EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000178997 (Gene tree)
Gene ID: 161829
Gene Symbol: EXD1
Alias: MGC33637|EXDL1
Full Name: exonuclease 3'-5' domain containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 48,350 bases
Position: chr15:41,182,725-41,231,074
Accession: 28507
RBP type: canonical RBP
Summary: EXD1 (Exonuclease 3'-5' Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5' exonuclease activity. An important paralog of this gene is EXOSC10.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000321029	DNA_pol_A_exo1	PF01612.20	1.8e-09	1	1
ENSP00000415056	DNA_pol_A_exo1	PF01612.20	2.2e-09	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558881	EXD1-204	2293	-	-	- (aa)	-	-
ENST00000558396	EXD1-203	483	-	ENSP00000452678	55 (aa)	-	H0YK66
ENST00000314992	EXD1-201	2942	XM_011521299	ENSP00000321029	514 (aa)	XP_011519601	Q8NHP7
ENST00000559743	EXD1-205	601	-	-	- (aa)	-	-
ENST00000458580	EXD1-202	2177	XM_006720415	ENSP00000415056	572 (aa)	XP_006720478	Q8NHP7

Gene Model

Click here to download ENSG00000178997's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000178997	rs2412608	15	41204515	?	White blood cell count	30595370			EFO_0004308
ENSG00000178997	rs7173086	15	41217090	T	Systolic blood pressure	30578418	[0.18-0.32] mmHg increase	0.2486	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000178997's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000178997	EXD1	54	46.290	ENSAPOG00000004287	-	68	52.709	Acanthochromis_polyacanthus
ENSG00000178997	EXD1	99	80.035	ENSAMEG00000016793	EXD1	99	80.035	Ailuropoda_melanoleuca
ENSG00000178997	EXD1	73	47.500	ENSAOCG00000009355	-	71	44.554	Amphiprion_ocellaris
ENSG00000178997	EXD1	73	47.500	ENSAPEG00000002194	-	86	46.154	Amphiprion_percula
ENSG00000178997	EXD1	89	53.061	ENSACAG00000003676	EXD1	100	57.975	Anolis_carolinensis
ENSG00000178997	EXD1	100	90.227	ENSANAG00000029058	EXD1	100	90.227	Aotus_nancymaae
ENSG00000178997	EXD1	70	40.842	ENSACLG00000001361	-	72	40.988	Astatotilapia_calliptera
ENSG00000178997	EXD1	75	48.780	ENSAMXG00000026016	-	75	41.278	Astyanax_mexicanus
ENSG00000178997	EXD1	92	80.632	ENSBTAG00000008363	EXD1	100	80.249	Bos_taurus
ENSG00000178997	EXD1	99	84.790	ENSCJAG00000020765	EXD1	99	84.790	Callithrix_jacchus
ENSG00000178997	EXD1	99	79.826	ENSCAFG00000009510	EXD1	100	79.826	Canis_familiaris
ENSG00000178997	EXD1	82	78.873	ENSCAFG00020005504	EXD1	100	78.873	Canis_lupus_dingo
ENSG00000178997	EXD1	99	77.113	ENSCHIG00000019606	EXD1	99	77.113	Capra_hircus
ENSG00000178997	EXD1	98	81.481	ENSCPOG00000010573	EXD1	100	74.520	Cavia_porcellus
ENSG00000178997	EXD1	100	87.260	ENSCCAG00000016905	EXD1	100	87.260	Cebus_capucinus
ENSG00000178997	EXD1	100	94.942	ENSCATG00000037400	EXD1	100	94.942	Cercocebus_atys
ENSG00000178997	EXD1	98	75.049	ENSCSAG00000007647	EXD1	100	75.049	Chlorocebus_sabaeus
ENSG00000178997	EXD1	98	74.308	ENSCHOG00000011441	EXD1	99	74.308	Choloepus_hoffmanni
ENSG00000178997	EXD1	99	52.840	ENSCPBG00000013511	EXD1	93	53.012	Chrysemys_picta_bellii
ENSG00000178997	EXD1	100	91.783	ENSCANG00000036848	EXD1	100	91.783	Colobus_angolensis_palliatus
ENSG00000178997	EXD1	99	75.868	ENSCGRG00001011355	Exd1	97	75.868	Cricetulus_griseus_chok1gshd
ENSG00000178997	EXD1	99	75.868	ENSCGRG00000011633	Exd1	99	75.868	Cricetulus_griseus_crigri
ENSG00000178997	EXD1	67	41.818	ENSCSEG00000000904	-	68	41.818	Cynoglossus_semilaevis
ENSG00000178997	EXD1	63	36.034	ENSDARG00000098669	exd1	85	40.684	Danio_rerio
ENSG00000178997	EXD1	100	80.836	ENSDNOG00000011410	EXD1	100	80.314	Dasypus_novemcinctus
ENSG00000178997	EXD1	84	86.957	ENSDORG00000012079	Exd1	100	74.382	Dipodomys_ordii
ENSG00000178997	EXD1	78	70.556	ENSETEG00000014257	-	79	70.556	Echinops_telfairi
ENSG00000178997	EXD1	98	83.333	ENSEASG00005016394	EXD1	100	80.139	Equus_asinus_asinus
ENSG00000178997	EXD1	100	82.056	ENSECAG00000021250	EXD1	100	82.056	Equus_caballus
ENSG00000178997	EXD1	98	71.937	ENSEEUG00000001232	EXD1	100	71.937	Erinaceus_europaeus
ENSG00000178997	EXD1	70	42.680	ENSELUG00000006324	-	67	42.822	Esox_lucius
ENSG00000178997	EXD1	99	82.548	ENSFCAG00000028533	EXD1	99	82.548	Felis_catus
ENSG00000178997	EXD1	56	45.897	ENSGMOG00000015956	-	96	45.593	Gadus_morhua
ENSG00000178997	EXD1	68	53.827	ENSGALG00000041449	EXD1	96	53.571	Gallus_gallus
ENSG00000178997	EXD1	70	41.855	ENSGAFG00000017161	-	72	41.353	Gambusia_affinis
ENSG00000178997	EXD1	99	52.405	ENSGAGG00000019200	EXD1	93	52.405	Gopherus_agassizii
ENSG00000178997	EXD1	100	98.833	ENSGGOG00000004594	EXD1	100	98.833	Gorilla_gorilla
ENSG00000178997	EXD1	50	48.649	ENSHBUG00000017880	-	64	49.421	Haplochromis_burtoni
ENSG00000178997	EXD1	100	76.614	ENSHGLG00000015369	EXD1	100	76.614	Heterocephalus_glaber_female
ENSG00000178997	EXD1	99	75.524	ENSHGLG00100007398	EXD1	100	75.524	Heterocephalus_glaber_male
ENSG00000178997	EXD1	100	83.595	ENSSTOG00000014980	EXD1	100	83.595	Ictidomys_tridecemlineatus
ENSG00000178997	EXD1	75	40.835	ENSLBEG00000000022	-	73	41.067	Labrus_bergylta
ENSG00000178997	EXD1	89	38.776	ENSLACG00000006680	EXD1	69	50.360	Latimeria_chalumnae
ENSG00000178997	EXD1	82	46.667	ENSLOCG00000012278	-	96	45.000	Lepisosteus_oculatus
ENSG00000178997	EXD1	99	77.104	ENSLAFG00000014739	EXD1	100	78.236	Loxodonta_africana
ENSG00000178997	EXD1	100	95.455	ENSMFAG00000034670	EXD1	100	95.455	Macaca_fascicularis
ENSG00000178997	EXD1	100	95.105	ENSMMUG00000013991	EXD1	100	95.105	Macaca_mulatta
ENSG00000178997	EXD1	100	95.629	ENSMNEG00000037333	EXD1	100	95.629	Macaca_nemestrina
ENSG00000178997	EXD1	100	98.182	ENSMLEG00000033153	EXD1	100	97.279	Mandrillus_leucophaeus
ENSG00000178997	EXD1	70	41.089	ENSMZEG00005009193	-	75	41.728	Maylandia_zebra
ENSG00000178997	EXD1	78	48.837	ENSMGAG00000011179	EXD1	99	53.133	Meleagris_gallopavo
ENSG00000178997	EXD1	99	75.524	ENSMAUG00000002698	Exd1	99	75.524	Mesocricetus_auratus
ENSG00000178997	EXD1	100	82.927	ENSMICG00000014337	EXD1	100	82.927	Microcebus_murinus
ENSG00000178997	EXD1	99	73.951	ENSMOCG00000018151	Exd1	99	73.951	Microtus_ochrogaster
ENSG00000178997	EXD1	98	57.143	ENSMODG00000000164	EXD1	100	65.085	Monodelphis_domestica
ENSG00000178997	EXD1	70	40.099	ENSMALG00000015814	-	86	40.695	Monopterus_albus
ENSG00000178997	EXD1	98	79.630	MGP_CAROLIEiJ_G0024145	Exd1	99	73.997	Mus_caroli
ENSG00000178997	EXD1	99	73.252	ENSMUSG00000048647	Exd1	99	73.252	Mus_musculus
ENSG00000178997	EXD1	98	79.630	MGP_PahariEiJ_G0025588	Exd1	99	68.476	Mus_pahari
ENSG00000178997	EXD1	99	73.601	MGP_SPRETEiJ_G0025061	Exd1	99	73.601	Mus_spretus
ENSG00000178997	EXD1	99	81.533	ENSMPUG00000008811	EXD1	99	81.533	Mustela_putorius_furo
ENSG00000178997	EXD1	99	80.196	ENSMLUG00000001466	EXD1	100	80.377	Myotis_lucifugus
ENSG00000178997	EXD1	99	75.874	ENSNGAG00000002319	Exd1	99	75.874	Nannospalax_galili
ENSG00000178997	EXD1	52	49.813	ENSNBRG00000003229	-	72	49.813	Neolamprologus_brichardi
ENSG00000178997	EXD1	100	96.109	ENSNLEG00000003456	EXD1	100	96.109	Nomascus_leucogenys
ENSG00000178997	EXD1	99	65.900	ENSOPRG00000016433	EXD1	100	65.900	Ochotona_princeps
ENSG00000178997	EXD1	68	41.730	ENSONIG00000012043	-	98	41.985	Oreochromis_niloticus
ENSG00000178997	EXD1	98	57.407	ENSOANG00000029781	-	91	51.601	Ornithorhynchus_anatinus
ENSG00000178997	EXD1	98	74.354	ENSOCUG00000013817	EXD1	99	75.049	Oryctolagus_cuniculus
ENSG00000178997	EXD1	67	42.708	ENSORLG00000026344	-	76	40.988	Oryzias_latipes
ENSG00000178997	EXD1	67	43.490	ENSORLG00020005465	-	73	43.490	Oryzias_latipes_hni
ENSG00000178997	EXD1	67	42.448	ENSORLG00015004848	-	73	41.860	Oryzias_latipes_hsok
ENSG00000178997	EXD1	67	43.411	ENSOMEG00000019812	-	77	41.565	Oryzias_melastigma
ENSG00000178997	EXD1	99	75.534	ENSOGAG00000013095	EXD1	100	75.240	Otolemur_garnettii
ENSG00000178997	EXD1	99	81.261	ENSOARG00000020330	EXD1	100	80.936	Ovis_aries
ENSG00000178997	EXD1	100	98.951	ENSPPAG00000033760	EXD1	100	98.951	Pan_paniscus
ENSG00000178997	EXD1	99	81.501	ENSPPRG00000011128	EXD1	99	81.501	Panthera_pardus
ENSG00000178997	EXD1	99	81.326	ENSPTIG00000020026	EXD1	99	81.326	Panthera_tigris_altaica
ENSG00000178997	EXD1	100	99.126	ENSPTRG00000006941	EXD1	100	99.126	Pan_troglodytes
ENSG00000178997	EXD1	100	95.280	ENSPANG00000019000	EXD1	100	95.280	Papio_anubis
ENSG00000178997	EXD1	68	41.837	ENSPKIG00000000671	-	70	41.221	Paramormyrops_kingsleyae
ENSG00000178997	EXD1	98	51.399	ENSPSIG00000014473	EXD1	92	51.399	Pelodiscus_sinensis
ENSG00000178997	EXD1	70	37.531	ENSPMGG00000015466	-	78	37.531	Periophthalmus_magnuspinnatus
ENSG00000178997	EXD1	89	77.551	ENSPCIG00000027845	EXD1	100	65.400	Phascolarctos_cinereus
ENSG00000178997	EXD1	69	41.191	ENSPFOG00000013673	-	97	39.951	Poecilia_formosa
ENSG00000178997	EXD1	70	41.791	ENSPLAG00000014262	-	72	41.294	Poecilia_latipinna
ENSG00000178997	EXD1	70	41.542	ENSPMEG00000012071	-	72	41.045	Poecilia_mexicana
ENSG00000178997	EXD1	70	41.294	ENSPREG00000019468	-	72	40.796	Poecilia_reticulata
ENSG00000178997	EXD1	100	97.276	ENSPPYG00000006369	EXD1	100	97.276	Pongo_abelii
ENSG00000178997	EXD1	76	71.320	ENSPCAG00000005269	-	76	71.574	Procavia_capensis
ENSG00000178997	EXD1	100	90.909	ENSPCOG00000026598	EXD1	100	82.398	Propithecus_coquereli
ENSG00000178997	EXD1	99	80.934	ENSPVAG00000003149	EXD1	99	80.934	Pteropus_vampyrus
ENSG00000178997	EXD1	68	43.038	ENSPNAG00000008931	exd1	76	43.038	Pygocentrus_nattereri
ENSG00000178997	EXD1	99	72.251	ENSRNOG00000025360	Exd1	99	72.251	Rattus_norvegicus
ENSG00000178997	EXD1	100	67.949	ENSRBIG00000037257	EXD1	100	96.875	Rhinopithecus_bieti
ENSG00000178997	EXD1	100	95.629	ENSRROG00000034491	EXD1	100	95.629	Rhinopithecus_roxellana
ENSG00000178997	EXD1	100	81.152	ENSSBOG00000024842	EXD1	100	81.152	Saimiri_boliviensis_boliviensis
ENSG00000178997	EXD1	92	63.956	ENSSHAG00000016701	EXD1	100	63.956	Sarcophilus_harrisii
ENSG00000178997	EXD1	66	44.000	ENSSDUG00000004368	exd1	63	43.501	Seriola_dumerili
ENSG00000178997	EXD1	99	75.146	ENSSARG00000009556	-	99	75.146	Sorex_araneus
ENSG00000178997	EXD1	91	58.000	ENSSPUG00000001716	EXD1	73	52.048	Sphenodon_punctatus
ENSG00000178997	EXD1	100	90.909	ENSSSCG00000004752	EXD1	100	81.565	Sus_scrofa
ENSG00000178997	EXD1	67	38.677	ENSTNIG00000017431	-	93	38.422	Tetraodon_nigroviridis
ENSG00000178997	EXD1	82	68.160	ENSTBEG00000003085	EXD1	99	68.160	Tupaia_belangeri
ENSG00000178997	EXD1	99	80.550	ENSTTRG00000009809	EXD1	99	80.550	Tursiops_truncatus
ENSG00000178997	EXD1	99	80.836	ENSUMAG00000012170	EXD1	99	80.836	Ursus_maritimus
ENSG00000178997	EXD1	99	80.350	ENSVPAG00000007758	EXD1	99	80.350	Vicugna_pacos
ENSG00000178997	EXD1	100	92.727	ENSVVUG00000026704	EXD1	100	79.826	Vulpes_vulpes
ENSG00000178997	EXD1	68	49.367	ENSXETG00000017895	exd1	95	48.861	Xenopus_tropicalis
ENSG00000178997	EXD1	58	42.598	ENSXCOG00000010879	-	84	42.598	Xiphophorus_couchianus
ENSG00000178997	EXD1	61	42.816	ENSXMAG00000014462	-	86	42.515	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	ISS	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0008408	3'-5' exonuclease activity	-	ISS	Function
GO:0031047	gene silencing by RNA	-	ISS	Process
GO:0034587	piRNA metabolic process	-	ISS	Process
GO:0042803	protein homodimerization activity	-	ISS	Function
GO:0043186	P granule	-	ISS	Component
GO:0051321	meiotic cell cycle	-	IEA	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process
GO:1990923	PET complex	-	ISS	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr15	41209569	Missense_Mutation	novel	Q98K	0.67
BLCA	chr15	41189972	Missense_Mutation	NA	R283S	0.05
BLCA	chr15	41189966	Missense_Mutation	novel	G285R	0.16
BLCA	chr15	41190062	Missense_Mutation	NA	A253T	0.75	DNA_pol_A_exo1
BLCA	chr15	41230578	5'UTR	novel		0.17
BLCA	chr15	41184398	Missense_Mutation	novel	F360V	0.48
BLCA	chr15	41230631	5'UTR	novel		0.16
BLCA	chr15	41189966	Missense_Mutation	novel	G285R	0.22
BRCA	chr15	41217097	Missense_Mutation	novel	S29I	0.16
BRCA	chr15	41183900	3'UTR	novel		0.19
BRCA	chr15	41184134	Missense_Mutation	rs369400894	E448K	0.06
BRCA	chr15	41191495	Missense_Mutation	NA	Q213E	0.17	DNA_pol_A_exo1
CESC	chr15	41184543	Silent	novel	Q311Q	0.23
CESC	chr15	41184278	Missense_Mutation	NA	E400K	0.28
CESC	chr15	41184279	Silent	NA	E399E	0.28
CESC	chr15	41190040	Missense_Mutation	rs755887471	R260H	0.35	DNA_pol_A_exo1
CHOL	chr15	41191454	Silent	novel	Q226Q	0.23
COAD	chr15	41184535	Missense_Mutation	NA	R314L	0.18
COAD	chr15	41184109	Missense_Mutation	novel	K456T	0.27
COAD	chr15	41191465	Nonsense_Mutation	NA	E223*	0.33	DNA_pol_A_exo1
COAD	chr15	41184346	Missense_Mutation	rs773636600	V377E	0.37
COAD	chr15	41190196	Intron	novel		0.18
COAD	chr15	41184262	Missense_Mutation	novel	E405V	0.18
COAD	chr15	41184348	Silent	novel	D376D	0.08
COAD	chr15	41230612	5'UTR	novel		0.11
COAD	chr15	41190114	Silent	novel	V235V	0.45
COAD	chr15	41230496	Missense_Mutation	rs772980179	S4N	0.26
COAD	chr15	41183854	3'UTR	novel		0.34
COAD	chr15	41184532	Missense_Mutation	novel	R315M	0.29
COAD	chr15	41190194	Intron	novel		0.48
COAD	chr15	41190114	Silent	novel	V235V	0.13
DLBC	chr15	41189953	Missense_Mutation	rs769539024	R289Q	0.2
ESCA	chr15	41184304	Missense_Mutation	novel	N391T	0.38
GBM	chr15	41184045	Silent	novel	V477V	0.5
GBM	chr15	41195985	Missense_Mutation	novel	R138Q	0.23
GBM	chr15	41209526	Missense_Mutation	rs762464159	R112H	0.4
GBM	chr15	41195951	Missense_Mutation	NA	E149D	0.3	DNA_pol_A_exo1
GBM	chr15	41191554	Missense_Mutation	rs200349978	T193M	0.31	DNA_pol_A_exo1
GBM	chr15	41184318	Missense_Mutation	novel	N386K	0.09
HNSC	chr15	41184260	Missense_Mutation	NA	D406N	0.35
HNSC	chr15	41184536	Missense_Mutation	rs527801980	R314C	0.28
HNSC	chr15	41184217	Missense_Mutation	novel	E420V	0.12
HNSC	chr15	41184218	Missense_Mutation	novel	E420K	0.12
KICH	chr15	41209508	Nonsense_Mutation	novel	W118*	0.43
LAML	chr15	41190104	Nonsense_Mutation	rs371217636	R239*	0.45	DNA_pol_A_exo1
LGG	chr15	41184379	Missense_Mutation	NA	P366L	0.37
LGG	chr15	41195939	Missense_Mutation	NA	I153M	0.32	DNA_pol_A_exo1
LIHC	chr15	41184396	Silent	novel	F360F	0.14
LIHC	chr15	41183729	3'UTR	novel		0.5
LUAD	chr15	41195798	Missense_Mutation	rs765118229	L175M	0.15	DNA_pol_A_exo1
LUAD	chr15	41184320	Frame_Shift_Del	novel	N386*	0.03
LUAD	chr15	41189971	Missense_Mutation	rs771880504	R283H	0.14
LUAD	chr15	41191519	Frame_Shift_Del	novel	*Q205Rfs4**	0.07	DNA_pol_A_exo1
LUAD	chr15	41184429	Missense_Mutation	NA	E349D	0.13
LUAD	chr15	41184090	Silent	rs199676061	T462T	0.53
LUAD	chr15	41195950	Missense_Mutation	NA	D150Y	0.34	DNA_pol_A_exo1
LUSC	chr15	41191495	Nonsense_Mutation	novel	Q213*	0.14	DNA_pol_A_exo1
LUSC	chr15	41195823	Silent	novel	C166C	0.25
LUSC	chr15	41183939	Missense_Mutation	novel	L513V	0.11
LUSC	chr15	41184023	Missense_Mutation	rs748056334	P485A	0.04
LUSC	chr15	41184090	Silent	rs199676061	T462T	0.71
LUSC	chr15	41184411	Missense_Mutation	novel	L355F	0.33
LUSC	chr15	41184560	Missense_Mutation	novel	Q306K	0.28
OV	chr15	41215824	Missense_Mutation	novel	E75V	0.42
OV	chr15	41189952	Silent	novel	R289R	0.15
OV	chr15	41183651	3'UTR	novel		0.25
PAAD	chr15	41209527	Missense_Mutation	rs144824409	R112C	0.61
PAAD	chr15	41183882	3'UTR	novel		0.05
READ	chr15	41195945	Missense_Mutation	novel	K151N	0.43	DNA_pol_A_exo1
SARC	chr15	41191477	Missense_Mutation	novel	L219V	0.27	DNA_pol_A_exo1
SKCM	chr15	41184313	Missense_Mutation	novel	Q388L	0.87
SKCM	chr15	41184314	Missense_Mutation	novel	Q388K	0.87
SKCM	chr15	41183990	Missense_Mutation	novel	P496S	0.23
SKCM	chr15	41190129	Splice_Site	NA	X231_splice	0.57
SKCM	chr15	41190094	Missense_Mutation	NA	S242L	0.32	DNA_pol_A_exo1
SKCM	chr15	41190105	Silent	novel	I238I	0.29
SKCM	chr15	41184000	Silent	NA	S492S	0.29
SKCM	chr15	41184301	Missense_Mutation	NA	P392L	0.08
SKCM	chr15	41184569	Missense_Mutation	NA	E303K	0.29
SKCM	chr15	41189957	Missense_Mutation	NA	D288N	0.31
SKCM	chr15	41184475	Missense_Mutation	NA	V334E	0.21
SKCM	chr15	41189994	Silent	NA	V275V	0.19
SKCM	chr15	41195943	Missense_Mutation	novel	R152K	0.28	DNA_pol_A_exo1
SKCM	chr15	41184274	Missense_Mutation	NA	G401E	0.38
SKCM	chr15	41191564	Missense_Mutation	novel	S190P	0.4	DNA_pol_A_exo1
SKCM	chr15	41184531	Silent	rs544379314	R315R	0.34
SKCM	chr15	41191586	Splice_Site	NA	X183_splice	0.19
SKCM	chr15	41195813	Nonsense_Mutation	novel	Q170*	0.21	DNA_pol_A_exo1
SKCM	chr15	41190111	Nonsense_Mutation	NA	W236*	0.38	DNA_pol_A_exo1
SKCM	chr15	41184552	Silent	NA	K308K	0.63
SKCM	chr15	41184056	Missense_Mutation	NA	E474K	0.23
SKCM	chr15	41191563	Missense_Mutation	NA	S190F	0.45	DNA_pol_A_exo1
SKCM	chr15	41216700	Missense_Mutation	novel	S61F	0.39
SKCM	chr15	41189965	Missense_Mutation	novel	G285A	0.22
SKCM	chr15	41195960	Missense_Mutation	novel	M146I	0.47	DNA_pol_A_exo1
SKCM	chr15	41195856	Splice_Site	rs746622334	X156_splice	0.24
STAD	chr15	41189941	Missense_Mutation	rs758861605	T293I	0.61
STAD	chr15	41189963	Missense_Mutation	NA	S286T	0.09
STAD	chr15	41217126	Silent	NA	G19G	0.15
STAD	chr15	41184271	Missense_Mutation	novel	E402G	0.2
STAD	chr15	41184536	Missense_Mutation	rs527801980	R314C	0.39
STAD	chr15	41209542	In_Frame_Del	rs772638562	E106del	0.2
STAD	chr15	41184413	Missense_Mutation	novel	L355I	0.1
THCA	chr15	41184108	Nonsense_Mutation	novel	*K456Nfs3**	0.05
UCEC	chr15	41183913	3'UTR	novel		0.36
UCEC	chr15	41184297	Missense_Mutation	novel	Q393H	0.15
UCEC	chr15	41190161	Intron	novel		0.22
UCEC	chr15	41195841	Silent	novel	C160C	0.4
UCEC	chr15	41230507	5'UTR	novel		0.29
UCEC	chr15	41226495	Intron	rs76260178		0.38
UCEC	chr15	41183635	3'UTR	novel		1
UCEC	chr15	41209538	Missense_Mutation	novel	A108V	0.41
UCEC	chr15	41195787	Silent	novel	V178V	0.17
UCEC	chr15	41230526	5'UTR	novel		0.12
UCEC	chr15	41183804	3'UTR	novel		0.21
UCEC	chr15	41216751	Missense_Mutation	NA	D44G	0.41
UCEC	chr15	41184380	Missense_Mutation	NA	P366S	0.22
UCEC	chr15	41191445	Silent	NA	I229I	0.2
UCEC	chr15	41216773	Missense_Mutation	rs778839057	M37V	0.25
UCEC	chr15	41217115	Missense_Mutation	NA	A23E	0.21
UCEC	chr15	41209525	Silent	novel	R112R	0.18
UCEC	chr15	41191477	Missense_Mutation	novel	L219F	0.05	DNA_pol_A_exo1
UCEC	chr15	41219840	Intron	novel		0.41
UCEC	chr15	41190076	Missense_Mutation	novel	I248N	0.6	DNA_pol_A_exo1
UCEC	chr15	41191524	Missense_Mutation	novel	T203I	0.45	DNA_pol_A_exo1
UCEC	chr15	41209526	Missense_Mutation	rs762464159	R112H	0.42
UCEC	chr15	41209507	Nonsense_Mutation	novel	W118*	0.32
UCEC	chr15	41184278	Nonsense_Mutation	novel	E400*	0.21
UCEC	chr15	41190075	Missense_Mutation	novel	I248M	0.16	DNA_pol_A_exo1
UCEC	chr15	41230617	5'UTR	novel		0.13
UCEC	chr15	41226441	Intron	novel		0.42
UCEC	chr15	41219885	Intron	novel		0.44
UCEC	chr15	41226440	Intron	novel		0.36
UCEC	chr15	41184457	Nonsense_Mutation	novel	L340*	0.04
UCEC	chr15	41184082	Missense_Mutation	novel	A465D	0.15
UCEC	chr15	41184389	Missense_Mutation	NA	D363Y	0.21
UCEC	chr15	41226463	Intron	novel		0.17
UCEC	chr15	41190032	Missense_Mutation	novel	L263I	0.34	DNA_pol_A_exo1
UCEC	chr15	41215776	Missense_Mutation	rs763820609	A91V	0.22
UCEC	chr15	41184325	Missense_Mutation	NA	S384Y	0.48
UCEC	chr15	41195943	Missense_Mutation	rs544203582	R152I	0.5	DNA_pol_A_exo1
UCEC	chr15	41195939	Missense_Mutation	NA	I153M	0.42	DNA_pol_A_exo1
UCEC	chr15	41190119	Nonsense_Mutation	NA	E234*	0.48	DNA_pol_A_exo1
UCEC	chr15	41226495	Intron	rs76260178		0.38
UCEC	chr15	41183966	Missense_Mutation	rs759675298	D504N	0.45
UCEC	chr15	41184255	Silent	novel	S407S	0.44
UCEC	chr15	41190160	Intron	novel		0.19
UCEC	chr15	41209577	Missense_Mutation	novel	I95S	0.45
UCEC	chr15	41183914	3'UTR	novel		0.37
UCEC	chr15	41184462	Missense_Mutation	novel	K338N	0.48
UCEC	chr15	41216795	Splice_Region	novel	S29S	0.28
UCEC	chr15	41184389	Missense_Mutation	NA	D363Y	0.28
UCEC	chr15	41230610	5'UTR	novel		0.35
UCEC	chr15	41190148	Intron	novel		0.43
UCEC	chr15	41184275	Missense_Mutation	novel	G401W	0.29
UCEC	chr15	41190047	Missense_Mutation	rs770380501	P258S	0.27	DNA_pol_A_exo1
UCEC	chr15	41230620	5'UTR	novel		0.29
UVM	chr15	41209531	Silent	rs370262959	V110V	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2333	0.079424
CESC	DEL	0.2	0.00049652
COAD	DEL	0.3548	2.3878e-07
GBM	DEL	0.2149	3.453e-12
HNSC	DEL	0.1686	0.11567
KICH	AMP	0.2727	0.21756
KIRP	DEL	0.1076	0.2062
LUAD	DEL	0.3953	6.8561e-07
MESO	DEL	0.3103	4.5411e-10
PAAD	DEL	0.1359	0.13216
READ	DEL	0.4364	0.025797
SARC	DEL	0.2023	0.18974
STAD	DEL	0.1927	3.2335e-05
UCEC	DEL	0.2412	7.1012e-08

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.012	Kaplan-Meier Survival Analysis
ACC	0.002	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
COAD	0.014	Kaplan-Meier Survival Analysis
PCPG	0.039	Kaplan-Meier Survival Analysis
BLCA	0.05	Kaplan-Meier Survival Analysis
CESC	0.015	Kaplan-Meier Survival Analysis
LIHC	0.019	Kaplan-Meier Survival Analysis
UVM	0.045	Kaplan-Meier Survival Analysis