENSNGAG00000022428	Exosc4	100	97.143	Nannospalax_galili
ENSG00000178896	EXOSC4	69	33.918	ENSNGAG00000005929	Exosc5	80	34.314	Nannospalax_galili
ENSG00000178896	EXOSC4	100	74.694	ENSNBRG00000012326	exosc4	100	74.694	Neolamprologus_brichardi
ENSG00000178896	EXOSC4	96	33.871	ENSNBRG00000007400	exosc6	88	33.871	Neolamprologus_brichardi
ENSG00000178896	EXOSC4	69	34.503	ENSNLEG00000013696	EXOSC5	80	33.005	Nomascus_leucogenys
ENSG00000178896	EXOSC4	100	100.000	ENSNLEG00000010449	EXOSC4	100	100.000	Nomascus_leucogenys
ENSG00000178896	EXOSC4	100	94.286	ENSMEUG00000011002	EXOSC4	100	94.286	Notamacropus_eugenii
ENSG00000178896	EXOSC4	77	93.617	ENSOPRG00000016625	EXOSC4	100	93.617	Ochotona_princeps
ENSG00000178896	EXOSC4	73	35.079	ENSODEG00000020448	EXOSC6	70	35.079	Octodon_degus
ENSG00000178896	EXOSC4	100	98.776	ENSODEG00000013951	EXOSC4	100	98.776	Octodon_degus
ENSG00000178896	EXOSC4	96	32.558	ENSONIG00000011184	exosc6	89	32.558	Oreochromis_niloticus
ENSG00000178896	EXOSC4	100	74.694	ENSONIG00000009617	exosc4	100	74.694	Oreochromis_niloticus
ENSG00000178896	EXOSC4	100	84.898	ENSOANG00000014904	EXOSC4	100	84.898	Ornithorhynchus_anatinus
ENSG00000178896	EXOSC4	100	96.735	ENSOCUG00000021243	EXOSC4	100	96.735	Oryctolagus_cuniculus
ENSG00000178896	EXOSC4	56	35.036	ENSORLG00000023035	exosc5	58	35.036	Oryzias_latipes
ENSG00000178896	EXOSC4	93	31.381	ENSORLG00000013325	exosc6	86	31.381	Oryzias_latipes
ENSG00000178896	EXOSC4	99	75.207	ENSORLG00000017295	exosc4	99	75.207	Oryzias_latipes
ENSG00000178896	EXOSC4	93	31.381	ENSORLG00020017597	exosc6	86	31.381	Oryzias_latipes_hni
ENSG00000178896	EXOSC4	99	75.207	ENSORLG00020009788	exosc4	99	75.207	Oryzias_latipes_hni
ENSG00000178896	EXOSC4	69	31.361	ENSORLG00020017279	exosc5	72	31.361	Oryzias_latipes_hni
ENSG00000178896	EXOSC4	94	31.667	ENSORLG00015007795	exosc6	86	31.667	Oryzias_latipes_hsok
ENSG00000178896	EXOSC4	99	75.207	ENSORLG00015009754	exosc4	99	75.207	Oryzias_latipes_hsok
ENSG00000178896	EXOSC4	96	30.453	ENSOMEG00000014317	exosc6	89	30.453	Oryzias_melastigma
ENSG00000178896	EXOSC4	99	75.620	ENSOMEG00000005800	exosc4	99	75.620	Oryzias_melastigma
ENSG00000178896	EXOSC4	73	35.079	ENSOGAG00000034381	EXOSC6	70	35.079	Otolemur_garnettii
ENSG00000178896	EXOSC4	100	99.592	ENSOGAG00000007411	EXOSC4	100	99.592	Otolemur_garnettii
ENSG00000178896	EXOSC4	69	33.918	ENSOGAG00000016075	EXOSC5	80	32.512	Otolemur_garnettii
ENSG00000178896	EXOSC4	83	30.918	ENSOARG00000007412	EXOSC5	83	30.918	Ovis_aries
ENSG00000178896	EXOSC4	100	96.356	ENSOARG00000015188	EXOSC4	100	96.356	Ovis_aries
ENSG00000178896	EXOSC4	100	100.000	ENSPPAG00000035746	EXOSC4	100	100.000	Pan_paniscus
ENSG00000178896	EXOSC4	69	33.918	ENSPPAG00000024210	EXOSC5	80	32.512	Pan_paniscus
ENSG00000178896	EXOSC4	100	98.367	ENSPPRG00000019782	EXOSC4	100	98.367	Panthera_pardus
ENSG00000178896	EXOSC4	73	34.031	ENSPPRG00000021385	EXOSC6	70	34.031	Panthera_pardus
ENSG00000178896	EXOSC4	69	33.333	ENSPPRG00000003713	EXOSC5	80	32.020	Panthera_pardus
ENSG00000178896	EXOSC4	69	33.333	ENSPTIG00000015884	EXOSC5	80	32.020	Panthera_tigris_altaica
ENSG00000178896	EXOSC4	77	97.872	ENSPTIG00000020006	EXOSC4	77	97.872	Panthera_tigris_altaica
ENSG00000178896	EXOSC4	69	33.918	ENSPTRG00000011024	EXOSC5	80	32.512	Pan_troglodytes
ENSG00000178896	EXOSC4	72	34.392	ENSPTRG00000008296	EXOSC6	70	34.555	Pan_troglodytes
ENSG00000178896	EXOSC4	100	100.000	ENSPTRG00000020677	EXOSC4	100	100.000	Pan_troglodytes
ENSG00000178896	EXOSC4	72	33.862	ENSPANG00000003331	EXOSC6	70	34.031	Papio_anubis
ENSG00000178896	EXOSC4	69	33.918	ENSPANG00000004945	EXOSC5	80	32.512	Papio_anubis
ENSG00000178896	EXOSC4	100	100.000	ENSPANG00000023276	EXOSC4	100	100.000	Papio_anubis
ENSG00000178896	EXOSC4	89	33.036	ENSPKIG00000022020	exosc6	84	34.914	Paramormyrops_kingsleyae
ENSG00000178896	EXOSC4	100	72.653	ENSPKIG00000018362	exosc4	100	72.653	Paramormyrops_kingsleyae
ENSG00000178896	EXOSC4	73	35.359	ENSPMGG00000016974	exosc6	74	35.359	Periophthalmus_magnuspinnatus
ENSG00000178896	EXOSC4	100	75.918	ENSPMGG00000019307	exosc4	100	75.918	Periophthalmus_magnuspinnatus
ENSG00000178896	EXOSC4	76	32.804	ENSPEMG00000018589	Exosc5	88	31.674	Peromyscus_maniculatus_bairdii
ENSG00000178896	EXOSC4	100	97.143	ENSPEMG00000017031	Exosc4	100	97.143	Peromyscus_maniculatus_bairdii
ENSG00000178896	EXOSC4	99	76.639	ENSPMAG00000001175	exosc4	99	76.639	Petromyzon_marinus
ENSG00000178896	EXOSC4	75	33.505	ENSPCIG00000010685	EXOSC6	68	35.821	Phascolarctos_cinereus
ENSG00000178896	EXOSC4	100	94.286	ENSPCIG00000009102	EXOSC4	100	94.286	Phascolarctos_cinereus
ENSG00000178896	EXOSC4	72	33.149	ENSPCIG00000006274	-	52	33.149	Phascolarctos_cinereus
ENSG00000178896	EXOSC4	71	32.203	ENSPCIG00000016745	EXOSC5	71	32.558	Phascolarctos_cinereus
ENSG00000178896	EXOSC4	62	33.333	ENSPFOG00000014158	exosc5	65	33.333	Poecilia_formosa
ENSG00000178896	EXOSC4	99	75.620	ENSPFOG00000015214	exosc4	99	75.620	Poecilia_formosa
ENSG00000178896	EXOSC4	96	31.855	ENSPFOG00000015869	exosc6	89	31.855	Poecilia_formosa
ENSG00000178896	EXOSC4	99	75.620	ENSPLAG00000018751	exosc4	99	75.620	Poecilia_latipinna
ENSG00000178896	EXOSC4	96	31.855	ENSPLAG00000014150	exosc6	89	31.855	Poecilia_latipinna
ENSG00000178896	EXOSC4	99	75.620	ENSPMEG00000023116	exosc4	99	75.620	Poecilia_mexicana
ENSG00000178896	EXOSC4	96	31.855	ENSPMEG00000019665	exosc6	89	31.855	Poecilia_mexicana
ENSG00000178896	EXOSC4	96	31.855	ENSPREG00000019548	exosc6	89	31.855	Poecilia_reticulata
ENSG00000178896	EXOSC4	99	76.446	ENSPREG00000009632	exosc4	99	76.446	Poecilia_reticulata
ENSG00000178896	EXOSC4	72	34.184	ENSPPYG00000007545	EXOSC6	70	34.343	Pongo_abelii
ENSG00000178896	EXOSC4	98	99.163	ENSPPYG00000018959	EXOSC4	100	99.163	Pongo_abelii
ENSG00000178896	EXOSC4	60	34.000	ENSPPYG00000010016	-	89	32.597	Pongo_abelii
ENSG00000178896	EXOSC4	100	97.959	ENSPCAG00000014920	EXOSC4	100	97.959	Procavia_capensis
ENSG00000178896	EXOSC4	73	35.079	ENSPCAG00000012874	EXOSC6	70	35.079	Procavia_capensis
ENSG00000178896	EXOSC4	69	34.302	ENSPCOG00000020582	EXOSC5	80	32.843	Propithecus_coquereli
ENSG00000178896	EXOSC4	100	98.776	ENSPCOG00000020992	EXOSC4	100	98.776	Propithecus_coquereli
ENSG00000178896	EXOSC4	100	98.367	ENSPVAG00000007100	EXOSC4	100	98.367	Pteropus_vampyrus
ENSG00000178896	EXOSC4	73	34.555	ENSPVAG00000000668	EXOSC6	70	34.555	Pteropus_vampyrus
ENSG00000178896	EXOSC4	54	31.343	ENSPVAG00000013083	EXOSC5	64	31.343	Pteropus_vampyrus
ENSG00000178896	EXOSC4	100	74.694	ENSPNYG00000014429	exosc4	100	74.694	Pundamilia_nyererei
ENSG00000178896	EXOSC4	96	33.871	ENSPNYG00000010784	exosc6	88	33.871	Pundamilia_nyererei
ENSG00000178896	EXOSC4	92	30.901	ENSPNAG00000008453	exosc6	85	30.901	Pygocentrus_nattereri
ENSG00000178896	EXOSC4	99	61.157	ENSPNAG00000013750	exosc4	99	61.157	Pygocentrus_nattereri
ENSG00000178896	EXOSC4	56	35.766	ENSPNAG00000030099	exosc5	58	35.766	Pygocentrus_nattereri
ENSG00000178896	EXOSC4	73	35.602	ENSRNOG00000018582	Exosc6	70	35.602	Rattus_norvegicus
ENSG00000178896	EXOSC4	100	97.551	ENSRNOG00000012348	Exosc4	100	97.551	Rattus_norvegicus
ENSG00000178896	EXOSC4	76	32.275	ENSRNOG00000020635	Exosc5	88	31.674	Rattus_norvegicus
ENSG00000178896	EXOSC4	100	100.000	ENSRBIG00000038476	EXOSC4	100	100.000	Rhinopithecus_bieti
ENSG00000178896	EXOSC4	72	30.851	ENSRBIG00000003409	EXOSC6	70	31.579	Rhinopithecus_bieti
ENSG00000178896	EXOSC4	69	34.503	ENSRBIG00000040585	EXOSC5	73	33.005	Rhinopithecus_bieti
ENSG00000178896	EXOSC4	69	33.918	ENSRROG00000044020	EXOSC5	73	32.512	Rhinopithecus_roxellana
ENSG00000178896	EXOSC4	100	100.000	ENSRROG00000038556	EXOSC4	100	100.000	Rhinopithecus_roxellana
ENSG00000178896	EXOSC4	96	35.865	YGR195W	SKI6	96	35.865	Saccharomyces_cerevisiae
ENSG00000178896	EXOSC4	64	34.375	ENSSBOG00000031753	EXOSC5	72	34.375	Saimiri_boliviensis_boliviensis
ENSG00000178896	EXOSC4	72	36.413	ENSSHAG00000004175	EXOSC6	67	36.413	Sarcophilus_harrisii
ENSG00000178896	EXOSC4	100	94.694	ENSSHAG00000005397	EXOSC4	100	94.694	Sarcophilus_harrisii
ENSG00000178896	EXOSC4	64	33.125	ENSSFOG00015011830	exosc6	69	33.125	Scleropages_formosus
ENSG00000178896	EXOSC4	100	74.286	ENSSFOG00015004133	exosc4	100	74.286	Scleropages_formosus
ENSG00000178896	EXOSC4	100	75.510	ENSSMAG00000020020	exosc4	100	75.510	Scophthalmus_maximus
ENSG00000178896	EXOSC4	94	31.250	ENSSMAG00000014550	exosc6	86	31.250	Scophthalmus_maximus
ENSG00000178896	EXOSC4	100	74.694	ENSSDUG00000018966	exosc4	100	74.694	Seriola_dumerili
ENSG00000178896	EXOSC4	96	31.855	ENSSDUG00000021109	exosc6	89	31.855	Seriola_dumerili
ENSG00000178896	EXOSC4	96	32.389	ENSSLDG00000017776	exosc6	87	32.389	Seriola_lalandi_dorsalis
ENSG00000178896	EXOSC4	76	69.355	ENSSLDG00000006678	-	95	69.355	Seriola_lalandi_dorsalis
ENSG00000178896	EXOSC4	100	74.694	ENSSLDG00000008003	exosc4	100	74.694	Seriola_lalandi_dorsalis
ENSG00000178896	EXOSC4	77	75.132	ENSSPUG00000009644	EXOSC4	93	75.132	Sphenodon_punctatus
ENSG00000178896	EXOSC4	100	75.102	ENSSPAG00000016707	exosc4	93	75.102	Stegastes_partitus
ENSG00000178896	EXOSC4	96	31.579	ENSSPAG00000001379	exosc6	88	31.579	Stegastes_partitus
ENSG00000178896	EXOSC4	69	33.333	ENSSSCG00000003015	EXOSC5	71	33.333	Sus_scrofa
ENSG00000178896	EXOSC4	100	96.735	ENSSSCG00000005925	EXOSC4	100	96.735	Sus_scrofa
ENSG00000178896	EXOSC4	73	35.602	ENSSSCG00000002719	EXOSC6	70	35.602	Sus_scrofa
ENSG00000178896	EXOSC4	100	73.469	ENSTRUG00000025054	exosc4	100	73.469	Takifugu_rubripes
ENSG00000178896	EXOSC4	96	32.787	ENSTRUG00000023811	exosc6	76	32.787	Takifugu_rubripes
ENSG00000178896	EXOSC4	93	31.602	ENSTNIG00000004018	exosc6	90	31.602	Tetraodon_nigroviridis
ENSG00000178896	EXOSC4	100	73.878	ENSTNIG00000008519	exosc4	100	73.878	Tetraodon_nigroviridis
ENSG00000178896	EXOSC4	63	33.758	ENSTBEG00000007203	EXOSC5	70	33.758	Tupaia_belangeri
ENSG00000178896	EXOSC4	77	95.213	ENSTBEG00000000727	EXOSC4	100	95.213	Tupaia_belangeri
ENSG00000178896	EXOSC4	69	34.503	ENSTTRG00000012863	EXOSC5	80	33.005	Tursiops_truncatus
ENSG00000178896	EXOSC4	100	98.776	ENSUAMG00000020173	EXOSC4	100	98.776	Ursus_americanus
ENSG00000178896	EXOSC4	70	33.908	ENSUMAG00000005660	EXOSC5	73	33.908	Ursus_maritimus
ENSG00000178896	EXOSC4	60	97.279	ENSUMAG00000020831	EXOSC4	100	97.279	Ursus_maritimus
ENSG00000178896	EXOSC4	69	33.918	ENSVVUG00000005320	EXOSC5	80	32.512	Vulpes_vulpes
ENSG00000178896	EXOSC4	100	97.959	ENSVVUG00000009675	EXOSC4	100	97.959	Vulpes_vulpes
ENSG00000178896	EXOSC4	80	35.714	ENSXETG00000007667	exosc6	90	32.271	Xenopus_tropicalis
ENSG00000178896	EXOSC4	77	76.190	ENSXETG00000004668	exosc4	98	76.190	Xenopus_tropicalis
ENSG00000178896	EXOSC4	99	74.380	ENSXCOG00000015017	exosc4	99	74.380	Xiphophorus_couchianus
ENSG00000178896	EXOSC4	97	30.924	ENSXCOG00000013623	exosc6	89	30.924	Xiphophorus_couchianus
ENSG00000178896	EXOSC4	97	30.924	ENSXMAG00000006280	exosc6	89	30.924	Xiphophorus_maculatus
ENSG00000178896	EXOSC4	99	74.380	ENSXMAG00000016287	exosc4	99	74.380	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	11110791.	NAS	Function
GO:0000176	nuclear exosome (RNase complex)	21873635.	IBA	Component
GO:0000177	cytoplasmic exosome (RNase complex)	21873635.	IBA	Component
GO:0000178	exosome (RNase complex)	20531389.	IDA	Component
GO:0000460	maturation of 5.8S rRNA	20368444.	IMP	Process
GO:0000956	nuclear-transcribed mRNA catabolic process	17545563.	IMP	Process
GO:0004532	exoribonuclease activity	17174896.	IDA	Function
GO:0005515	protein binding	11719186.12419256.12788944.15231747.17545563.20531386.20531389.21255825.21791617.25043052.25416956.26496610.30021884.	IPI	Function
GO:0005634	nucleus	17545563.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	11110791.	NAS	Component
GO:0005737	cytoplasm	17545563.	IDA	Component
GO:0005737	cytoplasm	11110791.	NAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006364	rRNA processing	11110791.	NAS	Process
GO:0006364	rRNA processing	-	TAS	Process
GO:0016075	rRNA catabolic process	21873635.	IBA	Process
GO:0017091	AU-rich element binding	16912217.	IDA	Function
GO:0030307	positive regulation of cell growth	17545563.	IMP	Process
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	21873635.	IBA	Process
GO:0034475	U4 snRNA 3'-end processing	21873635.	IBA	Process
GO:0035327	transcriptionally active chromatin	20699273.	IMP	Component
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process
GO:0045006	DNA deamination	21255825.	IDA	Process
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0051607	defense response to virus	21791617.	IMP	Process
GO:0071028	nuclear mRNA surveillance	21873635.	IBA	Process
GO:0071028	nuclear mRNA surveillance	17545563.	IMP	Process
GO:0071044	histone mRNA catabolic process	18172165.	IMP	Process
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	21873635.	IBA	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr8	144080607	3'UTR	novel		0.19
BLCA	chr8	144078849	Missense_Mutation	rs144570195	I41V	0.27
BLCA	chr8	144080004	Missense_Mutation	NA	S78L	0.43
BLCA	chr8	144079956	Missense_Mutation	NA	R62L	0.22
BLCA	chr8	144080463	Silent	NA	E200E	0.49
BRCA	chr8	144078805	In_Frame_Del	novel	R28_A48del	0.32
BRCA	chr8	144080587	Missense_Mutation	novel	L242M	0.27	RNase_PH
BRCA	chr8	144078735	Missense_Mutation	NA	G3R	0.41
CESC	chr8	144080140	Missense_Mutation	NA	I123M	0.29
COAD	chr8	144080453	Missense_Mutation	rs376508817	A197V	0.23	RNase_PH
COAD	chr8	144080474	Missense_Mutation	rs373942429	R204Q	0.11	RNase_PH
ESCA	chr8	144080124	Missense_Mutation	novel	R118H	0.18
GBM	chr8	144080140	Silent	novel	I123I	0.47
GBM	chr8	144080520	Missense_Mutation	novel	Q219H	0.09	RNase_PH
GBM	chr8	144080602	3'UTR	novel		0.13
HNSC	chr8	144080402	Missense_Mutation	novel	A180V	0.1	RNase_PH
KIRP	chr8	144080029	Silent	NA	R86R	0.34
LIHC	chr8	144078674	5'UTR	novel		0.31
LUAD	chr8	144080356	Missense_Mutation	NA	V165M	0.1
LUAD	chr8	144080029	Silent	NA	R86R	0.14
LUSC	chr8	144080559	Silent	novel	V232V	0.2
LUSC	chr8	144080374	Missense_Mutation	novel	A171S	0.47
LUSC	chr8	144080608	3'UTR	novel		0.13
LUSC	chr8	144080083	Silent	NA	R104R	0.59
LUSC	chr8	144080449	Missense_Mutation	NA	I196V	0.18	RNase_PH
LUSC	chr8	144080104	Missense_Mutation	novel	I111M	0.11
LUSC	chr8	144080537	Missense_Mutation	NA	H225L	0.46	RNase_PH
LUSC	chr8	144080561	Missense_Mutation	rs782316494	R233Q	0.2	RNase_PH
MESO	chr8	144079971	Frame_Shift_Ins	novel	*D68Sfs20**	0.05
OV	chr8	144080376	Silent	rs147555477	A171A	0.11
OV	chr8	144080590	Missense_Mutation	novel	L243M	0.11
PRAD	chr8	144080453	Missense_Mutation	NA	A197E	0.15	RNase_PH
READ	chr8	144080082	Missense_Mutation	rs201630396	R104H	0.61
READ	chr8	144080339	Missense_Mutation	rs145830532	A159V	0.49
SARC	chr8	144080135	Missense_Mutation	novel	D122H	0.16
SKCM	chr8	144080080	Silent	novel	L103L	0.39
SKCM	chr8	144080142	Missense_Mutation	novel	Y124C	0.21
SKCM	chr8	144080409	Silent	novel	G182G	0.32
SKCM	chr8	144080410	Missense_Mutation	novel	P183S	0.32	RNase_PH
STAD	chr8	144080407	Missense_Mutation	NA	G182R	0.07	RNase_PH
STAD	chr8	144080422	Missense_Mutation	NA	L187M	0.12	RNase_PH
STAD	chr8	144080288	Missense_Mutation	NA	A142V	0.13
UCEC	chr8	144080388	Silent	novel	H175H	0.27
UCEC	chr8	144079995	Missense_Mutation	novel	Q75R	0.61
UCEC	chr8	144080330	Missense_Mutation	novel	F156Y	0.26
UCEC	chr8	144080474	Missense_Mutation	rs373942429	R204Q	0.2	RNase_PH
UCEC	chr8	144079970	Missense_Mutation	novel	P67S	0.29
UCEC	chr8	144080028	Missense_Mutation	rs782502364	R86H	0.66
UCEC	chr8	144080454	Silent	rs201609181	A197A	0.38
UCEC	chr8	144080140	Silent	novel	I123I	0.43
UCEC	chr8	144080542	Missense_Mutation	novel	L227I	0.3	RNase_PH
UCEC	chr8	144078693	5'UTR	novel		0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.25	0.018626
KIRC	AMP	0.1193	0.15559
LGG	DEL	0.0468	0.014004
SARC	AMP	0.2529	0.18425
SKCM	AMP	0.4523	2.8957e-05
TGCT	AMP	0.56	0.13696
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00058	Kaplan-Meier Survival Analysis
ACC	0.0017	Kaplan-Meier Survival Analysis
UCS	0.022	Kaplan-Meier Survival Analysis
HNSC	0.016	Kaplan-Meier Survival Analysis
SKCM	0.035	Kaplan-Meier Survival Analysis
CESC	0.013	Kaplan-Meier Survival Analysis
LAML	0.00028	Kaplan-Meier Survival Analysis
LIHC	0.00066	Kaplan-Meier Survival Analysis
LGG	0.00024	Kaplan-Meier Survival Analysis
UVM	0.00012	Kaplan-Meier Survival Analysis
OV	0.00054	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742