EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000179271 (Gene tree)
Gene ID: 90480
Gene Symbol: GADD45GIP1
Alias: PLINP-1|MGC4667|MGC4758|CKBBP2|PRG6|Plinp1|CRIF1|CKbetaBP2
Full Name: GADD45G interacting protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 4,136 bases
Position: chr19:12,953,119-12,957,254
Accession: 29996
RBP type: non-canonical RBP
Summary: This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000316939	GADD45GIP1-201	1782	-	ENSP00000323065	222 (aa)	-	Q8TAE8

Gene Model

Click here to download ENSG00000179271's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000179271's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	12716909.18200042.25416956.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005840	ribosome	-	IEA	Component
GO:0016032	viral process	-	IEA	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process
GO:0071850	mitotic cell cycle arrest	24520316.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17804717	NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor.	Cancer Res	2007 Sep 1	Nakayama K	-
25997448	Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells.	Oncol Rep	2015 Jul	Vahedi S	doi: 10.3892/or.2015.3990
24103312	Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer.	Mol Cell Endocrinol	2014 Jan 25	Tan JA	doi: 10.1016/j.mce.2013.09.036
17885209	CR6-interacting factor 1 represses the transactivation of androgen receptor by direct interaction.	Mol Endocrinol	2008 Jan	Suh JH	-
28235567	CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines.	Biochim Biophys Acta Gene Regul Mech	2017 Apr	Yan HX	doi: 10.1016/j.bbagrm.2017.02.006

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr19	12954510	Missense_Mutation	novel	E123Q	0.12
BLCA	chr19	12956885	Missense_Mutation	novel	E110K	0.33
BLCA	chr19	12954505	Silent	novel	C124C	0.32
BLCA	chr19	12954402	Missense_Mutation	novel	E159K	0.12
BRCA	chr19	12954274	Silent	NA	A201A	0.09
BRCA	chr19	12954165	3'UTR	novel		0.39
CESC	chr19	12953577	3'UTR	novel		0.45
CESC	chr19	12954159	3'UTR	novel		0.09
CESC	chr19	12953474	3'UTR	novel		0.26
COAD	chr19	12954433	Silent	novel	A148A	0.36
COAD	chr19	12957166	Missense_Mutation	novel	A16V	0.15
COAD	chr19	12954291	Frame_Shift_Del	rs752340689	*K196Tfs43**	0.49
ESCA	chr19	12954322	Silent	rs746106552	K185K	0.38
GBM	chr19	12954393	Frame_Shift_Del	novel	*Q161Afs77**	0.09
HNSC	chr19	12956992	Missense_Mutation	rs373898905	S74L	0.41
HNSC	chr19	12954167	3'UTR	novel		0.21
HNSC	chr19	12954330	Missense_Mutation	novel	E183K	0.06
HNSC	chr19	12954330	Missense_Mutation	novel	E183Q	0.11
KIRP	chr19	12954186	3'UTR	novel		0.47
KIRP	chr19	12954284	Missense_Mutation	novel	K198T	0.09
LGG	chr19	12954356	Missense_Mutation	rs763367169	R174H	0.36
LUAD	chr19	12954413	Missense_Mutation	novel	R155L	0.21
LUSC	chr19	12957009	Silent	novel	S68S	1
OV	chr19	12954388	Silent	NA	L163L	0.17
OV	chr19	12954157	3'UTR	novel		0.11
PRAD	chr19	12954398	Missense_Mutation	novel	A160V	0.41
READ	chr19	12953119	3'UTR	rs533190392		0.46
SKCM	chr19	12954525	Missense_Mutation	NA	E118K	0.23
STAD	chr19	12954272	Missense_Mutation	rs371504821	R202Q	0.3
THYM	chr19	12954321	Nonsense_Mutation	novel	E186*	0.24
UCEC	chr19	12954317	Missense_Mutation	rs779779033	R187H	0.48
UCEC	chr19	12953353	3'UTR	rs556006629		0.16
UCEC	chr19	12953321	3'UTR	novel		0.34
UCEC	chr19	12953433	3'UTR	novel		0.41
UCEC	chr19	12953136	3'UTR	novel		0.75
UCEC	chr19	12953400	3'UTR	rs537667466		0.34
UCEC	chr19	12953400	3'UTR	novel		0.19
UCEC	chr19	12954312	Missense_Mutation	rs755977311	R189C	0.46
UCEC	chr19	12954311	Missense_Mutation	rs147251319	R189H	0.45
UCEC	chr19	12954235	Silent	novel	P214P	0.55
UCEC	chr19	12953248	3'UTR	novel		1
UCEC	chr19	12954356	Missense_Mutation	rs763367169	R174H	0.4
UCEC	chr19	12953383	3'UTR	novel		0.29
UCEC	chr19	12954292	Missense_Mutation	novel	Q195H	0.4
UCEC	chr19	12953325	3'UTR	novel		0.44
UCEC	chr19	12956912	Missense_Mutation	novel	E101K	0.3
UCEC	chr19	12957029	Missense_Mutation	novel	A62T	0.3
UCEC	chr19	12953400	3'UTR	novel		0.33
UCEC	chr19	12953400	3'UTR	rs537667466		0.92
UCEC	chr19	12953400	3'UTR	rs537667466		0.44
UCEC	chr19	12953390	3'UTR	novel		0.53
UCEC	chr19	12953568	3'UTR	novel		0.22
UCEC	chr19	12954318	Missense_Mutation	rs753799047	R187C	0.32
UCS	chr19	12954465	Nonsense_Mutation	novel	Q138*	0.04

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1085	0.10492
READ	DEL	0.0848	0.23023
THCA	DEL	0.014	0.10598

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0014	Kaplan-Meier Survival Analysis
MESO	0.035	Kaplan-Meier Survival Analysis
ACC	0.0031	Kaplan-Meier Survival Analysis
SKCM	0.019	Kaplan-Meier Survival Analysis
LUSC	0.013	Kaplan-Meier Survival Analysis
LAML	0.036	Kaplan-Meier Survival Analysis
GBM	0.047	Kaplan-Meier Survival Analysis
CHOL	0.046	Kaplan-Meier Survival Analysis
UVM	0.0095	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742