EuRBPDB

Description

Ensembl ID: ENSG00000179335 (Gene tree)
Gene ID: 1198
Gene Symbol: CLK3
Alias: clk3
Full Name: CDC like kinase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 46,943 bases
Position: chr15:74,598,476-74,645,418
Accession: 2071
RBP type: non-canonical RBP
Summary: This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000570296	CLK3-227	916	-	-	- (aa)	-	-
ENST00000567805	CLK3-219	327	-	-	- (aa)	-	-
ENST00000569063	CLK3-225	833	-	ENSP00000456278	173 (aa)	-	H3BRK0
ENST00000561673	CLK3-205	639	-	-	- (aa)	-	-
ENST00000563112	CLK3-210	665	-	-	- (aa)	-	-
ENST00000568232	CLK3-222	958	-	-	- (aa)	-	-
ENST00000483723	CLK3-204	1749	-	ENSP00000431825	152 (aa)	-	P49761
ENST00000562626	CLK3-208	812	-	-	- (aa)	-	-
ENST00000562078	CLK3-206	2455	-	-	- (aa)	-	-
ENST00000568488	CLK3-223	481	-	ENSP00000457936	160 (aa)	-	H3BV35
ENST00000564468	CLK3-216	929	-	ENSP00000454785	59 (aa)	-	H3BNC8
ENST00000566126	CLK3-217	732	-	ENSP00000457696	224 (aa)	-	H3BUL5
ENST00000568605	CLK3-224	1047	-	-	- (aa)	-	-
ENST00000567992	CLK3-220	603	-	-	- (aa)	-	-
ENST00000563418	CLK3-212	10498	-	ENSP00000456431	70 (aa)	-	H3BRW2
ENST00000562389	CLK3-207	572	-	ENSP00000456399	117 (aa)	-	H3BRT8
ENST00000569406	CLK3-226	3591	-	-	- (aa)	-	-
ENST00000395066	CLK3-202	2621	XM_005254151	ENSP00000378505	638 (aa)	XP_005254208	P49761
ENST00000566926	CLK3-218	646	-	ENSP00000454961	193 (aa)	-	H3BNQ5
ENST00000563297	CLK3-211	526	-	ENSP00000457362	19 (aa)	-	H3BTW9
ENST00000454830	CLK3-203	3787	-	-	- (aa)	-	-
ENST00000563842	CLK3-213	860	-	ENSP00000456202	190 (aa)	-	H3BRE4
ENST00000564096	CLK3-214	805	-	ENSP00000458099	239 (aa)	-	H3BVF8
ENST00000345005	CLK3-201	1846	XM_017021908	ENSP00000344112	490 (aa)	XP_016877397	P49761
ENST00000568139	CLK3-221	918	-	ENSP00000455762	306 (aa)	-	H3BQG1
ENST00000562670	CLK3-209	544	-	ENSP00000455905	145 (aa)	-	H3BQR7
ENST00000564353	CLK3-215	2847	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000179335	Transferrin	6.486e-005	-
ENSG00000179335	Cleft Lip	6E-11	28232668
ENSG00000179335	Cleft Palate	6E-11	28232668
ENSG00000179335	Urinary Bladder Neoplasms	4E-9	25281661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000179335	rs11543198	15	74619987	G	Bladder cancer	25281661	[1.26-1.59]	1.41	EFO_0000292
ENSG00000179335	rs6495117	15	74607159	A	Nonsyndromic cleft lip with cleft palate	28232668	[NR]	1.2048193	HP_0000175\|EFO_0003959
ENSG00000179335	rs56298217	15	74622308	?	Lung function (FVC)	30595370			EFO_0004312

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001669	acrosomal vesicle	-	IEA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004674	protein serine/threonine kinase activity	-	ISS	Function
GO:0004712	protein serine/threonine/tyrosine kinase activity	-	IEA	Function
GO:0004713	protein tyrosine kinase activity	-	IEA	Function
GO:0005515	protein binding	16189514.21044950.21516116.23455924.23602568.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	9637771.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006468	protein phosphorylation	9637771.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0018108	peptidyl-tyrosine phosphorylation	-	IEA	Process
GO:0042802	identical protein binding	25416956.	IPI	Function
GO:0043484	regulation of RNA splicing	9637771.	IDA	Process
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0046777	protein autophosphorylation	-	IEA	Process