EuRBPDB

Description

Ensembl ID: ENSG00000179134 (Gene tree)
Gene ID: 55095
Gene Symbol: SAMD4B
Alias: FLJ10211|MGC99832|SMGB|hSmaug2
Full Name: sterile alpha motif domain containing 4B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 48,365 bases
Position: chr19:39,342,396-39,390,760
Accession: 25492
RBP type: non-canonical RBP
Summary: (Sterile Alpha Motif Domain Containing 4B) is a Protein Coding gene. An important paralog of this gene is SAMD4A.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26609159	A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis.	J Neurosci	2015 Nov 25	Amadei G	doi: 10.1523/JNEUROSCI.2172-15.2015.
21725060	Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome.	Mol Cell Proteomics	2011 Oct	Johnson C	doi: 10.1074/mcp.M110.005751

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000611159	SAMD4B-214	3662	XM_011527057	ENSP00000482861	663 (aa)	XP_011525359	A0A087WZT0
ENST00000596368	SAMD4B-206	1176	-	ENSP00000471509	325 (aa)	-	M0R0X3
ENST00000610417	SAMD4B-213	3664	XM_017026921	ENSP00000484229	694 (aa)	XP_016882410	Q5PRF9
ENST00000595476	SAMD4B-203	710	-	-	- (aa)	-	-
ENST00000601613	SAMD4B-211	2690	-	-	- (aa)	-	-
ENST00000602243	SAMD4B-212	672	-	ENSP00000469404	75 (aa)	-	M0QXV2
ENST00000594204	SAMD4B-202	626	-	-	- (aa)	-	-
ENST00000599712	SAMD4B-209	925	-	ENSP00000469620	219 (aa)	-	M0QY61
ENST00000598605	SAMD4B-207	555	-	ENSP00000468891	94 (aa)	-	M0QX45
ENST00000596319	SAMD4B-205	604	-	-	- (aa)	-	-
ENST00000314471	SAMD4B-201	4519	XM_011527063	ENSP00000317224	694 (aa)	XP_011525365	Q5PRF9
ENST00000598913	SAMD4B-208	2877	XM_011527064	ENSP00000470237	692 (aa)	XP_011525366	M0QZ22
ENST00000600018	SAMD4B-210	144	-	ENSP00000470821	48 (aa)	-	M0QZW7
ENST00000596271	SAMD4B-204	578	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000179134	Motor Activity	6E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000179134	rs562638	19	39359149	G	Obesity-related traits	23251661	[NR] min/d increase	0.02	EFO_0003940
ENSG00000179134	rs140996761	19	39383218	G	Interleukin-16 levels	27989323	[0.17-0.43] SD units increase	0.2986	EFO_0008173

Protein-Protein Interaction (PPI)

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	21873635.	IBA	Process
GO:0000932	P-body	21873635.	IBA	Component
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0017148	negative regulation of translation	21873635.	IBA	Process
GO:0030371	translation repressor activity	21873635.	IBA	Function
GO:0043488	regulation of mRNA stability	21873635.	IBA	Process